FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5396, 633 aa 1>>>pF1KB5396 633 - 633 aa - 633 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4978+/-0.000464; mu= 21.4453+/- 0.030 mean_var=412.8048+/-87.589, 0's: 0 Z-trim(121.3): 108 B-trim: 3945 in 2/56 Lambda= 0.063125 statistics sampled from 37553 (37715) to 37553 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.442), width: 16 Scan time: 12.120 The best scores are: opt bits E(85289) NP_005817 (OMIM: 607201) heterogeneous nuclear rib ( 633) 4363 412.2 2.8e-114 XP_005245768 (OMIM: 607201) PREDICTED: heterogeneo ( 633) 4363 412.2 2.8e-114 XP_011538773 (OMIM: 607201) PREDICTED: heterogeneo ( 636) 4347 410.7 7.8e-114 NP_001095868 (OMIM: 607201) heterogeneous nuclear ( 636) 4347 410.7 7.8e-114 NP_001095867 (OMIM: 607201) heterogeneous nuclear ( 532) 3722 353.7 9.9e-97 NP_001095869 (OMIM: 607201) heterogeneous nuclear ( 535) 3706 352.2 2.7e-96 NP_006363 (OMIM: 616686) heterogeneous nuclear rib ( 623) 3551 338.2 5.1e-92 XP_005248694 (OMIM: 616686) PREDICTED: heterogeneo ( 623) 3551 338.2 5.1e-92 XP_016865665 (OMIM: 616686) PREDICTED: heterogeneo ( 605) 3394 323.9 1e-87 XP_016865666 (OMIM: 616686) PREDICTED: heterogeneo ( 604) 3387 323.3 1.6e-87 NP_001284549 (OMIM: 607201) heterogeneous nuclear ( 595) 3295 314.9 5.2e-85 XP_016855497 (OMIM: 607201) PREDICTED: heterogeneo ( 595) 3295 314.9 5.2e-85 NP_001284551 (OMIM: 607201) heterogeneous nuclear ( 494) 3293 314.5 5.5e-85 XP_011538777 (OMIM: 607201) PREDICTED: heterogeneo ( 598) 3279 313.4 1.4e-84 XP_011538776 (OMIM: 607201) PREDICTED: heterogeneo ( 598) 3279 313.4 1.4e-84 XP_011538778 (OMIM: 607201) PREDICTED: heterogeneo ( 497) 3277 313.1 1.5e-84 XP_005248693 (OMIM: 616686) PREDICTED: heterogeneo ( 525) 3100 297.0 1.1e-79 XP_005248692 (OMIM: 616686) PREDICTED: heterogeneo ( 561) 3094 296.5 1.7e-79 XP_016865668 (OMIM: 616686) PREDICTED: heterogeneo ( 561) 3094 296.5 1.7e-79 NP_001153148 (OMIM: 616686) heterogeneous nuclear ( 561) 3094 296.5 1.7e-79 XP_016865667 (OMIM: 616686) PREDICTED: heterogeneo ( 562) 3085 295.7 2.9e-79 NP_001153149 (OMIM: 616686) heterogeneous nuclear ( 562) 3085 295.7 2.9e-79 NP_001284550 (OMIM: 607201) heterogeneous nuclear ( 473) 2889 277.7 6.4e-74 XP_016855499 (OMIM: 607201) PREDICTED: heterogeneo ( 574) 2889 277.9 7e-74 XP_016855498 (OMIM: 607201) PREDICTED: heterogeneo ( 574) 2889 277.9 7e-74 XP_011538779 (OMIM: 607201) PREDICTED: heterogeneo ( 476) 2873 276.3 1.8e-73 XP_011538774 (OMIM: 607201) PREDICTED: heterogeneo ( 577) 2873 276.4 1.9e-73 XP_016865669 (OMIM: 616686) PREDICTED: heterogeneo ( 463) 2643 255.3 3.5e-67 NP_001153145 (OMIM: 616686) heterogeneous nuclear ( 464) 2634 254.5 6.3e-67 NP_001240700 (OMIM: 616686) heterogeneous nuclear ( 410) 2241 218.6 3.5e-56 NP_001153147 (OMIM: 616686) heterogeneous nuclear ( 588) 1752 174.3 1e-42 NP_001153146 (OMIM: 616686) heterogeneous nuclear ( 527) 1714 170.8 1.1e-41 NP_919225 (OMIM: 609385) dead end protein homolog ( 353) 469 57.1 1.3e-07 XP_006722896 (OMIM: 612680) PREDICTED: CUGBP Elav- ( 484) 296 41.6 0.0079 NP_001166144 (OMIM: 612680) CUGBP Elav-like family ( 409) 294 41.3 0.0084 NP_068757 (OMIM: 612680) CUGBP Elav-like family me ( 485) 294 41.4 0.009 XP_006722895 (OMIM: 612680) PREDICTED: CUGBP Elav- ( 485) 294 41.4 0.009 >>NP_005817 (OMIM: 607201) heterogeneous nuclear ribonuc (633 aa) initn: 4363 init1: 4363 opt: 4363 Z-score: 2172.6 bits: 412.2 E(85289): 2.8e-114 Smith-Waterman score: 4363; 100.0% identity (100.0% similar) in 633 aa overlap (1-633:1-633) 10 20 30 40 50 60 pF1KB5 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 ISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 DYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIA 550 560 570 580 590 600 610 620 630 pF1KB5 QQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK ::::::::::::::::::::::::::::::::: NP_005 QQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK 610 620 630 >>XP_005245768 (OMIM: 607201) PREDICTED: heterogeneous n (633 aa) initn: 4363 init1: 4363 opt: 4363 Z-score: 2172.6 bits: 412.2 E(85289): 2.8e-114 Smith-Waterman score: 4363; 100.0% identity (100.0% similar) in 633 aa overlap (1-633:1-633) 10 20 30 40 50 60 pF1KB5 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 ISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQ 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 DYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIA 550 560 570 580 590 600 610 620 630 pF1KB5 QQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK ::::::::::::::::::::::::::::::::: XP_005 QQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK 610 620 630 >>XP_011538773 (OMIM: 607201) PREDICTED: heterogeneous n (636 aa) initn: 2597 init1: 2597 opt: 4347 Z-score: 2164.7 bits: 410.7 E(85289): 7.8e-114 Smith-Waterman score: 4347; 99.5% identity (99.5% similar) in 636 aa overlap (1-633:1-636) 10 20 30 40 50 60 pF1KB5 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 ISVANNRLFVGSIPKNKTKENILEEFSKVT---EGLVDVILYHQPDDKKKNRGFCFLEYE :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: XP_011 ISVANNRLFVGSIPKNKTKENILEEFSKVTGLTEGLVDVILYHQPDDKKKNRGFCFLEYE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 DHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEIL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 EKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 ERQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGY 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 DYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ 550 560 570 580 590 600 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::::::::::::::::::::::::::::::: XP_011 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK 610 620 630 >>NP_001095868 (OMIM: 607201) heterogeneous nuclear ribo (636 aa) initn: 2597 init1: 2597 opt: 4347 Z-score: 2164.7 bits: 410.7 E(85289): 7.8e-114 Smith-Waterman score: 4347; 99.5% identity (99.5% similar) in 636 aa overlap (1-633:1-636) 10 20 30 40 50 60 pF1KB5 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYVDL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVC 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 ISVANNRLFVGSIPKNKTKENILEEFSKVT---EGLVDVILYHQPDDKKKNRGFCFLEYE :::::::::::::::::::::::::::::: ::::::::::::::::::::::::::: NP_001 ISVANNRLFVGSIPKNKTKENILEEFSKVTGLTEGLVDVILYHQPDDKKKNRGFCFLEYE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 DHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEIL 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 EKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 ERQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGY 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 DYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYHDYRGGYEDPYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ 550 560 570 580 590 600 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::::::::::::::::::::::::::::::: NP_001 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK 610 620 630 >>NP_001095867 (OMIM: 607201) heterogeneous nuclear ribo (532 aa) initn: 3722 init1: 3722 opt: 3722 Z-score: 1857.6 bits: 353.7 E(85289): 9.9e-97 Smith-Waterman score: 3722; 100.0% identity (100.0% similar) in 532 aa overlap (102-633:1-532) 80 90 100 110 120 130 pF1KB5 NEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALL :::::::::::::::::::::::::::::: NP_001 MKTYRQREKQGSKVQESTKGPDEAKIKALL 10 20 30 140 150 160 170 180 190 pF1KB5 ERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPI 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB5 WDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVG 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB5 SIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMS 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB5 GKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVK 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB5 KLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAY 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB5 EDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYY 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB5 GYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQ 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB5 QQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYS 460 470 480 490 500 510 620 630 pF1KB5 GNYGYNNDNQEFYQDTYGQQWK :::::::::::::::::::::: NP_001 GNYGYNNDNQEFYQDTYGQQWK 520 530 >>NP_001095869 (OMIM: 607201) heterogeneous nuclear ribo (535 aa) initn: 2597 init1: 2597 opt: 3706 Z-score: 1849.8 bits: 352.2 E(85289): 2.7e-96 Smith-Waterman score: 3706; 99.4% identity (99.4% similar) in 535 aa overlap (102-633:1-535) 80 90 100 110 120 130 pF1KB5 NEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQESTKGPDEAKIKALL :::::::::::::::::::::::::::::: NP_001 MKTYRQREKQGSKVQESTKGPDEAKIKALL 10 20 30 140 150 160 170 180 190 pF1KB5 ERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYEDELVPLFEKAGPI 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB5 WDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLGVCISVANNRLFVG 100 110 120 130 140 150 260 270 280 290 300 pF1KB5 SIPKNKTKENILEEFSKVT---EGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRR ::::::::::::::::::: :::::::::::::::::::::::::::::::::::::: NP_001 SIPKNKTKENILEEFSKVTGLTEGLVDVILYHQPDDKKKNRGFCFLEYEDHKSAAQARRR 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 LMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLE 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 RVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRS 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 TAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYED 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB5 PYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PYYGYDDGYAVRGRGGGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGG 400 410 420 430 440 450 550 560 570 580 590 600 pF1KB5 PAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGG 460 470 480 490 500 510 610 620 630 pF1KB5 DYSGNYGYNNDNQEFYQDTYGQQWK ::::::::::::::::::::::::: NP_001 DYSGNYGYNNDNQEFYQDTYGQQWK 520 530 >>NP_006363 (OMIM: 616686) heterogeneous nuclear ribonuc (623 aa) initn: 2899 init1: 2505 opt: 3551 Z-score: 1773.0 bits: 338.2 E(85289): 5.1e-92 Smith-Waterman score: 3551; 82.1% identity (93.6% similar) in 636 aa overlap (1-633:1-623) 10 20 30 40 50 pF1KB5 MANQ-VNGNAVQLKEEEEPMDTSS-VTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYV ::.. ::::.. ::::::.: : :.:...::..:::::::::.::::. .::::. NP_006 MATEHVNGNGT-----EEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHS 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQES :::::::.::.::::.:::.::::::.:::::::::::::::::::::::::::.:: .: NP_006 DLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 TKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYE .::::::::::::::::::::::::::::::::::::::: ::..:::.:::::::::.: NP_006 SKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 DELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLG :::::::::::::::::::::::.: ::::::.::: :::::::::: ...::: :::.: NP_006 DELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 VCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYED :::::::::::::::::.::::.::::::::::::.:::::::::::::::::::::::: NP_006 VCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYED 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 HKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILE ::.::::::::::::::::::: :::::::.:.::::::::::::::::::.:::::::: NP_006 HKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 KSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKE :.::.:::::::::::::::.::..: .:::::.:::::..:::.::::.:::::.:::: NP_006 KAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 RQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYD :.: :::... :.::::. ::.:::: ::::::: :::::::::::::::::: ::::: NP_006 RKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD-YYGYD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 YHDYRGGYEDPYYGYDDGYAVRGRG-GGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG ::.::::::::::::.: . : .:: ::::.::: : ::::: ::::::::::::.: : NP_006 YHNYRGGYEDPYYGYED-FQVGARGRGGRGARGAAPS-RGRGAAPPRGRAGYSQRGGP-G 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :: ::.::: :::::::: ::.::.::::::::::::::::::::::::::: ::::: NP_006 SARGVRGARGG-AQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQ-NWGSQ 540 550 560 570 580 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::: :::.::::::...::::::::.::::: NP_006 PIAQQPLQ-GGDHSGNYGYKSENQEFYQDTFGQQWK 590 600 610 620 >>XP_005248694 (OMIM: 616686) PREDICTED: heterogeneous n (623 aa) initn: 2899 init1: 2505 opt: 3551 Z-score: 1773.0 bits: 338.2 E(85289): 5.1e-92 Smith-Waterman score: 3551; 82.1% identity (93.6% similar) in 636 aa overlap (1-633:1-623) 10 20 30 40 50 pF1KB5 MANQ-VNGNAVQLKEEEEPMDTSS-VTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYV ::.. ::::.. ::::::.: : :.:...::..:::::::::.::::. .::::. XP_005 MATEHVNGNGT-----EEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHS 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQES :::::::.::.::::.:::.::::::.:::::::::::::::::::::::::::.:: .: XP_005 DLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 TKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYE .::::::::::::::::::::::::::::::::::::::: ::..:::.:::::::::.: XP_005 SKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 DELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLG :::::::::::::::::::::::.: ::::::.::: :::::::::: ...::: :::.: XP_005 DELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 VCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYED :::::::::::::::::.::::.::::::::::::.:::::::::::::::::::::::: XP_005 VCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYED 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 HKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILE ::.::::::::::::::::::: :::::::.:.::::::::::::::::::.:::::::: XP_005 HKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 KSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKE :.::.:::::::::::::::.::..: .:::::.:::::..:::.::::.:::::.:::: XP_005 KAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 RQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYD :.: :::... :.::::. ::.:::: ::::::: :::::::::::::::::: ::::: XP_005 RKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD-YYGYD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 YHDYRGGYEDPYYGYDDGYAVRGRG-GGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG ::.::::::::::::.: . : .:: ::::.::: : ::::: ::::::::::::.: : XP_005 YHNYRGGYEDPYYGYED-FQVGARGRGGRGARGAAPS-RGRGAAPPRGRAGYSQRGGP-G 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :: ::.::: :::::::: ::.::.::::::::::::::::::::::::::: ::::: XP_005 SARGVRGARGG-AQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQ-NWGSQ 540 550 560 570 580 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::: :::.::::::...::::::::.::::: XP_005 PIAQQPLQ-GGDHSGNYGYKSENQEFYQDTFGQQWK 590 600 610 620 >>XP_016865665 (OMIM: 616686) PREDICTED: heterogeneous n (605 aa) initn: 2900 init1: 2505 opt: 3394 Z-score: 1695.8 bits: 323.9 E(85289): 1e-87 Smith-Waterman score: 3394; 82.1% identity (93.3% similar) in 610 aa overlap (1-607:1-598) 10 20 30 40 50 pF1KB5 MANQ-VNGNAVQLKEEEEPMDTSS-VTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYV ::.. ::::.. ::::::.: : :.:...::..:::::::::.::::. .::::. XP_016 MATEHVNGNGT-----EEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHS 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQES :::::::.::.::::.:::.::::::.:::::::::::::::::::::::::::.:: .: XP_016 DLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 TKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYE .::::::::::::::::::::::::::::::::::::::: ::..:::.:::::::::.: XP_016 SKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 DELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLG :::::::::::::::::::::::.: ::::::.::: :::::::::: ...::: :::.: XP_016 DELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 VCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYED :::::::::::::::::.::::.::::::::::::.:::::::::::::::::::::::: XP_016 VCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYED 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 HKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILE ::.::::::::::::::::::: :::::::.:.::::::::::::::::::.:::::::: XP_016 HKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 KSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKE :.::.:::::::::::::::.::..: .:::::.:::::..:::.::::.:::::.:::: XP_016 KAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 RQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYD :.: :::... :.::::. ::.:::: ::::::: :::::::::::::::::: ::::: XP_016 RKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD-YYGYD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 YHDYRGGYEDPYYGYDDGYAVRGRG-GGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG ::.::::::::::::.: . : .:: ::::.::: : ::::: ::::::::::::.: : XP_016 YHNYRGGYEDPYYGYED-FQVGARGRGGRGARGAAPS-RGRGAAPPRGRAGYSQRGGP-G 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :: ::.::: :::::::: ::.::.::::::::::::::::::::::::::: ::::: XP_016 SARGVRGARGG-AQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQ-NWGSQ 540 550 560 570 580 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::: : XP_016 PIAQQPLQAGKRGRGRS 590 600 >>XP_016865666 (OMIM: 616686) PREDICTED: heterogeneous n (604 aa) initn: 2783 init1: 2505 opt: 3387 Z-score: 1692.4 bits: 323.3 E(85289): 1.6e-87 Smith-Waterman score: 3387; 82.2% identity (93.4% similar) in 608 aa overlap (1-605:1-596) 10 20 30 40 50 pF1KB5 MANQ-VNGNAVQLKEEEEPMDTSS-VTHTEHYKTLIEAGLPQKVAERLDEIFQTGLVAYV ::.. ::::.. ::::::.: : :.:...::..:::::::::.::::. .::::. XP_016 MATEHVNGNGT-----EEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHS 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 DLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVMKTYRQREKQGSKVQES :::::::.::.::::.:::.::::::.:::::::::::::::::::::::::::.:: .: XP_016 DLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 TKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQPGIGTEVFVGKIPRDLYE .::::::::::::::::::::::::::::::::::::::: ::..:::.:::::::::.: XP_016 SKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 DELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEAAQEAVKLCDSYEIRPGKHLG :::::::::::::::::::::::.: ::::::.::: :::::::::: ...::: :::.: XP_016 DELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 VCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDVILYHQPDDKKKNRGFCFLEYED :::::::::::::::::.::::.::::::::::::.:::::::::::::::::::::::: XP_016 VCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYED 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 HKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDPEVMAKVKVLFVRNLATTVTEEILE ::.::::::::::::::::::: :::::::.:.::::::::::::::::::.:::::::: XP_016 HKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 KSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMNGKEIEGEEIEIVLAKPPDKKRKE :.::.:::::::::::::::.::..: .:::::.:::::..:::.::::.:::::.:::: XP_016 KAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKE 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 RQAARQASRSTAYEDYYYHPPPRMPPPIRGRGRGGGRGGYGYPPDYYGYEDYYDDYYGYD :.: :::... :.::::. ::.:::: ::::::: :::::::::::::::::: ::::: XP_016 RKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGG-RGGYGYPPDYYGYEDYYD-YYGYD 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 YHDYRGGYEDPYYGYDDGYAVRGRG-GGRGGRGAPPPPRGRGAPPPRGRAGYSQRGAPLG ::.::::::::::::.: . : .:: ::::.::: : ::::: ::::::::::::.: : XP_016 YHNYRGGYEDPYYGYED-FQVGARGRGGRGARGAAPS-RGRGAAPPRGRAGYSQRGGP-G 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 PPRGSRGGRGGPAQQQRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWGSQ :: ::.::: :::::::: ::.::.::::::::::::::::::::::::::: ::::: XP_016 SARGVRGARGG-AQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQ-NWGSQ 540 550 560 570 580 600 610 620 630 pF1KB5 PIAQQPLQQGGDYSGNYGYNNDNQEFYQDTYGQQWK :::::::: XP_016 PIAQQPLQGKRGRGRS 590 600 633 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:18:03 2016 done: Thu Nov 3 17:18:05 2016 Total Scan time: 12.120 Total Display time: 0.170 Function used was FASTA [36.3.4 Apr, 2011]