FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5490, 494 aa 1>>>pF1KB5490 494 - 494 aa - 494 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5126+/-0.000425; mu= 16.6268+/- 0.027 mean_var=66.3265+/-13.586, 0's: 0 Z-trim(110.4): 27 B-trim: 209 in 2/50 Lambda= 0.157482 statistics sampled from 18782 (18798) to 18782 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.573), E-opt: 0.2 (0.22), width: 16 Scan time: 8.990 The best scores are: opt bits E(85289) NP_003350 (OMIM: 603370) UDP-glucose 6-dehydrogena ( 494) 3271 752.5 6.1e-217 XP_005262724 (OMIM: 603370) PREDICTED: UDP-glucose ( 507) 3271 752.5 6.2e-217 NP_001171630 (OMIM: 603370) UDP-glucose 6-dehydrog ( 397) 2612 602.8 5.9e-172 NP_001171629 (OMIM: 603370) UDP-glucose 6-dehydrog ( 427) 2247 519.9 5.8e-147 >>NP_003350 (OMIM: 603370) UDP-glucose 6-dehydrogenase i (494 aa) initn: 3271 init1: 3271 opt: 3271 Z-score: 4015.8 bits: 752.5 E(85289): 6.1e-217 Smith-Waterman score: 3271; 100.0% identity (100.0% similar) in 494 aa overlap (1-494:1-494) 10 20 30 40 50 60 pF1KB5 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP 430 440 450 460 470 480 490 pF1KB5 KFSLQDPPNKKPKV :::::::::::::: NP_003 KFSLQDPPNKKPKV 490 >>XP_005262724 (OMIM: 603370) PREDICTED: UDP-glucose 6-d (507 aa) initn: 3271 init1: 3271 opt: 3271 Z-score: 4015.6 bits: 752.5 E(85289): 6.2e-217 Smith-Waterman score: 3271; 100.0% identity (100.0% similar) in 494 aa overlap (1-494:14-507) 10 20 30 40 pF1KB5 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNS ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MWSSGLLIQDSTIMFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 PTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB5 YIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB5 AIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFL 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB5 AQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYL 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB5 CEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRE 310 320 330 340 350 360 350 360 370 380 390 400 pF1KB5 SSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDG 370 380 390 400 410 420 410 420 430 440 450 460 pF1KB5 AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVS 430 440 450 460 470 480 470 480 490 pF1KB5 SKRIPYAPSGEIPKFSLQDPPNKKPKV ::::::::::::::::::::::::::: XP_005 SKRIPYAPSGEIPKFSLQDPPNKKPKV 490 500 >>NP_001171630 (OMIM: 603370) UDP-glucose 6-dehydrogenas (397 aa) initn: 2612 init1: 2612 opt: 2612 Z-score: 3208.1 bits: 602.8 E(85289): 5.9e-172 Smith-Waterman score: 2612; 100.0% identity (100.0% similar) in 397 aa overlap (98-494:1-397) 70 80 90 100 110 120 pF1KB5 NLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVT :::::::::::::::::::::::::::::: NP_001 MGKGRAADLKYIEACARRIVQNSNGYKIVT 10 20 30 130 140 150 160 170 180 pF1KB5 EKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPE 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 GQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGAD 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 VEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMN 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 DYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIY 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 DPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYER 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 IHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDP 340 350 360 370 380 390 490 pF1KB5 PNKKPKV ::::::: NP_001 PNKKPKV >>NP_001171629 (OMIM: 603370) UDP-glucose 6-dehydrogenas (427 aa) initn: 2246 init1: 2246 opt: 2247 Z-score: 2759.4 bits: 519.9 E(85289): 5.8e-147 Smith-Waterman score: 2700; 86.4% identity (86.4% similar) in 494 aa overlap (1-494:1-427) 10 20 30 40 50 60 pF1KB5 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS ::::::::::::::::::::::::::::: NP_001 VESCRGKNLFFSTNIDDAIKEADLVFISV------------------------------- 70 80 130 140 150 160 170 180 pF1KB5 NGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI :::::::::::::::::::::::: NP_001 ------------------------------------LSNPEFLAEGTAIKDLKNPDRVLI 90 100 110 190 200 210 220 230 240 pF1KB5 GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISAL 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB5 CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB5 QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB5 GAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMF 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB5 KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP 360 370 380 390 400 410 490 pF1KB5 KFSLQDPPNKKPKV :::::::::::::: NP_001 KFSLQDPPNKKPKV 420 494 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:02:09 2016 done: Sat Nov 5 13:02:10 2016 Total Scan time: 8.990 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]