FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5444, 724 aa 1>>>pF1KB5444 724 - 724 aa - 724 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.3321+/-0.000546; mu= -4.3164+/- 0.034 mean_var=238.4826+/-48.892, 0's: 0 Z-trim(114.6): 25 B-trim: 748 in 2/52 Lambda= 0.083051 statistics sampled from 24514 (24537) to 24514 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.615), E-opt: 0.2 (0.288), width: 16 Scan time: 12.370 The best scores are: opt bits E(85289) NP_031381 (OMIM: 140572) heat shock protein HSP 90 ( 724) 4664 572.8 1.6e-162 NP_001258899 (OMIM: 140572) heat shock protein HSP ( 724) 4664 572.8 1.6e-162 NP_001258898 (OMIM: 140572) heat shock protein HSP ( 724) 4664 572.8 1.6e-162 NP_005339 (OMIM: 140571) heat shock protein HSP 90 ( 732) 4122 507.9 5.8e-143 XP_011535020 (OMIM: 140571) PREDICTED: heat shock ( 853) 4122 507.9 6.7e-143 NP_001017963 (OMIM: 140571) heat shock protein HSP ( 854) 4122 507.9 6.7e-143 NP_001258900 (OMIM: 140572) heat shock protein HSP ( 676) 3911 482.6 2.2e-135 NP_001258901 (OMIM: 140572) heat shock protein HSP ( 714) 3873 478.0 5.5e-134 NP_003290 (OMIM: 191175) endoplasmin precursor [Ho ( 803) 1823 232.4 5.3e-60 XP_011520647 (OMIM: 606219) PREDICTED: heat shock ( 564) 628 89.2 4.9e-17 NP_001258978 (OMIM: 606219) heat shock protein 75 ( 651) 628 89.2 5.6e-17 NP_057376 (OMIM: 606219) heat shock protein 75 kDa ( 704) 628 89.2 6e-17 XP_016878340 (OMIM: 606219) PREDICTED: heat shock ( 405) 592 84.8 7.4e-16 >>NP_031381 (OMIM: 140572) heat shock protein HSP 90-bet (724 aa) initn: 4664 init1: 4664 opt: 4664 Z-score: 3038.6 bits: 572.8 E(85289): 1.6e-162 Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724) 10 20 30 40 50 60 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_031 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM 670 680 690 700 710 720 pF1KB5 EEVD :::: NP_031 EEVD >>NP_001258899 (OMIM: 140572) heat shock protein HSP 90- (724 aa) initn: 4664 init1: 4664 opt: 4664 Z-score: 3038.6 bits: 572.8 E(85289): 1.6e-162 Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724) 10 20 30 40 50 60 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM 670 680 690 700 710 720 pF1KB5 EEVD :::: NP_001 EEVD >>NP_001258898 (OMIM: 140572) heat shock protein HSP 90- (724 aa) initn: 4664 init1: 4664 opt: 4664 Z-score: 3038.6 bits: 572.8 E(85289): 1.6e-162 Smith-Waterman score: 4664; 100.0% identity (100.0% similar) in 724 aa overlap (1-724:1-724) 10 20 30 40 50 60 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM 670 680 690 700 710 720 pF1KB5 EEVD :::: NP_001 EEVD >>NP_005339 (OMIM: 140571) heat shock protein HSP 90-alp (732 aa) initn: 2811 init1: 2811 opt: 4122 Z-score: 2687.6 bits: 507.9 E(85289): 5.8e-143 Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:1-732) 10 20 30 40 50 pF1KB5 MPEEVHHG-----EEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIR ::::.. ::::::::::::::::::::::::::::::::::::::.:::::::: NP_005 MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 YESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFME ::::::::::::::::.:..::: :.::::.::::::::::::::::::::::::::::: NP_005 YESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFME 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 ALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPI ::::::::::::::::::::::::::::.::::::::::::::::::::::::.: :::. NP_005 ALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPM 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 GRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKG ::::::::::::::::::::::.::.::::::::::::::..::::.::.:::::::.. NP_005 GRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKED 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 ---EKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRN :::.:.:..:.::.:::::::::... ::: ::::::::::::::::::::::: NP_005 KEEEKEKEEKESEDKPEIEDVGSDEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 PDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNN :::::.::::::::::::::::::::::::::::::::::::.:::::::::::.::::: NP_005 PDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 IKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKC ::::::::::::.:.::::::::::::::::::::::::::::::::::::::::.:::: NP_005 IKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKC 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 LELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEY ::::.:::::::::::::: ::::.:::::::: ::..:::::::.:: :::::.::..: NP_005 LELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDY 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 VSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKS .::::.:: :::::::.:.::::::::::.::.:.::.:: ::::::::::::::.::. NP_005 CTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 LVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIV ::::::::::::::::::::.::.:.:::::::.::.::.::::::..:::::.:::::: NP_005 LVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIV 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 TSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVK :::::::::::::::::::::::::::: ::::::::::: :.::::::::::::::.:: NP_005 TSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVK 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 DLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLE :::.::.:::::::::::::::::.::::::::::::::::. .:.. .::: .:.:::: NP_005 DLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMPPLE 670 680 690 700 710 720 720 pF1KB5 GDEDASRMEEVD ::.:.::::::: NP_005 GDDDTSRMEEVD 730 >>XP_011535020 (OMIM: 140571) PREDICTED: heat shock prot (853 aa) initn: 2811 init1: 2811 opt: 4122 Z-score: 2686.5 bits: 507.9 E(85289): 6.7e-143 Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:122-853) 10 20 pF1KB5 MPEEVHHG-----EEEVETFAFQAEIAQLM ::::.. ::::::::::::::::: XP_011 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM 100 110 120 130 140 150 30 40 50 60 70 80 pF1KB5 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.:::: XP_011 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT 160 170 180 190 200 210 90 100 110 120 130 140 pF1KB5 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: XP_011 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV 220 230 240 250 260 270 150 160 170 180 190 200 pF1KB5 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.:::: XP_011 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH 280 290 300 310 320 330 210 220 230 240 250 260 pF1KB5 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG ::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::... XP_011 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK 340 350 360 370 380 390 270 280 290 300 310 320 pF1KB5 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS ::: ::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_011 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS 400 410 420 430 440 450 330 340 350 360 370 380 pF1KB5 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD ::::::::::::.:::::::::::.:::::::::::::::::.:.::::::::::::::: XP_011 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD 460 470 480 490 500 510 390 400 410 420 430 440 pF1KB5 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.::::: XP_011 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH 520 530 540 550 560 570 450 460 470 480 490 500 pF1KB5 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.:::::::::: XP_011 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER 580 590 600 610 620 630 510 520 530 540 550 560 pF1KB5 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.:::: XP_011 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN 640 650 660 670 680 690 570 580 590 600 610 620 pF1KB5 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: : XP_011 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA 700 710 720 730 740 750 630 640 650 660 670 680 pF1KB5 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.::::: XP_011 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR 760 770 780 790 800 810 690 700 710 720 pF1KB5 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD :::::::::::. .:.. .::: .:.::::::.:.::::::: XP_011 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD 820 830 840 850 >>NP_001017963 (OMIM: 140571) heat shock protein HSP 90- (854 aa) initn: 2811 init1: 2811 opt: 4122 Z-score: 2686.5 bits: 507.9 E(85289): 6.7e-143 Smith-Waterman score: 4122; 85.8% identity (96.0% similar) in 732 aa overlap (1-724:123-854) 10 20 pF1KB5 MPEEVHHG-----EEEVETFAFQAEIAQLM ::::.. ::::::::::::::::: NP_001 VTASLAFRQSQGAGQHLYKDLQPFILLRLLMPEETQTQDQPMEEEEVETFAFQAEIAQLM 100 110 120 130 140 150 30 40 50 60 70 80 pF1KB5 SLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLT :::::::::::::::::::::.::::::::::::::::::::::::.:..::: :.:::: NP_001 SLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLT 160 170 180 190 200 210 90 100 110 120 130 140 pF1KB5 LVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV .:::::::::::::::::::::::::::::::::::::::::::::::::::::::::.: NP_001 IVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV 220 230 240 250 260 270 150 160 170 180 190 200 pF1KB5 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKH :::::::::::::::::::::::.: :::.::::::::::::::::::::::.::.:::: NP_001 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKH 280 290 300 310 320 330 210 220 230 240 250 260 pF1KB5 SQFIGYPITLYLEKEREKEISDDEAEEEKG---EKEEEDKDDEEKPKIEDVGSDEEDDSG ::::::::::..::::.::.:::::::.. :::.:.:..:.::.:::::::::... NP_001 SQFIGYPITLFVEKERDKEVSDDEAEEKEDKEEEKEKEEKESEDKPEIEDVGSDEEEEKK 340 350 360 370 380 390 270 280 290 300 310 320 pF1KB5 KDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFS ::: ::::::::::::::::::::::::::::.:::::::::::::::::::::::: NP_001 DGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFS 400 410 420 430 440 450 330 340 350 360 370 380 pF1KB5 VEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVD ::::::::::::.:::::::::::.:::::::::::::::::.:.::::::::::::::: NP_001 VEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVD 460 470 480 490 500 510 390 400 410 420 430 440 pF1KB5 SEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIH :::::::::::::::::::::::::.::::::::.:::::::::::::: ::::.::::: NP_001 SEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIH 520 530 540 550 560 570 450 460 470 480 490 500 pF1KB5 EDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVER ::: ::..:::::::.:: :::::.::..: .::::.:: :::::::.:.:::::::::: NP_001 EDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVER 580 590 600 610 620 630 510 520 530 540 550 560 pF1KB5 VRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFEN .::.:.::.:: ::::::::::::::.::.::::::::::::::::::::.::.:.:::: NP_001 LRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFEN 640 650 660 670 680 690 570 580 590 600 610 620 pF1KB5 LCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMA :::.::.::.::::::..:::::.:::::::::::::::::::::::::::::::::: : NP_001 LCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAA 700 710 720 730 740 750 630 640 650 660 670 680 pF1KB5 KKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYR :::::::::: :.::::::::::::::.:::::.::.:::::::::::::::::.::::: NP_001 KKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYR 760 770 780 790 800 810 690 700 710 720 pF1KB5 MIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD :::::::::::. .:.. .::: .:.::::::.:.::::::: NP_001 MIKLGLGIDEDDPTADDTSAAVTEEMPPLEGDDDTSRMEEVD 820 830 840 850 >>NP_001258900 (OMIM: 140572) heat shock protein HSP 90- (676 aa) initn: 3911 init1: 3911 opt: 3911 Z-score: 2551.5 bits: 482.6 E(85289): 2.2e-135 Smith-Waterman score: 4260; 93.4% identity (93.4% similar) in 724 aa overlap (1-724:1-676) 10 20 30 40 50 60 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG ::::::::::::::: NP_001 DPSKLDSGKELKIDI--------------------------------------------- 70 130 140 150 160 170 180 pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---SMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ 380 390 400 410 420 430 490 500 510 520 530 540 pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG 440 450 460 470 480 490 550 560 570 580 590 600 pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA 500 510 520 530 540 550 610 620 630 640 650 660 pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE 560 570 580 590 600 610 670 680 690 700 710 720 pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM 620 630 640 650 660 670 pF1KB5 EEVD :::: NP_001 EEVD >>NP_001258901 (OMIM: 140572) heat shock protein HSP 90- (714 aa) initn: 3873 init1: 3873 opt: 3873 Z-score: 2526.5 bits: 478.0 E(85289): 5.5e-134 Smith-Waterman score: 4571; 98.6% identity (98.6% similar) in 724 aa overlap (1-724:1-714) 10 20 30 40 50 60 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-- 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 ADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------FGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTK 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEE 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEE 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELA 360 370 380 390 400 410 430 440 450 460 470 480 pF1KB5 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQ 420 430 440 450 460 470 490 500 510 520 530 540 pF1KB5 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG 480 490 500 510 520 530 550 560 570 580 590 600 pF1KB5 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTA 540 550 560 570 580 590 610 620 630 640 650 660 pF1KB5 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFE 600 610 620 630 640 650 670 680 690 700 710 720 pF1KB5 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRM 660 670 680 690 700 710 pF1KB5 EEVD :::: NP_001 EEVD >>NP_003290 (OMIM: 191175) endoplasmin precursor [Homo s (803 aa) initn: 1677 init1: 447 opt: 1823 Z-score: 1198.2 bits: 232.4 E(85289): 5.3e-60 Smith-Waterman score: 2207; 47.8% identity (75.7% similar) in 737 aa overlap (4-724:65-783) 10 20 30 pF1KB5 MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFY .... .:. : ::::::. ..:.::::..: NP_003 LGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLY 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB5 SNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGM .::::::::::::::::::::: :::: . :....:: . : . .. : ..:::.:: NP_003 KNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGM 100 110 120 130 140 150 100 110 120 130 140 pF1KB5 TKADLINNLGTIAKSGTKAFM----EALQAGADIS-MIGQFGVGFYSAYLVAEKVVVITK :. .:..::::::::::. :. :: . : . : .:::::::::::.:::.::.: .: NP_003 TREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSK 160 170 180 190 200 210 150 160 170 180 190 200 pF1KB5 HNDDEQYAWESSAGGSFTVRAD-HGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQ ::.: :. :::... :.: :: .:. .:::: . : :::. ..::: .:..:::.:: NP_003 HNNDTQHIWESDSN-EFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQ 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB5 FIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKK ::..:: :. . . . . . ::: ...:.:..::: .. .::.. .:: NP_003 FINFPI--YVWSSKTETVEEPMEEEEAAKEEKEESDDE-------AAVEEEEE---EKKP 280 290 300 310 320 270 280 290 300 310 320 pF1KB5 KTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQL ::::... : : .: :::: : .. ..:: ::::.... .: .: ::..::.. NP_003 KTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEV 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB5 EFRALLFIPRRAPFDLFEN--KKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSED :...::.: :: ::.. .::.. :::::::::: :. ...:.::::..:::::.: NP_003 TFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDD 390 400 410 420 430 440 390 400 410 420 430 440 pF1KB5 LPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDS ::::.::: ::: :.::::::..:.: :......:.:: : :.. :. :.:::. :: NP_003 LPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYN-DTFWKEFGTNIKLGVIEDH 450 460 470 480 490 500 450 460 470 480 490 500 pF1KB5 TNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRK .:: ::..:::...:. ..:::..:: :::: : .::...: :.... .: ::::. : NP_003 SNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLK 510 520 530 540 550 560 510 520 530 540 550 560 pF1KB5 RGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCK .:.::.:.:::.::::.: : ::::: . .:.:::... :.:. :.. : . .:: : . NP_003 KGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLN 570 580 590 600 610 620 570 580 590 600 610 620 pF1KB5 LMKE-ILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQAL---RDNSTMGYMM ::. : :.::...:.::. ::: .:.: :::..:::::::::: .: :: : NP_003 WMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYAS 630 640 650 660 670 680 630 640 650 660 670 680 pF1KB5 AKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIY :: .:::: ::... . .. . :..::.: ::.:.::::: : ::. : : .....:: NP_003 QKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIE 690 700 710 720 730 740 690 700 710 720 pF1KB5 RMIKLGLGIDED----EVAAEEPNAAVPDEIPPLEGDEDASRMEEVD ::..:.:.:: : : :::. .. : : ::: ::.: NP_003 RMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDED----EEMDVGTDEEEETAKES 750 760 770 780 790 NP_003 TAEKDEL 800 >>XP_011520647 (OMIM: 606219) PREDICTED: heat shock prot (564 aa) initn: 736 init1: 289 opt: 628 Z-score: 426.8 bits: 89.2 E(85289): 4.9e-17 Smith-Waterman score: 960; 29.9% identity (61.7% similar) in 629 aa overlap (71-684:1-557) 50 60 70 80 90 100 pF1KB5 RELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLIN ..: . : .. :.:. :::::::. .:.. XP_011 MEIHLQTNAEKGTITIQDTGIGMTQEELVS 10 20 30 110 120 130 140 150 pF1KB5 NLGTIAKSGTKAFMEALQAGADIS--MIGQFGVGFYSAYLVAEKVVVITKHNDDEQ--YA ::::::.::.:::..::: :. : .:::::::::::..::..: : .. . : XP_011 NLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQ 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 WESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLY : :...: : . : . :::.:.::: : :. : ::..:: :.:.:...: :: XP_011 WLSDGSGVFEIAEASG--VRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFP--LY 100 110 120 130 140 220 230 240 250 260 270 pF1KB5 LEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKY :. .: XP_011 LNGRR------------------------------------------------------- 150 280 290 300 310 320 330 pF1KB5 IDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIP .: . :: .: :. . .. :::. ... . . :..... :..:.....: XP_011 -----MNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVP 160 170 180 190 200 340 350 360 370 380 390 pF1KB5 RRAPFDLFE-NKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREML : ..:. ... ... :: :.:.:. . ...:..: ::::::::::.:::.:::.: XP_011 DMKP-SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELL 210 220 230 240 250 260 400 410 420 430 440 450 pF1KB5 QQSKILKVIRKNIVKKCLELFSELAE-DKENYKKFYEAFSKNLKLGI--HEDSTNRRRLS :.: ... .: . .. ...: . .. : :.: ::.: .. .. :: .. .. .. XP_011 QESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIA 270 280 290 300 310 320 460 470 480 490 500 510 pF1KB5 ELLRYHTSQ--SGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEV .::::..: :: ..::::::.:::. ..:::. . ... . .: . : ..:. :: XP_011 KLLRYESSALPSG-QLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEV 330 340 350 360 370 380 520 530 540 550 560 pF1KB5 VYMTEPIDEYCVQQLKEFDGKSLVSVTKEGL--ELPEDE-EEKKKMEE--SKAKFENLCK .. : .:: . .:.::: :.:.:: . . . :.. :... : :. . :.: XP_011 LFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMA 390 400 410 420 430 440 570 580 590 600 610 620 pF1KB5 LMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKH :...: ..: .: .. :: . : ... .: ..... : : .. .. . XP_011 WMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMG---AARHFLRMQQLAKTQEERAQLLQPT 450 460 470 480 490 500 630 640 650 660 670 680 pF1KB5 LEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIK ::::: : ... : : .. . .. :: ..:.:....:. ..::.. .:. ... XP_011 LEINPRHALIKKLNQLRASEPG--LAQLLVDQIYENAMIAAGL-VDDPRAMVGRLNELLV 510 520 530 540 550 690 700 710 720 pF1KB5 LGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD XP_011 KALERH 560 724 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 22:32:37 2016 done: Thu Nov 3 22:32:38 2016 Total Scan time: 12.370 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]