FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5441, 339 aa 1>>>pF1KB5441 339 - 339 aa - 339 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3672+/-0.00078; mu= 16.5890+/- 0.047 mean_var=86.0078+/-16.584, 0's: 0 Z-trim(110.2): 23 B-trim: 7 in 1/52 Lambda= 0.138295 statistics sampled from 11437 (11454) to 11437 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.352), width: 16 Scan time: 2.660 The best scores are: opt bits E(32554) CCDS5986.1 CTSB gene_id:1508|Hs108|chr8 ( 339) 2474 503.2 1.2e-142 CCDS72745.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 362) 412 91.8 9.1e-19 CCDS55586.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 436) 412 91.9 1e-18 CCDS343.1 TINAGL1 gene_id:64129|Hs108|chr1 ( 467) 412 91.9 1.1e-18 CCDS8282.1 CTSC gene_id:1075|Hs108|chr11 ( 463) 323 74.2 2.4e-13 >>CCDS5986.1 CTSB gene_id:1508|Hs108|chr8 (339 aa) initn: 2474 init1: 2474 opt: 2474 Z-score: 2674.2 bits: 503.2 E(32554): 1.2e-142 Smith-Waterman score: 2474; 100.0% identity (100.0% similar) in 339 aa overlap (1-339:1-339) 10 20 30 40 50 60 pF1KB5 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS59 AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW 250 260 270 280 290 300 310 320 330 pF1KB5 NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI ::::::::::::::::::::::::::::::::::::::: CCDS59 NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI 310 320 330 >>CCDS72745.1 TINAGL1 gene_id:64129|Hs108|chr1 (362 aa) initn: 536 init1: 144 opt: 412 Z-score: 450.4 bits: 91.8 E(32554): 9.1e-19 Smith-Waterman score: 583; 33.0% identity (59.3% similar) in 327 aa overlap (29-326:40-348) 10 20 30 40 50 pF1KB5 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHN--FYNVDMSYLK .... .:. : ::::.. :... .. CCDS72 LGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGI 10 20 30 40 50 60 60 70 80 90 100 pF1KB5 RLCGTFLGGPKPPQRVMFTEDLK--------LPASFDAREQWPQCPTIKEIRDQGSCGSC : :: .: . :: ... ::..:.: :.::. :.: :::.:.. CCDS72 RY---RLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN--LIHEPLDQGNCAGS 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 WAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLV :::... . :::. ::. .:.. .: ..::.: . .:: :: :: : :.:.: CCDS72 WAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSC-DTHQQQGCRGGRLDGAWWFLRRRGVV 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 SGGLYESHVGCRPYSIPPCEHHVNGSRPPCT------GEGDTPKCSKICEPGYSPTYKQD : .: : :.: :. : ::: :.: . . : .: . ..: CCDS72 S-----DH--CYPFS--GRERDEAGPAPPCMMHSRAMGRGKR-QATAHCPNSY--VNNND 190 200 210 220 230 230 240 250 260 270 pF1KB5 KHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEM-------- . : .....:.:: :...::::.. . :. ::.:::.:.:.:. . CCDS72 IYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRR 240 250 260 270 280 290 280 290 300 310 320 pF1KB5 MGGHAIRILGWGVE---NGTP--YWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGI : :...: ::: : .: :: .::::. ::. : :.:.:: ..: ::: :. CCDS72 HGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVW 300 310 320 330 340 350 330 pF1KB5 PRTDQYWEKI CCDS72 GRVGMEDMGHH 360 >>CCDS55586.1 TINAGL1 gene_id:64129|Hs108|chr1 (436 aa) initn: 487 init1: 144 opt: 412 Z-score: 449.3 bits: 91.9 E(32554): 1e-18 Smith-Waterman score: 572; 33.4% identity (58.9% similar) in 326 aa overlap (30-326:115-422) 10 20 30 40 50 pF1KB5 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHN--FYNVDMSYLKR : .: .. : ::::.. :... .. : CCDS55 CPDFWDFCLGVPPPFPPIQGCMHGGRIYPVLGTYWDNCNRCWQAGNHSAFWGMTLDEGIR 90 100 110 120 130 140 60 70 80 90 100 pF1KB5 LCGTFLGGPKPPQRVMFTEDLK--------LPASFDAREQWPQCPTIKEIRDQGSCGSCW :: .: . :: ... ::..:.: :.::. :.: :::.:.. : CCDS55 Y---RLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN--LIHEPLDQGNCAGSW 150 160 170 180 190 110 120 130 140 150 160 pF1KB5 AFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVS ::... . :::. ::. .:.. .: ..::.: . .:: :: :: : :.:.:: CCDS55 AFSTAAVASDRVSIHSLGHMTPVLSPQNLLSC-DTHQQQGCRGGRLDGAWWFLRRRGVVS 200 210 220 230 240 250 170 180 190 200 210 220 pF1KB5 GGLYESHVGCRPYSIPPCEHHVNGSRPPCT------GEGDTPKCSKICEPGYSPTYKQDK .: : :.: :. : ::: :.: . . : .: . ..: CCDS55 -----DH--CYPFS--GRERDEAGPAPPCMMHSRAMGRGKR-QATAHCPNSY--VNNNDI 260 270 280 290 300 230 240 250 260 270 pF1KB5 HYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEM--------M . : .....:.:: :...::::.. . :. ::.:::.:.:.:. . CCDS55 YQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRRH 310 320 330 340 350 360 280 290 300 310 320 330 pF1KB5 GGHAIRILGWGVE---NGTP--YWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIP : :...: ::: : .: :: .::::. ::. : :.:.:: ..: ::: :. CCDS55 GTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVWG 370 380 390 400 410 420 pF1KB5 RTDQYWEKI CCDS55 RVGMEDMGHH 430 >>CCDS343.1 TINAGL1 gene_id:64129|Hs108|chr1 (467 aa) initn: 487 init1: 144 opt: 412 Z-score: 448.9 bits: 91.9 E(32554): 1.1e-18 Smith-Waterman score: 583; 33.0% identity (59.3% similar) in 327 aa overlap (29-326:145-453) 10 20 30 40 50 pF1KB5 MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHN--FYNVDMSYLK .... .:. : ::::.. :... .. CCDS34 LGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGI 120 130 140 150 160 170 60 70 80 90 100 pF1KB5 RLCGTFLGGPKPPQRVMFTEDLK--------LPASFDAREQWPQCPTIKEIRDQGSCGSC : :: .: . :: ... ::..:.: :.::. :.: :::.:.. CCDS34 RY---RLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPN--LIHEPLDQGNCAGS 180 190 200 210 220 110 120 130 140 150 160 pF1KB5 WAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLV :::... . :::. ::. .:.. .: ..::.: . .:: :: :: : :.:.: CCDS34 WAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSC-DTHQQQGCRGGRLDGAWWFLRRRGVV 230 240 250 260 270 280 170 180 190 200 210 220 pF1KB5 SGGLYESHVGCRPYSIPPCEHHVNGSRPPCT------GEGDTPKCSKICEPGYSPTYKQD : .: : :.: :. : ::: :.: . . : .: . ..: CCDS34 S-----DH--CYPFS--GRERDEAGPAPPCMMHSRAMGRGKR-QATAHCPNSY--VNNND 290 300 310 320 330 230 240 250 260 270 pF1KB5 KHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEM-------- . : .....:.:: :...::::.. . :. ::.:::.:.:.:. . CCDS34 IYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPERYRR 340 350 360 370 380 390 280 290 300 310 320 pF1KB5 MGGHAIRILGWGVE---NGTP--YWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGI : :...: ::: : .: :: .::::. ::. : :.:.:: ..: ::: :. CCDS34 HGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIESFVLGVW 400 410 420 430 440 450 330 pF1KB5 PRTDQYWEKI CCDS34 GRVGMEDMGHH 460 >>CCDS8282.1 CTSC gene_id:1075|Hs108|chr11 (463 aa) initn: 391 init1: 183 opt: 323 Z-score: 353.0 bits: 74.2 E(32554): 2.4e-13 Smith-Waterman score: 469; 31.3% identity (57.0% similar) in 335 aa overlap (14-330:156-459) 10 20 30 40 pF1KB5 MWQLWASLCCLLVLANARSRPS--FHPLSDELVNYVNKRNTTW : :.. . : .. . ..:. .: . .: CCDS82 VHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSW 130 140 150 160 170 180 50 60 70 80 90 pF1KB5 QAG--HNFYNVDMSYLKRLCGTF---LGGPKP-PQRVMFTED-LKLPASFDAREQWPQCP : .. .. .. . : : . ::: : . . . :.::.:.: :. CCDS82 TATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV-HGIN 190 200 210 220 230 240 100 110 120 130 140 150 pF1KB5 TIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGY .. .:.:.:::::..:... . :: : :: . .: .....: :. ..::.::. CCDS82 FVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSC--SQYAQGCEGGF 250 260 270 280 290 300 160 170 180 190 200 210 pF1KB5 PAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPG : . . : . :: : .: ::. :. :: . : : CCDS82 PY----LIAGKYAQDFGLVEE--ACFPYT---------GTDSPCKMKED-------CFRY 310 320 330 340 220 230 240 250 260 270 pF1KB5 YSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEM :: : :: . :. : : . :. ..::. :: ::.::: ::.:.:.: :: CCDS82 YSSEY----HYVGGFYGGCN-EALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH-TGLR 350 360 370 380 390 280 290 300 310 320 pF1KB5 -------MGGHAIRILGWGVEN--GTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEV . .::. ..:.:... : ::.: :::.: ::.::.:.: :: :.:.::: . CCDS82 DPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIA 400 410 420 430 440 450 330 pF1KB5 VAGIPRTDQYWEKI ::. : CCDS82 VAATPIPKL 460 339 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:23:52 2016 done: Thu Nov 3 17:23:53 2016 Total Scan time: 2.660 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]