FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5576, 164 aa 1>>>pF1KB5576 164 - 164 aa - 164 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6677+/-0.000252; mu= 12.0570+/- 0.016 mean_var=82.9474+/-16.406, 0's: 0 Z-trim(122.7): 11 B-trim: 373 in 1/57 Lambda= 0.140823 statistics sampled from 41138 (41149) to 41138 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.822), E-opt: 0.2 (0.482), width: 16 Scan time: 5.460 The best scores are: opt bits E(85289) NP_000380 (OMIM: 116899) cyclin-dependent kinase i ( 164) 1144 240.7 8e-64 NP_510867 (OMIM: 116899) cyclin-dependent kinase i ( 164) 1144 240.7 8e-64 NP_001207707 (OMIM: 116899) cyclin-dependent kinas ( 164) 1144 240.7 8e-64 NP_001207706 (OMIM: 116899) cyclin-dependent kinas ( 164) 1144 240.7 8e-64 NP_001278478 (OMIM: 116899) cyclin-dependent kinas ( 198) 1144 240.8 9.3e-64 NP_004055 (OMIM: 600778,610755) cyclin-dependent k ( 198) 220 53.0 3e-07 XP_005252789 (OMIM: 130650,600856,614732) PREDICTE ( 175) 175 43.9 0.00015 NP_001116103 (OMIM: 130650,600856,614732) cyclin-d ( 305) 177 44.4 0.00018 NP_001116102 (OMIM: 130650,600856,614732) cyclin-d ( 305) 177 44.4 0.00018 NP_000067 (OMIM: 130650,600856,614732) cyclin-depe ( 316) 177 44.4 0.00019 XP_016872577 (OMIM: 130650,600856,614732) PREDICTE ( 316) 177 44.4 0.00019 >>NP_000380 (OMIM: 116899) cyclin-dependent kinase inhib (164 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 1266.8 bits: 240.7 E(85289): 8e-64 Smith-Waterman score: 1144; 98.8% identity (99.4% similar) in 164 aa overlap (1-164:1-164) 10 20 30 40 50 60 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPLE :::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::::: NP_000 MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV 70 80 90 100 110 120 130 140 150 160 pF1KB5 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP :::::::::::::::::::::::::::::::::::::::::::: NP_000 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP 130 140 150 160 >>NP_510867 (OMIM: 116899) cyclin-dependent kinase inhib (164 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 1266.8 bits: 240.7 E(85289): 8e-64 Smith-Waterman score: 1144; 98.8% identity (99.4% similar) in 164 aa overlap (1-164:1-164) 10 20 30 40 50 60 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPLE :::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::::: NP_510 MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV 70 80 90 100 110 120 130 140 150 160 pF1KB5 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP :::::::::::::::::::::::::::::::::::::::::::: NP_510 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP 130 140 150 160 >>NP_001207707 (OMIM: 116899) cyclin-dependent kinase in (164 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 1266.8 bits: 240.7 E(85289): 8e-64 Smith-Waterman score: 1144; 98.8% identity (99.4% similar) in 164 aa overlap (1-164:1-164) 10 20 30 40 50 60 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPLE :::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::::: NP_001 MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV 70 80 90 100 110 120 130 140 150 160 pF1KB5 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP :::::::::::::::::::::::::::::::::::::::::::: NP_001 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP 130 140 150 160 >>NP_001207706 (OMIM: 116899) cyclin-dependent kinase in (164 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 1266.8 bits: 240.7 E(85289): 8e-64 Smith-Waterman score: 1144; 98.8% identity (99.4% similar) in 164 aa overlap (1-164:1-164) 10 20 30 40 50 60 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPLE :::::::::::::::::::::::::::.:: ::::::::::::::::::::::::::::: NP_001 MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLV 70 80 90 100 110 120 130 140 150 160 pF1KB5 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP :::::::::::::::::::::::::::::::::::::::::::: NP_001 PRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP 130 140 150 160 >>NP_001278478 (OMIM: 116899) cyclin-dependent kinase in (198 aa) initn: 1144 init1: 1144 opt: 1144 Z-score: 1265.6 bits: 240.8 E(85289): 9.3e-64 Smith-Waterman score: 1144; 98.8% identity (99.4% similar) in 164 aa overlap (1-164:35-198) 10 20 30 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQL :::::::::::::::::::::::::::.:: NP_001 FRRQTTHSSNPPLPGQQSCCNHRDFFCSGAMSEPAGDVRQNPCGSKACRRLFGPVDSEQL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB5 RRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELG ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELG 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB5 GGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDF 130 140 150 160 170 180 160 pF1KB5 YHSKRRLIFSKRKP :::::::::::::: NP_001 YHSKRRLIFSKRKP 190 >>NP_004055 (OMIM: 600778,610755) cyclin-dependent kinas (198 aa) initn: 219 init1: 195 opt: 220 Z-score: 251.1 bits: 53.0 E(85289): 3e-07 Smith-Waterman score: 220; 32.3% identity (57.0% similar) in 158 aa overlap (7-155:17-166) 10 20 30 40 pF1KB5 MSEPAGDVRQ--NPCGSKACRRLFGPVDSDQLRRDCDALMAGC--IQEAR :.:: .: : ::: :::::: ..: :: : : ..:: NP_004 MSNVRVSNGSPSLERMDARQAEHPKPS-ACRNLFGPVDHEELTRD---LEKHCRDMEEAS 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 ER-WNFDFVTETPLEGDFAWERVRGLGLPKLYL-PTGPRRGRDELGGGRRP---GTSPAL .: ::::: .. :::: . :..:. .::..: : : .: .. . . :. :: NP_004 QRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAA 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 LQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSK : . : : . :.. . .... : . : ..: .. . ..:: NP_004 PLIGAPANSEDTHL---VDPKT-DPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEE 120 130 140 150 160 170 pF1KB5 RKP NP_004 NVSDGSPNAGSVEQTPKKPGLRRRQT 180 190 >>XP_005252789 (OMIM: 130650,600856,614732) PREDICTED: c (175 aa) initn: 194 init1: 154 opt: 175 Z-score: 202.5 bits: 43.9 E(85289): 0.00015 Smith-Waterman score: 175; 31.3% identity (56.0% similar) in 134 aa overlap (15-141:16-143) 10 20 30 40 50 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPL ..::: :::::: ..: :. .: .: : ..::..:: . :: XP_005 MERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EGD--FAWERVRGLGLPKLYLPT----GPRRGRDELGGGRRPGTSPALLQGTAEEDHVDL .: . : .: . ..: .: : .: .::. .:: . :: . : : XP_005 RGPGRLQWTEVDSDSVPAFYRETVQISSPS-ARDQRLRSRR-AMSPRRVPLQAPP----L 70 80 90 100 110 120 130 140 150 160 pF1KB5 SLSCTLVPRSGEQAEGSPGGP-GDSQGRKRRQTSMTDFYHSKRRLIFSKRKP . . ::. .: .: : :. :.. XP_005 AWARWSRPRARGCGEPKPKEPRGNLPGQRTLEGRWASAGTVHVAATGGGCRRAAFGFVFK 120 130 140 150 160 170 >>NP_001116103 (OMIM: 130650,600856,614732) cyclin-depen (305 aa) initn: 173 init1: 152 opt: 177 Z-score: 201.2 bits: 44.4 E(85289): 0.00018 Smith-Waterman score: 177; 37.3% identity (63.9% similar) in 83 aa overlap (15-95:16-97) 10 20 30 40 50 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPL ..::: :::::: ..: :. .: .: : ..::..:: . :: NP_001 MERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EGD--FAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSC .: . : .: . ..: .: : . :: .: . :: NP_001 RGPGRLQWTEVDSDSVPAFYRET-VQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLE 70 80 90 100 110 120 130 140 150 160 pF1KB5 TLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP NP_001 EAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAP 120 130 140 150 160 170 >>NP_001116102 (OMIM: 130650,600856,614732) cyclin-depen (305 aa) initn: 173 init1: 152 opt: 177 Z-score: 201.2 bits: 44.4 E(85289): 0.00018 Smith-Waterman score: 177; 37.3% identity (63.9% similar) in 83 aa overlap (15-95:16-97) 10 20 30 40 50 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARERWNFDFVTETPL ..::: :::::: ..: :. .: .: : ..::..:: . :: NP_001 MERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EGD--FAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSC .: . : .: . ..: .: : . :: .: . :: NP_001 RGPGRLQWTEVDSDSVPAFYRET-VQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLE 70 80 90 100 110 120 130 140 150 160 pF1KB5 TLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP NP_001 EAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAP 120 130 140 150 160 170 >>NP_000067 (OMIM: 130650,600856,614732) cyclin-dependen (316 aa) initn: 173 init1: 152 opt: 177 Z-score: 201.0 bits: 44.4 E(85289): 0.00019 Smith-Waterman score: 177; 37.3% identity (63.9% similar) in 83 aa overlap (15-95:27-108) 10 20 30 40 pF1KB5 MSEPAGDVRQNPCGSKACRRLFGPVDSDQLRRDCDALMAGCIQEARER ..::: :::::: ..: :. .: .: : ..: NP_000 MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNR 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 WNFDFVTETPLEGD--FAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTA :..:: . ::.: . : .: . ..: .: : . :: .: . :: NP_000 WDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRET-VQVGRCRLLLAPRPVAVAVAVSPPL 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 EEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP NP_000 EPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLA 120 130 140 150 160 170 164 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:38:49 2016 done: Thu Nov 3 17:38:50 2016 Total Scan time: 5.460 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]