FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5484, 650 aa 1>>>pF1KB5484 650 - 650 aa - 650 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.6982+/-0.000305; mu= 10.7909+/- 0.019 mean_var=171.6354+/-34.263, 0's: 0 Z-trim(122.9): 23 B-trim: 532 in 1/55 Lambda= 0.097897 statistics sampled from 41896 (41919) to 41896 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.8), E-opt: 0.2 (0.491), width: 16 Scan time: 13.880 The best scores are: opt bits E(85289) NP_005157 (OMIM: 104775) amyloid-like protein 1 is ( 650) 4446 639.9 8.4e-183 NP_001019978 (OMIM: 104775) amyloid-like protein 1 ( 651) 4434 638.2 2.7e-182 XP_016882227 (OMIM: 104775) PREDICTED: amyloid-lik ( 597) 2522 368.1 5e-101 XP_016882226 (OMIM: 104775) PREDICTED: amyloid-lik ( 598) 2522 368.1 5e-101 NP_001315611 (OMIM: 104776) amyloid-like protein 2 ( 707) 801 125.1 8.4e-28 NP_001135749 (OMIM: 104776) amyloid-like protein 2 ( 695) 798 124.7 1.1e-27 NP_001315614 (OMIM: 104776) amyloid-like protein 2 ( 644) 779 122.0 6.7e-27 NP_001135750 (OMIM: 104776) amyloid-like protein 2 ( 522) 762 119.5 3e-26 NP_001315615 (OMIM: 104776) amyloid-like protein 2 ( 730) 764 119.9 3.2e-26 NP_001633 (OMIM: 104776) amyloid-like protein 2 is ( 763) 764 119.9 3.3e-26 NP_001135748 (OMIM: 104776) amyloid-like protein 2 ( 751) 761 119.5 4.4e-26 NP_001230228 (OMIM: 104776) amyloid-like protein 2 ( 761) 761 119.5 4.4e-26 NP_001315613 (OMIM: 104776) amyloid-like protein 2 ( 700) 742 116.8 2.7e-25 NP_001129601 (OMIM: 104300,104760,605714) amyloid ( 639) 719 113.5 2.4e-24 NP_001129603 (OMIM: 104300,104760,605714) amyloid ( 660) 719 113.5 2.4e-24 NP_001191232 (OMIM: 104300,104760,605714) amyloid ( 677) 719 113.5 2.5e-24 NP_958817 (OMIM: 104300,104760,605714) amyloid bet ( 695) 719 113.6 2.5e-24 NP_001191231 (OMIM: 104300,104760,605714) amyloid ( 733) 702 111.2 1.4e-23 NP_001129488 (OMIM: 104300,104760,605714) amyloid ( 746) 702 111.2 1.4e-23 NP_958816 (OMIM: 104300,104760,605714) amyloid bet ( 751) 702 111.2 1.4e-23 NP_001129602 (OMIM: 104300,104760,605714) amyloid ( 714) 683 108.5 8.8e-23 NP_001191230 (OMIM: 104300,104760,605714) amyloid ( 752) 683 108.5 9.1e-23 NP_000475 (OMIM: 104300,104760,605714) amyloid bet ( 770) 683 108.5 9.3e-23 >>NP_005157 (OMIM: 104775) amyloid-like protein 1 isofor (650 aa) initn: 4446 init1: 4446 opt: 4446 Z-score: 3402.9 bits: 639.9 E(85289): 8.4e-183 Smith-Waterman score: 4446; 100.0% identity (100.0% similar) in 650 aa overlap (1-650:1-650) 10 20 30 40 50 60 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 610 620 630 640 650 >>NP_001019978 (OMIM: 104775) amyloid-like protein 1 iso (651 aa) initn: 3573 init1: 3573 opt: 4434 Z-score: 3393.7 bits: 638.2 E(85289): 2.7e-182 Smith-Waterman score: 4434; 99.8% identity (99.8% similar) in 651 aa overlap (1-650:1-651) 10 20 30 40 50 60 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD-DTPMTLPKGSTEQDAASPEKEK ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: NP_001 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 610 620 630 640 650 >>XP_016882227 (OMIM: 104775) PREDICTED: amyloid-like pr (597 aa) initn: 2491 init1: 2491 opt: 2522 Z-score: 1934.8 bits: 368.1 E(85289): 5e-101 Smith-Waterman score: 3996; 91.8% identity (91.8% similar) in 650 aa overlap (1-650:1-597) 10 20 30 40 50 60 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNE-------- 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE ::::::::::::::: XP_016 ---------------------------------------------AERVLLALRRYLRAE 360 430 440 450 460 470 480 pF1KB5 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 370 380 390 400 410 420 490 500 510 520 530 540 pF1KB5 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKM 430 440 450 460 470 480 550 560 570 580 590 600 pF1KB5 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLSM 490 500 510 520 530 540 610 620 630 640 650 pF1KB5 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 550 560 570 580 590 >>XP_016882226 (OMIM: 104775) PREDICTED: amyloid-like pr (598 aa) initn: 3357 init1: 2492 opt: 2522 Z-score: 1934.8 bits: 368.1 E(85289): 5e-101 Smith-Waterman score: 3984; 91.7% identity (91.7% similar) in 651 aa overlap (1-650:1-598) 10 20 30 40 50 60 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGVDIYFGM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNE-------- 310 320 330 340 350 370 380 390 400 410 420 pF1KB5 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE ::::::::::::::: XP_016 ---------------------------------------------AERVLLALRRYLRAE 360 430 440 450 460 470 480 pF1KB5 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ 370 380 390 400 410 420 490 500 510 520 530 pF1KB5 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKD-DTPMTLPKGSTEQDAASPEKEK ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: XP_016 IQELLHSEHLGPSELEAPAPGGSSEDKGGLQPPDSKDADTPMTLPKGSTEQDAASPEKEK 430 440 450 460 470 480 540 550 560 570 580 590 pF1KB5 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPLEQYERKVNASVPRGFPFHSSEIQRDELAPAGTGVSREAVSGLLIMGAGGGSLIVLS 490 500 510 520 530 540 600 610 620 630 640 650 pF1KB5 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP 550 560 570 580 590 >>NP_001315611 (OMIM: 104776) amyloid-like protein 2 iso (707 aa) initn: 1612 init1: 768 opt: 801 Z-score: 620.2 bits: 125.1 E(85289): 8.4e-28 Smith-Waterman score: 1603; 40.5% identity (68.8% similar) in 696 aa overlap (23-648:15-704) 10 20 30 40 50 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSA :: :::. : : ::. .::: .. :.. : . NP_001 MAATGTAAAAATGRLLLLLLVGLTA-PAL-ALAGYIEALAANAGTGFAVAEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAI :.: .::.:..: ...::.::::: .. :.. ..::.::..:::::::. : .:.: . NP_001 QIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRH .. :: ... .: . :.::.:: :::::..::::: :.:.:.:::. ::. . : NP_001 SIDNWCRRDKK-QCK--SRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 120 130 140 150 160 180 190 200 210 220 pF1KB5 QEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPP---GT-------PDPSGTAVG ..::: .::. :.. ::::::: :.:.:.:::::: :. : NP_001 TVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEE 170 180 190 200 210 220 230 240 250 260 270 pF1KB5 D------------PSTRSWPPGSRVEGAEDEEEEESFPQPVDD--YFVEPPQAEEEEETV : :. . ... ::.:.:: . :.: :. . .... .: NP_001 DEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEEN 230 240 250 260 270 280 280 290 300 310 320 pF1KB5 P--PPSSHTLA---VVG--KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR : : :. :.. .. :: ::: ::. ::.:: .. .:: : .:: .:: :. NP_001 PTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRN 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL ....: .:: :. :.::::::.::.: .:::.....::.....:.:.::::: .:: :. NP_001 RMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAM 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQ .::.:: :::..:::::.:::. .:.: :::::.:::.:.. ::.:::::: ::::::: NP_001 LNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAA 410 420 430 440 450 460 450 460 470 480 490 500 pF1KB5 QMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAP---AP ::. :: :::.::::: ::::.:: . :..:::.. .:.:::. .. ... : .: NP_001 QMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETP 470 480 490 500 510 520 510 520 530 540 pF1KB5 GG---SSEDKGGLQP----------PDSKDDTP---MTLPKGST--EQDAA--SPEKEKM :::.. . : :...: : . ::: :::.. . :.. . NP_001 VDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVI 530 540 550 560 570 580 550 560 570 580 590 pF1KB5 NPLEQYERK--VNASVP-RGFPFHSSEI-----QRDELAP--AGTGVSREAVSGLLIMGA : .. ... .. .. . . :.. .. .:. ..: ..: :. :::.... NP_001 NSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAV 590 600 610 620 630 640 600 610 620 630 640 650 pF1KB5 GGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP . ...::.:...:: :. ::.::::.:::::::: ::..: ..: ::::::::..::. NP_001 AIATVIVISLVMLR-KRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 650 660 670 680 690 700 NP_001 I >>NP_001135749 (OMIM: 104776) amyloid-like protein 2 iso (695 aa) initn: 1612 init1: 768 opt: 798 Z-score: 618.0 bits: 124.7 E(85289): 1.1e-27 Smith-Waterman score: 1602; 40.6% identity (69.3% similar) in 684 aa overlap (23-648:15-692) 10 20 30 40 50 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSA :: :::. : : ::. .::: .. :.. : . NP_001 MAATGTAAAAATGRLLLLLLVGLTA-PAL-ALAGYIEALAANAGTGFAVAEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAI :.: .::.:..: ...::.::::: .. :.. ..::.::..:::::::. : .:.: . NP_001 QIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRH .. :: ... .: . :.::.:: :::::..::::: :.:.:.:::. ::. . : NP_001 SIDNWCRRDKK-QCK--SRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 120 130 140 150 160 180 190 200 210 220 pF1KB5 QEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPP---GT-------PDPSGTAVG ..::: .::. :.. ::::::: :.:.:.:::::: :. : NP_001 TVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEE 170 180 190 200 210 220 230 240 250 260 270 pF1KB5 D------------PSTRSWPPGSRVEGAEDEEEEESFPQPVDD--YFVEPPQAEEEEETV : :. . ... ::.:.:: . :.: :. . .... .: NP_001 DEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEEN 230 240 250 260 270 280 280 290 300 310 320 pF1KB5 P--PPSSHTLA---VVG--KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR : : :. :.. .. :: ::: ::. ::.:: .. .:: : .:: .:: :. NP_001 PTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRN 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL ....: .:: :. :.::::::.::.: .:::.....::.....:.:.::::: .:: :. NP_001 RMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAM 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQ .::.:: :::..:::::.:::. .:.: :::::.:::.:.. ::.:::::: ::::::: NP_001 LNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAA 410 420 430 440 450 460 450 460 470 480 490 pF1KB5 QMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAP ::. :: :::.::::: ::::.:: . :..:::.. .:.:::. .. ... :.: NP_001 QMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETP 470 480 490 500 510 520 500 510 520 530 540 550 pF1KB5 APGGSSEDKGGLQPPDSKDDTPMTLPK----GSTEQDAA--SPEKEKMNPLEQYERK--V . : ... :: .::. : :::.. . :.. .: .. ... . NP_001 VDVRVSSEESEEIPPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVI 530 540 550 560 570 580 560 570 580 590 600 pF1KB5 NASVP-RGFPFHSSEI-----QRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLL . .. . . :.. .. .:. ..: ..: :. :::..... ...::.:... NP_001 DETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVM 590 600 610 620 630 640 610 620 630 640 650 pF1KB5 LRRKKPYGAISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP :: :. ::.::::.:::::::: ::..: ..: ::::::::..::. NP_001 LR-KRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 650 660 670 680 690 >>NP_001315614 (OMIM: 104776) amyloid-like protein 2 iso (644 aa) initn: 1387 init1: 749 opt: 779 Z-score: 603.9 bits: 122.0 E(85289): 6.7e-27 Smith-Waterman score: 1564; 41.8% identity (67.7% similar) in 665 aa overlap (23-648:15-641) 10 20 30 40 50 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSA :: :::. : : ::. .::: .. :.. : . NP_001 MAATGTAAAAATGRLLLLLLVGLTA-PAL-ALAGYIEALAANAGTGFAVAEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAI :.: .::.:..: ...::.::::: .. :.. ..::.::..:::::::. : .:.: . NP_001 QIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRH .. :: ... .: . :.::.:: :::::..::::: :.:.:.:::. ::. . : NP_001 SIDNWCRRDKK-QCK--SRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 120 130 140 150 160 180 190 200 210 220 pF1KB5 QEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPP---GT-------PDPSGTAVG ..::: .::. :.. ::::::: :.:.:.:::::: :. : NP_001 TVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEE 170 180 190 200 210 220 230 240 250 260 270 pF1KB5 D------------PSTRSWPPGSRVEGAEDEEEEESFPQPVDD--YFVEPPQAEEEEETV : :. . ... ::.:.:: . :.: :. . .... .: NP_001 DEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEEN 230 240 250 260 270 280 280 290 300 310 320 pF1KB5 P--PPSSHTLA---VVG--KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMR : : :. :.. .. :: ::: ::. ::.:: .. .:: : .:: .:: :. NP_001 PTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRN 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 QINEVMREWAMADNQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIAL ....: .:: :. :.::::::.::.: .:::.....::.....:.:.::::: .:: :. NP_001 RMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAM 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 INDQRRAALEGFLAALQADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQ .::.:: :::..:::::.:::. .:.: :::::.:::.:.. ::.:::::: ::::::: NP_001 LNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAA 410 420 430 440 450 460 450 460 470 480 490 500 pF1KB5 QMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGGS ::. :: :::.::::: ::::.:: . :..::: ::: . : : NP_001 QMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQE----IQEEIGS--------------GV 470 480 490 500 510 520 530 540 550 560 pF1KB5 SEDKGGLQPPDSKDDTPMTLPKGSTEQDAASPEKEKMNPLEQYERKVNASVPRGFPFHSS .:. ::: . : . :...... . : :. : :: :. NP_001 GEQDGGLIGAEEK----VINSKNKVDENMVIDET-----LDVKEMIFNAERVGGL----- 510 520 530 540 550 570 580 590 600 610 620 pF1KB5 EIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDP : .:. ..: ..: :. :::..... ...::.:...:: :. ::.::::.::::: NP_001 EEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLR-KRQYGTISHGIVEVDP 560 570 580 590 600 610 630 640 650 pF1KB5 MLTLEEQQLRELQRHGYENPTYRFLEERP ::: ::..: ..: ::::::::..::. NP_001 MLTPEERHLNKMQNHGYENPTYKYLEQMQI 620 630 640 >>NP_001135750 (OMIM: 104776) amyloid-like protein 2 iso (522 aa) initn: 1253 init1: 762 opt: 762 Z-score: 592.2 bits: 119.5 E(85289): 3e-26 Smith-Waterman score: 1023; 33.7% identity (57.7% similar) in 653 aa overlap (23-648:15-519) 10 20 30 40 50 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSA :: :::. : : ::. .::: .. :.. : . NP_001 MAATGTAAAAATGRLLLLLLVGLTA-PAL-ALAGYIEALAANAGTGFAVAEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAI :.: .::.:..: ...::.::::: .. :.. ..::.::..:::::::. : .:.: . NP_001 QIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRH .. :: ... .: . :.::.:: :: NP_001 SIDNWCRRDKK-QCKS--RFVTPFKCL----------VP--------------------- 120 130 180 190 200 210 220 230 pF1KB5 QEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPG NP_001 ------------------------------------------------------------ 240 250 260 270 280 290 pF1KB5 SRVEGAEDEEEEESFPQPVDDYFVEPPQAEEEEETVPPPSSHTLAVVGKVTPTPRPTDGV ::: ::. : NP_001 ---------------------------------------------------PTPLPTNDV 140 300 310 320 330 340 350 pF1KB5 DIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHF :.:: .. .:: : .:: .:: :. ....: .:: :. :.::::::.::.: .:: NP_001 DVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHF 150 160 170 180 190 200 360 370 380 390 400 410 pF1KB5 QSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALR :.....::.....:.:.::::: .:: :..::.:: :::..:::::.:::. .:.: ::: NP_001 QAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALR 210 220 230 240 250 260 420 430 440 450 460 470 pF1KB5 RYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLA ::.:::.:.. ::.:::::: ::::::: ::. :: :::.::::: ::::.:: . :..: NP_001 RYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVA 270 280 290 300 310 320 480 490 500 510 520 pF1KB5 QELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPDSKDDTPMTLPK---- ::.. .:.:::. .. ... :.:. : ... :: .::. NP_001 QEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEGS 330 340 350 360 370 380 530 540 550 560 570 pF1KB5 GSTEQDAA--SPEKEKMNPLEQYERK--VNASVP-RGFPFHSSEI-----QRDELAP--A : :::.. . :.. .: .. ... .. .. . . :.. .. .:. ..: NP_001 GVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLRE 390 400 410 420 430 440 580 590 600 610 620 630 pF1KB5 GTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEEQQLREL ..: :. :::..... ...::.:...:: :. ::.::::.:::::::: ::..: .. NP_001 DFSLSSSALIGLLVIAVAIATVIVISLVMLR-KRQYGTISHGIVEVDPMLTPEERHLNKM 450 460 470 480 490 500 640 650 pF1KB5 QRHGYENPTYRFLEERP : ::::::::..::. NP_001 QNHGYENPTYKYLEQMQI 510 520 >>NP_001315615 (OMIM: 104776) amyloid-like protein 2 iso (730 aa) initn: 1418 init1: 761 opt: 764 Z-score: 591.7 bits: 119.9 E(85289): 3.2e-26 Smith-Waterman score: 1321; 35.9% identity (63.7% similar) in 716 aa overlap (26-648:17-727) 10 20 30 40 50 pF1KB5 MGPASPAARGLSRRPGQPPLPLLLPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSA ::::. . ::. .::: .. :.. : . NP_001 MAATGTAAAAATGRLLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEP 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 QVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAI :.: .::.:..: ...::.::::: .. :.. ..::.::..:::::::. : .:.: . NP_001 QIAMFCGKLNMHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 PMERWCGGSRSGSCAHPHHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRH .. :: ... .: . :.::.:: :::::..::::: :.:.:.:::. ::. . : NP_001 SIDNWCRRDKK-QCK--SRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWH 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 QEAQEA--CSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPGTPDPSG--TAVGDPSTRS ..:. .: . . :. . . : : :. : . .. NP_001 TVVKETKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDED 170 180 190 200 210 220 240 250 260 270 pF1KB5 WPPGSRV-EGAE--------DEEEEESFPQPVDDYFVEPPQAEEE------EETVPPPS- : .: : . :. .::. .: .: . . .. .:.. : NP_001 EEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTGPCR 230 240 250 260 270 280 280 290 300 pF1KB5 ---------------------------------SHTLAVV-GKVTPTPRPTDGVDIYFGM .. .:: . . ::: ::. ::.:: NP_001 AVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVYFET 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB5 PGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSILQT .. .:: : .:: .:: :. ....: .:: :. :.::::::.::.: .:::..... NP_001 SADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKA 350 360 370 380 390 400 370 380 390 400 410 420 pF1KB5 LEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYLRAE ::.....:.:.::::: .:: :..::.:: :::..:::::.:::. .:.: :::::.::: NP_001 LEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAE 410 420 430 440 450 460 430 440 450 460 470 480 pF1KB5 QKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQELRPQ .:.. ::.:::::: ::::::: ::. :: :::.::::: ::::.:: . :..:::.. . NP_001 NKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEE 470 480 490 500 510 520 490 500 510 520 pF1KB5 IQELLHSEHLGPSELEAP---APGG---SSEDKGGLQP----------PDSKDDTP---M :.:::. .. ... : .: :::.. . : :...: : NP_001 IDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPELYH 530 540 550 560 570 580 530 540 550 560 pF1KB5 TLPKGST--EQDAA--SPEKEKMNPLEQYERK--VNASVP-RGFPFHSSEI-----QRDE . ::: :::.. . :.. .: .. ... .. .. . . :.. .. .:. NP_001 PMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERES 590 600 610 620 630 640 570 580 590 600 610 620 pF1KB5 LAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLTLEE ..: ..: :. :::..... ...::.:...:: :. ::.::::.:::::::: :: NP_001 VGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLR-KRQYGTISHGIVEVDPMLTPEE 650 660 670 680 690 700 630 640 650 pF1KB5 QQLRELQRHGYENPTYRFLEERP ..: ..: ::::::::..::. NP_001 RHLNKMQNHGYENPTYKYLEQMQI 710 720 730 >>NP_001633 (OMIM: 104776) amyloid-like protein 2 isofor (763 aa) initn: 1605 init1: 761 opt: 764 Z-score: 591.5 bits: 119.9 E(85289): 3.3e-26 Smith-Waterman score: 1474; 37.8% identity (64.0% similar) in 714 aa overlap (55-648:51-760) 30 40 50 60 70 80 pF1KB5 PLLLLLLRAQPAIGSLAGGSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRC :.: .::.:..: ...::.::::: .. : NP_001 VGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSC 30 40 50 60 70 80 90 100 110 120 130 140 pF1KB5 LRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVPFRCLPGE .. ..::.::..:::::::. : .:.: . .. :: ... .: :.::.:: :: NP_001 FETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTPFKCLVGE 90 100 110 120 130 150 160 170 180 190 200 pF1KB5 FVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRG :::..::::: :.:.:.:::. ::. . : ..::: .::. :.. ::::::: :.:.: NP_001 FVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHG 140 150 160 170 180 190 210 220 230 240 pF1KB5 VEYVCCPPP---GT-------------PDPSGTAVGDPSTRSWPPGSRVEG------AED .:::::: :. . . : .: . .: :: NP_001 TEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDED 200 210 220 230 240 250 250 260 270 pF1KB5 EEEEESFPQPVDD--YFVEPPQAEEEEETVP--PPSSHTL-------------------- .:.:: . :.: :. . .... .: : : :. :. NP_001 DEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKAVCSQEAMTG 260 270 280 290 300 310 280 290 pF1KB5 ---AVV---------GK-----------------------------VTPTPRPTDGVDIY ::. :: . ::: ::. ::.: NP_001 PCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVCKAMIPPTPLPTNDVDVY 320 330 340 350 360 370 300 310 320 330 340 350 pF1KB5 FGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQSKNLPKADRQALNEHFQSI : .. .:: : .:: .:: :. ....: .:: :. :.::::::.::.: .:::.. NP_001 FETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAM 380 390 400 410 420 430 360 370 380 390 400 410 pF1KB5 LQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQADPPQAERVLLALRRYL ...::.....:.:.::::: .:: :..::.:: :::..:::::.:::. .:.: :::::. NP_001 VKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYV 440 450 460 470 480 490 420 430 440 450 460 470 pF1KB5 RAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEERVNQSLGLLDQNPHLAQEL :::.:.. ::.:::::: ::::::: ::. :: :::.::::: ::::.:: . :..:::. NP_001 RAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEI 500 510 520 530 540 550 480 490 500 510 520 pF1KB5 RPQIQELLHSEHLGPSELEAP---APGG---SSEDKGGLQP----------PDSKDDTP- . .:.:::. .. ... : .: :::.. . : :...: : NP_001 QEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFHPFPALPENEDTQPE 560 570 580 590 600 610 530 540 550 560 pF1KB5 --MTLPKGST--EQDAA--SPEKEKMNPLEQYERK--VNASVP-RGFPFHSSEI-----Q . ::: :::.. . :.. .: .. ... .. .. . . :.. .. . NP_001 LYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLEEE 620 630 640 650 660 670 570 580 590 600 610 620 pF1KB5 RDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVEVDPMLT :. ..: ..: :. :::..... ...::.:...:: :. ::.::::.:::::::: NP_001 RESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLR-KRQYGTISHGIVEVDPMLT 680 690 700 710 720 730 630 640 650 pF1KB5 LEEQQLRELQRHGYENPTYRFLEERP ::..: ..: ::::::::..::. NP_001 PEERHLNKMQNHGYENPTYKYLEQMQI 740 750 760 650 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 03:49:17 2016 done: Fri Nov 4 03:49:19 2016 Total Scan time: 13.880 Total Display time: 0.150 Function used was FASTA [36.3.4 Apr, 2011]