FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5448, 193 aa 1>>>pF1KB5448 193 - 193 aa - 193 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2647+/-0.000358; mu= 13.7504+/- 0.023 mean_var=78.9158+/-15.666, 0's: 0 Z-trim(115.9): 399 B-trim: 597 in 1/53 Lambda= 0.144375 statistics sampled from 26247 (26731) to 26247 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.313), width: 16 Scan time: 5.930 The best scores are: opt bits E(85289) NP_001300870 (OMIM: 165390) transforming protein R ( 193) 1306 281.1 7.7e-76 NP_001655 (OMIM: 165390) transforming protein RhoA ( 193) 1306 281.1 7.7e-76 NP_001036143 (OMIM: 165380) rho-related GTP-bindin ( 193) 1222 263.6 1.4e-70 NP_786886 (OMIM: 165380) rho-related GTP-binding p ( 193) 1222 263.6 1.4e-70 NP_001036144 (OMIM: 165380) rho-related GTP-bindin ( 193) 1222 263.6 1.4e-70 NP_004031 (OMIM: 165370) rho-related GTP-binding p ( 196) 1122 242.8 2.7e-64 NP_001300872 (OMIM: 165390) transforming protein R ( 187) 944 205.7 3.8e-53 NP_001300873 (OMIM: 165390) transforming protein R ( 173) 889 194.2 1e-49 NP_001300874 (OMIM: 165390) transforming protein R ( 112) 766 168.4 3.7e-42 NP_008839 (OMIM: 602048) ras-related C3 botulinum ( 192) 735 162.1 4.9e-40 NP_001656 (OMIM: 179505) rho-related GTP-binding p ( 191) 724 159.9 2.4e-39 XP_016873208 (OMIM: 179505) PREDICTED: rho-related ( 191) 724 159.9 2.4e-39 XP_005252973 (OMIM: 179505) PREDICTED: rho-related ( 191) 724 159.9 2.4e-39 NP_001782 (OMIM: 116952,616737) cell division cont ( 191) 705 155.9 3.7e-38 NP_001034891 (OMIM: 116952,616737) cell division c ( 191) 705 155.9 3.7e-38 NP_005043 (OMIM: 602050) ras-related C3 botulinum ( 192) 704 155.7 4.3e-38 NP_002863 (OMIM: 602049,608203) ras-related C3 bot ( 192) 700 154.9 7.6e-38 NP_426359 (OMIM: 116952,616737) cell division cont ( 191) 696 154.0 1.4e-37 NP_055393 (OMIM: 605781) rho-related GTP-binding p ( 210) 682 151.1 1.1e-36 NP_036381 (OMIM: 605857) rho-related GTP-binding p ( 205) 679 150.5 1.7e-36 NP_001241667 (OMIM: 602924) rho-related GTP-bindin ( 244) 661 146.8 2.6e-35 NP_005159 (OMIM: 602924) rho-related GTP-binding p ( 244) 661 146.8 2.6e-35 NP_005431 (OMIM: 601555) rho-related GTP-binding p ( 227) 650 144.5 1.2e-34 XP_011523618 (OMIM: 601555) PREDICTED: rho-related ( 234) 650 144.5 1.2e-34 NP_065714 (OMIM: 607653) rho-related GTP-binding p ( 214) 641 142.6 4.2e-34 NP_001303236 (OMIM: 602050) ras-related C3 botulin ( 170) 619 137.9 8.4e-33 XP_006724349 (OMIM: 602049,608203) PREDICTED: ras- ( 161) 604 134.8 7e-32 XP_016859205 (OMIM: 605857) PREDICTED: rho-related ( 172) 591 132.1 4.8e-31 NP_067028 (OMIM: 606366) rho-related GTP-binding p ( 258) 593 132.7 4.9e-31 XP_011531028 (OMIM: 605857) PREDICTED: rho-related ( 192) 590 131.9 6e-31 NP_055285 (OMIM: 609038) rho-related GTP-binding p ( 232) 550 123.7 2.2e-28 XP_006720277 (OMIM: 607653) PREDICTED: rho-related ( 176) 547 123.0 2.8e-28 XP_011523619 (OMIM: 601555) PREDICTED: rho-related ( 206) 535 120.5 1.8e-27 NP_001265296 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 XP_016863677 (OMIM: 602037) PREDICTED: rho-related ( 191) 512 115.7 4.7e-26 NP_001265289 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265294 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 XP_011511994 (OMIM: 602037) PREDICTED: rho-related ( 191) 512 115.7 4.7e-26 XP_016863678 (OMIM: 602037) PREDICTED: rho-related ( 191) 512 115.7 4.7e-26 NP_001265298 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265293 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265290 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265291 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265292 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265297 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265295 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_001265288 (OMIM: 602037) rho-related GTP-bindin ( 191) 512 115.7 4.7e-26 NP_004301 (OMIM: 602037) rho-related GTP-binding p ( 191) 512 115.7 4.7e-26 XP_011531030 (OMIM: 605857) PREDICTED: rho-related ( 157) 445 101.7 6.4e-22 NP_001300875 (OMIM: 165390) transforming protein R ( 109) 391 90.3 1.2e-18 >>NP_001300870 (OMIM: 165390) transforming protein RhoA (193 aa) initn: 1306 init1: 1306 opt: 1306 Z-score: 1482.5 bits: 281.1 E(85289): 7.7e-76 Smith-Waterman score: 1306; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL ::::::::::::: NP_001 ARRGKKKSGCLVL 190 >>NP_001655 (OMIM: 165390) transforming protein RhoA iso (193 aa) initn: 1306 init1: 1306 opt: 1306 Z-score: 1482.5 bits: 281.1 E(85289): 7.7e-76 Smith-Waterman score: 1306; 100.0% identity (100.0% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL ::::::::::::: NP_001 ARRGKKKSGCLVL 190 >>NP_001036143 (OMIM: 165380) rho-related GTP-binding pr (193 aa) initn: 1222 init1: 1222 opt: 1222 Z-score: 1388.0 bits: 263.6 E(85289): 1.4e-70 Smith-Waterman score: 1222; 91.7% identity (98.4% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_001 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL .:..:.. :: .: NP_001 VRKNKRRRGCPIL 190 >>NP_786886 (OMIM: 165380) rho-related GTP-binding prote (193 aa) initn: 1222 init1: 1222 opt: 1222 Z-score: 1388.0 bits: 263.6 E(85289): 1.4e-70 Smith-Waterman score: 1222; 91.7% identity (98.4% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_786 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_786 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_786 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL .:..:.. :: .: NP_786 VRKNKRRRGCPIL 190 >>NP_001036144 (OMIM: 165380) rho-related GTP-binding pr (193 aa) initn: 1222 init1: 1222 opt: 1222 Z-score: 1388.0 bits: 263.6 E(85289): 1.4e-70 Smith-Waterman score: 1222; 91.7% identity (98.4% similar) in 193 aa overlap (1-193:1-193) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ ::.::::::::::::::::. ::::::::::.::::.:::::::.::::::::::::.:: NP_001 LRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECSAKTKEGVREVFEMATRAGLQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL .:..:.. :: .: NP_001 VRKNKRRRGCPIL 190 >>NP_004031 (OMIM: 165370) rho-related GTP-binding prote (196 aa) initn: 1130 init1: 1110 opt: 1122 Z-score: 1275.3 bits: 242.8 E(85289): 2.7e-64 Smith-Waterman score: 1122; 85.3% identity (94.8% similar) in 191 aa overlap (1-191:1-190) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT :::::::::.::::::::::::::::::.::::::::::::::::::::::::::::::: NP_004 MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::.:::::::::::::.:::::::::::::::.:::: NP_004 AGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ ::.:::.: :::.::::::. ..:: :: :: :. :.:::::::.::::::: ::::::: NP_004 LRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQ 130 140 150 160 170 180 190 pF1KB5 ARRGKKKSGCLVL : :.. .::. NP_004 KRYGSQ-NGCINCCKVL 190 >>NP_001300872 (OMIM: 165390) transforming protein RhoA (187 aa) initn: 944 init1: 944 opt: 944 Z-score: 1075.2 bits: 205.7 E(85289): 3.8e-53 Smith-Waterman score: 944; 100.0% identity (100.0% similar) in 138 aa overlap (1-138:1-138) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ :::::::::::::::::: NP_001 LRNDEHTRRELAKMKQEPHCVARLECCGTILAQLQPPPPRFKRFPCLSLLSSWGYRRPLP 130 140 150 160 170 180 >>NP_001300873 (OMIM: 165390) transforming protein RhoA (173 aa) initn: 889 init1: 889 opt: 889 Z-score: 1013.8 bits: 194.2 E(85289): 1e-49 Smith-Waterman score: 1124; 89.6% identity (89.6% similar) in 193 aa overlap (1-193:1-173) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT ::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYV----------------- 10 20 30 40 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---EDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ 110 120 130 140 150 160 190 pF1KB5 ARRGKKKSGCLVL ::::::::::::: NP_001 ARRGKKKSGCLVL 170 >>NP_001300874 (OMIM: 165390) transforming protein RhoA (112 aa) initn: 766 init1: 766 opt: 766 Z-score: 877.9 bits: 168.4 E(85289): 3.7e-42 Smith-Waterman score: 766; 100.0% identity (100.0% similar) in 112 aa overlap (82-193:1-112) 60 70 80 90 100 110 pF1KB5 QVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVP :::::::::::::::::::::::::::::: NP_001 MCFSIDSPDSLENIPEKWTPEVKHFCPNVP 10 20 30 120 130 140 150 160 170 pF1KB5 IILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVF 40 50 60 70 80 90 180 190 pF1KB5 EMATRAALQARRGKKKSGCLVL :::::::::::::::::::::: NP_001 EMATRAALQARRGKKKSGCLVL 100 110 >>NP_008839 (OMIM: 602048) ras-related C3 botulinum toxi (192 aa) initn: 719 init1: 719 opt: 735 Z-score: 839.8 bits: 162.1 E(85289): 4.9e-40 Smith-Waterman score: 735; 57.7% identity (76.3% similar) in 194 aa overlap (1-193:1-192) 10 20 30 40 50 60 pF1KB5 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT : :: : :.::::: ::::::: .. . :: :.::::.:: :.. :::: :.:.:::: NP_008 MQAI--KCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD :::::::::::::::.:::.:.:::. :: :.::. :: :::.: :::.::::::.: : NP_008 AGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLD 60 70 80 90 100 110 130 140 150 160 170 pF1KB5 LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAAL- ::.:. : ..: . : :. .: ::..::: :.:::: :. :.. ::. : ::.: NP_008 LRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLC 120 130 140 150 160 170 180 190 pF1KB5 QARRGKKKSGCLVL :.: ::.: NP_008 PPPVKKRKRKCLLL 180 190 193 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:24:30 2016 done: Thu Nov 3 17:24:32 2016 Total Scan time: 5.930 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]