FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5474, 246 aa 1>>>pF1KB5474 246 - 246 aa - 246 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4240+/-0.000963; mu= 9.2922+/- 0.058 mean_var=84.1534+/-16.838, 0's: 0 Z-trim(105.3): 23 B-trim: 106 in 1/52 Lambda= 0.139810 statistics sampled from 8345 (8353) to 8345 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.624), E-opt: 0.2 (0.257), width: 16 Scan time: 2.280 The best scores are: opt bits E(32554) CCDS13339.1 YWHAB gene_id:7529|Hs108|chr20 ( 246) 1568 325.9 1.5e-89 CCDS6290.1 YWHAZ gene_id:7534|Hs108|chr8 ( 245) 1368 285.6 2.1e-77 CCDS1666.1 YWHAQ gene_id:10971|Hs108|chr2 ( 245) 1287 269.3 1.7e-72 CCDS5584.1 YWHAG gene_id:7532|Hs108|chr7 ( 247) 1164 244.5 5.1e-65 CCDS13901.1 YWHAH gene_id:7533|Hs108|chr22 ( 246) 1150 241.6 3.6e-64 CCDS288.1 SFN gene_id:2810|Hs108|chr1 ( 248) 1060 223.5 1.1e-58 CCDS11001.1 YWHAE gene_id:7531|Hs108|chr17 ( 255) 1024 216.2 1.7e-56 >>CCDS13339.1 YWHAB gene_id:7529|Hs108|chr20 (246 aa) initn: 1568 init1: 1568 opt: 1568 Z-score: 1721.2 bits: 325.9 E(32554): 1.5e-89 Smith-Waterman score: 1568; 100.0% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 WRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 WRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 LKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 YEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 YEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGD 190 200 210 220 230 240 pF1KB5 AGEGEN :::::: CCDS13 AGEGEN >>CCDS6290.1 YWHAZ gene_id:7534|Hs108|chr8 (245 aa) initn: 1367 init1: 1367 opt: 1368 Z-score: 1503.2 bits: 285.6 E(32554): 2.1e-77 Smith-Waterman score: 1368; 87.3% identity (96.3% similar) in 245 aa overlap (3-246:1-245) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :::.:::::::::::::::::::: ::.::::: :::::::::::::::::::::::: CCDS62 MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSS 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 WRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFY :::.:::::::: ::::::..:::::::.::.::::::: ::.:.:::::.: :::::: CCDS62 WRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFY 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 LKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY :::::::.:::.:::.::.:. :..:::::::::::::::::::::::::::::::::: CCDS62 LKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 YEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGD ::::::::::::::::::::::::::::.:::::::::::::::::::::::..::::.. CCDS62 YEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAE 180 190 200 210 220 230 pF1KB5 AGEG-EN :::: :: CCDS62 AGEGGEN 240 >>CCDS1666.1 YWHAQ gene_id:10971|Hs108|chr2 (245 aa) initn: 1286 init1: 1286 opt: 1287 Z-score: 1414.9 bits: 269.3 E(32554): 1.7e-72 Smith-Waterman score: 1287; 81.6% identity (94.3% similar) in 245 aa overlap (3-246:1-245) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :.:.::.::::::::::::::::. :::::::: :::::::::::::::::::.:::. CCDS16 MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNVVGGRRSA 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 WRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFY :::::::::::. ..:: :. :.::::.:.::..::. :::::::::: :::.::::::: CCDS16 WRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLDKYLIANATNPESKVFY 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 LKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFY :::::::::::.::: ::... :..::: ::::::.:::::::::::::::::::::::: CCDS16 LKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQEAFDISKKEMQPTHPIRLGLALNFSVFY 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 YEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGD :::::.:: ::.::::::::::::::::::.:::::::::::::::::::::.. :.: : CCDS16 YEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECD 180 190 200 210 220 230 pF1KB5 AGEG-EN :.:: :: CCDS16 AAEGAEN 240 >>CCDS5584.1 YWHAG gene_id:7532|Hs108|chr7 (247 aa) initn: 1021 init1: 669 opt: 1164 Z-score: 1280.8 bits: 244.5 E(32554): 5.1e-65 Smith-Waterman score: 1164; 75.4% identity (89.5% similar) in 248 aa overlap (3-246:2-247) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS .:. .:::::.:::::::::::::::: ::: .. ::::::::::::::::::::::: CCDS55 MVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSS 10 20 30 40 50 70 80 90 100 110 pF1KB5 WRVISSIEQKT--ERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNA--TQPES ::::::::::: . :::: .: . :::::: ::. .:.::: :::.::: : :: :: CCDS55 WRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYES 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 KVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNF :::::::::::.:::.:::.:... :.: .:..::.:: ::::..::::::::::::::. CCDS55 KVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNY 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQG ::::::: :.::.:: :::::::.::::::::::.:::::::::::::::::::::..: CCDS55 SVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQD 180 190 200 210 220 230 240 pF1KB5 DEGDAGEGEN :.: :::.: CCDS55 DDG--GEGNN 240 >>CCDS13901.1 YWHAH gene_id:7533|Hs108|chr22 (246 aa) initn: 1003 init1: 658 opt: 1150 Z-score: 1265.5 bits: 241.6 E(32554): 3.6e-64 Smith-Waterman score: 1150; 75.5% identity (89.0% similar) in 245 aa overlap (4-244:3-245) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :. .:.:.:.::::::::::::.::::::: .. ::::.:::::::::::::::::: CCDS13 MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSS 10 20 30 40 50 70 80 90 100 110 pF1KB5 WRVISSIEQKT--ERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNAT--QPES ::::::::::: . :::: . : :::::: ::. .::::: ::::.:: : . : :: CCDS13 WRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYES 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 KVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNF :::::::::::.:::.:::::..:...: :. ::.:::::::..::::::::::::::: CCDS13 KVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 SVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQG ::::::: :.::.:: ::: :::.::::::::::.:::::::::::::::::::::..: CCDS13 SVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQD 180 190 200 210 220 230 240 pF1KB5 DEGDAGEGEN .: :::: CCDS13 EE--AGEGN 240 >>CCDS288.1 SFN gene_id:2810|Hs108|chr1 (248 aa) initn: 1053 init1: 739 opt: 1060 Z-score: 1167.4 bits: 223.5 E(32554): 1.1e-58 Smith-Waterman score: 1060; 67.3% identity (89.0% similar) in 245 aa overlap (3-245:1-245) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :... :.::::::::::::.:::: ::...:.:.::: :::::::::::::::..:.. CCDS28 MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAA 10 20 30 40 50 70 80 90 100 110 pF1KB5 WRVISSIEQKT--ERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKV :::.::::::. : .:.: .:::::.:.::: .:. :: :::..:: .: . ::.: CCDS28 WRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 FYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSV :::::::::.:::.:::.::.:. ......:::::..:::::: ::.:::::::::::: CCDS28 FYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 FYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDE :.::: ::::.: :::::.::::.:.: ::.:.::::::::::::::::::::..: :.: CCDS28 FHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEE 180 190 200 210 220 230 240 pF1KB5 GDAGEGEN : . : CCDS28 GGEAPQEPQS 240 >>CCDS11001.1 YWHAE gene_id:7531|Hs108|chr17 (255 aa) initn: 736 init1: 736 opt: 1024 Z-score: 1127.9 bits: 216.2 E(32554): 1.7e-56 Smith-Waterman score: 1024; 66.1% identity (83.7% similar) in 245 aa overlap (4-246:3-243) 10 20 30 40 50 60 pF1KB5 MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSS :. .:: .:::::::::::.:. .:: :. . ::. :::::::::::::.::::.: CCDS11 MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRAS 10 20 30 40 50 70 80 90 100 110 pF1KB5 WRVISSIEQKTERN--EKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKV ::.::::::: : . : : .: .:::. .:.::. :: :.:..:::.::: :. :::: CCDS11 WRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 FYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSV :: :::::: :::.: :.:.... .. :: ::. : .:. :. ::::::::::::::: CCDS11 FYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSV 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 FYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDE :::::::::..:: :::.:::.::::::::.:::::::::::::::::::::::. ::: CCDS11 FYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGD- 180 190 200 210 220 230 240 pF1KB5 GDAGEGEN :: .: CCDS11 ---GEEQNKEALQDVEDENQ 240 250 246 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:00:18 2016 done: Sat Nov 5 13:00:18 2016 Total Scan time: 2.280 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]