FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5447, 413 aa 1>>>pF1KB5447 413 - 413 aa - 413 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3649+/-0.00092; mu= 16.0110+/- 0.055 mean_var=57.7077+/-11.909, 0's: 0 Z-trim(104.4): 24 B-trim: 0 in 0/49 Lambda= 0.168833 statistics sampled from 7893 (7903) to 7893 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.243), width: 16 Scan time: 2.590 The best scores are: opt bits E(32554) CCDS7479.1 GOT1 gene_id:2805|Hs108|chr10 ( 413) 2781 685.9 1.9e-197 CCDS10801.1 GOT2 gene_id:2806|Hs108|chr16 ( 430) 1323 330.7 1.6e-90 CCDS67045.1 GOT2 gene_id:2806|Hs108|chr16 ( 387) 1075 270.3 2.2e-72 CCDS47839.1 GOT1L1 gene_id:137362|Hs108|chr8 ( 421) 761 193.8 2.5e-49 >>CCDS7479.1 GOT1 gene_id:2805|Hs108|chr10 (413 aa) initn: 2781 init1: 2781 opt: 2781 Z-score: 3658.3 bits: 685.9 E(32554): 1.9e-197 Smith-Waterman score: 2781; 100.0% identity (100.0% similar) in 413 aa overlap (1-413:1-413) 10 20 30 40 50 60 pF1KB5 MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS74 FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ 370 380 390 400 410 >>CCDS10801.1 GOT2 gene_id:2806|Hs108|chr16 (430 aa) initn: 1293 init1: 914 opt: 1323 Z-score: 1738.7 bits: 330.7 E(32554): 1.6e-90 Smith-Waterman score: 1323; 48.9% identity (78.1% similar) in 407 aa overlap (5-411:31-430) 10 20 30 pF1KB5 MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKV : ...: .. : .. .: :..: . .:. CCDS10 MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 NLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSP :::::::: :. .:.::: :.:.: .:: : :..::::: ::::: . ...::::..: CCDS10 NLGVGAYRDDNGKPYVLPSVRKAEAQIAAKN-LDKEYLPIGGLAEFCKASAELALGENSE 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 ALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFK .:: : ::...:::::::::.:: :... . . :.. .::: ::. .: ::.. CCDS10 VLKSGRFVTVQTISGTGALRIGASFLQRFFKFSRD----VFLPKPTWGNHTPIFRDAGMQ 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 DIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMK ...:::.: . :.:. : ..:. . :: :...::::::::::.:: :::::.::.:.: CCDS10 -LQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVK 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 HRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVV .: :: ::: ::::::::. ..::::.:.:. .:.. ::..::.:::.:::: .:.: CCDS10 KRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMV 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 GKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM :. . .: ::.. ..: .:::: .::::.:. :..:.: ..: .::.:::::. : CCDS10 CKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGM 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLT :..: . :. . .:.::::::::: ::::.:.::: :..: ::. .:::.:.:.: CCDS10 RTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVT 360 370 380 390 400 410 400 410 pF1KB5 TKNLDYVATSIHEAVTKIQ ..:. :.: .::. ::: CCDS10 SSNVGYLAHAIHQ-VTK 420 430 >>CCDS67045.1 GOT2 gene_id:2806|Hs108|chr16 (387 aa) initn: 1165 init1: 914 opt: 1075 Z-score: 1413.0 bits: 270.3 E(32554): 2.2e-72 Smith-Waterman score: 1107; 43.5% identity (70.3% similar) in 407 aa overlap (5-411:31-387) 10 20 30 pF1KB5 MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKV : ...: .. : .. .: :..: . .:. CCDS67 MALLHSGRVLPGIAAAFHPGLAAAASARASSWWTHVEMGPPDPILGVTEAFKRDTNSKKM 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 NLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSP :::::::: :. .:.::: :.: : . CCDS67 NLGVGAYRDDNGKPYVLPSVRK-----------------------FVT------------ 70 80 100 110 120 130 140 150 pF1KB5 ALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFK ::...:::::::::.:: :... . . :.. .::: ::. .: ::.. CCDS67 ---------VQTISGTGALRIGASFLQRFFKFSRD----VFLPKPTWGNHTPIFRDAGMQ 90 100 110 120 130 160 170 180 190 200 210 pF1KB5 DIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMK ...:::.: . :.:. : ..:. . :: :...::::::::::.:: :::::.::.:.: CCDS67 -LQGYRYYDPKTCGFDFTGAVEDISKIPEQSVLLLHACAHNPTGVDPRPEQWKEIATVVK 140 150 160 170 180 190 220 230 240 250 260 270 pF1KB5 HRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVV .: :: ::: ::::::::. ..::::.:.:. .:.. ::..::.:::.:::: .:.: CCDS67 KRNLFAFFDMAYQGFASGDGDKDAWAVRHFIEQGINVCLCQSYAKNMGLYGERVGAFTMV 200 210 220 230 240 250 280 290 300 310 320 330 pF1KB5 GKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTM :. . .: ::.. ..: .:::: .::::.:. :..:.: ..: .::.:::::. : CCDS67 CKDADEAKRVESQLKILIRPMYSNPPLNGARIAAAILNTPDLRKQWLQEVKVMADRIIGM 260 270 280 290 300 310 340 350 360 370 380 390 pF1KB5 RSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLT :..: . :. . .:.::::::::: ::::.:.::: :..: ::. .:::.:.:.: CCDS67 RTQLVSNLKKEGSTHNWQHITDQIGMFCFTGLKPEQVERLIKEFSIYMTKDGRISVAGVT 320 330 340 350 360 370 400 410 pF1KB5 TKNLDYVATSIHEAVTKIQ ..:. :.: .::. ::: CCDS67 SSNVGYLAHAIHQ-VTK 380 >>CCDS47839.1 GOT1L1 gene_id:137362|Hs108|chr8 (421 aa) initn: 1015 init1: 682 opt: 761 Z-score: 999.1 bits: 193.8 E(32554): 2.5e-49 Smith-Waterman score: 1038; 40.3% identity (68.5% similar) in 409 aa overlap (1-409:1-399) 10 20 30 40 50 60 pF1KB5 MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK : ::: .:: :. : .: ...: : :. :. . :.. :::: ::.:.. . CCDS47 MPTLSVFMDVPLAHK-LEGSLLKTYKQDDYPNKIFLAYRVCMTNEGHPWVSLVVQKTRLQ 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL :..: :::.:::: .:: : . . : .: : :. :.:::::...: .::...:..:: CCDS47 ISQDPSLNYEYLPTMGLKSFIQASLALLFGKHSQAIVENRVGGVHTVGDSGAFQLGVQFL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN :.. . ::. : : :. ::. :: . : :: .: .: . .:: .:. CCDS47 RAWHKDARI----VYIISSQKELHGLVFQDMGFT-VYEYSVWDPKKLCMDPDILLNVVEQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA :. ..:. : :: : .. :..: . .::::: ::. ...::.:. CCDS47 IPHGCVLVMG----NIIDCKLTPSGWAKLMSMIKSKQIFPFFDIPCQGLYTSDLEEDTRI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP ..::::.::::::.::.:::::.:.: :: :.::. . ...: ::::.: ... : ::: CCDS47 LQYFVSQGFEFFCSQSLSKNFGIYDEGVGMLVVVAVNNQQLLCVLSQLEGLAQALWLNPP 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM :::...: : :: :. :: ..: ... :. . ... .:. : :::.:.:::.: : CCDS47 NTGARVITSILCNPALLGEWKQSLKEVVENIMLTKEKVKEKLQLLGTPGSWGHITEQSGT 300 310 320 330 340 350 370 380 390 400 410 pF1KB5 FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ .. ::: .:::::: .::::. .:.:: : ....:..:.. .:.::: CCDS47 HGYLGLNSQQVEYLVRKKHIYIPKNGQINFSCINANNINYITEGINEAVLLTESSEMCLP 360 370 380 390 400 410 CCDS47 KEKKTLIGIKL 420 413 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:39:35 2016 done: Sat Nov 5 19:39:35 2016 Total Scan time: 2.590 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]