Result of FASTA (omim) for
pF1KB5454
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5454, 514 aa
1>>>pF1KB5454 514 - 514 aa - 514 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3231+/-0.000405; mu= 19.0170+/- 0.025
mean_var=76.4108+/-15.125, 0's: 0 Z-trim(112.3): 57 B-trim: 41 in 1/52
Lambda= 0.146723
statistics sampled from 21158 (21188) to 21158 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.248), width: 16
Scan time: 9.180
The best scores are: opt bits E(85289)
NP_006504 (OMIM: 607529) serine--tRNA ligase, cyto ( 514) 3406 730.8 2.4e-210
NP_001317598 (OMIM: 607529) serine--tRNA ligase, c ( 536) 2787 599.7 6.7e-171
NP_060297 (OMIM: 612804,613845) serine--tRNA ligas ( 518) 590 134.7 6.5e-31
NP_001139373 (OMIM: 612804,613845) serine--tRNA li ( 520) 590 134.7 6.5e-31
>>NP_006504 (OMIM: 607529) serine--tRNA ligase, cytoplas (514 aa)
initn: 3406 init1: 3406 opt: 3406 Z-score: 3897.5 bits: 730.8 E(85289): 2.4e-210
Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 514 aa overlap (1-514:1-514)
10 20 30 40 50 60
pF1KB5 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEP
430 440 450 460 470 480
490 500 510
pF1KB5 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
::::::::::::::::::::::::::::::::::
NP_006 SKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
490 500 510
>>NP_001317598 (OMIM: 607529) serine--tRNA ligase, cytop (536 aa)
initn: 2787 init1: 2787 opt: 2787 Z-score: 3189.1 bits: 599.7 E(85289): 6.7e-171
Smith-Waterman score: 3352; 95.9% identity (95.9% similar) in 536 aa overlap (1-514:1-536)
10 20 30 40 50 60
pF1KB5 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYH
310 320 330 340 350 360
370 380 390 400 410
pF1KB5 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDK-
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKR
370 380 390 400 410 420
420 430 440 450
pF1KB5 ---------------------VEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKE
:::::::::::::::::::::::::::::::::::::::
NP_001 KNNLHLSTQNKLEASLFSPKKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKE
430 440 450 460 470 480
460 470 480 490 500 510
pF1KB5 FMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
490 500 510 520 530
>>NP_060297 (OMIM: 612804,613845) serine--tRNA ligase, m (518 aa)
initn: 433 init1: 287 opt: 590 Z-score: 676.0 bits: 134.7 E(85289): 6.5e-31
Smith-Waterman score: 596; 30.1% identity (66.4% similar) in 342 aa overlap (123-460:158-485)
100 110 120 130 140 150
pF1KB5 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
.:: . . . .. : ::.::.. ::. .
NP_060 EVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPVG-DES-Q
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
.: .. :: : . .:... .: .. .. . :.: :.:.:.:. ..:...:...
NP_060 ARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
190 200 210 220 230 240
220 230 240 250 260
pF1KB5 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
.. : ::. :. .: ..: :.. .. . . ..:.. : . . :
NP_060 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
250 260 270 280 290
270 280 290 300 310 320
pF1KB5 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
.:.: .:. :. . .:::.... :::.: :... :.. ::..:::.: :.:.:
NP_060 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB5 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
..: ..: ...::... :. ::. ...... . :. : .:.:.:::.:: : :
NP_060 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB5 RELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG
:..: :::::.:.:::.: . ::. ...:.: .::: ::. : . :.::. : . :
NP_060 GEVTSASNCTDFQSRRLHIMF-QTEA--GELQFAHTVNATACAVPRLLIALLESNQQKDG
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB5 -ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQN
. :: :. ..
NP_060 SVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
480 490 500 510
>>NP_001139373 (OMIM: 612804,613845) serine--tRNA ligase (520 aa)
initn: 433 init1: 287 opt: 590 Z-score: 676.0 bits: 134.7 E(85289): 6.5e-31
Smith-Waterman score: 596; 30.1% identity (66.4% similar) in 342 aa overlap (123-460:160-487)
100 110 120 130 140 150
pF1KB5 DALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVD
.:: . . . .. : ::.::.. ::. .
NP_001 QQVRLDPGAGSIFGPTFLPFPGQLSLLVEAQLEEQFYLQALKLPNQTHPDVPVG-DES-Q
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 NKVERIWGDCTVR--KKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQY
.: .. :: : . .:... .: .. .. . :.: :.:.:.:. ..:...:...
NP_001 ARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQHGLVNF
190 200 210 220 230 240
220 230 240 250 260
pF1KB5 ALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDE-ELYKVIGKGSEKSDDNSYDEKYLI
.. : ::. :. .: ..: :.. .. . . ..:.. : . . :
NP_001 TFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNI--------DPARFKDLNLA
250 260 270 280 290
270 280 290 300 310 320
pF1KB5 ATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVY
.:.: .:. :. . .:::.... :::.: :... :.. ::..:::.: :.:.:
NP_001 GTAEVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNT-GQEPRGLYRVHHFTKVEMFGV
300 310 320 330 340 350
330 340 350 360 370 380
pF1KB5 SSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAF
..: ..: ...::... :. ::. ...... . :. : .:.:.:::.:: : :
NP_001 TGPGLEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRF
360 370 380 390 400 410
390 400 410 420 430 440
pF1KB5 RELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKG
:..: :::::.:.:::.: . ::. ...:.: .::: ::. : . :.::. : . :
NP_001 GEVTSASNCTDFQSRRLHIMF-QTEA--GELQFAHTVNATACAVPRLLIALLESNQQKDG
420 430 440 450 460 470
450 460 470 480 490 500
pF1KB5 -ITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQN
. :: :. ..
NP_001 SVLVPPALQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
480 490 500 510 520
514 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 12:50:31 2016 done: Sat Nov 5 12:50:33 2016
Total Scan time: 9.180 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]