FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5572, 381 aa 1>>>pF1KB5572 381 - 381 aa - 381 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1722+/-0.000454; mu= 8.1923+/- 0.028 mean_var=165.0528+/-32.321, 0's: 0 Z-trim(116.2): 81 B-trim: 0 in 0/52 Lambda= 0.099830 statistics sampled from 27078 (27163) to 27078 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.318), width: 16 Scan time: 8.460 The best scores are: opt bits E(85289) NP_001545 (OMIM: 602369) protein CYR61 precursor [ ( 381) 2749 408.2 1.6e-113 NP_001892 (OMIM: 121009) connective tissue growth ( 349) 662 107.6 4.5e-23 NP_003872 (OMIM: 603399) WNT1-inducible-signaling ( 250) 581 95.8 1.2e-19 NP_001310299 (OMIM: 603399) WNT1-inducible-signali ( 250) 581 95.8 1.2e-19 NP_002505 (OMIM: 164958) protein NOV homolog precu ( 357) 576 95.2 2.5e-19 NP_543028 (OMIM: 603398) WNT1-inducible-signaling ( 280) 512 85.9 1.2e-16 NP_003873 (OMIM: 603398) WNT1-inducible-signaling ( 367) 512 86.0 1.5e-16 XP_011534525 (OMIM: 208230,603400) PREDICTED: WNT1 ( 160) 474 80.2 3.7e-15 XP_011534522 (OMIM: 208230,603400) PREDICTED: WNT1 ( 354) 416 72.2 2.1e-12 NP_003871 (OMIM: 208230,603400) WNT1-inducible-sig ( 354) 416 72.2 2.1e-12 NP_937882 (OMIM: 208230,603400) WNT1-inducible-sig ( 372) 416 72.2 2.2e-12 NP_001191799 (OMIM: 603398) WNT1-inducible-signali ( 122) 311 56.6 3.5e-08 XP_011534524 (OMIM: 208230,603400) PREDICTED: WNT1 ( 158) 293 54.2 2.6e-07 NP_001310298 (OMIM: 603399) WNT1-inducible-signali ( 218) 280 52.4 1.2e-06 XP_016883606 (OMIM: 603399) PREDICTED: WNT1-induci ( 162) 276 51.7 1.4e-06 NP_001191798 (OMIM: 603398) WNT1-inducible-signali ( 155) 254 48.5 1.2e-05 NP_001284488 (OMIM: 608785) serine protease HTRA3 ( 357) 199 40.9 0.0055 XP_011511898 (OMIM: 608785) PREDICTED: serine prot ( 373) 199 41.0 0.0056 NP_444272 (OMIM: 608785) serine protease HTRA3 iso ( 453) 199 41.0 0.0065 >>NP_001545 (OMIM: 602369) protein CYR61 precursor [Homo (381 aa) initn: 2749 init1: 2749 opt: 2749 Z-score: 2159.1 bits: 408.2 E(85289): 1.6e-113 Smith-Waterman score: 2749; 100.0% identity (100.0% similar) in 381 aa overlap (1-381:1-381) 10 20 30 40 50 60 pF1KB5 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP 310 320 330 340 350 360 370 380 pF1KB5 HANEAAFPFYRLFNDIHKFRD ::::::::::::::::::::: NP_001 HANEAAFPFYRLFNDIHKFRD 370 380 >>NP_001892 (OMIM: 121009) connective tissue growth fact (349 aa) initn: 1198 init1: 611 opt: 662 Z-score: 535.1 bits: 107.6 E(85289): 4.5e-23 Smith-Waterman score: 1258; 47.6% identity (69.9% similar) in 372 aa overlap (9-376:11-348) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHLTRLALS-TCPAACHCPLE-APKCAPGVGLVRDGCGCCKVC .:.:: : .: :.. .: . :.:: : ::.: ::.:: ::::::.:: NP_001 MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRVC 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 AKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPN ::::.: :.. .::: ::: :.::. .. :.: :. .: :: ... .:..::::: . NP_001 AKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAK-DGAPCIFGGTVYRSGESFQSS 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 CKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQD ::.::::.::::::.::: ... ::. :: :: ::. :.::::::::: : .:: NP_001 CKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDE-----P-KDQT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 GLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSW ..: :. : ..: : :: .: .. .:.:::: : NP_001 -VVGPALA--AYRLEDT-------------------FGPDPTMIR-----ANCLVQTTEW 180 190 200 240 250 260 270 280 290 pF1KB5 SQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPV : :::::: :::::::::: ::: :..:.: :::: . ..:::::: .: : .:. NP_001 SACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPI 210 220 230 240 250 260 300 310 320 330 340 350 pF1KB5 RFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCN .: .:: :.: :: :.:: :.:::::::. : :. ..:.: :::...::.:.:..: :. NP_001 KFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACH 270 280 290 300 310 320 360 370 380 pF1KB5 YNCPHANEAAFPFY--RLFNDIHKFRD :::: :. .: ....:. NP_001 YNCPGDNDIFESLYYRKMYGDMA 330 340 >>NP_003872 (OMIM: 603399) WNT1-inducible-signaling path (250 aa) initn: 783 init1: 573 opt: 581 Z-score: 474.0 bits: 95.8 E(85289): 1.2e-19 Smith-Waterman score: 696; 38.8% identity (60.1% similar) in 263 aa overlap (11-272:10-237) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHL-TRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQ :. .:: : ... . ::. : :: :.: :: :: ::::::.:::.. NP_003 MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARR 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKH :.: :.. . :: ..:: :. ::. . ..: . :: :.:.:..::.:::.:. NP_003 LGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 QCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLL .: : ::. :.::: ... ::. ::.:: :.: :.:: :::: : : : NP_003 RCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVC----------GQGGGL 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 GKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQC : . : : .: ... : : .. : : : .:.:. : NP_003 GTQ--------------PLPA--QGPQFSGL-VSSLPP--------GVPCPEWSTAWGPC 170 180 190 200 240 250 260 270 280 290 pF1KB5 SKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFT : ::: :..:::.:.: ::: . :.: ::: NP_003 STTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF 210 220 230 240 250 300 310 320 330 340 350 pF1KB5 YAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNC >>NP_001310299 (OMIM: 603399) WNT1-inducible-signaling p (250 aa) initn: 783 init1: 573 opt: 581 Z-score: 474.0 bits: 95.8 E(85289): 1.2e-19 Smith-Waterman score: 696; 38.8% identity (60.1% similar) in 263 aa overlap (11-272:10-237) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHL-TRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQ :. .:: : ... . ::. : :: :.: :: :: ::::::.:::.. NP_001 MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARR 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 LNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKH :.: :.. . :: ..:: :. ::. . ..: . :: :.:.:..::.:::.:. NP_001 LGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 QCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLL .: : ::. :.::: ... ::. ::.:: :.: :.:: :::: : : : NP_001 RCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVC----------GQGGGL 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 GKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQC : . : : .: ... : : .. : : : .:.:. : NP_001 GTQ--------------PLPA--QGPQFSGL-VSSLPP--------GVPCPEWSTAWGPC 170 180 190 200 240 250 260 270 280 290 pF1KB5 SKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFT : ::: :..:::.:.: ::: . :.: ::: NP_001 STTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF 210 220 230 240 250 300 310 320 330 340 350 pF1KB5 YAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNC >>NP_002505 (OMIM: 164958) protein NOV homolog precursor (357 aa) initn: 1148 init1: 345 opt: 576 Z-score: 468.1 bits: 95.2 E(85289): 2.5e-19 Smith-Waterman score: 1112; 44.2% identity (65.5% similar) in 362 aa overlap (9-365:16-343) 10 20 30 40 pF1KB5 MSSRIARALALVVTLLHLTRLALST--CPAAC--HCPLEAPKCAPGVGLVRDG : :. :::: . .: :: : .:: : ::::: : :: NP_002 MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDG 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 CGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQN :.:: :::.: .:.:: .:::...:: :. .:. . ::: : :: : ... ::.. NP_002 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTA-VEGDNCVFDGVIYRS 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 GESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIK ::.:::.:: :::: :: .::.: : .. ::. .:: :: :.: :.:::.:.: : NP_002 GEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPD--- 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 DPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKC ..:.: : : . : . : : . :. . ::.. : NP_002 ----EEDSLGG--LTLAAYRPEATLGVEV----SDSSVN--------------------C 180 190 200 230 240 250 260 270 280 pF1KB5 IVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQ-PVYSSLKKGKKCSK : ::: :. :::.:: :.:::::: : .:...:.::.: :::: : : . :::::: . NP_002 IEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLR 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB5 TKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVM :::: . ... . .: :.. :.:..:: : :::::::. :.:.. .:.: :. .: :: NP_002 TKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVM 270 280 290 300 310 320 350 360 370 380 pF1KB5 MIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD .: .: :. :::. ::: NP_002 VIGTCTCHTNCPKNNEAFLQELELKTTRGKM 330 340 350 >>NP_543028 (OMIM: 603398) WNT1-inducible-signaling path (280 aa) initn: 734 init1: 507 opt: 512 Z-score: 419.6 bits: 85.9 E(85289): 1.2e-16 Smith-Waterman score: 529; 28.7% identity (45.5% similar) in 356 aa overlap (26-381:49-274) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKV : :.:: :.: ::.:. ::: :::. NP_543 TVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKM 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB5 CAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQP ::.::...:... :: .:: :.. : :: : : : NP_543 CAQQLGDNCTEAAICDPHRGLYCDY--------------SGDRP-----R-YAIGV---- 80 90 100 110 120 130 140 150 160 170 pF1KB5 NCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQ : : ::: . : : NP_543 -CAH-------AVGEV---------------------------EAW-------------- 120 180 190 200 210 220 230 pF1KB5 DGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTS :: ::. :. NP_543 -----------------HRN---------------------------------CIAYTSP 130 240 250 260 270 280 290 pF1KB5 WSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEP :: :: .:: :.:::..: : .: .:.:.:..::: ... .: :::: . . NP_543 WSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEAS 140 150 160 170 180 190 300 310 320 330 340 350 pF1KB5 VRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKC . :: :::.:...:.::::: :.:.::: : ..:. . :.: :: ::..:. :..: : NP_543 MNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFC 200 210 220 230 240 250 360 370 380 pF1KB5 NYNCPHANEAAFPFYRLFNDIHKFRD : .: . :. .: :.... : NP_543 NLSCRNPND-------IFADLESYPDFSEIAN 260 270 280 >>NP_003873 (OMIM: 603398) WNT1-inducible-signaling path (367 aa) initn: 1031 init1: 507 opt: 512 Z-score: 418.1 bits: 86.0 E(85289): 1.5e-16 Smith-Waterman score: 1016; 39.8% identity (62.2% similar) in 357 aa overlap (26-381:49-361) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKV : :.:: :.: ::.:. ::: :::. NP_003 TVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKM 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB5 CAKQLNEDCSKTQPCDHTKGLECNF-GASSTALKGICRAQSEGRPCEYNSRIYQNGESFQ ::.::...:... :: .:: :.. : :.: :: : : .. :.::.::: NP_003 CAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVC-AQVVGVGCVLDGVRYNNGQSFQ 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB5 PNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMED ::::..:::::::::: ::: .. : : ::.:: :.. :.:::.::: ::. : : . NP_003 PNCKYNCTCIDGAVGCTPLC-LRVRPPRLWCPHPRRVSIPGHCCEQWVC-EDDAKRPRKT 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB5 QDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTT : .::: ::. . .: .::. :. NP_003 APRDTG---AFDA-------------VGEVEAWHR------------------NCIAYTS 200 210 220 240 250 260 270 280 290 pF1KB5 SWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPE :: :: .:: :.:::..: : .: .:.:.:..::: ... .: :::: . . NP_003 PWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 PVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCK . :: :::.:...:.::::: :.:.::: : ..:. . :.: :: ::..:. :..: NP_003 SMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACF 290 300 310 320 330 340 360 370 380 pF1KB5 CNYNCPHANEAAFPFYRLFNDIHKFRD :: .: . :. .: :.... : NP_003 CNLSCRNPND-------IFADLESYPDFSEIAN 350 360 >>XP_011534525 (OMIM: 208230,603400) PREDICTED: WNT1-ind (160 aa) initn: 497 init1: 255 opt: 474 Z-score: 393.2 bits: 80.2 E(85289): 3.7e-15 Smith-Waterman score: 474; 40.7% identity (74.1% similar) in 135 aa overlap (227-359:13-147) 200 210 220 230 240 250 pF1KB5 ELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNP .::.::.:.:. ::.::: :::.::::.: XP_011 MPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENS 10 20 30 40 260 270 280 290 300 310 pF1KB5 ECRLVKETRICEVRPCGQPVYSSLK--KGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYC .:.. :: :.: ..:: . . ...: ::: :. : . . .:...:: :...:.: .: XP_011 NCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFC 50 60 70 80 90 100 320 330 340 350 360 370 pF1KB5 GSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFN : :.: ::: :. .. . ..: : . .:. ... : :: :. :: XP_011 GICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL 110 120 130 140 150 160 380 pF1KB5 DIHKFRD >>XP_011534522 (OMIM: 208230,603400) PREDICTED: WNT1-ind (354 aa) initn: 855 init1: 396 opt: 416 Z-score: 343.6 bits: 72.2 E(85289): 2.1e-12 Smith-Waterman score: 825; 36.2% identity (61.4% similar) in 337 aa overlap (26-359:48-341) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKV : :.:: . :.: :::.::::::::::. XP_011 CCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKI 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB5 CAKQLNEDCSKTQPCDHTKGLECNFGASSTALK-GICRAQSEGRPCEYNSRIYQNGESFQ :::: .: :.... :: ::: :..... . :.: : . ::.:. :.::. :: XP_011 CAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVC-AYLVAVGCEFNQVHYHNGQVFQ 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB5 PNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMED :: .: :..::.:: :: .: :..:. : XP_011 PNPLFSCLCVSGAIGCTPLF-----IP----------KLAGSHC---------------- 140 150 160 180 190 200 210 220 230 pF1KB5 QDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTT .: : . . : :. : : . ..: : .:.. : : .::.::.: XP_011 -SGAKGGKKS-DQSNCSL----EPLLQQLSTSYKTMPAYRNLPLI-----WKKKCLVQAT 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLK--KGKKCSKTKKS .:. ::.::: :::.::::.: .:.. :: :.: ..:: . . ...: ::: :. : . XP_011 KWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQL 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 PEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQS . .:...:: :...:.: .:: :.: ::: :. .. . ..: : . .:. ... : : XP_011 SKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITS 280 290 300 310 320 330 360 370 380 pF1KB5 CKCNYNCPHANEAAFPFYRLFNDIHKFRD : :. :: XP_011 CVCQRNCREPGDIFSELKIL 340 350 >>NP_003871 (OMIM: 208230,603400) WNT1-inducible-signali (354 aa) initn: 855 init1: 396 opt: 416 Z-score: 343.6 bits: 72.2 E(85289): 2.1e-12 Smith-Waterman score: 825; 36.2% identity (61.4% similar) in 337 aa overlap (26-359:48-341) 10 20 30 40 50 pF1KB5 MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKV : :.:: . :.: :::.::::::::::. NP_003 CCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKI 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB5 CAKQLNEDCSKTQPCDHTKGLECNFGASSTALK-GICRAQSEGRPCEYNSRIYQNGESFQ :::: .: :.... :: ::: :..... . :.: : . ::.:. :.::. :: NP_003 CAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVC-AYLVAVGCEFNQVHYHNGQVFQ 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB5 PNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMED :: .: :..::.:: :: .: :..:. : NP_003 PNPLFSCLCVSGAIGCTPLF-----IP----------KLAGSHC---------------- 140 150 160 180 190 200 210 220 230 pF1KB5 QDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTT .: : . . : :. : : . ..: : .:.. : : .::.::.: NP_003 -SGAKGGKKS-DQSNCSL----EPLLQQLSTSYKTMPAYRNLPLI-----WKKKCLVQAT 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLK--KGKKCSKTKKS .:. ::.::: :::.::::.: .:.. :: :.: ..:: . . ...: ::: :. : . NP_003 KWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQL 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 PEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQS . .:...:: :...:.: .:: :.: ::: :. .. . ..: : . .:. ... : : NP_003 SKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITS 280 290 300 310 320 330 360 370 380 pF1KB5 CKCNYNCPHANEAAFPFYRLFNDIHKFRD : :. :: NP_003 CVCQRNCREPGDIFSELKIL 340 350 381 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:12:18 2016 done: Sat Nov 5 21:12:19 2016 Total Scan time: 8.460 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]