FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5389, 479 aa 1>>>pF1KB5389 479 - 479 aa - 479 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0868+/-0.00101; mu= 13.9234+/- 0.061 mean_var=73.8669+/-14.221, 0's: 0 Z-trim(104.7): 74 B-trim: 65 in 2/49 Lambda= 0.149228 statistics sampled from 7984 (8060) to 7984 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.248), width: 16 Scan time: 3.030 The best scores are: opt bits E(32554) CCDS10888.1 DDX19B gene_id:11269|Hs108|chr16 ( 479) 3108 678.7 3.7e-195 CCDS10889.1 DDX19A gene_id:55308|Hs108|chr16 ( 478) 3012 658.0 6.1e-189 CCDS42187.1 DDX19B gene_id:11269|Hs108|chr16 ( 370) 2430 532.7 2.5e-151 CCDS32475.1 DDX19B gene_id:11269|Hs108|chr16 ( 448) 2289 502.4 4.2e-142 CCDS58478.1 DDX19B gene_id:11269|Hs108|chr16 ( 453) 2289 502.4 4.2e-142 CCDS82009.1 DDX19A gene_id:55308|Hs108|chr16 ( 447) 2271 498.5 6.1e-141 CCDS44766.1 DDX25 gene_id:29118|Hs108|chr11 ( 483) 2074 456.1 3.8e-128 CCDS81646.1 DDX25 gene_id:29118|Hs108|chr11 ( 369) 1797 396.4 2.7e-110 CCDS3282.1 EIF4A2 gene_id:1974|Hs108|chr3 ( 407) 923 208.3 1.3e-53 CCDS11113.1 EIF4A1 gene_id:1973|Hs108|chr17 ( 406) 915 206.5 4.2e-53 CCDS11767.1 EIF4A3 gene_id:9775|Hs108|chr17 ( 411) 865 195.8 7.5e-50 CCDS4697.1 DDX39B gene_id:7919|Hs108|chr6 ( 428) 724 165.4 1.1e-40 CCDS44751.1 DDX6 gene_id:1656|Hs108|chr11 ( 483) 719 164.4 2.5e-40 CCDS12308.1 DDX39A gene_id:10212|Hs108|chr19 ( 427) 716 163.7 3.5e-40 CCDS58511.1 EIF4A1 gene_id:1973|Hs108|chr17 ( 347) 686 157.2 2.6e-38 CCDS842.1 DDX20 gene_id:11218|Hs108|chr1 ( 824) 679 155.8 1.6e-37 CCDS8655.1 DDX47 gene_id:51202|Hs108|chr12 ( 455) 588 136.2 7.3e-32 CCDS32704.1 DDX42 gene_id:11325|Hs108|chr17 ( 938) 550 128.1 4.1e-29 CCDS13416.1 DDX27 gene_id:55661|Hs108|chr20 ( 796) 545 127.0 7.5e-29 CCDS12390.1 DDX49 gene_id:54555|Hs108|chr19 ( 483) 527 123.0 6.9e-28 CCDS11323.1 DDX52 gene_id:11056|Hs108|chr17 ( 599) 513 120.0 6.8e-27 CCDS30964.1 DDX59 gene_id:83479|Hs108|chr1 ( 619) 505 118.3 2.3e-26 CCDS31907.1 DDX54 gene_id:79039|Hs108|chr12 ( 881) 493 115.8 1.9e-25 CCDS44984.1 DDX54 gene_id:79039|Hs108|chr12 ( 882) 493 115.8 1.9e-25 CCDS4977.1 DDX43 gene_id:55510|Hs108|chr6 ( 648) 490 115.1 2.3e-25 CCDS33646.1 DDX17 gene_id:10521|Hs108|chr22 ( 729) 485 114.0 5.3e-25 CCDS46706.1 DDX17 gene_id:10521|Hs108|chr22 ( 731) 485 114.0 5.3e-25 CCDS82190.1 DDX5 gene_id:1655|Hs108|chr17 ( 614) 472 111.2 3.2e-24 CCDS11659.1 DDX5 gene_id:1655|Hs108|chr17 ( 614) 472 111.2 3.2e-24 CCDS34240.1 DDX46 gene_id:9879|Hs108|chr5 (1031) 471 111.1 5.9e-24 CCDS75306.1 DDX46 gene_id:9879|Hs108|chr5 (1032) 471 111.1 5.9e-24 CCDS35214.1 DDX53 gene_id:168400|Hs108|chrX ( 631) 453 107.1 5.5e-23 CCDS14782.1 DDX3Y gene_id:8653|Hs108|chrY ( 660) 435 103.3 8.5e-22 CCDS8342.1 DDX10 gene_id:1662|Hs108|chr11 ( 875) 430 102.2 2.3e-21 CCDS2120.1 DDX18 gene_id:8886|Hs108|chr2 ( 670) 425 101.1 3.8e-21 CCDS55404.1 DDX3X gene_id:1654|Hs108|chrX ( 646) 423 100.7 5e-21 CCDS43931.1 DDX3X gene_id:1654|Hs108|chrX ( 662) 423 100.7 5.1e-21 CCDS73144.1 DDX21 gene_id:9188|Hs108|chr10 ( 715) 401 96.0 1.5e-19 CCDS31211.1 DDX21 gene_id:9188|Hs108|chr10 ( 783) 401 96.0 1.6e-19 CCDS54855.1 DDX4 gene_id:54514|Hs108|chr5 ( 575) 386 92.7 1.1e-18 CCDS47208.1 DDX4 gene_id:54514|Hs108|chr5 ( 690) 386 92.7 1.3e-18 CCDS54854.1 DDX4 gene_id:54514|Hs108|chr5 ( 704) 386 92.7 1.3e-18 CCDS3969.1 DDX4 gene_id:54514|Hs108|chr5 ( 724) 386 92.7 1.4e-18 CCDS4427.1 DDX41 gene_id:51428|Hs108|chr5 ( 622) 378 91.0 4e-18 CCDS7283.1 DDX50 gene_id:79009|Hs108|chr10 ( 737) 373 89.9 9.7e-18 CCDS8656.1 DDX47 gene_id:51202|Hs108|chr12 ( 406) 341 83.0 6.7e-16 CCDS59053.1 DDX56 gene_id:54606|Hs108|chr7 ( 507) 302 74.6 2.8e-13 CCDS8770.1 DDX23 gene_id:9416|Hs108|chr12 ( 820) 296 73.4 1.1e-12 CCDS9251.1 DDX55 gene_id:57696|Hs108|chr12 ( 600) 268 67.3 5.2e-11 >>CCDS10888.1 DDX19B gene_id:11269|Hs108|chr16 (479 aa) initn: 3108 init1: 3108 opt: 3108 Z-score: 3617.2 bits: 678.7 E(32554): 3.7e-195 Smith-Waterman score: 3108; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KB5 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 NALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 NALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN 430 440 450 460 470 >>CCDS10889.1 DDX19A gene_id:55308|Hs108|chr16 (478 aa) initn: 2835 init1: 2835 opt: 3012 Z-score: 3505.5 bits: 658.0 E(32554): 6.1e-189 Smith-Waterman score: 3012; 96.0% identity (99.6% similar) in 479 aa overlap (1-479:1-478) 10 20 30 40 50 60 pF1KB5 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS ::::::::::::::::..:..::..::::.: :::: ..::...:::::::::::::::: CCDS10 MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNG-IIKTSTTAEKTDEEEKEDRAAQS 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 NALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK ::::.:::::::::::::::::::::::::::::.:::...::::::::::::::::::: CCDS10 NALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPSDRYPQCLCLSPTYELALQTGK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN 360 370 380 390 400 410 430 440 450 460 470 pF1KB5 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS10 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN 420 430 440 450 460 470 >>CCDS42187.1 DDX19B gene_id:11269|Hs108|chr16 (370 aa) initn: 2430 init1: 2430 opt: 2430 Z-score: 2830.2 bits: 532.7 E(32554): 2.5e-151 Smith-Waterman score: 2430; 100.0% identity (100.0% similar) in 370 aa overlap (110-479:1-370) 80 90 100 110 120 130 pF1KB5 LQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQ :::::::::::::::::::::::::::::: CCDS42 MGFNRPSKIQENALPLMLAEPPQNLIAQSQ 10 20 30 140 150 160 170 180 190 pF1KB5 SGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 SGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB5 GNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 GNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIR 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB5 IQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 IQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDE 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB5 KFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 KFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERF 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB5 REGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS42 REGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLA 280 290 300 310 320 330 440 450 460 470 pF1KB5 VNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN :::::::::::::::::::::::::::::::::::::::: CCDS42 VNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN 340 350 360 370 >>CCDS32475.1 DDX19B gene_id:11269|Hs108|chr16 (448 aa) initn: 2289 init1: 2289 opt: 2289 Z-score: 2664.8 bits: 502.4 E(32554): 4.2e-142 Smith-Waterman score: 2829; 93.5% identity (93.5% similar) in 479 aa overlap (1-479:1-448) 10 20 30 40 50 60 pF1KB5 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE ::::::::::::::::::::::::::::::::::::::: CCDS32 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRL--------------------- 70 80 90 130 140 150 160 170 180 pF1KB5 NALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 ----------PQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK 100 110 120 130 140 190 200 210 220 230 240 pF1KB5 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB5 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB5 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB5 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN 330 340 350 360 370 380 430 440 450 460 470 pF1KB5 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS32 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN 390 400 410 420 430 440 >>CCDS58478.1 DDX19B gene_id:11269|Hs108|chr16 (453 aa) initn: 2289 init1: 2289 opt: 2289 Z-score: 2664.7 bits: 502.4 E(32554): 4.2e-142 Smith-Waterman score: 2711; 93.3% identity (93.3% similar) in 460 aa overlap (20-479:25-453) 10 20 30 40 50 pF1KB5 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKED :::::::::::::::::::::::::::::::::::: CCDS58 MAGAAGRVQDRALRRFPITLPVGDLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKED 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 RAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRP :::::::::::::::::::::::::::::::::::::::::::: CCDS58 RAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRL---------------- 70 80 90 100 120 130 140 150 160 170 pF1KB5 SKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELA ::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ---------------PQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELA 110 120 130 140 180 190 200 210 220 230 pF1KB5 LQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK 150 160 170 180 190 200 240 250 260 270 280 290 pF1KB5 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB5 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK 270 280 290 300 310 320 360 370 380 390 400 410 pF1KB5 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD 330 340 350 360 370 380 420 430 440 450 460 470 pF1KB5 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE 390 400 410 420 430 440 pF1KB5 KIAN :::: CCDS58 KIAN 450 >>CCDS82009.1 DDX19A gene_id:55308|Hs108|chr16 (447 aa) initn: 2464 init1: 2271 opt: 2271 Z-score: 2643.8 bits: 498.5 E(32554): 6.1e-141 Smith-Waterman score: 2735; 89.8% identity (93.1% similar) in 479 aa overlap (1-479:1-447) 10 20 30 40 50 60 pF1KB5 MATDSWALAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNANAEKTDEEEKEDRAAQS ::::::::::::::::..:..::..::::.: :::: ..::...:::::::::::::::: CCDS82 MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNG-IIKTSTTAEKTDEEEKEDRAAQS 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE ::::::::::::::::::::::::::::::::::::::: CCDS82 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRL--------------------- 60 70 80 90 130 140 150 160 170 180 pF1KB5 NALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGK ::::::::::::::::::::::::.:::...::::::::::::::::::: CCDS82 ----------PQNLIAQSQSGTGKTAAFVLAMLSRVEPSDRYPQCLCLSPTYELALQTGK 100 110 120 130 140 190 200 210 220 230 240 pF1KB5 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 VIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFV 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB5 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKRE 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB5 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 EETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQV 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB5 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDN 330 340 350 360 370 380 430 440 450 460 470 pF1KB5 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN 390 400 410 420 430 440 >>CCDS44766.1 DDX25 gene_id:29118|Hs108|chr11 (483 aa) initn: 2096 init1: 1976 opt: 2074 Z-score: 2414.1 bits: 456.1 E(32554): 3.8e-128 Smith-Waterman score: 2074; 64.1% identity (86.7% similar) in 482 aa overlap (1-477:1-481) 10 20 30 40 50 pF1KB5 MATDSWA--LAVDEQEAAAESLSNLHLKEEKIKPDTNGAVVKTNA---NAEKTDEEEKED ::. :. .. :.: .::: .... . :: . .. : .. :::. : CCDS44 MASLLWGGDAGAAESERLNSHFSNLSQPRKNLWGIKSTAVRNIDGSINNINEDDEEDVVD 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 RAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRP ::.:::::::...::.....:::::.::.:::::::.::::::: .::.:.:::::::: CCDS44 LAANSLLNKLIHQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 SKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELA ::::: :::.:::.:::::::::::::::::::::::::.:. . .::::::.:::::: CCDS44 SKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 LQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK ::::.:.:::::: .... ::.:::.. :: :..::.::::::::::: :::.:: : CCDS44 LQTGRVVEQMGKFCVDVQVMYAIRGNRIPRGTDITKQIIIGTPGTVLDWCFKLKLIDLTK 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI :.::::::::::: ::: .:.:::::: :: .:::::::::::::::.::....:::::: CCDS44 IRVFVLDEADVMIDTQGFSDHSIRIQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK ::..:: ::..:.:::::: : .:.:::::.::.:::.::.:::.::..:.::..:. . CCDS44 KLRKEELTLNNIRQYYVLCEHRKDKYQALCNIYGSITIGQAIIFCQTRRNAKWLTVEMIQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD .::::.:::::. :::::..:.:::.::::::.:::::::::::.::..:.:::::: . CCDS44 DGHQVSLLSGELTVEQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQG 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE .:: :::::::::::::::.::: ::.. . . : .::.:::..:..:...:.:::: CCDS44 EEPDYETYLHRIGRTGRFGKKGLAFNMIEVDE-LPSLMKIQDHFNSSIKQLNAEDMDEIE 430 440 450 460 470 pF1KB5 KIAN :: CCDS44 KIDY 480 >>CCDS81646.1 DDX25 gene_id:29118|Hs108|chr11 (369 aa) initn: 1800 init1: 1706 opt: 1797 Z-score: 2093.7 bits: 396.4 E(32554): 2.7e-110 Smith-Waterman score: 1797; 69.8% identity (90.8% similar) in 368 aa overlap (110-477:1-367) 80 90 100 110 120 130 pF1KB5 LQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEPPQNLIAQSQ ::::::::::: :::.:::.:::::::::: CCDS81 MGFNRPSKIQEMALPMMLAHPPQNLIAQSQ 10 20 30 140 150 160 170 180 190 pF1KB5 SGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVR :::::::::::::::.:. . .::::::.::::::::::.:.:::::: .... ::.: CCDS81 SGTGKTAAFVLAMLSRVNALELFPQCLCLAPTYELALQTGRVVEQMGKFCVDVQVMYAIR 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB5 GNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIR ::.. :: :..::.::::::::::: :::.:: ::.::::::::::: ::: .:.::: CCDS81 GNRIPRGTDITKQIIIGTPGTVLDWCFKLKLIDLTKIRVFVLDEADVMIDTQGFSDHSIR 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB5 IQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDE ::: :: .:::::::::::::::.::....::::::::..:: ::..:.:::::: : . CCDS81 IQRALPSECQMLLFSATFEDSVWHFAERIIPDPNVIKLRKEELTLNNIRQYYVLCEHRKD 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB5 KFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERF :.:::::.::.:::.::.:::.::..:.::..:. ..::::.:::::. :::::..:.:: CCDS81 KYQALCNIYGSITIGQAIIFCQTRRNAKWLTVEMIQDGHQVSLLSGELTVEQRASIIQRF 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB5 REGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLA :.::::::.:::::::::::.::..:.:::::: . .:: :::::::::::::::.::: CCDS81 RDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVKQGEEPDYETYLHRIGRTGRFGKKGLA 280 290 300 310 320 330 440 450 460 470 pF1KB5 VNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN ::.. . . : .::.:::..:..:...:.:::::: CCDS81 FNMIEVDE-LPSLMKIQDHFNSSIKQLNAEDMDEIEKIDY 340 350 360 >>CCDS3282.1 EIF4A2 gene_id:1974|Hs108|chr3 (407 aa) initn: 744 init1: 422 opt: 923 Z-score: 1076.1 bits: 208.3 E(32554): 1.3e-53 Smith-Waterman score: 923; 40.3% identity (70.6% similar) in 402 aa overlap (83-474:19-407) 60 70 80 90 100 pF1KB5 KEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDPNSPLYS-----VKSFEELRLKPQLLQGV ::.. . : : .:... :: .::.:. CCDS32 MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGI 10 20 30 40 110 120 130 140 150 160 pF1KB5 YAMGFNRPSKIQENAL-PLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCL ::.::..:: ::. :. : . . ..:::.::::::::.:....:.:.: : : : CCDS32 YAYGFEKPSAIQQRAIIPCIKG---YDVIAQAQSGTGKTATFAISILQQLEIEFKETQAL 50 60 70 80 90 100 170 180 190 200 210 220 pF1KB5 CLSPTYELALQTGKVIEQMGKFYPELKLA----YAVRGNKLERGQKISEQIVIGTPGTVL :.:: ::: : ::: .: .. : :: :.... : . .::.:::: :. CCDS32 VLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVR-NEMQKLQAEAPHIVVGTPGRVF 110 120 130 140 150 160 230 240 250 260 270 280 pF1KB5 DWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVW : .. ....:: ::.::::::: :. ..: .:: .: . : . :..:.:::. .: CCDS32 DMLNR-RYLSPKWIKMFVLDEADEML-SRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVL 170 180 190 200 210 220 290 300 310 320 330 340 pF1KB5 KFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHT . ..: . :: : .:.:: ::. :::.:. .. :...::.:: ..::.::.:: .: CCDS32 EVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNT 230 240 250 260 270 280 350 360 370 380 390 400 pF1KB5 RKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQV :. ..::. .. . :. : :.: ..: .....:: :. .::.::.. ::::::.:: CCDS32 RRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQV 290 300 310 320 330 340 410 420 430 440 450 460 pF1KB5 SVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKK :.:::.:::... :.:.::::: ::::..:.:.:.: .... :: :. .: CCDS32 SLVINYDLPTNR------ENYIHRIGRGGRFGRKGVAINFV-TEEDKRILRDIETFYNTT 350 360 370 380 390 470 pF1KB5 IERLDTDDLDEIEKIAN .:.. . : : CCDS32 VEEMPMNVADLI 400 >>CCDS11113.1 EIF4A1 gene_id:1973|Hs108|chr17 (406 aa) initn: 644 init1: 423 opt: 915 Z-score: 1066.8 bits: 206.5 E(32554): 4.2e-53 Smith-Waterman score: 915; 40.4% identity (71.2% similar) in 389 aa overlap (91-474:31-406) 70 80 90 100 110 120 pF1KB5 LLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQE : ::... :. .::.:.::.::..:: ::. CCDS11 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ 10 20 30 40 50 60 130 140 150 160 170 pF1KB5 NA-LPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTG : :: . ..:::.::::::::.:....:.:.: : : : :.:: ::: : CCDS11 RAILPCI---KGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQ 70 80 90 100 110 180 190 200 210 220 230 pF1KB5 KVIEQMGKFYPELKLA----YAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKK ::. .: .. : ::. .... : . .:..:::: :.: .. ....:: CCDS11 KVVMALGDYMGASCHACIGGTNVRA-EVQKLQMEAPHIIVGTPGRVFDMLNR-RYLSPKY 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB5 IKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVI ::.::::::: :. ..: .:: : . : : :..:.:::. ..: . ..: . :: : CCDS11 IKMFVLDEADEML-SRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRI 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB5 KLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSK .:.:: ::. :.:.:. .. :...::.:: ..::.::.:: .::. ..::. .. CCDS11 LVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHA 240 250 260 270 280 290 360 370 380 390 400 410 pF1KB5 EGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKD . :. . :.: ..: .....:: :. .::.::.. ::::::.:::.:::.:::... CCDS11 RDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNR- 300 310 320 330 340 350 420 430 440 450 460 470 pF1KB5 GNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIE :.:.::::: ::::..:.:.::: .... : :. .: .::.. . : : CCDS11 -----ENYIHRIGRGGRFGRKGVAINMV-TEEDKRTLRDIETFYNTSIEEMPLNVADLI 360 370 380 390 400 pF1KB5 KIAN 479 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:43:56 2016 done: Fri Nov 4 21:43:57 2016 Total Scan time: 3.030 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]