FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5378, 739 aa 1>>>pF1KB5378 739 - 739 aa - 739 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9269+/-0.000434; mu= 16.5866+/- 0.027 mean_var=73.1815+/-15.070, 0's: 0 Z-trim(111.0): 88 B-trim: 944 in 1/52 Lambda= 0.149925 statistics sampled from 19348 (19439) to 19348 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.228), width: 16 Scan time: 12.100 The best scores are: opt bits E(85289) NP_001240781 (OMIM: 607245,614066) AP-4 complex su ( 739) 4916 1073.3 0 NP_006585 (OMIM: 607245,614066) AP-4 complex subun ( 739) 4916 1073.3 0 XP_016855577 (OMIM: 607245,614066) PREDICTED: AP-4 ( 700) 4655 1016.8 0 NP_001240782 (OMIM: 607245,614066) AP-4 complex su ( 640) 4254 930.1 0 XP_011538826 (OMIM: 607245,614066) PREDICTED: AP-4 ( 664) 4178 913.6 0 XP_011538825 (OMIM: 607245,614066) PREDICTED: AP-4 ( 664) 4178 913.6 0 NP_001295241 (OMIM: 607245,614066) AP-4 complex su ( 571) 3556 779.1 0 XP_016855579 (OMIM: 607245,614066) PREDICTED: AP-4 ( 571) 3556 779.1 0 XP_011538827 (OMIM: 607245,614066) PREDICTED: AP-4 ( 646) 3556 779.1 0 XP_016855582 (OMIM: 607245,614066) PREDICTED: AP-4 ( 405) 2643 581.5 2.2e-165 XP_016855578 (OMIM: 607245,614066) PREDICTED: AP-4 ( 635) 2642 581.4 3.8e-165 XP_016855581 (OMIM: 607245,614066) PREDICTED: AP-4 ( 414) 2446 538.9 1.5e-152 XP_011538830 (OMIM: 607245,614066) PREDICTED: AP-4 ( 414) 2446 538.9 1.5e-152 XP_016855580 (OMIM: 607245,614066) PREDICTED: AP-4 ( 542) 1573 350.2 1.3e-95 XP_016879776 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 1026 231.9 7.2e-60 XP_005257998 (OMIM: 601025) PREDICTED: AP-2 comple ( 733) 1026 231.9 7.2e-60 XP_016879773 (OMIM: 601025) PREDICTED: AP-2 comple ( 937) 1026 231.9 9e-60 NP_001273 (OMIM: 601025) AP-2 complex subunit beta ( 937) 1026 231.9 9e-60 NP_001025177 (OMIM: 601025) AP-2 complex subunit b ( 951) 1026 231.9 9.1e-60 XP_005257995 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 1026 231.9 9.1e-60 XP_005257994 (OMIM: 601025) PREDICTED: AP-2 comple ( 951) 1026 231.9 9.1e-60 XP_011522753 (OMIM: 601025) PREDICTED: AP-2 comple ( 969) 1026 231.9 9.3e-60 XP_011522751 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 1026 231.9 9.4e-60 XP_011522752 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 1026 231.9 9.4e-60 XP_011522750 (OMIM: 601025) PREDICTED: AP-2 comple ( 983) 1026 231.9 9.4e-60 NP_001159491 (OMIM: 600157) AP-1 complex subunit b ( 919) 996 225.4 7.9e-58 NP_663782 (OMIM: 600157) AP-1 complex subunit beta ( 939) 996 225.4 8.1e-58 NP_001118 (OMIM: 600157) AP-1 complex subunit beta ( 949) 996 225.4 8.2e-58 XP_011522757 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 962 218.1 1.3e-55 XP_016879775 (OMIM: 601025) PREDICTED: AP-2 comple ( 880) 962 218.1 1.3e-55 XP_016879774 (OMIM: 601025) PREDICTED: AP-2 comple ( 894) 962 218.1 1.3e-55 XP_011522756 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 962 218.1 1.3e-55 XP_011522755 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 962 218.1 1.3e-55 XP_011522754 (OMIM: 601025) PREDICTED: AP-2 comple ( 926) 962 218.1 1.3e-55 NP_001265440 (OMIM: 602166) AP-3 complex subunit b (1050) 389 94.2 3e-18 XP_016878130 (OMIM: 602166) PREDICTED: AP-3 comple ( 629) 344 84.3 1.6e-15 XP_016878129 (OMIM: 602166) PREDICTED: AP-3 comple (1058) 344 84.4 2.6e-15 NP_004635 (OMIM: 602166) AP-3 complex subunit beta (1082) 344 84.4 2.6e-15 NP_001265441 (OMIM: 602166) AP-3 complex subunit b (1101) 344 84.4 2.6e-15 XP_005248676 (OMIM: 603401,608233) PREDICTED: AP-3 ( 871) 327 80.7 2.7e-14 XP_016865490 (OMIM: 603401,608233) PREDICTED: AP-3 (1004) 327 80.7 3.1e-14 NP_001258698 (OMIM: 603401,608233) AP-3 complex su (1045) 327 80.8 3.2e-14 XP_005248675 (OMIM: 603401,608233) PREDICTED: AP-3 (1053) 327 80.8 3.3e-14 NP_003655 (OMIM: 603401,608233) AP-3 complex subun (1094) 327 80.8 3.4e-14 NP_057212 (OMIM: 615525) coatomer subunit gamma-1 ( 874) 240 61.9 1.3e-08 NP_057535 (OMIM: 600959) coatomer subunit beta [Ho ( 953) 163 45.3 0.0014 NP_001137534 (OMIM: 600959) coatomer subunit beta ( 953) 163 45.3 0.0014 NP_001137533 (OMIM: 600959) coatomer subunit beta ( 953) 163 45.3 0.0014 >>NP_001240781 (OMIM: 607245,614066) AP-4 complex subuni (739 aa) initn: 4916 init1: 4916 opt: 4916 Z-score: 5743.0 bits: 1073.3 E(85289): 0 Smith-Waterman score: 4916; 99.9% identity (99.9% similar) in 739 aa overlap (1-739:1-739) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 670 680 690 700 710 720 730 pF1KB5 NSFISVLETVIGTIEEIKS ::::::::::::::::::: NP_001 NSFISVLETVIGTIEEIKS 730 >>NP_006585 (OMIM: 607245,614066) AP-4 complex subunit b (739 aa) initn: 4916 init1: 4916 opt: 4916 Z-score: 5743.0 bits: 1073.3 E(85289): 0 Smith-Waterman score: 4916; 99.9% identity (99.9% similar) in 739 aa overlap (1-739:1-739) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 670 680 690 700 710 720 730 pF1KB5 NSFISVLETVIGTIEEIKS ::::::::::::::::::: NP_006 NSFISVLETVIGTIEEIKS 730 >>XP_016855577 (OMIM: 607245,614066) PREDICTED: AP-4 com (700 aa) initn: 4655 init1: 4655 opt: 4655 Z-score: 5438.3 bits: 1016.8 E(85289): 0 Smith-Waterman score: 4655; 99.9% identity (99.9% similar) in 700 aa overlap (40-739:1-700) 10 20 30 40 50 60 pF1KB5 VKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVY :::::::::::::::::::::::::::::: XP_016 MTQGLDMSGVFMEMVKASATVDIVQKKLVY 10 20 30 70 80 90 100 110 120 pF1KB5 LYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQ 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 EGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSP 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 GVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 HFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIF 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 AIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEEN 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB5 IQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTASLRLFLSRPA :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: XP_016 IQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPA 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB5 ECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPA 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB5 ERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERV 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB5 QELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTI 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB5 AMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLET 640 650 660 670 680 690 730 pF1KB5 VIGTIEEIKS :::::::::: XP_016 VIGTIEEIKS 700 >>NP_001240782 (OMIM: 607245,614066) AP-4 complex subuni (640 aa) initn: 4254 init1: 4254 opt: 4254 Z-score: 4970.1 bits: 930.1 E(85289): 0 Smith-Waterman score: 4254; 99.8% identity (99.8% similar) in 640 aa overlap (100-739:1-640) 70 80 90 100 110 120 pF1KB5 LYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGL :::::::::::::::::::::::::::::: NP_001 MVRGLALRSMCSLRMPGVQEYIQQPILNGL 10 20 30 130 140 150 160 170 180 pF1KB5 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQ 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 EGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSP 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 GVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPG 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 HFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIF 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 AIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEEN 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 IQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTASLRLFLSRPA :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: NP_001 IQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPA 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB5 ECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLGLLEDPA 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB5 ERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPLIPEENKERV 460 470 480 490 500 510 610 620 630 640 650 660 pF1KB5 QELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMALQVVNIQTI 520 530 540 550 560 570 670 680 690 700 710 720 pF1KB5 AMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETLNSFISVLET 580 590 600 610 620 630 730 pF1KB5 VIGTIEEIKS :::::::::: NP_001 VIGTIEEIKS 640 >>XP_011538826 (OMIM: 607245,614066) PREDICTED: AP-4 com (664 aa) initn: 4172 init1: 4172 opt: 4178 Z-score: 4881.0 bits: 913.6 E(85289): 0 Smith-Waterman score: 4256; 89.7% identity (89.7% similar) in 739 aa overlap (1-739:1-664) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::: XP_011 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIR---------------------- 10 20 30 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY ::::::: XP_011 -----------------------------------------------------MPGVQEY 40 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 170 180 190 200 210 220 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 230 240 250 260 270 280 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 290 300 310 320 330 340 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 350 360 370 380 390 400 490 500 510 520 530 540 pF1KB5 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 410 420 430 440 450 460 550 560 570 580 590 600 pF1KB5 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 470 480 490 500 510 520 610 620 630 640 650 660 pF1KB5 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 530 540 550 560 570 580 670 680 690 700 710 720 pF1KB5 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 590 600 610 620 630 640 730 pF1KB5 NSFISVLETVIGTIEEIKS ::::::::::::::::::: XP_011 NSFISVLETVIGTIEEIKS 650 660 >>XP_011538825 (OMIM: 607245,614066) PREDICTED: AP-4 com (664 aa) initn: 4172 init1: 4172 opt: 4178 Z-score: 4881.0 bits: 913.6 E(85289): 0 Smith-Waterman score: 4256; 89.7% identity (89.7% similar) in 739 aa overlap (1-739:1-664) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::: XP_011 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIR---------------------- 10 20 30 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY ::::::: XP_011 -----------------------------------------------------MPGVQEY 40 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 50 60 70 80 90 100 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 110 120 130 140 150 160 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 170 180 190 200 210 220 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 230 240 250 260 270 280 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 290 300 310 320 330 340 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 350 360 370 380 390 400 490 500 510 520 530 540 pF1KB5 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 410 420 430 440 450 460 550 560 570 580 590 600 pF1KB5 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 470 480 490 500 510 520 610 620 630 640 650 660 pF1KB5 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 530 540 550 560 570 580 670 680 690 700 710 720 pF1KB5 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 590 600 610 620 630 640 730 pF1KB5 NSFISVLETVIGTIEEIKS ::::::::::::::::::: XP_011 NSFISVLETVIGTIEEIKS 650 660 >>NP_001295241 (OMIM: 607245,614066) AP-4 complex subuni (571 aa) initn: 3556 init1: 3556 opt: 3556 Z-score: 4155.0 bits: 779.1 E(85289): 0 Smith-Waterman score: 3556; 99.8% identity (99.8% similar) in 534 aa overlap (206-739:38-571) 180 190 200 210 220 230 pF1KB5 VVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFD :::::::::::::::::::::::::::::: NP_001 DVVKELKKALCNPHIQADRLRYRNVIQRVIRMSKLDQWGQAEVLNFLLRYQPRSEEELFD 10 20 30 40 50 60 240 250 260 270 280 290 pF1KB5 ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFV 70 80 90 100 110 120 300 310 320 330 340 350 pF1KB5 ALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGY 130 140 150 160 170 180 360 370 380 390 400 410 pF1KB5 CTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC 190 200 210 220 230 240 420 430 440 450 460 470 pF1KB5 TEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKME 250 260 270 280 290 300 480 490 500 510 520 530 pF1KB5 LLTASLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCS :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCS 310 320 330 340 350 360 540 550 560 570 580 590 pF1KB5 PKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFA 370 380 390 400 410 420 600 610 620 630 640 650 pF1KB5 ASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPD 430 440 450 460 470 480 660 670 680 690 700 710 pF1KB5 TLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEA 490 500 510 520 530 540 720 730 pF1KB5 RTETLNSFISVLETVIGTIEEIKS :::::::::::::::::::::::: NP_001 RTETLNSFISVLETVIGTIEEIKS 550 560 570 >-- initn: 246 init1: 246 opt: 246 Z-score: 285.7 bits: 63.1 E(85289): 3.5e-09 Smith-Waterman score: 246; 100.0% identity (100.0% similar) in 37 aa overlap (1-37:1-37) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV ::::::::::::::::::::::::::::::::::::: NP_001 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRMSKLDQWGQAEVLNFLLRYQPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY NP_001 SEEELFDILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSE 70 80 90 100 110 120 >>XP_016855579 (OMIM: 607245,614066) PREDICTED: AP-4 com (571 aa) initn: 3556 init1: 3556 opt: 3556 Z-score: 4155.0 bits: 779.1 E(85289): 0 Smith-Waterman score: 3556; 99.8% identity (99.8% similar) in 534 aa overlap (206-739:38-571) 180 190 200 210 220 230 pF1KB5 VVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFD :::::::::::::::::::::::::::::: XP_016 DVVKELKKALCNPHIQADRLRYRNVIQRVIRMSKLDQWGQAEVLNFLLRYQPRSEEELFD 10 20 30 40 50 60 240 250 260 270 280 290 pF1KB5 ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFV 70 80 90 100 110 120 300 310 320 330 340 350 pF1KB5 ALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGY 130 140 150 160 170 180 360 370 380 390 400 410 pF1KB5 CTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTDVSADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC 190 200 210 220 230 240 420 430 440 450 460 470 pF1KB5 TEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKME 250 260 270 280 290 300 480 490 500 510 520 530 pF1KB5 LLTASLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCS :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCS 310 320 330 340 350 360 540 550 560 570 580 590 pF1KB5 PKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PKSDPTLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFA 370 380 390 400 410 420 600 610 620 630 640 650 pF1KB5 ASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPD 430 440 450 460 470 480 660 670 680 690 700 710 pF1KB5 TLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLQMALQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEA 490 500 510 520 530 540 720 730 pF1KB5 RTETLNSFISVLETVIGTIEEIKS :::::::::::::::::::::::: XP_016 RTETLNSFISVLETVIGTIEEIKS 550 560 570 >-- initn: 246 init1: 246 opt: 246 Z-score: 285.7 bits: 63.1 E(85289): 3.5e-09 Smith-Waterman score: 246; 100.0% identity (100.0% similar) in 37 aa overlap (1-37:1-37) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV ::::::::::::::::::::::::::::::::::::: XP_016 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRMSKLDQWGQAEVLNFLLRYQPR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY XP_016 SEEELFDILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSE 70 80 90 100 110 120 >>XP_011538827 (OMIM: 607245,614066) PREDICTED: AP-4 com (646 aa) initn: 3556 init1: 3556 opt: 3556 Z-score: 4154.1 bits: 779.1 E(85289): 0 Smith-Waterman score: 4106; 87.3% identity (87.3% similar) in 739 aa overlap (1-739:1-646) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRM------ 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL XP_011 ------------------------------------------------------------ 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL ::::::::::::::::::::::::::::::::: XP_011 ---------------------------SKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 120 130 140 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 150 160 170 180 190 200 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 210 220 230 240 250 260 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 270 280 290 300 310 320 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 330 340 350 360 370 380 490 500 510 520 530 540 pF1KB5 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 390 400 410 420 430 440 550 560 570 580 590 600 pF1KB5 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 450 460 470 480 490 500 610 620 630 640 650 660 pF1KB5 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 510 520 530 540 550 560 670 680 690 700 710 720 pF1KB5 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 570 580 590 600 610 620 730 pF1KB5 NSFISVLETVIGTIEEIKS ::::::::::::::::::: XP_011 NSFISVLETVIGTIEEIKS 630 640 >>XP_016855582 (OMIM: 607245,614066) PREDICTED: AP-4 com (405 aa) initn: 2643 init1: 2643 opt: 2643 Z-score: 3090.1 bits: 581.5 E(85289): 2.2e-165 Smith-Waterman score: 2643; 99.5% identity (99.8% similar) in 401 aa overlap (1-401:1-401) 10 20 30 40 50 60 pF1KB5 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC ::::::::::::::::::::::::::::::::::::::: . XP_016 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTEIQPES 370 380 390 400 430 440 450 460 470 480 pF1KB5 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAS 739 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 22:30:05 2016 done: Thu Nov 3 22:30:07 2016 Total Scan time: 12.100 Total Display time: 0.200 Function used was FASTA [36.3.4 Apr, 2011]