FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5459, 391 aa 1>>>pF1KB5459 391 - 391 aa - 391 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5865+/-0.000812; mu= 9.8949+/- 0.049 mean_var=75.9360+/-15.064, 0's: 0 Z-trim(107.6): 19 B-trim: 0 in 0/51 Lambda= 0.147181 statistics sampled from 9692 (9703) to 9692 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.298), width: 16 Scan time: 2.910 The best scores are: opt bits E(32554) CCDS72876.1 TXNIP gene_id:10628|Hs108|chr1 ( 391) 2628 567.4 8e-162 CCDS81368.1 TXNIP gene_id:10628|Hs108|chr1 ( 336) 2097 454.6 6e-128 CCDS10377.1 ARRDC4 gene_id:91947|Hs108|chr15 ( 418) 1143 252.1 7.1e-67 CCDS34202.1 ARRDC3 gene_id:57561|Hs108|chr5 ( 414) 946 210.2 2.7e-54 CCDS12370.1 ARRDC2 gene_id:27106|Hs108|chr19 ( 407) 891 198.5 8.8e-51 CCDS32956.1 ARRDC2 gene_id:27106|Hs108|chr19 ( 402) 868 193.7 2.6e-49 >>CCDS72876.1 TXNIP gene_id:10628|Hs108|chr1 (391 aa) initn: 2628 init1: 2628 opt: 2628 Z-score: 3018.8 bits: 567.4 E(32554): 8e-162 Smith-Waterman score: 2628; 100.0% identity (100.0% similar) in 391 aa overlap (1-391:1-391) 10 20 30 40 50 60 pF1KB5 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 VDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 SARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 HIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS72 GLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQD 310 320 330 340 350 360 370 380 390 pF1KB5 SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ ::::::::::::::::::::::::::::::: CCDS72 SPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ 370 380 390 >>CCDS81368.1 TXNIP gene_id:10628|Hs108|chr1 (336 aa) initn: 2097 init1: 2097 opt: 2097 Z-score: 2410.6 bits: 454.6 E(32554): 6e-128 Smith-Waterman score: 2097; 99.7% identity (100.0% similar) in 310 aa overlap (82-391:27-336) 60 70 80 90 100 110 pF1KB5 AKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLG :.:::::::::::::::::::::::::::: CCDS81 MPPKHSLSHRCILSVTASLMATRFSFPSGENEMVIMRPGNKYEYKFGFELPQGPLG 10 20 30 40 50 120 130 140 150 160 170 pF1KB5 TSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 TSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCM 60 70 80 90 100 110 180 190 200 210 220 230 pF1KB5 FIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 FIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLT 120 130 140 150 160 170 240 250 260 270 280 290 pF1KB5 QKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 QKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILD 180 190 200 210 220 230 300 310 320 330 340 350 pF1KB5 LPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS81 LPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPL 240 250 260 270 280 290 360 370 380 390 pF1KB5 LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ :::::::::::::::::::::::::::::::::::::::: CCDS81 LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ 300 310 320 330 >>CCDS10377.1 ARRDC4 gene_id:91947|Hs108|chr15 (418 aa) initn: 986 init1: 717 opt: 1143 Z-score: 1314.1 bits: 252.1 E(32554): 7.1e-67 Smith-Waterman score: 1143; 45.4% identity (72.8% similar) in 394 aa overlap (6-383:16-403) 10 20 30 40 pF1KB5 MVMFKKIKSFEVVFNDPEK-VYGSGEKVAGRVIVEVCEVTRVKAVRILAC ..::. .::.: .: :.::: :::.:..:. : . ..:.:. : CCDS10 MGGEAGCAAAVGAEGRVKSLGLVFEDERKGCYSSGETVAGHVLLEASEPVALRALRLEAQ 10 20 30 40 50 60 50 60 70 80 90 pF1KB5 GVAKVLWMQGSQQCKQTS------------EYLRYEDTLLLEDQPTGENEMVIMRPGNKY : : . : : . : ..: ::: . : :.. :.::. .....:: :. CCDS10 GRATAAW--GPSTCPRASASTAALAVFSEVEYLNVR--LSLREPPAGEG-IILLQPG-KH 70 80 90 100 110 100 110 120 130 140 150 pF1KB5 EYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLM :. : :.::. :: ::: :::: ..: :.: :.::. : : .:....::. :::::: :. CCDS10 EFPFRFQLPSEPLVTSFTGKYGSIQYCVRAVLERPKVPDQSVKRELQVVSHVDVNTPALL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB5 APVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVA .:: .:: :.: :. .: ::.::.:.:::.:.:. : :.:..:: ::..:::::: CCDS10 TPVLKTQEKMVGCWFFTSGPVSLSAKIERKGYCNGEAIPIYAEIENCSSRLIVPKAAIFQ 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB5 RHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLL .::::.:.::.. . ...:::::: ::. .: ::.:.. . :::: : :.::.::: CCDS10 TQTYLASGKTKTIRHMVANVRGNHIASGSTDTWNGKTLKIPPVTPSILDCCIIRVDYSLA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB5 IYVSVPGSKKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYM .:. .::.::..:.::::::. .:..::.::.::. : .:::. :..:. ::::: : CCDS10 VYIHIPGAKKLMLELPLVIGTIPYNGFGSRNSSIASQFSMDMSWLTLTLPEQPEAPPNYA 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB5 DVIPEDHRLES-PTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ ::. :.. . : : . .: :.: ::.:.::: :.:::: CCDS10 DVVSEEEFSRHIPPYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPV 360 370 380 390 400 410 CCDS10 SFIL >>CCDS34202.1 ARRDC3 gene_id:57561|Hs108|chr5 (414 aa) initn: 1038 init1: 672 opt: 946 Z-score: 1088.1 bits: 210.2 E(32554): 2.7e-54 Smith-Waterman score: 1049; 42.1% identity (70.8% similar) in 401 aa overlap (2-383:1-399) 10 20 30 40 50 pF1KB5 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW ... :.::. . : :: . ::.::. :.::: .:: :::...: : : ::: : CCDS34 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW 10 20 30 40 50 60 70 80 90 100 pF1KB5 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL . :: :. . ::. ..: :. .:. ..:. . .. : ..:: :.::: CCDS34 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE :: ::.:::.:..: : ::::: : :: . ::.: : . .:.:::.:..: .. :: CCDS34 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG : . : : .: .:.::.:.:::. :. :.: :..:: ::.::::::: ... :.: CCDS34 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS . : . : ....::. . :: .: :: :.. . :::: :.:.::::::..::..::. CCDS34 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR ..:.::::::. ..:::::..:. : .:.:..:..:. ::::: : .:. :..: CCDS34 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR 300 310 320 330 340 350 350 360 370 380 390 pF1KB5 LESPTTPL--LDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ .. .:. ::.. . ..:.: : ::.:.::: :.:.:: CCDS34 -RNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR 360 370 380 390 400 410 >>CCDS12370.1 ARRDC2 gene_id:27106|Hs108|chr19 (407 aa) initn: 808 init1: 529 opt: 891 Z-score: 1025.1 bits: 198.5 E(32554): 8.8e-51 Smith-Waterman score: 891; 38.8% identity (66.4% similar) in 399 aa overlap (2-383:1-393) 10 20 30 40 50 pF1KB5 MVMFKKIKSFEVVFNDP----EKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW ..: :.:.: : .. : :...:. :::::..:. ..:: :.:. : : :.: : CCDS12 MLFDKVKAFSVQLDGATAGVEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHW 10 20 30 40 50 60 70 80 90 100 pF1KB5 MQ----GS-----QQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQ . :: :. .. : . .. ::: : :::. . . :: ..:. :.:.:: CCDS12 TESRSAGSSTAYTQSYSERVEVVSHRATLLAPD--TGET--TTLPPG-RHEFLFSFQLPP 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 GPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKK : :::.::.: : : .:: : :: :.....: : :.. ::.::: :.:: .. .:: CCDS12 -TLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDINTPALLAPQAGAREKV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 VSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQT . . : ::.::.:::::. :. : . :...: .: :.:.::.: .:..: : CCDS12 ARSWYCNRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLPRAAVVQTQTFMARGAR 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 KVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKK : ..:. :. . : : :.:..::. . :::: : .:.:.:.: . :..::..: CCDS12 KQKRAVVASLAGEPVGPGQRALWQGRALRIPPVGPSILHCRVLHVDYALKVCVDIPGTSK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 VILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIP--EDHR ..:.::::::. ..::.::..:..: ..: .:. ::::: : .:. :. CCDS12 LLLELPLVIGTIPLHPFGSRSSSVGSHASFLLDWRLGALPERPEAPPEYSEVVADTEEAA 300 310 320 330 340 350 350 360 370 380 390 pF1KB5 LESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ : . :: .: : : ..:.: : ::.. ::: :.: :: CCDS12 LGQSPFPLPQDPDMSLEGPFFAYIQEFRYRPPPLYSEEDPNPLLGDMRPRCMTC 360 370 380 390 400 >>CCDS32956.1 ARRDC2 gene_id:27106|Hs108|chr19 (402 aa) initn: 815 init1: 529 opt: 868 Z-score: 998.8 bits: 193.7 E(32554): 2.6e-49 Smith-Waterman score: 868; 38.5% identity (66.4% similar) in 390 aa overlap (7-383:6-388) 10 20 30 40 50 pF1KB5 MVMFKKIKSFEVVFN-DPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQG ..:: . . : .: .::.. :::..:. ::.:... : : : . :..: CCDS32 MRSGGVRSFALELARGPGGAYRGGERLCGRVLLEAAAPLRVRALEVKARGGAATHWLEG 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 --------SQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLG :.. . ::: .. :::.: :::. . . :: ..:. :.:.:: : CCDS32 RSVGVNAVSSDYAAAETYLRRRQ-LLLRD--TGET--TTLPPG-RHEFLFSFQLPP-TLV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 TSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCM :::.::.: : : .:: : :: :.....: : :.. ::.::: :.:: .. .:: . CCDS32 TSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDINTPALLAPQAGAREKVARSW 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 FIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLT . : ::.::.:::::. :. : . :...: .: :.:.::.: .:..: : : CCDS32 YCNRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLPRAAVVQTQTFMARGARKQKR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 QKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILD ..:. :. . : : :.:..::. . :::: : .:.:.:.: . :..::..:..:. CCDS32 AVVASLAGEPVGPGQRALWQGRALRIPPVGPSILHCRVLHVDYALKVCVDIPGTSKLLLE 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 LPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIP--EDHRLESP ::::::. ..::.::..:..: ..: .:. ::::: : .:. :. : . CCDS32 LPLVIGTIPLHPFGSRSSSVGSHASFLLDWRLGALPERPEAPPEYSEVVADTEEAALGQS 300 310 320 330 340 350 350 360 370 380 390 pF1KB5 TTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ :: .: : : ..:.: : ::.. ::: :.: :: CCDS32 PFPLPQDPDMSLEGPFFAYIQEFRYRPPPLYSEEDPNPLLGDMRPRCMTC 360 370 380 390 400 391 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:40:11 2016 done: Fri Nov 4 21:40:12 2016 Total Scan time: 2.910 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]