Result of FASTA (omim) for
pF1KB5528
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5528, 1423 aa
1>>>pF1KB5528 1423 - 1423 aa - 1423 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 13.0627+/-0.000516; mu= -12.4420+/- 0.032
mean_var=502.5340+/-108.575, 0's: 0 Z-trim(119.4): 202 B-trim: 1833 in 1/56
Lambda= 0.057213
statistics sampled from 33252 (33460) to 33252 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.392), width: 16
Scan time: 19.670
The best scores are: opt bits E(85289)
NP_001167558 (OMIM: 601937) nuclear receptor coact (1423) 9596 808.4 0
NP_858045 (OMIM: 601937) nuclear receptor coactiva (1424) 9584 807.4 0
NP_006525 (OMIM: 601937) nuclear receptor coactiva (1420) 9565 805.8 0
NP_001167559 (OMIM: 601937) nuclear receptor coact (1415) 4086 353.6 6.2e-96
NP_001308632 (OMIM: 601993) nuclear receptor coact (1464) 2532 225.3 2.6e-57
NP_001308636 (OMIM: 601993) nuclear receptor coact (1464) 2532 225.3 2.6e-57
NP_006531 (OMIM: 601993) nuclear receptor coactiva (1464) 2532 225.3 2.6e-57
XP_016868458 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868450 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868455 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868456 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868451 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868459 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868453 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868457 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868452 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868454 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
XP_016868460 (OMIM: 601993) PREDICTED: nuclear rec (1533) 2453 218.8 2.5e-55
NP_001308640 (OMIM: 601993) nuclear receptor coact (1395) 2379 212.7 1.6e-53
NP_001308641 (OMIM: 601993) nuclear receptor coact (1395) 2379 212.7 1.6e-53
XP_016868462 (OMIM: 601993) PREDICTED: nuclear rec ( 799) 2216 199.0 1.2e-49
NP_001308642 (OMIM: 601993) nuclear receptor coact (1310) 1864 170.2 9.5e-41
XP_016868461 (OMIM: 601993) PREDICTED: nuclear rec (1379) 1785 163.7 9.1e-39
XP_005264685 (OMIM: 602691) PREDICTED: nuclear rec (1399) 1487 139.1 2.3e-31
XP_016860658 (OMIM: 602691) PREDICTED: nuclear rec (1399) 1487 139.1 2.3e-31
NP_671756 (OMIM: 602691) nuclear receptor coactiva (1399) 1487 139.1 2.3e-31
XP_016860657 (OMIM: 602691) PREDICTED: nuclear rec (1399) 1487 139.1 2.3e-31
XP_005264683 (OMIM: 602691) PREDICTED: nuclear rec (1440) 1487 139.1 2.4e-31
NP_671766 (OMIM: 602691) nuclear receptor coactiva (1440) 1487 139.1 2.4e-31
NP_003734 (OMIM: 602691) nuclear receptor coactiva (1441) 1487 139.1 2.4e-31
XP_005264682 (OMIM: 602691) PREDICTED: nuclear rec (1441) 1487 139.1 2.4e-31
XP_016884309 (OMIM: 607372) PREDICTED: mediator of ( 667) 386 47.9 0.00031
NP_001280164 (OMIM: 607372) mediator of RNA polyme ( 722) 386 47.9 0.00032
NP_001280166 (OMIM: 607372) mediator of RNA polyme ( 722) 386 47.9 0.00032
NP_056973 (OMIM: 607372) mediator of RNA polymeras ( 748) 386 48.0 0.00033
XP_016884311 (OMIM: 607372) PREDICTED: mediator of ( 406) 377 47.0 0.00035
XP_011528521 (OMIM: 607372) PREDICTED: mediator of ( 406) 377 47.0 0.00035
XP_011528522 (OMIM: 607372) PREDICTED: mediator of ( 406) 377 47.0 0.00035
XP_011528520 (OMIM: 607372) PREDICTED: mediator of ( 411) 377 47.0 0.00036
NP_001280163 (OMIM: 607372) mediator of RNA polyme ( 731) 382 47.6 0.00041
XP_016884310 (OMIM: 607372) PREDICTED: mediator of ( 520) 377 47.1 0.00042
XP_006724327 (OMIM: 607372) PREDICTED: mediator of ( 707) 377 47.2 0.00053
XP_016884307 (OMIM: 607372) PREDICTED: mediator of ( 707) 377 47.2 0.00053
XP_016884308 (OMIM: 607372) PREDICTED: mediator of ( 707) 377 47.2 0.00053
XP_011528517 (OMIM: 607372) PREDICTED: mediator of ( 741) 377 47.2 0.00055
XP_016884306 (OMIM: 607372) PREDICTED: mediator of ( 749) 377 47.2 0.00056
XP_011528516 (OMIM: 607372) PREDICTED: mediator of ( 762) 377 47.2 0.00056
NP_001003891 (OMIM: 607372) mediator of RNA polyme ( 788) 377 47.2 0.00058
NP_001280165 (OMIM: 607372) mediator of RNA polyme ( 677) 340 44.1 0.0043
XP_006724326 (OMIM: 607372) PREDICTED: mediator of ( 717) 331 43.4 0.0075
>>NP_001167558 (OMIM: 601937) nuclear receptor coactivat (1423 aa)
initn: 9596 init1: 9596 opt: 9596 Z-score: 4301.2 bits: 808.4 E(85289): 0
Smith-Waterman score: 9596; 100.0% identity (100.0% similar) in 1423 aa overlap (1-1423:1-1423)
10 20 30 40 50 60
pF1KB5 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 GGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KB5 QQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQP
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KB5 DPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQF
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420
pF1KB5 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
:::::::::::::::::::::::::::::::::::::::::::
NP_001 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
1390 1400 1410 1420
>>NP_858045 (OMIM: 601937) nuclear receptor coactivator (1424 aa)
initn: 8346 init1: 8346 opt: 9584 Z-score: 4295.8 bits: 807.4 E(85289): 0
Smith-Waterman score: 9584; 99.9% identity (99.9% similar) in 1424 aa overlap (1-1423:1-1424)
10 20 30 40 50 60
pF1KB5 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250
pF1KB5 GGAAVMRPMMQPQVSSQ-GFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQ
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_858 GGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQ
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KB5 QQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 QQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQ
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KB5 PDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_858 PDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQ
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420
pF1KB5 FAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
::::::::::::::::::::::::::::::::::::::::::::
NP_858 FAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
1390 1400 1410 1420
>>NP_006525 (OMIM: 601937) nuclear receptor coactivator (1420 aa)
initn: 8441 init1: 8260 opt: 9565 Z-score: 4287.4 bits: 805.8 E(85289): 0
Smith-Waterman score: 9565; 99.8% identity (99.8% similar) in 1423 aa overlap (1-1423:1-1420)
10 20 30 40 50 60
pF1KB5 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVS
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLK
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB5 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB5 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQV
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB5 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPE
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB5 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMN
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KB5 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KB5 GGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQ
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_006 GGAAVMRPMMQPQ---QGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQ
1210 1220 1230 1240 1250
1270 1280 1290 1300 1310 1320
pF1KB5 QQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQP
1260 1270 1280 1290 1300 1310
1330 1340 1350 1360 1370 1380
pF1KB5 DPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQF
1320 1330 1340 1350 1360 1370
1390 1400 1410 1420
pF1KB5 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
:::::::::::::::::::::::::::::::::::::::::::
NP_006 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
1380 1390 1400 1410 1420
>>NP_001167559 (OMIM: 601937) nuclear receptor coactivat (1415 aa)
initn: 6196 init1: 3841 opt: 4086 Z-score: 1843.3 bits: 353.6 E(85289): 6.2e-96
Smith-Waterman score: 9396; 98.0% identity (98.0% similar) in 1433 aa overlap (1-1423:1-1415)
10 20 30 40 50 60
pF1KB5 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDID
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRC
250 260 270 280 290 300
310 320 330 340 350
pF1KB5 IQRFFSLNDGQSWSQKRHYQE----------AYLNGHAETPVYRFSLADGTIVTAQTKSK
::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 IQRFFSLNDGQSWSQKRHYQEVTSDGIFSPTAYLNGHAETPVYRFSLADGTIVTAQTKSK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 LFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 MPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGS
430 440 450 460 470 480
480 490 500 510 520 530
pF1KB5 PGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAIS
490 500 510 520 530 540
540 550 560 570 580 590
pF1KB5 EGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSR
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB5 DHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESS
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB5 VSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDT
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB5 SSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCT
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB5 SSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQV
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB5 FQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPR
850 860 870 880 890 900
900 910 920 930 940 950
pF1KB5 MMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLP
::::::::::::: ::::::::::::::::::::::::::::::::
NP_001 MMDSQENYGSSMG---------------DWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLP
910 920 930 940
960 970 980 990 1000 1010
pF1KB5 RPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSW
950 960 970 980 990 1000
1020 1030 1040 1050 1060 1070
pF1KB5 PDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLE
1010 1020 1030 1040 1050 1060
1080 1090 1100 1110 1120 1130
pF1KB5 EIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQG
1070 1080 1090 1100 1110 1120
1140 1150 1160 1170 1180 1190
pF1KB5 QSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQA
1130 1140 1150 1160 1170 1180
1200 1210 1220 1230 1240 1250
pF1KB5 LELKMENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQ
::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 LELKMENPTAGGAAVMRPMMQPQ---QGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQ
1190 1200 1210 1220 1230 1240
1260 1270 1280 1290 1300 1310
pF1KB5 QQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPY
1250 1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KB5 QPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLA
1310 1320 1330 1340 1350 1360
1380 1390 1400 1410 1420
pF1KB5 RNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
1370 1380 1390 1400 1410
>>NP_001308632 (OMIM: 601993) nuclear receptor coactivat (1464 aa)
initn: 1785 init1: 580 opt: 2532 Z-score: 1149.9 bits: 225.3 E(85289): 2.6e-57
Smith-Waterman score: 3569; 42.9% identity (69.1% similar) in 1506 aa overlap (1-1420:1-1431)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
NP_001 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
NP_001 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
NP_001 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
NP_001 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
NP_001 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
NP_001 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
NP_001 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
NP_001 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
NP_001 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
NP_001 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::.
NP_001 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQ---
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
NP_001 --MEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
NP_001 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
NP_001 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
NP_001 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
NP_001 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
NP_001 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
NP_001 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
NP_001 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
NP_001 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
NP_001 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : .. . ..: : .:. .::::.:::.::.:..:.::.
NP_001 ISN-----VSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQR--------------
1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB5 QQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNY
:..:::: ::. ... :... :...: .: . ...: .::: ::::. :::
NP_001 -----QMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNY
1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KB5 GMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNS
:..:::::.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. ::
NP_001 GISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNS
1310 1320 1330 1340 1350 1360
1380 1390 1400 1410
pF1KB5 SFSQQ---QFAHQGNPAVYS---------------MVHMNGSSGHMGQMNMNPMPMSGMP
:::: .:..:.: ..:: : :: .:.... ... .: ::.
NP_001 MFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLS
1370 1380 1390 1400 1410 1420
1420
pF1KB5 -MGPDQKYC
:::.:
NP_001 SMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
1430 1440 1450 1460
>>NP_001308636 (OMIM: 601993) nuclear receptor coactivat (1464 aa)
initn: 1785 init1: 580 opt: 2532 Z-score: 1149.9 bits: 225.3 E(85289): 2.6e-57
Smith-Waterman score: 3569; 42.9% identity (69.1% similar) in 1506 aa overlap (1-1420:1-1431)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
NP_001 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
NP_001 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
NP_001 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
NP_001 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
NP_001 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
NP_001 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
NP_001 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
NP_001 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
NP_001 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
NP_001 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::.
NP_001 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQ---
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
NP_001 --MEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
NP_001 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
NP_001 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
NP_001 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
NP_001 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
NP_001 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
NP_001 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
NP_001 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
NP_001 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
NP_001 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : .. . ..: : .:. .::::.:::.::.:..:.::.
NP_001 ISN-----VSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQR--------------
1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB5 QQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNY
:..:::: ::. ... :... :...: .: . ...: .::: ::::. :::
NP_001 -----QMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNY
1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KB5 GMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNS
:..:::::.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. ::
NP_001 GISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNS
1310 1320 1330 1340 1350 1360
1380 1390 1400 1410
pF1KB5 SFSQQ---QFAHQGNPAVYS---------------MVHMNGSSGHMGQMNMNPMPMSGMP
:::: .:..:.: ..:: : :: .:.... ... .: ::.
NP_001 MFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLS
1370 1380 1390 1400 1410 1420
1420
pF1KB5 -MGPDQKYC
:::.:
NP_001 SMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
1430 1440 1450 1460
>>NP_006531 (OMIM: 601993) nuclear receptor coactivator (1464 aa)
initn: 1785 init1: 580 opt: 2532 Z-score: 1149.9 bits: 225.3 E(85289): 2.6e-57
Smith-Waterman score: 3569; 42.9% identity (69.1% similar) in 1506 aa overlap (1-1420:1-1431)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
NP_006 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
NP_006 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
NP_006 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
NP_006 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
NP_006 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
NP_006 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
NP_006 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
NP_006 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
NP_006 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
NP_006 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::.
NP_006 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQ---
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
NP_006 --MEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
NP_006 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
NP_006 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
NP_006 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
NP_006 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
NP_006 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
NP_006 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
NP_006 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
NP_006 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
NP_006 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : .. . ..: : .:. .::::.:::.::.:..:.::.
NP_006 ISN-----VSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQR--------------
1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KB5 QQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNY
:..:::: ::. ... :... :...: .: . ...: .::: ::::. :::
NP_006 -----QMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNY
1260 1270 1280 1290 1300
1320 1330 1340 1350 1360 1370
pF1KB5 GMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNS
:..:::::.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. ::
NP_006 GISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNS
1310 1320 1330 1340 1350 1360
1380 1390 1400 1410
pF1KB5 SFSQQ---QFAHQGNPAVYS---------------MVHMNGSSGHMGQMNMNPMPMSGMP
:::: .:..:.: ..:: : :: .:.... ... .: ::.
NP_006 MFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLS
1370 1380 1390 1400 1410 1420
1420
pF1KB5 -MGPDQKYC
:::.:
NP_006 SMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC
1430 1440 1450 1460
>>XP_016868458 (OMIM: 601993) PREDICTED: nuclear recepto (1533 aa)
initn: 1636 init1: 580 opt: 2453 Z-score: 1114.3 bits: 218.8 E(85289): 2.5e-55
Smith-Waterman score: 3397; 42.2% identity (67.3% similar) in 1515 aa overlap (1-1395:1-1456)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
XP_016 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
XP_016 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
XP_016 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
XP_016 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
XP_016 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
XP_016 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
XP_016 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
XP_016 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
XP_016 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
XP_016 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::
XP_016 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSD----
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
.. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
XP_016 -QMEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
XP_016 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
XP_016 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
XP_016 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
XP_016 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
XP_016 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
XP_016 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
XP_016 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
XP_016 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
XP_016 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : . . ..: : .:. .::::.:::.::.:..:.::.. : :::: ::.
XP_016 ISNVSN-----VNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQ---MHQQQQVQQR
1210 1220 1230 1240 1250 1260
1260 1270 1280
pF1KB5 QQQQQQQ-------------QQQQQQQQQQQQQQTQAF-----------SPPPNVT----
... : . ... . : ..: : :::: ..
XP_016 TLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGTGLRSPPPFTSPFSP
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320
pF1KB5 ASPS----------------------MDGLLAGPTMPQAPPQ--QFPYQP-NYGMGQQPD
.::: : : :.: : :: . .: . :..::::
XP_016 VSPSVGSQLLSHSSLHGSQMNLANQGMIGNLGGQLGPVRSPQVQHSTFQALSSGISQQPD
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KB5 PAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNSSFSQQQF
:.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. :: ::::.
XP_016 PGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSP
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420
pF1KB5 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
: :. : :: :
XP_016 PHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQV
1450 1460 1470 1480 1490 1500
>>XP_016868450 (OMIM: 601993) PREDICTED: nuclear recepto (1533 aa)
initn: 1636 init1: 580 opt: 2453 Z-score: 1114.3 bits: 218.8 E(85289): 2.5e-55
Smith-Waterman score: 3397; 42.2% identity (67.3% similar) in 1515 aa overlap (1-1395:1-1456)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
XP_016 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
XP_016 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
XP_016 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
XP_016 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
XP_016 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
XP_016 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
XP_016 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
XP_016 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
XP_016 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
XP_016 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::
XP_016 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSD----
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
.. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
XP_016 -QMEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
XP_016 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
XP_016 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
XP_016 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
XP_016 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
XP_016 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
XP_016 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
XP_016 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
XP_016 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
XP_016 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : . . ..: : .:. .::::.:::.::.:..:.::.. : :::: ::.
XP_016 ISNVSN-----VNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQ---MHQQQQVQQR
1210 1220 1230 1240 1250 1260
1260 1270 1280
pF1KB5 QQQQQQQ-------------QQQQQQQQQQQQQQTQAF-----------SPPPNVT----
... : . ... . : ..: : :::: ..
XP_016 TLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGTGLRSPPPFTSPFSP
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320
pF1KB5 ASPS----------------------MDGLLAGPTMPQAPPQ--QFPYQP-NYGMGQQPD
.::: : : :.: : :: . .: . :..::::
XP_016 VSPSVGSQLLSHSSLHGSQMNLANQGMIGNLGGQLGPVRSPQVQHSTFQALSSGISQQPD
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KB5 PAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNSSFSQQQF
:.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. :: ::::.
XP_016 PGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSP
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420
pF1KB5 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
: :. : :: :
XP_016 PHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQV
1450 1460 1470 1480 1490 1500
>>XP_016868455 (OMIM: 601993) PREDICTED: nuclear recepto (1533 aa)
initn: 1636 init1: 580 opt: 2453 Z-score: 1114.3 bits: 218.8 E(85289): 2.5e-55
Smith-Waterman score: 3397; 42.2% identity (67.3% similar) in 1515 aa overlap (1-1395:1-1456)
10 20 30 40 50
pF1KB5 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI
:::.::: :: ...:::: : : . . ::: ::::.:::::::::: ::..::
XP_016 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL
:::: ::::::::::::.:::::::: :. . : :.:::.:::::::::::::.:::..:
XP_016 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST
.:::::.:::: .::.:::::::::::.:.::.:.: :::.::: :. .:.::: :::
XP_016 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
130 140 150 160 170 180
180 190 200 210 220 230
pF1KB5 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME
::: ::..: :..:::::::::.: : :. . . : .:.::::::::.:::... :
XP_016 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB5 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII
::::::::.::::::. :: . ::: ::.::.::....::...:..:.::.::..
XP_016 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB5 RRCIQRFFSLNDGQSWSQ-KRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV
:::::.: . ..:.: : :::..:. .: : . .:::::.:::.:.:::::::.:. .
XP_016 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB5 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGM----SMSPNQGLQMP
::. . .: :.:.:::: ::. .:: . :. .:. . : .:.: . .
XP_016 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
370 380 390 400 410 420
420 430 440 450 460 470
pF1KB5 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG
:. . . :. : .:.:::... .. :::. .. :..::.:.:.:: ..:::
XP_016 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG
430 440 450 460 470
480 490 500 510 520
pF1KB5 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA
. :.: . :.:::.: :::.: ::::....:::.. ..::: ::...:::.:
XP_016 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA
480 490 500 510 520 530
530 540 550 560 570 580
pF1KB5 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE
:::.::: :.:: :.:.:: : :.::: ::: ::... :::. .:.: . : :
XP_016 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE
540 550 560 570 580 590
590 600 610 620 630
pF1KB5 SSMCQSNSRDHLSD-KESKES------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH
.. :..: : .. ::... : : :..: .:::. ::::::: .::
XP_016 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSD----
600 610 620 630 640 650
640 650 660 670 680 690
pF1KB5 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS
.. ::: :: .... ....:.. .... ::. :.:::.:::.:::...:
XP_016 -QMEPSPLASSLSDTN----------KDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS
660 670 680 690
700 710 720 730 740 750
pF1KB5 PAEVAKITAEATGKDTS---SITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL
:...::.:::::::: : : :. :. ..::: .::::::: ::::::::.:: .:
XP_016 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKEN-ALLRYLLDKDDTKDIG
700 710 720 730 740 750
760 770 780 790 800 810
pF1KB5 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD
:. :..: .:.: . ... . . . ::. ... : ... ...::::. :: :: .:.
XP_016 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ
760 770 780 790 800 810
820 830 840 850
pF1KB5 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQSV-QSIRPPY
. . .. :. :. :: ... :... .:. :::. .. ::
XP_016 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ
820 830 840 850 860 870
860 870 880 890 900
pF1KB5 ------NRAVSLD----SPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM
:. . :: ::...: ::..: : . ..: :: . :: :. .: : :.:
XP_016 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS
880 890 900 910 920 930
910 920 930 940 950
pF1KB5 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI--P-
: : . : ::.:. :.:.: :. ..: .. ::. :: : :
XP_016 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA
940 950 960 970 980
960 970 980 990 1000 1010
pF1KB5 -TLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAAS-NQLGSWPDGMLSM
..:.: .: :: : .::.: .... :.:. :.::. :.: : :: . ::...: .
XP_016 ASIPMRPSSQPGQRQTLQSQ--VMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI
990 1000 1010 1020 1030 1040
1020 1030 1040 1050 1060 1070
pF1KB5 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG
.:.: ..::: . .: :::. : :. ::: ::::::. : : : ::::::::::
XP_016 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG
1050 1060 1070 1080 1090 1100
1080 1090 1100 1110 1120 1130
pF1KB5 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNS
:::::.:.::..:.: :..:.. .:..::: .. : : .:. ::.. :.:.:..
XP_016 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYS-PMQDPNFHT
1110 1120 1130 1140 1150
1140 1150 1160 1170 1180 1190
pF1KB5 MMNQMNQQGNFPLQGMHPRANIMRPR---TNTPKQLRMQLQQRLQGQQFLNQSRQALELK
: .:. .. :.:: . .:: : :.:::.:::.:::.:: .:: : .
XP_016 M----GQRPSYATLRMQPRPG-LRPTGLVQNQPNQLRLQLQHRLQAQQ----NRQPLMNQ
1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KB5 MENPTAGGAAVMRPMMQPQVSSQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQ
. : . . ..: : .:. .::::.:::.::.:..:.::.. : :::: ::.
XP_016 ISNVSN-----VNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQ---MHQQQQVQQR
1210 1220 1230 1240 1250 1260
1260 1270 1280
pF1KB5 QQQQQQQ-------------QQQQQQQQQQQQQQTQAF-----------SPPPNVT----
... : . ... . : ..: : :::: ..
XP_016 TLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGTGLRSPPPFTSPFSP
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320
pF1KB5 ASPS----------------------MDGLLAGPTMPQAPPQ--QFPYQP-NYGMGQQPD
.::: : : :.: : :: . .: . :..::::
XP_016 VSPSVGSQLLSHSSLHGSQMNLANQGMIGNLGGQLGPVRSPQVQHSTFQALSSGISQQPD
1330 1340 1350 1360 1370 1380
1330 1340 1350 1360 1370 1380
pF1KB5 PAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLARNSSFSQQQF
:.: ...: . .:: ::. .:.::::. :: ::. :...:: .::.. :: ::::.
XP_016 PGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSP
1390 1400 1410 1420 1430 1440
1390 1400 1410 1420
pF1KB5 AHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC
: :. : :: :
XP_016 PHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQV
1450 1460 1470 1480 1490 1500
1423 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:30:49 2016 done: Thu Nov 3 17:30:52 2016
Total Scan time: 19.670 Total Display time: 0.810
Function used was FASTA [36.3.4 Apr, 2011]