FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5363, 154 aa 1>>>pF1KB5363 154 - 154 aa - 154 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9023+/-0.000264; mu= 6.3857+/- 0.017 mean_var=126.5075+/-25.638, 0's: 0 Z-trim(123.7): 123 B-trim: 2209 in 2/54 Lambda= 0.114029 statistics sampled from 43952 (44097) to 43952 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.838), E-opt: 0.2 (0.517), width: 16 Scan time: 5.940 The best scores are: opt bits E(85289) NP_055187 (OMIM: 612598) RING finger protein 11 [H ( 154) 1097 190.0 1.3e-48 NP_898864 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 207 44.1 0.00049 NP_898865 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 207 44.1 0.00049 XP_005266542 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 207 44.1 0.00049 XP_011533479 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 207 44.1 0.00049 NP_005968 (OMIM: 133239,604242) E3 ubiquitin-prote ( 685) 207 44.1 0.00049 XP_005266543 (OMIM: 133239,604242) PREDICTED: E3 u ( 685) 207 44.1 0.00049 XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 200 42.7 0.00072 XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 200 42.7 0.00072 XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 200 42.8 0.00076 XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 200 42.8 0.00076 XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 200 42.8 0.00076 XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 200 42.8 0.00076 XP_016869783 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 444) 200 42.8 0.00077 NP_919310 (OMIM: 612488) E3 ubiquitin-protein liga ( 465) 200 42.8 0.0008 XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 195 41.7 0.00081 NP_073618 (OMIM: 612488) E3 ubiquitin-protein liga ( 515) 200 42.8 0.00087 NP_001257458 (OMIM: 605840) E3 ubiquitin-protein l ( 985) 200 43.0 0.0015 XP_016877832 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 985) 200 43.0 0.0015 XP_016877831 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 986) 200 43.0 0.0015 NP_060080 (OMIM: 605840) E3 ubiquitin-protein liga ( 986) 200 43.0 0.0015 XP_016877829 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 993) 200 43.0 0.0015 XP_016877830 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 993) 200 43.0 0.0015 XP_016877828 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 994) 200 43.0 0.0015 XP_016877827 (OMIM: 605840) PREDICTED: E3 ubiquiti ( 994) 200 43.0 0.0015 NP_001257459 (OMIM: 605840) E3 ubiquitin-protein l ( 994) 200 43.0 0.0015 NP_001257457 (OMIM: 605840) E3 ubiquitin-protein l ( 995) 200 43.0 0.0015 XP_016877826 (OMIM: 605840) PREDICTED: E3 ubiquiti (1002) 200 43.0 0.0015 XP_006720642 (OMIM: 605840) PREDICTED: E3 ubiquiti (1003) 200 43.0 0.0015 NP_001317260 (OMIM: 605840) E3 ubiquitin-protein l (1003) 200 43.0 0.0015 XP_016877825 (OMIM: 605840) PREDICTED: E3 ubiquiti (1009) 200 43.0 0.0015 XP_011520001 (OMIM: 605840) PREDICTED: E3 ubiquiti (1014) 200 43.0 0.0015 XP_006720638 (OMIM: 605840) PREDICTED: E3 ubiquiti (1026) 200 43.0 0.0015 XP_011519999 (OMIM: 605840) PREDICTED: E3 ubiquiti (1030) 200 43.0 0.0015 XP_011519998 (OMIM: 605840) PREDICTED: E3 ubiquiti (1031) 200 43.0 0.0015 XP_011519996 (OMIM: 605840) PREDICTED: E3 ubiquiti (1039) 200 43.0 0.0015 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 186 40.4 0.0029 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 186 40.4 0.0029 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 186 40.4 0.0029 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 186 40.4 0.0029 XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193) 182 39.6 0.0031 NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 186 40.4 0.0032 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 186 40.4 0.0032 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 186 40.4 0.0032 >>NP_055187 (OMIM: 612598) RING finger protein 11 [Homo (154 aa) initn: 1097 init1: 1097 opt: 1097 Z-score: 993.9 bits: 190.0 E(85289): 1.3e-48 Smith-Waterman score: 1097; 100.0% identity (100.0% similar) in 154 aa overlap (1-154:1-154) 10 20 30 40 50 60 pF1KB5 MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 QLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHI 70 80 90 100 110 120 130 140 150 pF1KB5 YHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN :::::::::::::::::::::::::::::::::: NP_055 YHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN 130 140 150 >>NP_898864 (OMIM: 133239,604242) E3 ubiquitin-protein l (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: NP_898 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: NP_898 WLSENCTCPICRQPVLGSNIANNG 670 680 >>NP_898865 (OMIM: 133239,604242) E3 ubiquitin-protein l (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: NP_898 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: NP_898 WLSENCTCPICRQPVLGSNIANNG 670 680 >>XP_005266542 (OMIM: 133239,604242) PREDICTED: E3 ubiqu (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: XP_005 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: XP_005 WLSENCTCPICRQPVLGSNIANNG 670 680 >>XP_011533479 (OMIM: 133239,604242) PREDICTED: E3 ubiqu (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: XP_011 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: XP_011 WLSENCTCPICRQPVLGSNIANNG 670 680 >>NP_005968 (OMIM: 133239,604242) E3 ubiquitin-protein l (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: NP_005 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: NP_005 WLSENCTCPICRQPVLGSNIANNG 670 680 >>XP_005266543 (OMIM: 133239,604242) PREDICTED: E3 ubiqu (685 aa) initn: 207 init1: 207 opt: 207 Z-score: 193.4 bits: 44.1 E(85289): 0.00049 Smith-Waterman score: 207; 51.1% identity (73.3% similar) in 45 aa overlap (99-143:632-676) 70 80 90 100 110 120 pF1KB5 RIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDD : .:. :.: :. .: ::::: .:. ::: XP_005 RIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVCISDYVTGNKLRQLPCMHEFHIHCIDR 610 620 630 640 650 660 130 140 150 pF1KB5 WLMRSFTCPSCMEPVDAALLSSYETN :: .. ::: : .:: XP_005 WLSENCTCPICRQPVLGSNIANNG 670 680 >>XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 225 init1: 171 opt: 200 Z-score: 190.5 bits: 42.7 E(85289): 0.00072 Smith-Waterman score: 219; 33.9% identity (54.3% similar) in 127 aa overlap (36-139:267-390) 10 20 30 40 50 pF1KB5 KSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQV--------PVP-VYHPTPSQT :::::. .. ::: . :: : XP_016 HQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFS-F 240 250 260 270 280 290 60 70 80 90 100 pF1KB5 RLATQLTEEEQ----IRIAQRIGL----------IQHLPKGVYDPGRDGSEKKIRECVIC .: .. : :. . .:.:.: :..::. ..:. ::. . ::.: XP_016 ELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTL--CVVC 300 310 320 330 340 350 110 120 130 140 150 pF1KB5 MMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN : :: . .: ::: : .: :.: :: . ::: : XP_016 MCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE 360 370 380 390 400 >>XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (402 aa) initn: 225 init1: 171 opt: 200 Z-score: 190.5 bits: 42.7 E(85289): 0.00072 Smith-Waterman score: 219; 33.9% identity (54.3% similar) in 127 aa overlap (36-139:267-390) 10 20 30 40 50 pF1KB5 KSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQV--------PVP-VYHPTPSQT :::::. .. ::: . :: : XP_016 HQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFS-F 240 250 260 270 280 290 60 70 80 90 100 pF1KB5 RLATQLTEEEQ----IRIAQRIGL----------IQHLPKGVYDPGRDGSEKKIRECVIC .: .. : :. . .:.:.: :..::. ..:. ::. . ::.: XP_016 ELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTL--CVVC 300 310 320 330 340 350 110 120 130 140 150 pF1KB5 MMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN : :: . .: ::: : .: :.: :: . ::: : XP_016 MCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE 360 370 380 390 400 >>XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquitin-pr (432 aa) initn: 225 init1: 171 opt: 200 Z-score: 190.0 bits: 42.8 E(85289): 0.00076 Smith-Waterman score: 219; 33.9% identity (54.3% similar) in 127 aa overlap (36-139:297-420) 10 20 30 40 50 pF1KB5 KSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQV--------PVP-VYHPTPSQT :::::. .. ::: . :: : XP_006 HQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFS-F 270 280 290 300 310 320 60 70 80 90 100 pF1KB5 RLATQLTEEEQ----IRIAQRIGL----------IQHLPKGVYDPGRDGSEKKIRECVIC .: .. : :. . .:.:.: :..::. ..:. ::. . ::.: XP_006 ELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTL--CVVC 330 340 350 360 370 380 110 120 130 140 150 pF1KB5 MMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN : :: . .: ::: : .: :.: :: . ::: : XP_006 MCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE 390 400 410 420 430 154 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:15:03 2016 done: Thu Nov 3 17:15:04 2016 Total Scan time: 5.940 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]