FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5542, 358 aa 1>>>pF1KB5542 358 - 358 aa - 358 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0637+/-0.000361; mu= 18.0430+/- 0.022 mean_var=76.9060+/-16.373, 0's: 0 Z-trim(115.2): 147 B-trim: 2291 in 2/52 Lambda= 0.146249 statistics sampled from 25243 (25430) to 25243 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.676), E-opt: 0.2 (0.298), width: 16 Scan time: 8.330 The best scores are: opt bits E(85289) NP_005507 (OMIM: 143010) HLA class I histocompatib ( 358) 2453 527.0 2.4e-149 XP_016866298 (OMIM: 143010) PREDICTED: HLA class I ( 359) 2364 508.2 1.1e-143 XP_016866296 (OMIM: 143010) PREDICTED: HLA class I ( 399) 2327 500.5 2.7e-141 XP_016866297 (OMIM: 143010) PREDICTED: HLA class I ( 399) 2327 500.5 2.7e-141 NP_002107 (OMIM: 142800,608579) HLA class I histoc ( 365) 1925 415.6 8.5e-116 NP_005505 (OMIM: 106300,142830,608579) major histo ( 362) 1894 409.1 7.9e-114 NP_001229687 (OMIM: 142800,608579) HLA class I his ( 365) 1885 407.2 3e-113 XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA ( 362) 1876 405.3 1.1e-112 XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA ( 391) 1876 405.3 1.2e-112 NP_001229971 (OMIM: 142840,177900,609423) HLA clas ( 366) 1844 398.5 1.2e-110 NP_002108 (OMIM: 142840,177900,609423) HLA class I ( 366) 1840 397.7 2.1e-110 NP_002118 (OMIM: 142871,600807) HLA class I histoc ( 338) 1812 391.8 1.2e-108 XP_016866305 (OMIM: 142871,600807) PREDICTED: HLA ( 343) 1812 391.8 1.2e-108 XP_016866302 (OMIM: 143110) PREDICTED: HLA class I ( 388) 1726 373.7 3.9e-103 XP_016866301 (OMIM: 143110) PREDICTED: HLA class I ( 420) 1726 373.7 4.1e-103 NP_061823 (OMIM: 143110) HLA class I histocompatib ( 346) 1725 373.4 4.1e-103 XP_016866299 (OMIM: 143110) PREDICTED: HLA class I ( 435) 1726 373.7 4.2e-103 NP_001091949 (OMIM: 143110) HLA class I histocompa ( 442) 1726 373.7 4.3e-103 XP_011512866 (OMIM: 143110) PREDICTED: HLA class I ( 343) 1707 369.6 5.7e-102 XP_016866300 (OMIM: 143110) PREDICTED: HLA class I ( 431) 1702 368.6 1.4e-101 XP_011512859 (OMIM: 106300,142830,608579) PREDICTE ( 323) 1633 354.0 2.7e-97 XP_016866304 (OMIM: 143110) PREDICTED: HLA class I ( 228) 1192 260.8 2.2e-69 XP_016866303 (OMIM: 143110) PREDICTED: HLA class I ( 324) 1193 261.1 2.4e-69 NP_001091948 (OMIM: 143110) HLA class I histocompa ( 254) 899 199.0 9.6e-51 XP_016866307 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 801 178.3 1.6e-44 XP_016866306 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 801 178.3 1.6e-44 NP_001522 (OMIM: 600764) major histocompatibility ( 341) 793 176.8 6.4e-44 XP_011512845 (OMIM: 104300,176100,176200,235200,61 ( 348) 723 162.0 1.8e-39 NP_000401 (OMIM: 104300,176100,176200,235200,61263 ( 348) 723 162.0 1.8e-39 NP_001287678 (OMIM: 104300,176100,176200,235200,61 ( 337) 701 157.3 4.4e-38 NP_620578 (OMIM: 104300,176100,176200,235200,61263 ( 325) 680 152.9 9.3e-37 NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein ( 298) 618 139.8 7.6e-33 XP_011507765 (OMIM: 600764) PREDICTED: major histo ( 254) 558 127.1 4.4e-29 NP_620576 (OMIM: 104300,176100,176200,235200,61263 ( 260) 551 125.6 1.2e-28 NP_001181929 (OMIM: 600764) major histocompatibili ( 249) 516 118.2 2e-26 NP_001181964 (OMIM: 600764) major histocompatibili ( 214) 514 117.7 2.4e-26 NP_000238 (OMIM: 600169) MHC class I polypeptide-r ( 383) 510 117.1 6.6e-26 NP_005922 (OMIM: 602436) MHC class I polypeptide-r ( 383) 508 116.7 8.9e-26 NP_001170990 (OMIM: 600169) MHC class I polypeptid ( 332) 505 116.0 1.2e-25 NP_001276089 (OMIM: 602436) MHC class I polypeptid ( 351) 472 109.0 1.6e-23 NP_001129491 (OMIM: 601437) IgG receptor FcRn larg ( 365) 455 105.5 2e-22 NP_004098 (OMIM: 601437) IgG receptor FcRn large s ( 365) 455 105.5 2e-22 NP_001181928 (OMIM: 600764) major histocompatibili ( 296) 408 95.5 1.6e-19 NP_620579 (OMIM: 104300,176100,176200,235200,61263 ( 168) 379 89.1 7.5e-18 NP_001276081 (OMIM: 600169) MHC class I polypeptid ( 235) 379 89.3 9.6e-18 NP_001276082 (OMIM: 600169) MHC class I polypeptid ( 235) 379 89.3 9.6e-18 NP_620573 (OMIM: 104300,176100,176200,235200,61263 ( 256) 377 88.9 1.4e-17 NP_001297142 (OMIM: 600764) major histocompatibili ( 178) 358 84.7 1.7e-16 NP_620577 (OMIM: 104300,176100,176200,235200,61263 ( 246) 344 81.9 1.7e-15 NP_620575 (OMIM: 104300,176100,176200,235200,61263 ( 334) 344 82.0 2.1e-15 >>NP_005507 (OMIM: 143010) HLA class I histocompatibilit (358 aa) initn: 2453 init1: 2453 opt: 2453 Z-score: 2802.1 bits: 527.0 E(85289): 2.4e-149 Smith-Waterman score: 2453; 100.0% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL 310 320 330 340 350 >>XP_016866298 (OMIM: 143010) PREDICTED: HLA class I his (359 aa) initn: 2364 init1: 2364 opt: 2364 Z-score: 2700.6 bits: 508.2 E(85289): 1.1e-143 Smith-Waterman score: 2364; 100.0% identity (100.0% similar) in 345 aa overlap (1-345:1-345) 10 20 30 40 50 60 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL ::::::::::::::::::::::::::::::::::::::::::::: XP_016 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAECKCGAGAWRSSPTL 310 320 330 340 350 >>XP_016866296 (OMIM: 143010) PREDICTED: HLA class I his (399 aa) initn: 2327 init1: 2327 opt: 2327 Z-score: 2657.8 bits: 500.5 E(85289): 2.7e-141 Smith-Waterman score: 2327; 100.0% identity (100.0% similar) in 337 aa overlap (22-358:63-399) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDD :::::::::::::::::::::::::::::: XP_016 VERGRPGGGEGLGEPRREEGRADLSPSSPPGSHSLKYFHTSVSRPGRGEPRFISVGYVDD 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB5 TQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEA 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB5 GSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDA 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB5 SEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYP 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB5 AEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPV 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB5 TLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQ 340 350 360 370 380 390 pF1KB5 GSESHSL ::::::: XP_016 GSESHSL >>XP_016866297 (OMIM: 143010) PREDICTED: HLA class I his (399 aa) initn: 2327 init1: 2327 opt: 2327 Z-score: 2657.8 bits: 500.5 E(85289): 2.7e-141 Smith-Waterman score: 2327; 100.0% identity (100.0% similar) in 337 aa overlap (22-358:63-399) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDD :::::::::::::::::::::::::::::: XP_016 VERGRPGGGEGLGEPRREEGRADLSPSSPPGSHSLKYFHTSVSRPGRGEPRFISVGYVDD 40 50 60 70 80 90 60 70 80 90 100 110 pF1KB5 TQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEA 100 110 120 130 140 150 120 130 140 150 160 170 pF1KB5 GSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDA 160 170 180 190 200 210 180 190 200 210 220 230 pF1KB5 SEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYP 220 230 240 250 260 270 240 250 260 270 280 290 pF1KB5 AEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPV 280 290 300 310 320 330 300 310 320 330 340 350 pF1KB5 TLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLRWKPASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQ 340 350 360 370 380 390 pF1KB5 GSESHSL ::::::: XP_016 GSESHSL >>NP_002107 (OMIM: 142800,608579) HLA class I histocompa (365 aa) initn: 1944 init1: 1922 opt: 1925 Z-score: 2199.9 bits: 415.6 E(85289): 8.5e-116 Smith-Waterman score: 1925; 78.8% identity (91.8% similar) in 354 aa overlap (1-354:4-357) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRF :. ::::::: :::::::::::::..:: ::::::::::::::.:::::::::::: NP_002 MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 DNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQ :.:::: :: :::::.:::: ::::.:::... .: ::.: :::::::::::::::.: NP_002 DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 WMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQ :.::..: ::::::::.: :::::::..::::::::::.: ::::...: . : :::. NP_002 IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 RAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLT ::::. ::::::..:::.::::: . .:::::.::::::::::::::::::::::::::: NP_002 RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 WQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKP ::.::: .:::::::::::::::::::::::::::::::::::::::::::.:.::::. NP_002 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 ASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHS .::::::::::::::::::.:..:::::::.::.::: :::::..: :::::::. NP_002 SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL 310 320 330 340 350 360 pF1KB5 L NP_002 TACKV >>NP_005505 (OMIM: 106300,142830,608579) major histocomp (362 aa) initn: 1909 init1: 1885 opt: 1894 Z-score: 2164.6 bits: 409.1 E(85289): 7.9e-114 Smith-Waterman score: 1894; 77.4% identity (91.5% similar) in 354 aa overlap (1-354:4-357) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRF :. :.::::: :::::.:::::::..::.::::::::::::::::::::::::::: NP_005 MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 DNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQ :.:::::: :::::.:::: :::::.:. . :: : .::.:::::::::::::::: NP_005 DSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 WMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQ :.::..:::::.:::..:.:::::::..::::::::::.::::::...: . : :::.. NP_005 SMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 RAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLT ::::: :::::..:::.::. : . .::::::::::::::::::::::::::::::::: NP_005 RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 WQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKP ::.::: .:::::::::::::: ::::::::::::::::::::::::::::.:.::::.: NP_005 WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 ASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHS .:: :.:::::.:::..:. :: :::::::. :.:::::::::::.: :::::::. NP_005 SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL 310 320 330 340 350 360 pF1KB5 L NP_005 TA >>NP_001229687 (OMIM: 142800,608579) HLA class I histoco (365 aa) initn: 1954 init1: 1882 opt: 1885 Z-score: 2154.3 bits: 407.2 E(85289): 3e-113 Smith-Waterman score: 1885; 77.1% identity (91.0% similar) in 354 aa overlap (1-354:4-357) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRF :. ::::::: :::::::::::::..:: ::::::::::::::.:::::::::::: NP_001 MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 DNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQ :.:::: .: :::::.:::: ::::.:::. . .: :.:: :::::::::: ::::.: NP_001 DSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 WMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQ :.::..::::::::::.: :::::::..::::::::::.: ::::...: . . ::.. NP_001 IMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVHAAEQR 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 RAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLT :.::: ::. :..:::.::::: . .:::::.::::::::::::::::::::::::::: NP_001 RVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 WQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKP ::.::: .:::::::::::::::::::::::::::::::::::::::::::.:.::::. NP_001 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 ASQPTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHS .::::::::::::::::::.:..:::::::.::.::: :::::..: :::::::. NP_001 SSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSL 310 320 330 340 350 360 pF1KB5 L NP_001 TACKV >>XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA clas (362 aa) initn: 1895 init1: 1873 opt: 1876 Z-score: 2144.0 bits: 405.3 E(85289): 1.1e-112 Smith-Waterman score: 1876; 76.6% identity (90.7% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND :. ::.:::: :::::::::::::..:: ::::::::::::::.:::::::::::::.: XP_016 MAPRTLVLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH ::: :: :::::.:::: :::: :::... .: ::.: :::::::::::::::.: :. XP_016 AASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY ::..: : ::::::.:.:::::::..:.::::::::.: ::: ...: . : ::. ::: XP_016 GCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ :: ::::::..:::.::::: . . ::::.::: .::::::::::::.:::::::::::. XP_016 LEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ ::: .::::::::::::::::::::::::::::.::::::::::::::.:.::::.:.:: XP_016 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSSQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL ::::::::::::::.:.:..:::::::.::.::: ::::::.: :::::::. XP_016 PTIPIVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQGSDVSLTAC 310 320 330 340 350 360 XP_016 KV >>XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA clas (391 aa) initn: 1895 init1: 1873 opt: 1876 Z-score: 2143.6 bits: 405.3 E(85289): 1.2e-112 Smith-Waterman score: 1876; 76.6% identity (90.7% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND :. ::.:::: :::::::::::::..:: ::::::::::::::.:::::::::::::.: XP_005 MAPRTLVLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH ::: :: :::::.:::: :::: :::... .: ::.: :::::::::::::::.: :. XP_005 AASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY ::..: : ::::::.:.:::::::..:.::::::::.: ::: ...: . : ::. ::: XP_005 GCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ :: ::::::..:::.::::: . . ::::.::: .::::::::::::.:::::::::::. XP_005 LEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ ::: .::::::::::::::::::::::::::::.::::::::::::::.:.::::.:.:: XP_005 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSSQ 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL ::::::::::::::.:.:..:::::::.::.::: ::::::.: :::::::. XP_005 PTIPIVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQGSDVSLTAC 310 320 330 340 350 360 XP_005 KGESLEGLMCVGCWAEQWTQLCYGVSFHWMY 370 380 390 >>NP_001229971 (OMIM: 142840,177900,609423) HLA class I (366 aa) initn: 1862 init1: 1733 opt: 1844 Z-score: 2107.5 bits: 398.5 E(85289): 1.2e-110 Smith-Waterman score: 1844; 76.3% identity (90.1% similar) in 355 aa overlap (1-354:4-358) 10 20 30 40 50 pF1KB5 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRF :. .:::::: .::::.::: :::..:: :.::::::::::::::::::::::::: NP_001 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 DNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQ :.:::::: :::::.:::: :::::::.. . :: ::.::.::::::::: :::::: NP_001 DSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 WMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQ :.::.::::::.::::.: :::::::..::::::::::.::::::...: . : ::. NP_001 RMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 RAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLT ::::: ::::::..:::.::::: . :::::::::::.:::::::::::::::::::::: NP_001 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 WQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKP ::.::: .::::::::::::::::::::::::::::.:::::::.::::: ::.:: :.: NP_001 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 ASQPTIPIVGIIAGL-VLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESH .:::::::.::.::: ::. .: ::::.:.. :.::::::::: :.: :.:::::. NP_001 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES 310 320 330 340 350 360 pF1KB5 SL NP_001 LITCKA 358 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 22:39:57 2016 done: Thu Nov 3 22:39:59 2016 Total Scan time: 8.330 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]