FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5482, 245 aa 1>>>pF1KB5482 245 - 245 aa - 245 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5733+/-0.000758; mu= 13.0489+/- 0.046 mean_var=63.6813+/-12.431, 0's: 0 Z-trim(107.9): 37 B-trim: 8 in 2/49 Lambda= 0.160719 statistics sampled from 9808 (9845) to 9808 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.302), width: 16 Scan time: 2.290 The best scores are: opt bits E(32554) CCDS14665.1 FGF13 gene_id:2258|Hs108|chrX ( 245) 1605 380.4 5.8e-106 CCDS14664.1 FGF13 gene_id:2258|Hs108|chrX ( 192) 1209 288.6 2e-78 CCDS55512.1 FGF13 gene_id:2258|Hs108|chrX ( 199) 1208 288.4 2.5e-78 CCDS55511.1 FGF13 gene_id:2258|Hs108|chrX ( 226) 1202 287.0 7.3e-78 CCDS55513.1 FGF13 gene_id:2258|Hs108|chrX ( 255) 1202 287.0 8.1e-78 CCDS9501.1 FGF14 gene_id:2259|Hs108|chr13 ( 247) 1123 268.7 2.6e-72 CCDS3301.1 FGF12 gene_id:2257|Hs108|chr3 ( 243) 1062 254.5 4.6e-68 CCDS9500.1 FGF14 gene_id:2259|Hs108|chr13 ( 252) 919 221.4 4.6e-58 CCDS46983.1 FGF12 gene_id:2257|Hs108|chr3 ( 181) 856 206.7 8.5e-54 CCDS11105.1 FGF11 gene_id:2256|Hs108|chr17 ( 225) 823 199.1 2.1e-51 CCDS5998.1 FGF20 gene_id:26281|Hs108|chr8 ( 211) 394 99.6 1.7e-21 CCDS9298.1 FGF9 gene_id:2254|Hs108|chr13 ( 208) 391 98.9 2.7e-21 CCDS75996.1 FGF16 gene_id:8823|Hs108|chrX ( 207) 376 95.5 3e-20 CCDS3950.1 FGF10 gene_id:2255|Hs108|chr5 ( 208) 330 84.8 5e-17 CCDS34021.1 FGF5 gene_id:2250|Hs108|chr4 ( 268) 319 82.3 3.6e-16 CCDS10131.1 FGF7 gene_id:2252|Hs108|chr15 ( 194) 308 79.7 1.6e-15 CCDS8527.1 FGF6 gene_id:2251|Hs108|chr12 ( 208) 288 75.1 4.2e-14 CCDS8194.1 FGF4 gene_id:2249|Hs108|chr11 ( 206) 280 73.2 1.5e-13 CCDS12037.1 FGF22 gene_id:27006|Hs108|chr19 ( 170) 268 70.4 8.8e-13 CCDS4275.1 FGF1 gene_id:2246|Hs108|chr5 ( 155) 260 68.5 2.9e-12 CCDS8195.1 FGF3 gene_id:2248|Hs108|chr11 ( 239) 244 64.9 5.7e-11 >>CCDS14665.1 FGF13 gene_id:2258|Hs108|chrX (245 aa) initn: 1605 init1: 1605 opt: 1605 Z-score: 2015.8 bits: 380.4 E(32554): 5.8e-106 Smith-Waterman score: 1605; 100.0% identity (100.0% similar) in 245 aa overlap (1-245:1-245) 10 20 30 40 50 60 pF1KB5 MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MAAAIASSLIRQKRQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 RPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 RPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 LYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 KGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMS 190 200 210 220 230 240 pF1KB5 HNEST ::::: CCDS14 HNEST >>CCDS14664.1 FGF13 gene_id:2258|Hs108|chrX (192 aa) initn: 1209 init1: 1209 opt: 1209 Z-score: 1521.3 bits: 288.6 E(32554): 2e-78 Smith-Waterman score: 1209; 97.9% identity (98.4% similar) in 188 aa overlap (58-245:5-192) 30 40 50 60 70 80 pF1KB5 VSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADG :. ::::::::::::::::::::::::: CCDS14 MALLRKSYSEPQLKGIVTKLYSRQGYHLQLQADG 10 20 30 90 100 110 120 130 140 pF1KB5 TIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESV 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB5 FENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 FENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEP 100 110 120 130 140 150 210 220 230 240 pF1KB5 SLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST :::::::::::::::::::::::::::::::::::::: CCDS14 SLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 160 170 180 190 >>CCDS55512.1 FGF13 gene_id:2258|Hs108|chrX (199 aa) initn: 1202 init1: 1202 opt: 1208 Z-score: 1519.8 bits: 288.4 E(32554): 2.5e-78 Smith-Waterman score: 1208; 94.4% identity (96.4% similar) in 196 aa overlap (50-245:4-199) 20 30 40 50 60 70 pF1KB5 EKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGY :. :... ::::::::::::::::: CCDS55 MSGKVTKPKEEKDASKEPQLKGIVTKLYSRQGY 10 20 30 80 90 100 110 120 130 pF1KB5 HLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 HLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTP 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 ECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 ECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPL 100 110 120 130 140 150 200 210 220 230 240 pF1KB5 KVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST :::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 160 170 180 190 >>CCDS55511.1 FGF13 gene_id:2258|Hs108|chrX (226 aa) initn: 1202 init1: 1202 opt: 1202 Z-score: 1511.4 bits: 287.0 E(32554): 7.3e-78 Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 183 aa overlap (63-245:44-226) 40 50 60 70 80 90 pF1KB5 KGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGT :::::::::::::::::::::::::::::: CCDS55 KKESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYSRQGYHLQLQADGTIDGT 20 30 40 50 60 70 100 110 120 130 140 150 pF1KB5 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY 80 90 100 110 120 130 160 170 180 190 200 210 pF1KB5 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDL 140 150 160 170 180 190 220 230 240 pF1KB5 TEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST ::::::::::::::::::::::::::::::::: CCDS55 TEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 200 210 220 >>CCDS55513.1 FGF13 gene_id:2258|Hs108|chrX (255 aa) initn: 1202 init1: 1202 opt: 1202 Z-score: 1510.5 bits: 287.0 E(32554): 8.1e-78 Smith-Waterman score: 1202; 100.0% identity (100.0% similar) in 183 aa overlap (63-245:73-255) 40 50 60 70 80 90 pF1KB5 KGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGT :::::::::::::::::::::::::::::: CCDS55 KKESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLKGIVTKLYSRQGYHLQLQADGTIDGT 50 60 70 80 90 100 100 110 120 130 140 150 pF1KB5 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY 110 120 130 140 150 160 160 170 180 190 200 210 pF1KB5 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDL 170 180 190 200 210 220 220 230 240 pF1KB5 TEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST ::::::::::::::::::::::::::::::::: CCDS55 TEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 230 240 250 >>CCDS9501.1 FGF14 gene_id:2259|Hs108|chr13 (247 aa) initn: 1118 init1: 1032 opt: 1123 Z-score: 1411.8 bits: 268.7 E(32554): 2.6e-72 Smith-Waterman score: 1123; 67.6% identity (88.7% similar) in 247 aa overlap (1-245:1-247) 10 20 30 40 50 pF1KB5 MAAAIASSLIRQKRQARER--EKSNACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKRR :::::::.::::::::::. .. .: . :::::.. :. : ...::.:..:: :::: CCDS95 MAAAIASGLIRQKRQAREQHWDRPSASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 RRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQ :: .::::::::.:: ::::.::.. ::..:::::.... ::::::::::::::::::. CCDS95 LRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVK 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGE : ::.:::.::::: :::::::::::::::::::: ::::.::::.:::.:.:::::::. CCDS95 TGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQ 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 IMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKS ::::.:::.:::::::::::.::::.::::::. : . . ::.:: :.:...:::: CCDS95 AMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKP 190 200 210 220 230 240 240 pF1KB5 MSHNEST ......: CCDS95 VNKSKTT >>CCDS3301.1 FGF12 gene_id:2257|Hs108|chr3 (243 aa) initn: 1062 init1: 851 opt: 1062 Z-score: 1335.4 bits: 254.5 E(32554): 4.6e-68 Smith-Waterman score: 1062; 65.7% identity (86.5% similar) in 251 aa overlap (1-244:1-243) 10 20 30 40 50 pF1KB5 MAAAIASSLIRQKRQARER--EKSNACKCVSSPSK-GKTSCDKNKLNVFSRVKLFGSKKR :::::::::::::::::: .. .: : ::::: :.. :... :.:::.:.. ...:: CCDS33 MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 R-RRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQG :::::::::::::.:.:.::: ::.. ::::::::::.: :::::::::::::::::: CCDS33 PVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQG 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 VQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKE :...::.:::.:::::.:..::::::::::::::::: ::: .::::.:::.:.:::::: CCDS33 VKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKE 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 GEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTE---FSRSGSGTPTKSRSVSGVL :.:::::.:::.::..::.:::..: ::.:::::.. : ::..::::: . CCDS33 GQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPT--------M 190 200 210 220 230 240 pF1KB5 NGGKSMSHNEST :::: .... . CCDS33 NGGKVVNQDST 240 >>CCDS9500.1 FGF14 gene_id:2259|Hs108|chr13 (252 aa) initn: 938 init1: 902 opt: 919 Z-score: 1156.0 bits: 221.4 E(32554): 4.6e-58 Smith-Waterman score: 919; 65.9% identity (87.0% similar) in 208 aa overlap (44-245:45-252) 20 30 40 50 60 pF1KB5 RQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVK-----LFGSKKRRRRRP-EPQLK :.::. : :.. .. . : .:::: CCDS95 LLLCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLK 20 30 40 50 60 70 70 80 90 100 110 120 pF1KB5 GIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNS ::::.:: ::::.::.. ::..:::::.... ::::::::::::::::::.: ::.:::. CCDS95 GIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNG 80 90 100 110 120 130 130 140 150 160 170 180 pF1KB5 EGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKK ::::: :::::::::::::::::::: ::::.::::.:::.:.:::::::. ::::.::: CCDS95 EGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKK 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB5 NKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST .:::::::::::.::::.::::::. : . . ::.:: :.:...:::: ......: CCDS95 TKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT 200 210 220 230 240 250 >>CCDS46983.1 FGF12 gene_id:2257|Hs108|chr3 (181 aa) initn: 887 init1: 820 opt: 856 Z-score: 1079.3 bits: 206.7 E(32554): 8.5e-54 Smith-Waterman score: 856; 68.6% identity (88.6% similar) in 185 aa overlap (63-244:5-181) 40 50 60 70 80 90 pF1KB5 KGKTSCDKNKLNVFSRVKLFGSKKRRRRRPEPQLKGIVTKLYSRQGYHLQLQADGTIDGT :::::::::.:.:.::: ::.. ::::::: CCDS46 MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGT 10 20 30 100 110 120 130 140 150 pF1KB5 KDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYY :::.: :::::::::::::::::::...::.:::.:::::.:..:::::::::::::::: CCDS46 KDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYY 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 VTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDL : ::: .::::.:::.:.:::::::.:::::.:::.::..::.:::..: ::.:::::.. CCDS46 VIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEI 100 110 120 130 140 150 220 230 240 pF1KB5 TE---FSRSGSGTPTKSRSVSGVLNGGKSMSHNEST : ::..::::: .:::: .... . CCDS46 GEKQGRSRKSSGTPT--------MNGGKVVNQDST 160 170 180 >>CCDS11105.1 FGF11 gene_id:2256|Hs108|chr17 (225 aa) initn: 817 init1: 715 opt: 823 Z-score: 1036.5 bits: 199.1 E(32554): 2.1e-51 Smith-Waterman score: 823; 58.7% identity (80.0% similar) in 225 aa overlap (3-223:2-225) 10 20 30 40 50 pF1KB5 MAAAIASSLIRQKRQAREREKS---NACKCVSSPSKGKTSCDKNKLNVFSRVKLFGSKKR ::.:::::::::..:: : .: . : : :. :.:. : ..:.:.: :.. CCDS11 MAALASSLIRQKREVREPGGSRPVSAQRRVC-PRGTKSLCQKQLLILLSKVRLCGGRPA 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 RRRR-PEPQLKGIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQG : : ::::::::::::. :::..:: . ::.:.:: .. :..: :::::::::::.::. CCDS11 RPDRGPEPQLKGIVTKLFCRQGFYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 VQTKLYLAMNSEGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKE .. :.:::.:: ::.: :: ::.::: ::::::: :.: .:::..:::.:::::.:: CCDS11 AKLGHYMAMNAEGLLYSSPHFTAECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKE 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 GEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGG :..::::.:::.: ::::::: :.::::.:::::.. : : :. .: CCDS11 GQVMKGNRVKKTKAAAHFLPKLLEVAMYQEPSLHSVPEASPSSPPAP 180 190 200 210 220 240 pF1KB5 KSMSHNEST 245 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:01:34 2016 done: Sat Nov 5 13:01:34 2016 Total Scan time: 2.290 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]