Result of FASTA (omim) for
pF1KB5599
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5599, 932 aa
1>>>pF1KB5599 932 - 932 aa - 932 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4790+/-0.000434; mu= 15.8978+/- 0.027
mean_var=106.8230+/-20.819, 0's: 0 Z-trim(111.8): 75 B-trim: 24 in 1/58
Lambda= 0.124091
statistics sampled from 20493 (20551) to 20493 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.603), E-opt: 0.2 (0.241), width: 16
Scan time: 12.410
The best scores are: opt bits E(85289)
NP_079467 (OMIM: 610214) ER degradation-enhancing ( 932) 6177 1117.7 0
XP_005245556 (OMIM: 610214) PREDICTED: ER degradat ( 933) 6165 1115.5 0
XP_016857886 (OMIM: 610214) PREDICTED: ER degradat ( 855) 5647 1022.8 0
XP_011508314 (OMIM: 610214) PREDICTED: ER degradat ( 856) 5635 1020.6 0
NP_001306889 (OMIM: 610214) ER degradation-enhanci ( 948) 5326 965.3 0
XP_011508316 (OMIM: 610214) PREDICTED: ER degradat ( 854) 5296 959.9 0
XP_011508315 (OMIM: 610214) PREDICTED: ER degradat ( 855) 5284 957.8 0
XP_016857887 (OMIM: 610214) PREDICTED: ER degradat ( 777) 4766 865.0 0
NP_060687 (OMIM: 610302) ER degradation-enhancing ( 578) 992 189.3 4.8e-47
NP_001138497 (OMIM: 610302) ER degradation-enhanci ( 541) 980 187.1 2e-46
NP_055489 (OMIM: 607673) ER degradation-enhancing ( 657) 837 161.6 1.2e-38
XP_011532573 (OMIM: 607673) PREDICTED: ER degradat ( 497) 711 138.9 5.9e-32
XP_011532574 (OMIM: 607673) PREDICTED: ER degradat ( 497) 711 138.9 5.9e-32
NP_005898 (OMIM: 604344) mannosyl-oligosaccharide ( 653) 359 76.0 6.8e-13
XP_005267043 (OMIM: 604344) PREDICTED: mannosyl-ol ( 736) 359 76.0 7.5e-13
NP_065112 (OMIM: 616772) mannosyl-oligosaccharide ( 630) 350 74.4 2e-12
XP_011534135 (OMIM: 604344) PREDICTED: mannosyl-ol ( 464) 348 73.9 2e-12
XP_006710365 (OMIM: 604345) PREDICTED: mannosyl-ol ( 637) 346 73.7 3.4e-12
NP_006690 (OMIM: 604345) mannosyl-oligosaccharide ( 641) 345 73.5 3.8e-12
XP_016857349 (OMIM: 616772) PREDICTED: mannosyl-ol ( 387) 289 63.3 2.7e-09
XP_011538838 (OMIM: 604345) PREDICTED: mannosyl-ol ( 598) 247 55.9 6.9e-07
NP_001275939 (OMIM: 616772) mannosyl-oligosacchari ( 590) 243 55.2 1.1e-06
XP_016855604 (OMIM: 604345) PREDICTED: mannosyl-ol ( 329) 184 44.5 0.0011
XP_016869728 (OMIM: 604346,614202) PREDICTED: endo ( 632) 178 43.6 0.0038
NP_057303 (OMIM: 604346,614202) endoplasmic reticu ( 699) 178 43.6 0.0041
XP_006717008 (OMIM: 604346,614202) PREDICTED: endo ( 731) 178 43.6 0.0043
>>NP_079467 (OMIM: 610214) ER degradation-enhancing alph (932 aa)
initn: 6177 init1: 6177 opt: 6177 Z-score: 5979.3 bits: 1117.7 E(85289): 0
Smith-Waterman score: 6177; 100.0% identity (100.0% similar) in 932 aa overlap (1-932:1-932)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB5 NSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNPN
850 860 870 880 890 900
910 920 930
pF1KB5 VSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
::::::::::::::::::::::::::::::::
NP_079 VSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
910 920 930
>>XP_005245556 (OMIM: 610214) PREDICTED: ER degradation- (933 aa)
initn: 3788 init1: 3788 opt: 6165 Z-score: 5967.7 bits: 1115.5 E(85289): 0
Smith-Waterman score: 6165; 99.9% identity (99.9% similar) in 933 aa overlap (1-932:1-933)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
490 500 510 520 530 540
550 560 570 580 590
pF1KB5 YAQSIREPLKNVVDKSCPRGIIRV-EESFRSGAKPPLRARDFMATNPEHLEILKKMGVSL
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_005 YAQSIREPLKNVVDKSCPRGIIRVREESFRSGAKPPLRARDFMATNPEHLEILKKMGVSL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB5 IHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFG
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB5 RVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB5 ARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAI
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB5 REYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 REYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENS
790 800 810 820 830 840
840 850 860 870 880 890
pF1KB5 LNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQLQEQSETEEDSNP
850 860 870 880 890 900
900 910 920 930
pF1KB5 NVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
:::::::::::::::::::::::::::::::::
XP_005 NVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
910 920 930
>>XP_016857886 (OMIM: 610214) PREDICTED: ER degradation- (855 aa)
initn: 5647 init1: 5647 opt: 5647 Z-score: 5467.1 bits: 1022.8 E(85289): 0
Smith-Waterman score: 5647; 100.0% identity (100.0% similar) in 855 aa overlap (78-932:1-855)
50 60 70 80 90 100
pF1KB5 EKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTL
::::::::::::::::::::::::::::::
XP_016 MPLTCRGRVRGQEPSRGDVDDALGKFSLTL
10 20 30
110 120 130 140 150 160
pF1KB5 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPE
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 HLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPP
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 RAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIA
580 590 600 610 620 630
710 720 730 740 750 760
pF1KB5 LIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFL
640 650 660 670 680 690
770 780 790 800 810 820
pF1KB5 FSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEV
700 710 720 730 740 750
830 840 850 860 870 880
pF1KB5 DLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQL
760 770 780 790 800 810
890 900 910 920 930
pF1KB5 QEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 QEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
820 830 840 850
>>XP_011508314 (OMIM: 610214) PREDICTED: ER degradation- (856 aa)
initn: 3258 init1: 3258 opt: 5635 Z-score: 5455.5 bits: 1020.6 E(85289): 0
Smith-Waterman score: 5635; 99.9% identity (99.9% similar) in 856 aa overlap (78-932:1-856)
50 60 70 80 90 100
pF1KB5 EKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTL
::::::::::::::::::::::::::::::
XP_011 MPLTCRGRVRGQEPSRGDVDDALGKFSLTL
10 20 30
110 120 130 140 150 160
pF1KB5 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRV-EESFRSGAKPPLRARDFMATNP
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::
XP_011 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVREESFRSGAKPPLRARDFMATNP
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 EHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLP
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 PRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKI
580 590 600 610 620 630
710 720 730 740 750 760
pF1KB5 ALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLF
640 650 660 670 680 690
770 780 790 800 810 820
pF1KB5 LFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LFSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQE
700 710 720 730 740 750
830 840 850 860 870 880
pF1KB5 VDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQ
760 770 780 790 800 810
890 900 910 920 930
pF1KB5 LQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
820 830 840 850
>>NP_001306889 (OMIM: 610214) ER degradation-enhancing a (948 aa)
initn: 5296 init1: 5296 opt: 5326 Z-score: 5155.8 bits: 965.3 E(85289): 0
Smith-Waterman score: 6129; 98.2% identity (98.3% similar) in 948 aa overlap (1-932:1-948)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
730 740 750 760 770 780
790 800 810 820
pF1KB5 EYEEVEVLLSDKAKDR----------------DPEMENEEQPSSENDSQNQSGEQISSSS
:::::::::::::::: .:::::::::::::::::::::::::::
NP_001 EYEEVEVLLSDKAKDRAAILKGKMIPSYIINSNPEMENEEQPSSENDSQNQSGEQISSSS
790 800 810 820 830 840
830 840 850 860 870 880
pF1KB5 QEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEVDLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLD
850 860 870 880 890 900
890 900 910 920 930
pF1KB5 NQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQLQEQSETEEDSNPNVSWGKKVQPIDSILADWNEDIEAFEMMEKDEL
910 920 930 940
>>XP_011508316 (OMIM: 610214) PREDICTED: ER degradation- (854 aa)
initn: 5296 init1: 5296 opt: 5296 Z-score: 5127.5 bits: 959.9 E(85289): 0
Smith-Waterman score: 5296; 98.9% identity (99.4% similar) in 807 aa overlap (1-807:1-807)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFGR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEKA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAIR
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB5 EYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENSL
:::::::::::::::: .... ::
XP_011 EYEEVEVLLSDKAKDRAAILKGKMIPSYIINSSKYLALTSLKLYTYICIWVCVHTLKYIY
790 800 810 820 830 840
>>XP_011508315 (OMIM: 610214) PREDICTED: ER degradation- (855 aa)
initn: 3788 init1: 3788 opt: 5284 Z-score: 5115.9 bits: 957.8 E(85289): 0
Smith-Waterman score: 5284; 98.8% identity (99.3% similar) in 808 aa overlap (1-807:1-808)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQWYNDELL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEFAALS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYYEYLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFPGLQV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFAESTYFLYKATGDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLLFADKEDI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWTCPNTQILFPNDPL
490 500 510 520 530 540
550 560 570 580 590
pF1KB5 YAQSIREPLKNVVDKSCPRGIIRV-EESFRSGAKPPLRARDFMATNPEHLEILKKMGVSL
:::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::
XP_011 YAQSIREPLKNVVDKSCPRGIIRVREESFRSGAKPPLRARDFMATNPEHLEILKKMGVSL
550 560 570 580 590 600
600 610 620 630 640 650
pF1KB5 IHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPPRAVQIVSHPFFG
610 620 630 640 650 660
660 670 680 690 700 710
pF1KB5 RVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIALIQRGQCMFAEK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KB5 ARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFLFSKEGSIILDAI
730 740 750 760 770 780
780 790 800 810 820 830
pF1KB5 REYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEVDLVDQESSEENS
::::::::::::::::: .... ::
XP_011 REYEEVEVLLSDKAKDRAAILKGKMIPSYIINSSKYLALTSLKLYTYICIWVCVHTLKYI
790 800 810 820 830 840
>>XP_016857887 (OMIM: 610214) PREDICTED: ER degradation- (777 aa)
initn: 4766 init1: 4766 opt: 4766 Z-score: 4615.3 bits: 865.0 E(85289): 0
Smith-Waterman score: 4766; 98.8% identity (99.3% similar) in 730 aa overlap (78-807:1-730)
50 60 70 80 90 100
pF1KB5 EKQKLGNQVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTL
::::::::::::::::::::::::::::::
XP_016 MPLTCRGRVRGQEPSRGDVDDALGKFSLTL
10 20 30
110 120 130 140 150 160
pF1KB5 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKE
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB5 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTA
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB5 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSG
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB5 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTW
220 230 240 250 260 270
350 360 370 380 390 400
pF1KB5 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTDFRVHWAQHPLRPEFA
280 290 300 310 320 330
410 420 430 440 450 460
pF1KB5 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMF
340 350 360 370 380 390
470 480 490 500 510 520
pF1KB5 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KYLYLLFADKEDIIFDIEDYIFTTEAHLLPLWLSTTNQSISKKNTTSEYTELDDSNFDWT
400 410 420 430 440 450
530 540 550 560 570 580
pF1KB5 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CPNTQILFPNDPLYAQSIREPLKNVVDKSCPRGIIRVEESFRSGAKPPLRARDFMATNPE
460 470 480 490 500 510
590 600 610 620 630 640
pF1KB5 HLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HLEILKKMGVSLIHLKDGRVQLVQHAIQAASSIDAEDGLRFMQEMIELSSQQQKEQQLPP
520 530 540 550 560 570
650 660 670 680 690 700
pF1KB5 RAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAVQIVSHPFFGRVVLTAGPAQFGLDLSKHKETRGFVASSKPSNGCSELTNPEAVMGKIA
580 590 600 610 620 630
710 720 730 740 750 760
pF1KB5 LIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIQRGQCMFAEKARNIQNAGAIGGIVIDDNEGSSSDTAPLFQMAGDGKDTDDIKIPMLFL
640 650 660 670 680 690
770 780 790 800 810 820
pF1KB5 FSKEGSIILDAIREYEEVEVLLSDKAKDRDPEMENEEQPSSENDSQNQSGEQISSSSQEV
::::::::::::::::::::::::::::: .... ::
XP_016 FSKEGSIILDAIREYEEVEVLLSDKAKDRAAILKGKMIPSYIINSSKYLALTSLKLYTYI
700 710 720 730 740 750
830 840 850 860 870 880
pF1KB5 DLVDQESSEENSLNSHPESLSLADMDNAASISPSEQTSNPTENHETTNLNGECTDLDNQL
XP_016 CIWVCVHTLKYIYNFVSVDTMIISCVT
760 770
>>NP_060687 (OMIM: 610302) ER degradation-enhancing alph (578 aa)
initn: 1128 init1: 315 opt: 992 Z-score: 965.6 bits: 189.3 E(85289): 4.8e-47
Smith-Waterman score: 1083; 39.3% identity (61.7% similar) in 583 aa overlap (19-558:3-559)
10 20 30 40 50 60
pF1KB5 MSEAGGRGCGSPVPQRARWRLVAATAAFCLVSATSVWTAGAEPMSREEKQKLGNQVLEMF
.::. . .: . . : . : . . ..: ::
NP_060 MPFRLLIPLGLLCALLPQHHGAPGPDG-SAPDPAHYRERVKAMF
10 20 30 40
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
::: .:.:.:.: ::: :::: :. :. :.:::::::.::::..:...
NP_060 YHAYDSYLENAFPFDELRPLTCDGH------------DTWGSFSLTLIDALDTLLILGNV
50 60 70 80 90
130 140 150 160 170
pF1KB5 KEFEDAVRKVLRD-VNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQ--WY-N
.::. .: .::.: :..: :: .:::::::::.::::..: :. :. : .. : .
NP_060 SEFQRVV-EVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLS---KKAGVEVEAGWPCS
100 110 120 130 140
180 190 200 210 220 230
pF1KB5 DELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEF
::.::.. . ::::::.: .:.:: .:: :. .: : :::: ::.:.::
NP_060 GPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV-NP----GETPVTCTAGIGTFIVEF
150 160 170 180 190 200
240 250 260 270 280 290
pF1KB5 AALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYY
:.:: .:: .::. :: :: :::.:. . .::: :.. :: :: .:.:.:::.:::.
NP_060 ATLSSLTGDPVFEDVARVALMRLWESRS-DIGLVGNHIDVLTGKWVAQDAGIGAGVDSYF
210 220 230 240 250 260
300 310 320 330 340 350
pF1KB5 EYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFP
:::.:. .:: : ... : . :: : : :...: .. ... .: :..:
NP_060 EYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQ-SLEAYWP
270 280 290 300 310 320
360 370 380 390 400 410
pF1KB5 GLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTD--FRVHWAQ-HPLRPEFAESTYFL
::: : ::: :..: : : :. . ::: .. . :. . .:::::. ::...:
NP_060 GLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYL
330 340 350 360 370 380
420 430 440 450 460 470
pF1KB5 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLL
:.::::: ::.:. .:...: ..: ::::..::.: . ..::.:::::: ::::::
NP_060 YRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLL
390 400 410 420 430 440
480 490 500
pF1KB5 FADKEDII------FDIE------------DYIFTTEAHLL-PLWLSTTN----------
: : ..: :: :::.:::: . : : .
NP_060 F-DPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVE
450 460 470 480 490
510 520 530 540 550
pF1KB5 ----QSISKKNTTSEYTELDDSNFDWTCPNTQ-ILF-PNDPLYAQSIREPLKNVVDK-SC
. : : . :.. . :. : : :: :.. :. :.: :. : ::
NP_060 DLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARE-RKPAKQKVPLLSC
500 510 520 530 540 550
560 570 580 590 600 610
pF1KB5 PRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAA
:
NP_060 PSQPFTSKLALLGQVFLDSS
560 570
>>NP_001138497 (OMIM: 610302) ER degradation-enhancing a (541 aa)
initn: 1003 init1: 302 opt: 980 Z-score: 954.4 bits: 187.1 E(85289): 2e-46
Smith-Waterman score: 983; 40.5% identity (63.2% similar) in 511 aa overlap (91-558:25-522)
70 80 90 100 110 120
pF1KB5 DHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTLVVLNKT
:. . : : .:::::::.::::..:...
NP_001 MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYSFSLTLIDALDTLLILGNV
10 20 30 40 50
130 140 150 160 170
pF1KB5 KEFEDAVRKVLRD-VNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQ--WY-N
.::. .: .::.: :..: :: .:::::::::.::::..: :. :. : .. : .
NP_001 SEFQRVV-EVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLS---KKAGVEVEAGWPCS
60 70 80 90 100 110
180 190 200 210 220 230
pF1KB5 DELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLILEF
::.::.. . ::::::.: .:.:: .:: :. .: : :::: ::.:.::
NP_001 GPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV-NP----GETPVTCTAGIGTFIVEF
120 130 140 150 160
240 250 260 270 280 290
pF1KB5 AALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDSYY
:.:: .:: .::. :: :: :::.:. . .::: :.. :: :: .:.:.:::.:::.
NP_001 ATLSSLTGDPVFEDVARVALMRLWESRS-DIGLVGNHIDVLTGKWVAQDAGIGAGVDSYF
170 180 190 200 210 220
300 310 320 330 340 350
pF1KB5 EYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAFFP
:::.:. .:: : ... : . :: : : :...: .. ... .: :..:
NP_001 EYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQ-SLEAYWP
230 240 250 260 270 280
360 370 380 390 400 410
pF1KB5 GLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTD--FRVHWAQ-HPLRPEFAESTYFL
::: : ::: :..: : : :. . ::: .. . :. . .:::::. ::...:
NP_001 GLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYL
290 300 310 320 330 340
420 430 440 450 460 470
pF1KB5 YKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLYLL
:.::::: ::.:. .:...: ..: ::::..::.: . ..::.:::::: ::::::
NP_001 YRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLL
350 360 370 380 390 400
480 490 500
pF1KB5 FADKEDII------FDIE------------DYIFTTEAHLL-PLWLSTTN----------
: : ..: :: :::.:::: . : : .
NP_001 F-DPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVE
410 420 430 440 450 460
510 520 530 540 550
pF1KB5 ----QSISKKNTTSEYTELDDSNFDWTCPNTQ-ILF-PNDPLYAQSIREPLKNVVDK-SC
. : : . :.. . :. : : :: :.. :. :.: :. : ::
NP_001 DLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARE-RKPAKQKVPLLSC
470 480 490 500 510 520
560 570 580 590 600 610
pF1KB5 PRGIIRVEESFRSGAKPPLRARDFMATNPEHLEILKKMGVSLIHLKDGRVQLVQHAIQAA
:
NP_001 PSQPFTSKLALLGQVFLDSS
530 540
932 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:41:58 2016 done: Thu Nov 3 17:42:00 2016
Total Scan time: 12.410 Total Display time: 0.250
Function used was FASTA [36.3.4 Apr, 2011]