FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5467, 328 aa 1>>>pF1KB5467 328 - 328 aa - 328 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3497+/-0.000296; mu= 16.1569+/- 0.019 mean_var=75.9413+/-15.714, 0's: 0 Z-trim(118.0): 71 B-trim: 161 in 1/51 Lambda= 0.147175 statistics sampled from 30529 (30601) to 30529 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.724), E-opt: 0.2 (0.359), width: 16 Scan time: 8.710 The best scores are: opt bits E(85289) NP_001208 (OMIM: 604644) carbonic anhydrase-relate ( 328) 2244 485.5 6.6e-137 NP_001076002 (OMIM: 604642) carbonic anhydrase-rel ( 328) 1223 268.7 1.2e-71 NP_064563 (OMIM: 604642) carbonic anhydrase-relate ( 328) 1223 268.7 1.2e-71 NP_001076003 (OMIM: 604642) carbonic anhydrase-rel ( 328) 1223 268.7 1.2e-71 XP_016880367 (OMIM: 604642) PREDICTED: carbonic an ( 231) 874 194.5 1.8e-49 NP_000058 (OMIM: 259730,611492) carbonic anhydrase ( 260) 487 112.3 1.1e-24 NP_001730 (OMIM: 114761,615751) carbonic anhydrase ( 305) 449 104.3 3.3e-22 NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Ho ( 262) 447 103.9 4e-22 XP_016884736 (OMIM: 300230) PREDICTED: carbonic an ( 278) 438 102.0 1.6e-21 NP_009151 (OMIM: 300230) carbonic anhydrase 5B, mi ( 317) 438 102.0 1.7e-21 XP_005274499 (OMIM: 300230) PREDICTED: carbonic an ( 317) 438 102.0 1.7e-21 NP_005173 (OMIM: 114770) carbonic anhydrase 7 isof ( 264) 433 100.9 3.1e-21 NP_004047 (OMIM: 114815,613227) carbonic anhydrase ( 290) 430 100.3 5.3e-21 NP_001308766 (OMIM: 114815,613227) carbonic anhydr ( 290) 430 100.3 5.3e-21 NP_005172 (OMIM: 114750) carbonic anhydrase 3 [Hom ( 260) 429 100.0 5.6e-21 NP_001122301 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 412 96.4 6.9e-20 NP_001122303 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 412 96.4 6.9e-20 NP_001158302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 412 96.4 6.9e-20 NP_001122302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 412 96.4 6.9e-20 NP_001729 (OMIM: 114800) carbonic anhydrase 1 isof ( 261) 412 96.4 6.9e-20 XP_016879135 (OMIM: 114761,615751) PREDICTED: carb ( 314) 397 93.3 7.2e-19 XP_006711322 (OMIM: 604832) PREDICTED: carbonic an ( 318) 394 92.7 1.1e-18 XP_005245117 (OMIM: 604832) PREDICTED: carbonic an ( 319) 394 92.7 1.1e-18 XP_005245116 (OMIM: 604832) PREDICTED: carbonic an ( 336) 394 92.7 1.2e-18 NP_036245 (OMIM: 604832) carbonic anhydrase 14 pre ( 337) 394 92.7 1.2e-18 XP_011521613 (OMIM: 114770) PREDICTED: carbonic an ( 242) 386 90.9 3e-18 NP_001308767 (OMIM: 114815,613227) carbonic anhydr ( 263) 385 90.7 3.7e-18 XP_016884737 (OMIM: 300230) PREDICTED: carbonic an ( 248) 367 86.9 5e-17 XP_011521614 (OMIM: 114770) PREDICTED: carbonic an ( 208) 363 86.0 7.8e-17 NP_001014435 (OMIM: 114770) carbonic anhydrase 7 i ( 208) 363 86.0 7.8e-17 XP_005256193 (OMIM: 114770) PREDICTED: carbonic an ( 208) 363 86.0 7.8e-17 XP_016869307 (OMIM: 114815,613227) PREDICTED: carb ( 206) 359 85.1 1.4e-16 NP_001207 (OMIM: 603179) carbonic anhydrase 9 prec ( 459) 352 83.9 7.3e-16 NP_001278896 (OMIM: 114800) carbonic anhydrase 1 i ( 195) 347 82.5 7.8e-16 NP_996808 (OMIM: 143860,603263) carbonic anhydrase ( 343) 347 82.7 1.2e-15 NP_001209 (OMIM: 143860,603263) carbonic anhydrase ( 354) 347 82.7 1.2e-15 NP_001257429 (OMIM: 114780) carbonic anhydrase 6 i ( 313) 342 81.6 2.4e-15 XP_011540385 (OMIM: 114780) PREDICTED: carbonic an ( 294) 331 79.3 1.1e-14 NP_001206 (OMIM: 114780) carbonic anhydrase 6 isof ( 308) 331 79.3 1.2e-14 XP_011540386 (OMIM: 114780) PREDICTED: carbonic an ( 324) 331 79.3 1.2e-14 XP_016856382 (OMIM: 604832) PREDICTED: carbonic an ( 263) 327 78.4 1.9e-14 XP_006711324 (OMIM: 604832) PREDICTED: carbonic an ( 281) 327 78.4 2e-14 XP_011507681 (OMIM: 604832) PREDICTED: carbonic an ( 323) 327 78.4 2.2e-14 XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 319 77.2 2.3e-13 NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 319 77.2 2.3e-13 NP_001280571 (OMIM: 143860,603263) carbonic anhydr ( 283) 297 72.0 1.6e-12 NP_001280604 (OMIM: 259730,611492) carbonic anhydr ( 159) 293 71.0 1.9e-12 XP_011521612 (OMIM: 114761,615751) PREDICTED: carb ( 222) 287 69.8 5.9e-12 XP_011521611 (OMIM: 114761,615751) PREDICTED: carb ( 376) 289 70.4 6.7e-12 NP_000708 (OMIM: 114760,600852) carbonic anhydrase ( 312) 279 68.2 2.5e-11 >>NP_001208 (OMIM: 604644) carbonic anhydrase-related pr (328 aa) initn: 2244 init1: 2244 opt: 2244 Z-score: 2578.9 bits: 485.5 E(85289): 6.6e-137 Smith-Waterman score: 2244; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB5 MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSTPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALR 250 260 270 280 290 300 310 320 pF1KB5 GNRDPRHPERRCRGPNYRLHVDGVPHGR :::::::::::::::::::::::::::: NP_001 GNRDPRHPERRCRGPNYRLHVDGVPHGR 310 320 >>NP_001076002 (OMIM: 604642) carbonic anhydrase-related (328 aa) initn: 1210 init1: 1210 opt: 1223 Z-score: 1407.3 bits: 268.7 E(85289): 1.2e-71 Smith-Waterman score: 1223; 58.9% identity (84.0% similar) in 287 aa overlap (32-318:30-314) 10 20 30 40 50 60 pF1KB5 GAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSL : ::.::. .::.::: : ::::::.::.: NP_001 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNL 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 CAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSG :.::::::::..: .....:::: :::..:::.:. ::.::::::::. . .::.:: NP_001 CSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 GPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGL ::. ::::: :.:: ::..:. :::: .: :.::.::::::.:.::: : . :...:::: NP_001 GPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 AILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSL ...:.:..:...:::::.:.:::::::::.::::::.:: :..: :.::. .::::.::. NP_001 VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 STPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRG . ::: ::..::.... . :: .::::::::::: ::::: :.: : ::.::: .: .: NP_001 TIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRT 240 250 260 270 280 290 310 320 pF1KB5 NRDPRHPERRCRGPNYRLHVDGVPHGR : . . : :: : NP_001 NINFSLQGKDC--PNNRAQKLQYRVNEWLLK 300 310 320 >>NP_064563 (OMIM: 604642) carbonic anhydrase-related pr (328 aa) initn: 1210 init1: 1210 opt: 1223 Z-score: 1407.3 bits: 268.7 E(85289): 1.2e-71 Smith-Waterman score: 1223; 58.9% identity (84.0% similar) in 287 aa overlap (32-318:30-314) 10 20 30 40 50 60 pF1KB5 GAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSL : ::.::. .::.::: : ::::::.::.: NP_064 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNL 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 CAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSG :.::::::::..: .....:::: :::..:::.:. ::.::::::::. . .::.:: NP_064 CSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 GPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGL ::. ::::: :.:: ::..:. :::: .: :.::.::::::.:.::: : . :...:::: NP_064 GPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 AILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSL ...:.:..:...:::::.:.:::::::::.::::::.:: :..: :.::. .::::.::. NP_064 VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 STPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRG . ::: ::..::.... . :: .::::::::::: ::::: :.: : ::.::: .: .: NP_064 TIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRT 240 250 260 270 280 290 310 320 pF1KB5 NRDPRHPERRCRGPNYRLHVDGVPHGR : . . : :: : NP_064 NINFSLQGKDC--PNNRAQKLQYRVNEWLLK 300 310 320 >>NP_001076003 (OMIM: 604642) carbonic anhydrase-related (328 aa) initn: 1210 init1: 1210 opt: 1223 Z-score: 1407.3 bits: 268.7 E(85289): 1.2e-71 Smith-Waterman score: 1223; 58.9% identity (84.0% similar) in 287 aa overlap (32-318:30-314) 10 20 30 40 50 60 pF1KB5 GAAARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSL : ::.::. .::.::: : ::::::.::.: NP_001 MEIVWEVLFLLQANFIVCISAQQNSPKIHEGWWAYKEVVQGSFVPVPSFWGLVNSAWNL 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 CAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSG :.::::::::..: .....:::: :::..:::.:. ::.::::::::. . .::.:: NP_001 CSVGKRQSPVNIETSHMIFDPFLTPLRINTGGRKVSGTMYNTGRHVSLRLDKEHLVNISG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 GPLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGL ::. ::::: :.:: ::..:. :::: .: :.::.::::::.:.::: : . :...:::: NP_001 GPMTYSHRLEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 AILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSL ...:.:..:...:::::.:.:::::::::.::::::.:: :..: :.::. .::::.::. NP_001 VVVSIFIKVSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSM 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB5 STPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRG . ::: ::..::.... . :: .::::::::::: ::::: :.: : ::.::: .: .: NP_001 TIPPCYETASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRT 240 250 260 270 280 290 310 320 pF1KB5 NRDPRHPERRCRGPNYRLHVDGVPHGR : . . : :: : NP_001 NINFSLQGKDC--PNNRAQKLQYRVNEWLLK 300 310 320 >>XP_016880367 (OMIM: 604642) PREDICTED: carbonic anhydr (231 aa) initn: 863 init1: 863 opt: 874 Z-score: 1009.0 bits: 194.5 E(85289): 1.8e-49 Smith-Waterman score: 874; 57.5% identity (82.2% similar) in 219 aa overlap (100-318:1-217) 70 80 90 100 110 120 pF1KB5 PVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGRHVSFLPAPRPVVNVSGGPLLYSHR .::::::::. . .::.::::. :::: XP_016 MYNTGRHVSLRLDKEHLVNISGGPMTYSHR 10 20 30 130 140 150 160 170 180 pF1KB5 LSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVN : :.:: ::..:. :::: .: :.::.::::::.:.::: : . :...::::...:.:.. XP_016 LEEIRLHFGSEDSQGSEHLLNGQAFSGEVQLIHYNHELYTNVTEAAKSPNGLVVVSIFIK 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 VASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSET :...:::::.:.:::::::::.::::::.:: :..: :.::. .::::.::.. ::: :: XP_016 VSDSSNPFLNRMLNRDTITRITYKNDAYLLQGLNIEELYPETSSFITYDGSMTIPPCYET 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 VTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPE ..::.... . :: .::::::::::: ::::: :.: : ::.::: .: .: : . XP_016 ASWIIMNKPVYITRMQMHSLRLLSQNQPSQIFLSMSDNFRPVQPLNNRCIRTNINFSLQG 160 170 180 190 200 210 310 320 pF1KB5 RRCRGPNYRLHVDGVPHGR . : :: : XP_016 KDC--PNNRAQKLQYRVNEWLLK 220 230 >>NP_000058 (OMIM: 259730,611492) carbonic anhydrase 2 i (260 aa) initn: 442 init1: 199 opt: 487 Z-score: 564.2 bits: 112.3 E(85289): 1.1e-24 Smith-Waterman score: 487; 34.5% identity (68.6% similar) in 258 aa overlap (48-302:12-258) 20 30 40 50 60 70 pF1KB5 ALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKR :: : . . . : :.::::::.. . NP_000 MSHHWGYGKHNGPEHW---HKDFPI-AKGERQSPVDIDTHT 10 20 30 80 90 100 110 120 130 pF1KB5 VLYDPFLPPLRLSTG-GEKLRGTLYNTGR--HVSFLPAPRPVVNVSGGPLLYSHRLSELR . ::: : :: .: . .:: . :.:. .: : . .: ..:::: ..:: ... NP_000 AKYDPSLKPLSVSYDQATSLR--ILNNGHAFNVEFDDSQDKAV-LKGGPLDGTYRLIQFH 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 LLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTS . .:. :: :::: .... ..::..:.:.: . ::.:. : . :.:::.:..:..:.: . NP_000 FHWGSLDGQGSEHTVDKKKYAAELHLVHWNTK-YGDFGKAVQQPDGLAVLGIFLKVGS-A 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB5 NPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWIL .: :.... :.. :. :. . . ... . :.:::. . :: :::.::: : ::::. NP_000 KPGLQKVV--DVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIV 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB5 IDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRG . . ....: :. ..: :. : .. . . : :: ::: .: .... NP_000 LKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 220 230 240 250 260 320 pF1KB5 PNYRLHVDGVPHGR >>NP_001730 (OMIM: 114761,615751) carbonic anhydrase 5A, (305 aa) initn: 394 init1: 252 opt: 449 Z-score: 519.6 bits: 104.3 E(85289): 3.3e-22 Smith-Waterman score: 449; 33.2% identity (67.2% similar) in 235 aa overlap (65-297:61-290) 40 50 60 70 80 90 pF1KB5 WSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVLYDPFLPPLRLSTGGE : ::::.... . .::: : :::.: . NP_001 GRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAA 40 50 60 70 80 90 100 110 120 130 140 150 pF1KB5 KLRGTLYNTGR--HVSFLPAPRPVVNVSGGPLLYSHRLSELRLLFGARDGAGSEHQINHQ . ..::: .: : : . . ..::::: .::..... .:: . .:::: .. . NP_001 SCL-YIWNTGYLFQVEFDDATE-ASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGH 100 110 120 130 140 160 170 180 190 200 210 pF1KB5 GFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPFLSRLLNRDTITRISY .. ::..:.:.:. : :.. : : ::::....:..... . :.::. : . .:.. NP_001 AYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGA-HHQTLQRLV--DILPEIKH 150 160 170 180 190 200 220 230 240 250 260 270 pF1KB5 KNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDRALNITSLQMHSLRLL :. .. .. :.: . . :: :::.::: .:.::::. . .... :. ..: : NP_001 KDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTL 210 220 230 240 250 260 280 290 300 310 320 pF1KB5 SQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNYRLHVDGVPHGR . .. . . .: :::::: .: NP_001 LFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS 270 280 290 300 >>NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Homo s (262 aa) initn: 407 init1: 235 opt: 447 Z-score: 518.2 bits: 103.9 E(85289): 4e-22 Smith-Waterman score: 452; 31.9% identity (62.2% similar) in 270 aa overlap (35-302:6-260) 10 20 30 40 50 60 pF1KB5 ARLSAPRALVLWAALGAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAV :.:... :: : . : NP_940 MSRLSWGYREH------NGPIHW----KEFFPIAD 10 20 70 80 90 100 110 120 pF1KB5 GKRQSPVDVELKRVLYDPFLPPLRLSTGGEKLRGTLYNTGR--HVSFLPAPRPVVNVSGG : .:::.... :.: :: : :: .. . . . :.:. .:.: . : . :: NP_940 GDQQSPIEIKTKEVKYDSSLRPLSIKYDPSSAK-IISNSGHSFNVDFDDTENKSV-LRGG 30 40 50 60 70 80 130 140 150 160 170 180 pF1KB5 PLLYSHRLSELRLLFGARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLA :: :.:: ...: .:. : :::: .. ...::....:.:.. : .: :.. :.::: NP_940 PLTGSYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNSDKYPSFVEAAHEPDGLA 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB5 ILSLFVNVASTSNPFLSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLS .:..:.... : :... ::. :. :. . ...: :.: :. . :: :::. NP_940 VLGVFLQIGEP-NSQLQKI--TDTLDSIKEKGKQTRFTNFDLLSLLPPSWDYWTYPGSLT 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB5 TPPCSETVTWILIDRALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGN .:: :.::::.. . .::.: :. ..: : . .. : .: :: ::: : .:.. NP_940 VPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLKGRKVRAS 210 220 230 240 250 260 310 320 pF1KB5 RDPRHPERRCRGPNYRLHVDGVPHGR NP_940 FH >>XP_016884736 (OMIM: 300230) PREDICTED: carbonic anhydr (278 aa) initn: 403 init1: 247 opt: 438 Z-score: 507.5 bits: 102.0 E(85289): 1.6e-21 Smith-Waterman score: 438; 32.2% identity (63.1% similar) in 255 aa overlap (50-302:11-256) 20 30 40 50 60 70 pF1KB5 GAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVL :.: :. : : ::::.... . . XP_016 MLYQGQVGVHPLWESVD----LVPGGDRQSPINIRWRDSV 10 20 30 80 90 100 110 120 130 pF1KB5 YDPFLPPLRLSTGGEKLRGTLYNTGRH--VSFLPAPRPVVNVSGGPLLYSHRLSELRLLF ::: : :: .: ..:.: : : . : ..:::: ...::..... . XP_016 YDPGLKPLTISYDPATCLH-VWNNGYSFLVEFEDSTDKSV-IKGGPLEHNYRLKQFHFHW 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 GARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPF :: :. :::: .. . : ::..:.:.: . :: :. ::::....:..... . XP_016 GAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGK-HHKE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB5 LSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDR :..:. ::. :..:. . ... :.: . ::.:::.::: ::.::::. . XP_016 LQKLV--DTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQ 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB5 ALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNY ... :....: : . .. . . : :::::: .:..:.. XP_016 PVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKP 220 230 240 250 260 270 320 pF1KB5 RLHVDGVPHGR XP_016 ATSQATP >>NP_009151 (OMIM: 300230) carbonic anhydrase 5B, mitoch (317 aa) initn: 403 init1: 247 opt: 438 Z-score: 506.7 bits: 102.0 E(85289): 1.7e-21 Smith-Waterman score: 438; 32.2% identity (63.1% similar) in 255 aa overlap (50-302:50-295) 20 30 40 50 60 70 pF1KB5 GAAAHIGPAPDPEDWWSYKDNLQGNFVPGPPFWGLVNAAWSLCAVGKRQSPVDVELKRVL :.: :. : : ::::.... . . NP_009 WRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVD----LVPGGDRQSPINIRWRDSV 20 30 40 50 60 70 80 90 100 110 120 130 pF1KB5 YDPFLPPLRLSTGGEKLRGTLYNTGRH--VSFLPAPRPVVNVSGGPLLYSHRLSELRLLF ::: : :: .: ..:.: : : . : ..:::: ...::..... . NP_009 YDPGLKPLTISYDPATCLH-VWNNGYSFLVEFEDSTDKSV-IKGGPLEHNYRLKQFHFHW 80 90 100 110 120 130 140 150 160 170 180 190 pF1KB5 GARDGAGSEHQINHQGFSAEVQLIHFNQELYGNFSAASRGPNGLAILSLFVNVASTSNPF :: :. :::: .. . : ::..:.:.: . :: :. ::::....:..... . NP_009 GAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGK-HHKE 140 150 160 170 180 190 200 210 220 230 240 250 pF1KB5 LSRLLNRDTITRISYKNDAYFLQDLSLELLFPESFGFITYQGSLSTPPCSETVTWILIDR :..:. ::. :..:. . ... :.: . ::.:::.::: ::.::::. . NP_009 LQKLV--DTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQ 200 210 220 230 240 250 260 270 280 290 300 310 pF1KB5 ALNITSLQMHSLRLLSQNPPSQIFQSLSGNSRPLQPLAHRALRGNRDPRHPERRCRGPNY ... :....: : . .. . . : :::::: .:..:.. NP_009 PVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKP 260 270 280 290 300 310 320 pF1KB5 RLHVDGVPHGR NP_009 ATSQATP 328 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 12:52:33 2016 done: Sat Nov 5 12:52:34 2016 Total Scan time: 8.710 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]