FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5446, 655 aa 1>>>pF1KB5446 655 - 655 aa - 655 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2198+/-0.000409; mu= 20.6917+/- 0.025 mean_var=76.1993+/-15.709, 0's: 0 Z-trim(111.7): 58 B-trim: 59 in 1/49 Lambda= 0.146926 statistics sampled from 20312 (20370) to 20312 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.601), E-opt: 0.2 (0.239), width: 16 Scan time: 7.980 The best scores are: opt bits E(85289) NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 4259 912.8 0 NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 4133 886.1 0 XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 4103 879.8 0 NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 3829 821.7 0 NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 3768 808.7 0 XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 3120 671.4 2.7e-192 XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 3120 671.4 2.8e-192 NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 1697 369.7 1.7e-101 XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 1410 308.9 3.2e-83 XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 724 163.4 1.5e-39 NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 717 161.9 4.4e-39 NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 714 161.2 6.7e-39 NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 712 160.8 8.7e-39 NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 710 160.4 1.2e-38 XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 702 158.7 4.1e-38 XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 702 158.7 4.2e-38 NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 674 152.7 2e-36 XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 648 147.3 1.2e-34 XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 641 145.8 3.5e-34 NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 633 144.0 9.3e-34 NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 633 144.1 1e-33 NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 633 144.1 1e-33 XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 633 144.1 1.1e-33 XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 626 142.7 3.3e-33 XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 623 142.0 4.8e-33 XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 617 140.7 1e-32 XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 617 140.7 1.1e-32 NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 611 139.4 2.7e-32 XP_016861754 (OMIM: 611103,611126) PREDICTED: acyl ( 340) 588 134.5 6.3e-31 XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 576 131.9 3.5e-30 XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 576 131.9 3.7e-30 NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 576 132.0 4.3e-30 XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 565 129.7 2.1e-29 NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 565 129.7 2.2e-29 XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 561 128.8 3.6e-29 XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 551 126.6 1.5e-28 XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 551 126.7 1.8e-28 XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 551 126.7 1.8e-28 XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 539 124.2 1e-27 XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 505 116.8 1.1e-25 NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 481 111.8 4.9e-24 XP_016877647 (OMIM: 243500,607036) PREDICTED: isov ( 308) 466 108.6 3.6e-23 XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 446 104.4 8.1e-22 XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 446 104.4 8.1e-22 NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 436 102.1 2.4e-21 XP_005271562 (OMIM: 604773,611283) PREDICTED: isob ( 249) 342 82.2 2.5e-15 XP_016873038 (OMIM: 604773,611283) PREDICTED: isob ( 249) 342 82.2 2.5e-15 XP_016873037 (OMIM: 604773,611283) PREDICTED: isob ( 268) 340 81.8 3.5e-15 NP_115545 (OMIM: 614288) acyl-CoA dehydrogenase fa ( 780) 339 82.0 9.2e-15 NP_079523 (OMIM: 611181) acyl-CoA dehydrogenase fa (1059) 339 82.1 1.2e-14 >>NP_000009 (OMIM: 201475,609575) very long-chain specif (655 aa) initn: 4259 init1: 4259 opt: 4259 Z-score: 4877.7 bits: 912.8 E(85289): 0 Smith-Waterman score: 4259; 100.0% identity (100.0% similar) in 655 aa overlap (1-655:1-655) 10 20 30 40 50 60 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF 610 620 630 640 650 >>NP_001257376 (OMIM: 201475,609575) very long-chain spe (678 aa) initn: 4133 init1: 4133 opt: 4133 Z-score: 4733.1 bits: 886.1 E(85289): 0 Smith-Waterman score: 4133; 100.0% identity (100.0% similar) in 635 aa overlap (21-655:44-678) 10 20 30 40 50 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALD :::::::::::::::::::::::::::::: NP_001 MGKEIEAEAQRPLRQTWRPGQPPAMTAKTMSSRLTALLGQPRPGPARRPYAGGAAQLALD 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB5 KSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVS 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB5 RFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMH 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB5 DLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRT 200 210 220 230 240 250 240 250 260 270 280 290 pF1KB5 SAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGG 260 270 280 290 300 310 300 310 320 330 340 350 pF1KB5 ITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAG 320 330 340 350 360 370 360 370 380 390 400 410 pF1KB5 TMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATD 380 390 400 410 420 430 420 430 440 450 460 470 pF1KB5 FQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRL 440 450 460 470 480 490 480 490 500 510 520 530 pF1KB5 FVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELS 500 510 520 530 540 550 540 550 560 570 580 590 pF1KB5 RSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLS 560 570 580 590 600 610 600 610 620 630 640 650 pF1KB5 EGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTS 620 630 640 650 660 670 pF1KB5 NPLGF ::::: NP_001 NPLGF >>XP_006721579 (OMIM: 201475,609575) PREDICTED: very lon (662 aa) initn: 4109 init1: 3634 opt: 4103 Z-score: 4698.9 bits: 879.8 E(85289): 0 Smith-Waterman score: 4103; 96.1% identity (97.6% similar) in 662 aa overlap (1-655:1-662) 10 20 30 40 50 60 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 EQFATVVEAKLIKHKKGIVNEQF---LLQRLADGA----IDLYAMVVVLSRASRSLSEGH :::::::::::::::::::.:. :.: . : ..: ... .:::::::::: XP_006 EQFATVVEAKLIKHKKGIVSEEAGRECLSRRGPGPGSQPAQIYFHLLLPARASRSLSEGH 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 PTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPL 610 620 630 640 650 660 pF1KB5 GF :: XP_006 GF >>NP_001029031 (OMIM: 201475,609575) very long-chain spe (633 aa) initn: 3819 init1: 3819 opt: 3829 Z-score: 4385.3 bits: 821.7 E(85289): 0 Smith-Waterman score: 4065; 96.6% identity (96.6% similar) in 655 aa overlap (1-655:1-633) 10 20 30 40 50 60 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL :::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQ-------------- 10 20 30 40 70 80 90 100 110 120 pF1KB5 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 --------ESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB5 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB5 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB5 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB5 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB5 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB5 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK 520 530 540 550 560 570 610 620 630 640 650 pF1KB5 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF 580 590 600 610 620 630 >>NP_001257377 (OMIM: 201475,609575) very long-chain spe (579 aa) initn: 3768 init1: 3768 opt: 3768 Z-score: 4316.0 bits: 808.7 E(85289): 0 Smith-Waterman score: 3768; 100.0% identity (100.0% similar) in 579 aa overlap (77-655:1-579) 50 60 70 80 90 100 pF1KB5 LALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELV :::::::::::::::::::::::::::::: NP_001 MFKGQLTTDQVFPYPSVLNEEQTQFLKELV 10 20 30 110 120 130 140 150 160 pF1KB5 EPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEI 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 VGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAA 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 SIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVER 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 GFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAA 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 ALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQ 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 GATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTND 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 ILRLFVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILRLFVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVH 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB5 PELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRAS 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB5 RSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGG 520 530 540 550 560 570 650 pF1KB5 VVTSNPLGF ::::::::: NP_001 VVTSNPLGF >>XP_011522132 (OMIM: 201475,609575) PREDICTED: very lon (621 aa) initn: 3881 init1: 3120 opt: 3120 Z-score: 3573.2 bits: 671.4 E(85289): 2.7e-192 Smith-Waterman score: 3821; 92.1% identity (93.1% similar) in 655 aa overlap (1-655:1-621) 10 20 30 40 50 60 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMA- 430 440 450 460 470 490 500 510 520 530 540 pF1KB5 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL :.::.. . . :. .: ::::: XP_011 ----------------------GRAGQRPESQRTCPPGV-----------ESEWRAVRAL 480 490 500 550 560 570 580 590 600 pF1KB5 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EQFATVVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEK 510 520 530 540 550 560 610 620 630 640 650 pF1KB5 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF 570 580 590 600 610 620 >>XP_011522131 (OMIM: 201475,609575) PREDICTED: very lon (628 aa) initn: 3731 init1: 3120 opt: 3120 Z-score: 3573.1 bits: 671.4 E(85289): 2.8e-192 Smith-Waterman score: 3665; 88.2% identity (90.8% similar) in 662 aa overlap (1-655:1-628) 10 20 30 40 50 60 pF1KB5 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQAARMAASLGRQLLRLGGGSSRLTALLGQPRPGPARRPYAGGAAQLALDKSDSHPSDAL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TRKKPAKAESKSFAVGMFKGQLTTDQVFPYPSVLNEEQTQFLKELVEPVSRFFEEVNDPA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQGATDFQIEAAISKI 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMA- 430 440 450 460 470 490 500 510 520 530 540 pF1KB5 GKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHPELSRSGELAVRAL :.::.. . . :. .: ::::: XP_011 ----------------------GRAGQRPESQRTCPPGV-----------ESEWRAVRAL 480 490 500 550 560 570 580 590 pF1KB5 EQFATVVEAKLIKHKKGIVNEQF---LLQRLADGA----IDLYAMVVVLSRASRSLSEGH :::::::::::::::::::.:. :.: . : ..: ... .:::::::::: XP_011 EQFATVVEAKLIKHKKGIVSEEAGRECLSRRGPGPGSQPAQIYFHLLLPARASRSLSEGH 510 520 530 540 550 560 600 610 620 630 640 650 pF1KB5 PTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PTAQHEKMLCDTWCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPL 570 580 590 600 610 620 pF1KB5 GF :: XP_011 GF >>NP_054768 (OMIM: 611103,611126) acyl-CoA dehydrogenase (621 aa) initn: 948 init1: 566 opt: 1697 Z-score: 1943.0 bits: 369.7 E(85289): 1.7e-101 Smith-Waterman score: 1697; 46.6% identity (75.0% similar) in 599 aa overlap (60-653:29-617) 30 40 50 60 70 80 pF1KB5 QPRPGPARRPYAGGAAQLALDKSDSHPSDALTRKKPAKAESKSFAVGMFKGQLTTDQVFP : : .: ..:: .: :.. .::: NP_054 MSGCGLFLRTTAAARACRGLVVSTANRRLLRTSP---PVRAFAKELFLGKIKKKEVFP 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 YPSVLNEEQTQFLKELVEPVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSE .: : ..: .. ..... :: .:: : : : : . . : . :: :: :::::: : NP_054 FPEVSQDELNE-INQFLGPVEKFFTEEVDSRKIDQEGKIPDETLEKLKSLGLFGLQVPEE 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB5 LGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGE ::.:. ::.:.:: ::..: : .. .::.:::.::.:::.: ::. :: :::::::::: NP_054 YGGLGFSNTMYSRLGEIISM-DGSITVTLAAHQAIGLKGIILAGTEEQKAKYLPKLASGE 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB5 TVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTD .::::::::.:::::::::. :. : :.: :::::.::.:::::.:::::::: :.: NP_054 HIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVWITNGGLANIFTVFAKTEVVD 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB5 PATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSG . :.::.:::::.::: :::.:.: :: :.::..::: :: :.....: ::.:::::.: NP_054 -SDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCEVHFENTKIPVENILGEVGDG 240 250 260 270 280 290 330 340 350 360 370 380 pF1KB5 FKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVML :::::.:::.:::.:....:: .. .: ....: .: ::.... .:::::::.: :.. NP_054 FKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQFNKRLSEFGLIQEKFALMAQK 300 310 320 330 340 350 390 400 410 420 430 440 pF1KB5 QYVTESMAYMVSANMDQ-GATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGV :: :::.:.... .:: : : .::::. :.:.:::::. ..: .::.::.:. .. NP_054 AYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQCVSEALQILGGLGYTRDYPY 360 370 380 390 400 410 450 460 470 480 490 500 pF1KB5 ERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQ ::.::: ::. ::::::.:::...:: : . :. :. ::. .... .. .:.. NP_054 ERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRIHELKQ--AKVSTVMDTVGRR 420 430 440 450 460 470 510 520 530 540 550 560 pF1KB5 LRRRAGLGSGLSLSG---LVHPELSRSGELAVRALEQFATVVEAKLIKHKKGIVNEQFLL :: : :.:.: .::: :. :.. . :. .::. :.. : :..::..: NP_054 LRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGRTVETLLLRFGKTIMEEQLVL 480 490 500 510 520 530 570 580 590 600 610 620 pF1KB5 QRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEKMLCDTWCIEAAARIREGMAALQSDP .:.:. :.::.:..::::::::. : . .:: .: .:.:.:: ... .. : : NP_054 KRVANILINLYGMTAVLSRASRSIRIGLRNHDHEVLLANTFCVEA--YLQNLFSLSQLDK 540 550 560 570 580 630 640 650 pF1KB5 WQQE-LYRNFKSISKALVERGGVVTSNPLGF . : : ...:..:. ..:. . . ..:: NP_054 YAPENLDEQIKKVSQQILEKRAYICAHPLDRTC 590 600 610 620 >>XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl-CoA (537 aa) initn: 718 init1: 566 opt: 1410 Z-score: 1615.1 bits: 308.9 E(85289): 3.2e-83 Smith-Waterman score: 1410; 50.4% identity (78.1% similar) in 452 aa overlap (160-607:2-449) 130 140 150 160 170 180 pF1KB5 ETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGI :.:: ::..: : .. .::.:::.::.::: XP_016 MYSRLGEIISM-DGSITVTLAAHQAIGLKGI 10 20 30 190 200 210 220 230 240 pF1KB5 LLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLW .: ::. :: :::::::::: .::::::::.:::::::::. :. : :.: :::::.: XP_016 ILAGTEEQKAKYLPKLASGEHIAAFCLTEPASGSDAASIRSRATLSEDKKHYILNGSKVW 40 50 60 70 80 90 250 260 270 280 290 300 pF1KB5 ISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAE :.:::::.:::::::: :.: . :.::.:::::.::: :::.:.: :: :.::..::: : XP_016 ITNGGLANIFTVFAKTEVVD-SDGSVKDKITAFIVERDFGGVTNGKPEDKLGIRGSNTCE 100 110 120 130 140 310 320 330 340 350 360 pF1KB5 VFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQF : :.....: ::.:::::.::::::.:::.:::.:....:: .. .: ....: .: :: XP_016 VHFENTKIPVENILGEVGDGFKVAMNILNSGRFSMGSVVAGLLKRLIEMTAEYACTRKQF 150 160 170 180 190 200 370 380 390 400 410 420 pF1KB5 GEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQ-GATDFQIEAAISKIFGSEAAWK .... .:::::::.: :.. :: :::.:.... .:: : : .::::. :.:.:::::. XP_016 NKRLSEFGLIQEKFALMAQKAYVMESMTYLTAGMLDQPGFPDCSIEAAMVKVFSSEAAWQ 210 220 230 240 250 260 430 440 450 460 470 480 pF1KB5 VTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDILRLFVALQGCMDKGKELSGLG ..: .::.::.:. .. ::.::: ::. ::::::.:::...:: : . :. :. XP_016 CVSEALQILGGLGYTRDYPYERILRDTRILLIFEGTNEILRMYIALTGLQHAGRILTTRI 270 280 290 300 310 320 490 500 510 520 530 540 pF1KB5 SALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSG---LVHPELSRSGELAVRALEQFAT ::. .... .. .:..:: : :.:.: .::: :. :.. . :. XP_016 HELKQ--AKVSTVMDTVGRRLRDSLGRTVDLGLTGNHGVVHPSLADSANKFEENTYCFGR 330 340 350 360 370 380 550 560 570 580 590 600 pF1KB5 VVEAKLIKHKKGIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGHPTAQHEKMLCDT .::. :.. : :..::..:.:.:. :.::.:..::::::::. : . .::. . XP_016 TVETLLLRFGKTIMEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHDHEQGTDPA 390 400 410 420 430 440 610 620 630 640 650 pF1KB5 WCIEAAARIREGMAALQSDPWQQELYRNFKSISKALVERGGVVTSNPLGF : XP_016 HCPLCWREAGAVSEDPLYTRISACTFQSTCRYQDCDICLSEETGSEMLSHLLLGKGCWIR 450 460 470 480 490 500 >>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa) initn: 708 init1: 261 opt: 724 Z-score: 830.9 bits: 163.4 E(85289): 1.5e-39 Smith-Waterman score: 724; 32.2% identity (68.4% similar) in 395 aa overlap (79-472:17-398) 50 60 70 80 90 100 pF1KB5 LDKSDSHPSDALTRKKPAKAESKSFAVGMFKG-QLTTDQVFPYPSVLNEEQTQFLKELVE :: : . ... : . : . ...::.: . XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAELRQTMAKFLQEHLA 10 20 30 40 110 120 130 140 150 160 pF1KB5 PVSRFFEEVNDPAKNDALEMVEETTWQGLKELGAFGLQVPSELGGVGLCNTQYARLVEIV : . .:.. ... .. ..: :. : .::..:. .: . :: :: ... ..: . XP_016 PKA---QEID---RSNEFKNLREF-WKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEI 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 GMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLASGETVAAFCLTEPSSGSDAAS . . .::.. :::... .. .. :..:::::::::: ::: ..:. ..::..:::..: XP_016 SRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVS 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 IRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPVTDPATGAVKEKITAFVVERG .. .: . :..: :::.:.::.:: ::.. :.::: : :. ... ::::.::.: XP_016 MKLKAEKK--GNHYILNGNKFWITNGPDADVLIVYAKT---DLAAVPASRGITAFIVEKG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 FGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVGSGFKVAMHILNNGRFGMAAA . :.. . :.:...::: :..:. ..:. :.::. ..: : : :. :. .:.. XP_016 MPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGG 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 LAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMVMLQYVTESMAYMVSANMDQG : :.... ... . : ::.:: .: :.: :.: : .. ....: :. :.: XP_016 PLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEG 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 ATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDLRIFRIFEGTNDI . :.. ....: : .:. . :: .:: :.... . : ::: ....: ::... XP_016 HCTAKDCAGVI-LYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEV 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 LRLFVALQGCMDKGKELSGLGSALKNPFGNAGLLLGEAGKQLRRRAGLGSGLSLSGLVHP :: . XP_016 RRLVIGRAFNADFH 400 655 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:16:21 2016 done: Sat Nov 5 07:16:22 2016 Total Scan time: 7.980 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]