FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5487, 248 aa 1>>>pF1KB5487 248 - 248 aa - 248 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4133+/-0.000836; mu= 14.6350+/- 0.051 mean_var=82.3305+/-16.393, 0's: 0 Z-trim(108.8): 171 B-trim: 357 in 1/50 Lambda= 0.141349 statistics sampled from 10277 (10472) to 10277 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.322), width: 16 Scan time: 1.940 The best scores are: opt bits E(32554) CCDS3490.1 RASL11B gene_id:65997|Hs108|chr4 ( 248) 1619 339.5 1.3e-93 CCDS9321.1 RASL11A gene_id:387496|Hs108|chr13 ( 242) 797 171.8 3.7e-43 CCDS8673.1 RERG gene_id:85004|Hs108|chr12 ( 199) 395 89.8 1.5e-18 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 371 84.9 4.8e-17 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 371 84.9 5.1e-17 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 339 78.4 4.4e-15 CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 ( 208) 334 77.4 8.7e-15 CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 ( 204) 328 76.1 2e-14 CCDS66332.1 RERGL gene_id:79785|Hs108|chr12 ( 204) 325 75.5 3e-14 CCDS10200.1 RASL12 gene_id:51285|Hs108|chr15 ( 266) 326 75.8 3.2e-14 CCDS13181.1 REM1 gene_id:28954|Hs108|chr20 ( 298) 310 72.6 3.4e-13 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 301 70.6 8.5e-13 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 291 68.6 3.5e-12 CCDS3747.1 RAB33B gene_id:83452|Hs108|chr4 ( 229) 291 68.6 4.1e-12 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 285 67.3 8.2e-12 CCDS58036.1 RIT1 gene_id:6016|Hs108|chr1 ( 183) 283 66.9 1.1e-11 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 278 65.9 2.2e-11 CCDS31613.1 RAB1B gene_id:81876|Hs108|chr11 ( 201) 276 65.5 3.1e-11 CCDS4962.1 RAB23 gene_id:51715|Hs108|chr6 ( 237) 272 64.8 6.1e-11 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 270 64.3 6.7e-11 CCDS8679.1 RERGL gene_id:79785|Hs108|chr12 ( 205) 270 64.3 7.3e-11 CCDS46306.1 RAB1A gene_id:5861|Hs108|chr2 ( 205) 269 64.1 8.4e-11 >>CCDS3490.1 RASL11B gene_id:65997|Hs108|chr4 (248 aa) initn: 1619 init1: 1619 opt: 1619 Z-score: 1794.1 bits: 339.5 E(32554): 1.3e-93 Smith-Waterman score: 1619; 100.0% identity (100.0% similar) in 248 aa overlap (1-248:1-248) 10 20 30 40 50 60 pF1KB5 MRLIQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 MRLIQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 DYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 TDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS34 VSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSA 190 200 210 220 230 240 pF1KB5 KVRTVTSV :::::::: CCDS34 KVRTVTSV >>CCDS9321.1 RASL11A gene_id:387496|Hs108|chr13 (242 aa) initn: 779 init1: 365 opt: 797 Z-score: 888.3 bits: 171.8 E(32554): 3.7e-43 Smith-Waterman score: 797; 54.2% identity (83.8% similar) in 216 aa overlap (34-248:28-241) 10 20 30 40 50 60 pF1KB5 IQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYE .:.::.::. :::.:..::::::::::::: CCDS93 MRPLSMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGRVGKSAMIVRFLTKRFIGDYE 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 RNAGNLYTRQVQIEGETLALQVQDTPG-IQVHENSLSCSEQLNRCIRWADAVVIVFSITD :.:.::.: : .::. :.::.::::: .:.... . ..:..:..::.. ..:.:::: CCDS93 PNTGKLYSRLVYVEGDQLSLQIQDTPGGVQIQDSLPQVVDSLSKCVQWAEGFLLVYSITD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 YKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVS : :: : :.::....: .. ::..:.::.:::: .::. : :.:::. :: : :.: CCDS93 YDSYLSIRPLYQHIRKVHPDSKAPVIIVGNKGDLLHARQVQTQDGIQLANELGSLFLEIS 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 VSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKV .::::.:: ..:. ::::::. . :. :.::.:.::::.:::::::::::::::: :: CCDS93 TSENYEDVCDVFQHLCKEVSKMHGLSG--ERRRASIIPRPRSPNMQDLKRRFKQALSPKV 180 190 200 210 220 230 pF1KB5 RTVTSV .. ... CCDS93 KAPSALG 240 >>CCDS8673.1 RERG gene_id:85004|Hs108|chr12 (199 aa) initn: 394 init1: 225 opt: 395 Z-score: 446.5 bits: 89.8 E(32554): 1.5e-18 Smith-Waterman score: 395; 34.8% identity (71.2% similar) in 184 aa overlap (34-217:7-183) 10 20 30 40 50 60 pF1KB5 IQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYE ::.:. : .::::.:::::::::::: .:. CCDS86 MAKSAEVKLAIFGRAGVGKSALVVRFLTKRFIWEYD 10 20 30 70 80 90 100 110 120 pF1KB5 RNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSITDY . . : .:. :. :...... :: : .:... : . .::... :.:..::: CCDS86 PTLESTYRHQATIDDEVVSMEILDTAG---QEDTI----QREGHMRWGEGFVLVYDITDR 40 50 60 70 80 130 140 150 160 170 180 pF1KB5 KSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSV :.: . :.. ..... . ...:.::::: : .::. . : .::. :.:.::: :. CCDS86 GSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGEKLATELACAFYECSA 90 100 110 120 130 140 190 200 210 220 230 240 pF1KB5 SENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVR . ... :. ::.:: .... .. ..: .. CCDS86 CTGEGNITEIFYELCREVRRRRMVQGKTRRRSSTTHVKQAINKMLTKISS 150 160 170 180 190 pF1KB5 TVTSV >>CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 (219 aa) initn: 335 init1: 182 opt: 371 Z-score: 419.4 bits: 84.9 E(32554): 4.8e-17 Smith-Waterman score: 371; 28.5% identity (66.5% similar) in 221 aa overlap (17-236:4-213) 10 20 30 40 50 pF1KB5 MRLIQNMCTIAEYPAPGNAAASDCCVGAAG-RRLVKIAVVGASGVGKTALVVRFLTKRFI :. ...:: . :: : :....::.::::.:....:...:: CCDS11 MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFP 10 20 30 40 60 70 80 90 100 110 pF1KB5 GDYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFS :.. . . : ...:. : :.. :: : :.. ... .. .: ... .: .: CCDS11 EDHDPTIEDAYKIRIRIDDEPANLDILDTAG-QAEFTAMR-----DQYMRAGEGFIICYS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB5 ITDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFY ::: .:.. . ...: . ... :::.:.::.:: ...:: . :: :: ..: :. CCDS11 ITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFF 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 EVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALS :.:.. : . ..::.: .:. .:.. . .... .::. . :: :.. CCDS11 ETSAAYRYY-IDDVFHALVREIRRKEKEAVLAMEKKS----KPKNSVWKRLKSPFRKKKD 170 180 190 200 210 240 pF1KB5 AKVRTVTSV CCDS11 SVT >>CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 (236 aa) initn: 335 init1: 182 opt: 371 Z-score: 419.0 bits: 84.9 E(32554): 5.1e-17 Smith-Waterman score: 371; 28.5% identity (66.5% similar) in 221 aa overlap (17-236:21-230) 10 20 30 40 50 pF1KB5 MRLIQNMCTIAEYPAPGNAAASDCCVGAAG-RRLVKIAVVGASGVGKTALVVRFLT :. ...:: . :: : :....::.::::.:....:.. CCDS58 MERWLFLGATEEGPKRTMDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFIS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 KRFIGDYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVV .:: :.. . . : ...:. : :.. :: : :.. ... .. .: ... . CCDS58 HRFPEDHDPTIEDAYKIRIRIDDEPANLDILDTAG-QAEFTAMR-----DQYMRAGEGFI 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 IVFSITDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLG : .:::: .:.. . ...: . ... :::.:.::.:: ...:: . :: :: .. CCDS58 ICYSITDRRSFHEVREFKQLIYRVRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 CSFYEVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFK : :.:.:.. : . ..::.: .:. .:.. . .... .::. . :: :. CCDS58 CPFFETSAAYRYY-IDDVFHALVREIRRKEKEAVLAMEKKS----KPKNSVWKRLKSPFR 180 190 200 210 220 240 pF1KB5 QALSAKVRTVTSV . CCDS58 KKKDSVT 230 >>CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 (217 aa) initn: 261 init1: 117 opt: 339 Z-score: 384.2 bits: 78.4 E(32554): 4.4e-15 Smith-Waterman score: 339; 30.9% identity (68.1% similar) in 207 aa overlap (22-223:7-206) 10 20 30 40 50 pF1KB5 MRLIQNMCTIAEYPAPGNAAASDCCVGAA--GRRLVKIAVVGASGVGKTALVVRFLTKRF ..: :.: : : :....::.::::.:....:....: CCDS11 MEVENEASCSPGSASGGSREYKVVMLGAGGVGKSAMTMQFISHQF 10 20 30 40 60 70 80 90 100 110 pF1KB5 IGDYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVF .. . . : ::.:..: :.. :: : :.. ... :: .: ... .: . CCDS11 PDYHDPTIEDAYKTQVRIDNEPAYLDILDTAG-QAEFTAMR--EQY---MRGGEGFIICY 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 SITDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSF :.:: .:.. ..... . :.. ..:.:.:.:: :: ...::. . ::.::. .:.: CCDS11 SVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGLSLAQEYNCGF 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 YEVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEK---RRTSLIPRPKSPNMQDLKRRFK .:.:.. . . .::: : .:. .:.. : :: :. :: . : CCDS11 FETSAALRFC-IDDAFHGLVREIRKKESMPSLMEKKLKRKDSLWKKLKGSLKKKRENMT 160 170 180 190 200 210 240 pF1KB5 QALSAKVRTVTSV >>CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 (208 aa) initn: 302 init1: 182 opt: 334 Z-score: 379.0 bits: 77.4 E(32554): 8.7e-15 Smith-Waterman score: 334; 31.1% identity (68.9% similar) in 183 aa overlap (35-217:15-190) 10 20 30 40 50 60 pF1KB5 QNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYER :..::: .::::.::...:. : :. ::. CCDS31 MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDP 10 20 30 40 70 80 90 100 110 120 pF1KB5 NAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSITDYK . . : ....:... :.: :: : .:. . :: .: .:. .::.:.:: CCDS31 TIEDSYLKHTEIDNQWAILDVLDTAG---QEEFSAMREQY---MRTGDGFLIVYSVTDKA 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 SYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYEVSVS :.: ....:: . ... .:...::::.::.:.... . : ..:. . . :.:.. CCDS31 SFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAK 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB5 ENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALSAKVRT . .: .::: : . : ..: : .. .:.. . CCDS31 DPPLNVDKAFHDLVR-VIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL 160 170 180 190 200 pF1KB5 VTSV >>CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 (204 aa) initn: 292 init1: 157 opt: 328 Z-score: 372.5 bits: 76.1 E(32554): 2e-14 Smith-Waterman score: 328; 31.6% identity (67.4% similar) in 190 aa overlap (29-214:10-192) 10 20 30 40 50 60 pF1KB5 MRLIQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIG .:.. ...:::..::::.::...:. . :. CCDS78 MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVT 10 20 30 40 70 80 90 100 110 120 pF1KB5 DYERNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSI ::. . . ::.: :. .. :.. :: : .:. . :: .: ... ..:::. CCDS78 DYDPTIEDSYTKQCVIDDRAARLDILDTAG---QEEFGAMREQY---MRTGEGFLLVFSV 50 60 70 80 90 130 140 150 160 170 180 pF1KB5 TDYKSYELISQLHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFYE :: :.: : ...... ... ..:.....::::: : .:: . : ::: .: ...: CCDS78 TDRGSFEEIYKFQRQILRVKDRDEFPMILIGNKADLDHQRQVTQEEGQQLARQLKVTYME 100 110 120 130 140 150 190 200 210 220 230 pF1KB5 VSVSENYNDVYSAFHVLCKEVSHKQQ----PSSTPEKRRTSLIPRPKSPNMQDLKRRFKQ .:.. .: : .::: : . . . :. :: : .. CCDS78 ASAKIRMN-VDQAFHELVRVIRKFQEQECPPSPEPTRKEKDKKGCHCVIF 160 170 180 190 200 240 pF1KB5 ALSAKVRTVTSV >>CCDS66332.1 RERGL gene_id:79785|Hs108|chr12 (204 aa) initn: 251 init1: 177 opt: 325 Z-score: 369.2 bits: 75.5 E(32554): 3e-14 Smith-Waterman score: 325; 35.4% identity (64.6% similar) in 189 aa overlap (34-217:4-184) 10 20 30 40 50 60 pF1KB5 IQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYE ::.::.:. :.::.::.::::::::::.: CCDS66 MNDVKLAVLGGEGTGKSALTVRFLTKRFIGEYA 10 20 30 70 80 90 100 110 120 pF1KB5 RNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSITDY : ..: ... .: . : :.. : : :... ..: . .:. :::. :::..:.: CCDS66 SNFESIYKKHLCLERKQLNLEIYD-PCSQTQKAKFSLTSELH----WADGFVIVYDISDR 40 50 60 70 80 130 140 150 160 170 pF1KB5 KSYELISQLHQHV---QQLHL--GTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSF .:. . . : .. : : ... : .:.:: :: :...: . : .:: :.: CCDS66 SSFAFAKALIYRIREPQTSHCKRAVESAVFLVGNKRDLCHVREVGWEEGQKLALENRCQF 90 100 110 120 130 140 180 190 200 210 220 230 pF1KB5 YEVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQAL :.:..:. .: : . :.. . . :::: : CCDS66 CELSAAEQSLEVEMMFIRIIKDILINFK---LKEKRRPSGSKSMAKLINNVFGKRRKSV 150 160 170 180 190 200 240 pF1KB5 SAKVRTVTSV >>CCDS10200.1 RASL12 gene_id:51285|Hs108|chr15 (266 aa) initn: 275 init1: 160 opt: 326 Z-score: 368.7 bits: 75.8 E(32554): 3.2e-14 Smith-Waterman score: 326; 29.2% identity (60.7% similar) in 219 aa overlap (34-248:21-227) 10 20 30 40 50 60 pF1KB5 IQNMCTIAEYPAPGNAAASDCCVGAAGRRLVKIAVVGASGVGKTALVVRFLTKRFIGDYE :..:..: :.::.::.:.:::::::..:. CCDS10 MSSVFGKPRAGSGPQSAPLEVNLAILGRRGAGKSALTVKFLTKRFISEYD 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 RNAGNLYTRQVQIEGETLALQVQDTPGIQVHENSLSCSEQLNRCIRWADAVVIVFSITDY : . :. . .. . . :.:.:: ... .: : . :: :: : ..:.:. . CCDS10 PNLEDTYSSEETVDHQPVHLRVMDTADLDTPRN---CERYLN----WAHAFLVVYSVDSR 60 70 80 90 100 130 140 150 160 170 pF1KB5 KSYELISQ----LHQHVQQLHLGTRLPVVVVANKADLLHIKQVDPQLGLQLASMLGCSFY .:.. :. : :... . .:.....:: :. . .:: :. ::. .:: :. CCDS10 QSFDSSSSYLELLALHAKETQ--RSIPALLLGNKLDMAQYRQVTKAEGVALAGRFGCLFF 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 EVSVSENYNDVYSAFHVLCKEVSHKQQPSSTPEKRRTSLIPRPKSPNMQDLKRRFKQALS :::. ... : .:: .:. .. . : : : . . :.. : : : : CCDS10 EVSACLDFEHVQHVFHEAVREARRELEKS--PLTRPLFISEERALPHQAPLTARHGLA-S 170 180 190 200 210 240 pF1KB5 AKVRTVTSV :.... CCDS10 CTFNTLSTINLKEMPTVAQAKLVTVKSSRAQSKRKAPTLTLLKGFKIF 220 230 240 250 260 248 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:08:12 2016 done: Fri Nov 4 20:08:13 2016 Total Scan time: 1.940 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]