FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5605, 575 aa 1>>>pF1KB5605 575 - 575 aa - 575 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4718+/-0.000858; mu= 15.8732+/- 0.052 mean_var=170.6367+/-32.235, 0's: 0 Z-trim(114.5): 152 B-trim: 23 in 1/50 Lambda= 0.098183 statistics sampled from 14871 (15047) to 14871 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.781), E-opt: 0.2 (0.462), width: 16 Scan time: 4.070 The best scores are: opt bits E(32554) CCDS13148.1 THBD gene_id:7056|Hs108|chr20 ( 575) 4208 608.3 8.4e-174 CCDS83309.1 MATN2 gene_id:4147|Hs108|chr8 ( 915) 472 79.3 2.3e-14 CCDS55265.1 MATN2 gene_id:4147|Hs108|chr8 ( 937) 447 75.8 2.7e-13 CCDS55264.1 MATN2 gene_id:4147|Hs108|chr8 ( 956) 447 75.8 2.7e-13 CCDS32232.1 FBN1 gene_id:2200|Hs108|chr15 (2871) 432 74.2 2.4e-12 CCDS8103.1 LTBP3 gene_id:4054|Hs108|chr11 (1256) 418 71.8 5.6e-12 CCDS44647.1 LTBP3 gene_id:4054|Hs108|chr11 (1303) 418 71.8 5.7e-12 CCDS41237.1 MEGF6 gene_id:1953|Hs108|chr1 (1541) 415 71.5 8.6e-12 CCDS34222.1 FBN2 gene_id:2201|Hs108|chr5 (2912) 413 71.6 1.6e-11 CCDS46762.1 FBLN2 gene_id:2199|Hs108|chr3 (1184) 393 68.3 6.3e-11 CCDS46761.1 FBLN2 gene_id:2199|Hs108|chr3 (1231) 393 68.3 6.4e-11 >>CCDS13148.1 THBD gene_id:7056|Hs108|chr20 (575 aa) initn: 4208 init1: 4208 opt: 4208 Z-score: 3233.7 bits: 608.3 E(32554): 8.4e-174 Smith-Waterman score: 4208; 100.0% identity (100.0% similar) in 575 aa overlap (1-575:1-575) 10 20 30 40 50 60 pF1KB5 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS13 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR 490 500 510 520 530 540 550 560 570 pF1KB5 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL ::::::::::::::::::::::::::::::::::: CCDS13 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL 550 560 570 >>CCDS83309.1 MATN2 gene_id:4147|Hs108|chr8 (915 aa) initn: 346 init1: 209 opt: 472 Z-score: 371.4 bits: 79.3 E(32554): 2.3e-14 Smith-Waterman score: 530; 34.7% identity (57.7% similar) in 248 aa overlap (245-480:283-523) 220 230 240 250 260 270 pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ :..:. .::. : .::. ::: .: :: CCDS83 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP ::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .. : :. CCDS83 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTRINYCALNK 320 330 340 350 360 340 350 360 370 380 pF1KB5 SPCPQRCVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN--CEYQCQPLN-QTSYLCV : ..::: . .. :.:. .: : .:. :: : . . :: : :: . :..: CCDS83 PGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC--LNTEDSFVCQ 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB5 CAEGFAPIPHEPHRCQM--FC--NQTACPADC-DPNTQASCECPEGYIL-DDGFICTDID :.::: : .. . :. .: .. .: .: . . . .:.::::..: .:: :. .: CCDS83 CSEGFL-INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB5 ECENGGF-CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPG : : : : . .: : : : :. : : CCDS83 SCALGDHGCEHSCVSSEDSFVCQCFEGYIL-REDGKTCRRKDVCQAIDHGCEHICVNSDD 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB5 STLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVV CCDS83 SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC 550 560 570 580 590 600 >>CCDS55265.1 MATN2 gene_id:4147|Hs108|chr8 (937 aa) initn: 261 init1: 209 opt: 447 Z-score: 352.2 bits: 75.8 E(32554): 2.7e-13 Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535) 220 230 240 250 260 270 pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ :..:. .::. : .::. ::: .: :: CCDS55 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP ::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: : CCDS55 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC : ..::::. .. ::: .. : : . . .. : . .::..: ... :: : : CCDS55 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC 370 380 390 400 410 420 400 410 420 430 440 pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID .:.. :. . :. : : .: : ::. : :.: ::..... . :. .: CCDS55 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD 430 440 450 460 470 480 450 460 470 480 490 pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP : ..: : : :. .: : : :.. . : : : .:.:. :: : CCDS55 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP CCDS55 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED 550 560 570 580 590 600 >>CCDS55264.1 MATN2 gene_id:4147|Hs108|chr8 (956 aa) initn: 261 init1: 209 opt: 447 Z-score: 352.1 bits: 75.8 E(32554): 2.7e-13 Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535) 220 230 240 250 260 270 pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ :..:. .::. : .::. ::: .: :: CCDS55 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP ::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: : CCDS55 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN 320 330 340 350 360 340 350 360 370 380 390 pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC : ..::::. .. ::: .. : : . . .. : . .::..: ... :: : : CCDS55 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC 370 380 390 400 410 420 400 410 420 430 440 pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID .:.. :. . :. : : .: : ::. : :.: ::..... . :. .: CCDS55 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD 430 440 450 460 470 480 450 460 470 480 490 pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP : ..: : : :. .: : : :.. . : : : .:.:. :: : CCDS55 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV 490 500 510 520 530 540 500 510 520 530 540 550 pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP CCDS55 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED 550 560 570 580 590 600 >>CCDS32232.1 FBN1 gene_id:2200|Hs108|chr15 (2871 aa) initn: 784 init1: 198 opt: 432 Z-score: 335.1 bits: 74.2 E(32554): 2.4e-12 Smith-Waterman score: 438; 28.9% identity (53.3% similar) in 304 aa overlap (244-520:2405-2693) 220 230 240 250 260 270 pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHA-CNAIPGAPRCQCPAGAA .:.: . :... : :. .: : .: . CCDS32 CEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYT 2380 2390 2400 2410 2420 2430 280 290 300 310 320 pF1KB5 LQADGRSCTASATQSCNDL---CEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDC . : ::. . ::. :. .: . :::.: : :: : : . :.:.:.: CCDS32 PDITGTSCV--DLNECNQAPKPCNFIC---KNTEGSYQCSCPKGYILQEDGRSCKDLDEC 2440 2450 2460 2470 2480 330 340 350 360 370 380 pF1KB5 ILEPSPCPQRCVNTQGGFECHCYPNY-----DLVDG-ECVEPVDPCFRANCEYQCQPLNQ . : :::: ::: :.: :.. . .:. ::. .. : . . :: . CCDS32 ATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLC---GSKGICQN-TP 2490 2500 2510 2520 2530 2540 390 400 410 420 430 pF1KB5 TSYLCVCAEGFAPIPHEPHRCQMF--CNQTA-CPADCDPNTQA-SCECPEGYILDDGFI- :. : : .::. . . :. :. . : :. . : ::.::. . CCDS32 GSFTCECQRGFS-LDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQ 2550 2560 2570 2580 2590 2600 440 450 460 470 480 490 pF1KB5 CTDIDECENGGFCSGV-CHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPP :.: .:: .. .:.:. ::: :...:.: : . .... :. : .. ::.. : CCDS32 CVDENECLSAHICGGASCHNTLGSYKCMC-PAGFQYEQFSGGCQ----DINECGSAQAPC 2610 2620 2630 2640 2650 500 510 520 530 540 pF1KB5 S----PTPGSTLT--PPA---VGLVH--SGLLIGISIASLCLVVALLALLCHLRKKQGAA : : :. : ::. .: : ::. .: CCDS32 SYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECK 2660 2670 2680 2690 2700 2710 550 560 570 pF1KB5 RAKMEYKCAAPSKEVVLQHVRTERTPQRL CCDS32 INGYPKRGRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILE 2720 2730 2740 2750 2760 2770 >>CCDS8103.1 LTBP3 gene_id:4054|Hs108|chr11 (1256 aa) initn: 375 init1: 216 opt: 418 Z-score: 328.5 bits: 71.8 E(32554): 5.6e-12 Smith-Waterman score: 463; 27.9% identity (47.0% similar) in 481 aa overlap (103-507:626-1078) 80 90 100 110 120 130 pF1KB5 LLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDN-NTSYSRWARLDLNGAP :: ::. :: . : .: :: . :: CCDS81 DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV-GAG 600 610 620 630 640 650 140 150 160 170 180 190 pF1KB5 LCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSI : :: .. : . : . : .:: .: ..::. . :: : CCDS81 --GRSCVDLN--ECAKP-------HLC---GDGGFC-INFPGHYK-CNCYPGYRLKASRP 660 670 680 690 200 210 220 230 240 250 pF1KB5 TYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWA-REAPGAWDCSVENG . . : .. : :. : ... . : :: : :.. .:. :.. CCDS81 PVCEDID-ECRDPSSCPDGKCEN-KPGSFKCIACQPGYRSQGGGACRDVN---ECA-EGS 700 710 720 730 740 750 260 270 280 290 300 pF1KB5 GCEHA-CNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSC : . :. .::. :: : : : ::::: .:.:.. .: . :::..: CCDS81 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGIC---SNTPGSFQC 760 770 780 790 800 310 320 330 340 350 360 pF1KB5 MCETGYRLAADQHRCEDVDDCILEPSPC-PQRCVNTQGGFECHCYPNYDLVDGECVEPVD .: .::.:. :. .:::.:.: . :. : :.::.:...: : .. :: :. . .: CCDS81 QCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDID 810 820 830 840 850 860 370 380 390 400 pF1KB5 PCFR--ANC--EYQCQPLNQTSYLCVCAEGFAPI-----------PHEPHRCQM------ : . . : . :. : : ::.::: :::.: ::. ..: . CCDS81 ECSQDPSLCLPHGACKNL-QGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV 870 880 890 900 910 920 410 420 430 pF1KB5 FCN--------QTACPADCDPNTQASCE---------------CPEG--YILDDGFIC-- ::. : : . . :: ::.: : :.... CCDS81 FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG 930 940 950 960 970 980 440 450 460 470 480 pF1KB5 ----TDIDECENGG--FCS-GVCHNLPGTFECICGP----DSALARHIGTD-------CD ::::: : .:. : : : .:: : :. : . . .: : CCDS81 IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR 990 1000 1010 1020 1030 1040 490 500 510 520 530 pF1KB5 SGKVD---GGDSGSGEPPP--SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALL .: . :: . :: ::. . :.: CCDS81 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAG 1050 1060 1070 1080 1090 1100 540 550 560 570 pF1KB5 CHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL CCDS81 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS 1110 1120 1130 1140 1150 1160 >>CCDS44647.1 LTBP3 gene_id:4054|Hs108|chr11 (1303 aa) initn: 375 init1: 216 opt: 418 Z-score: 328.3 bits: 71.8 E(32554): 5.7e-12 Smith-Waterman score: 463; 27.9% identity (47.0% similar) in 481 aa overlap (103-507:626-1078) 80 90 100 110 120 130 pF1KB5 LLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDN-NTSYSRWARLDLNGAP :: ::. :: . : .: :: . :: CCDS44 DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV-GAG 600 610 620 630 640 650 140 150 160 170 180 190 pF1KB5 LCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSI : :: .. : . : . : .:: .: ..::. . :: : CCDS44 --GRSCVDLN--ECAKP-------HLC---GDGGFC-INFPGHYK-CNCYPGYRLKASRP 660 670 680 690 200 210 220 230 240 250 pF1KB5 TYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWA-REAPGAWDCSVENG . . : .. : :. : ... . : :: : :.. .:. :.. CCDS44 PVCEDID-ECRDPSSCPDGKCEN-KPGSFKCIACQPGYRSQGGGACRDVN---ECA-EGS 700 710 720 730 740 750 260 270 280 290 300 pF1KB5 GCEHA-CNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSC : . :. .::. :: : : : ::::: .:.:.. .: . :::..: CCDS44 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGIC---SNTPGSFQC 760 770 780 790 800 310 320 330 340 350 360 pF1KB5 MCETGYRLAADQHRCEDVDDCILEPSPC-PQRCVNTQGGFECHCYPNYDLVDGECVEPVD .: .::.:. :. .:::.:.: . :. : :.::.:...: : .. :: :. . .: CCDS44 QCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDID 810 820 830 840 850 860 370 380 390 400 pF1KB5 PCFR--ANC--EYQCQPLNQTSYLCVCAEGFAPI-----------PHEPHRCQM------ : . . : . :. : : ::.::: :::.: ::. ..: . CCDS44 ECSQDPSLCLPHGACKNL-QGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV 870 880 890 900 910 920 410 420 430 pF1KB5 FCN--------QTACPADCDPNTQASCE---------------CPEG--YILDDGFIC-- ::. : : . . :: ::.: : :.... CCDS44 FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG 930 940 950 960 970 980 440 450 460 470 480 pF1KB5 ----TDIDECENGG--FCS-GVCHNLPGTFECICGP----DSALARHIGTD-------CD ::::: : .:. : : : .:: : :. : . . .: : CCDS44 IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR 990 1000 1010 1020 1030 1040 490 500 510 520 530 pF1KB5 SGKVD---GGDSGSGEPPP--SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALL .: . :: . :: ::. . :.: CCDS44 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYRCE 1050 1060 1070 1080 1090 1100 540 550 560 570 pF1KB5 CHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL CCDS44 CRPPWVPGPSGRDCQLPESPAERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQG 1110 1120 1130 1140 1150 1160 >>CCDS41237.1 MEGF6 gene_id:1953|Hs108|chr1 (1541 aa) initn: 288 init1: 179 opt: 415 Z-score: 325.2 bits: 71.5 E(32554): 8.6e-12 Smith-Waterman score: 539; 33.3% identity (53.8% similar) in 288 aa overlap (224-493:147-421) 200 210 220 230 240 250 pF1KB5 GTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCE : ::: :: : . .: ..::::. CCDS41 QPDEEGCLSAECSASLCFHGGRCVPGSAQPCHCPPG-FQG--PRCQYDVDECRTHNGGCQ 120 130 140 150 160 170 260 270 280 290 300 310 pF1KB5 HACNAIPGAPRCQCPAGAALQADGRSCTASATQSC---NDLCEHFCVPNPDQPGSYSCMC : : ::. :.: : :..:.:.: : .:: : :.: :: . :.: CCDS41 HRCVNTPGSYLCECKPGFRLHTDSRTCL--AINSCALGNGGCQHHCVQLTIT--RHRCQC 180 190 200 210 220 320 330 340 350 360 pF1KB5 ETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPC . :..: : ..: . : . . : .:: ..: .:.:. .:.:. ::. : :: : CCDS41 RPGFQLQEDGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDEC 230 240 250 260 270 280 370 380 390 400 410 pF1KB5 FR--ANCEYQCQPLN-QTSYLCVCAEGFAPIPHEPHRCQMF-------C--NQTACPADC :.: . : :: : :. ::: :. . . ..: . : :. .: : CCDS41 AAGLAQCAHGC--LNTQGSFKCVCHAGYE-LGADGRQCYRIEMEIVNSCEANNGGCSHGC 290 300 310 320 330 340 420 430 440 450 460 470 pF1KB5 DPNTQAS-CECPEGYILD-DGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARH . .. . : ::.:: :: : : :.:.: .. :. :: : :: .:: : :. CCDS41 SHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSAD 350 360 370 380 390 400 480 490 500 510 520 530 pF1KB5 IGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLAL : :.. :: :. : CCDS41 -GCGCED--VDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDG 410 420 430 440 450 460 >>CCDS34222.1 FBN2 gene_id:2201|Hs108|chr5 (2912 aa) initn: 405 init1: 196 opt: 413 Z-score: 320.5 bits: 71.6 E(32554): 1.6e-11 Smith-Waterman score: 450; 27.8% identity (50.7% similar) in 367 aa overlap (124-468:2382-2723) 100 110 120 130 140 150 pF1KB5 PGCGDPKRLGPLRGFQWVTGDNNTSYSRWARLDLNGAPLCGPLCVAVSAAEATVPSEPIW : : : . .: .:... : . CCDS34 GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKS--- 2360 2370 2380 2390 2400 160 170 180 190 200 pF1KB5 EEQQCEV-KADGFLCEFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGADF---QALP- : :. .. : ::. : :: ::.: .: ... : :. ...: CCDS34 -ECCCDGGRGWGHQCEL-----C-PL---PGTAQYKKICPHGPGYTTDGRDIDECKVMPN 2410 2420 2430 2440 2450 210 220 230 240 250 260 pF1KB5 -VGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQC .. . .: .. : : . . .:: :.. :. :. .:.: CCDS34 LCTNGQCINTMG-SFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSC 2460 2470 2480 2490 2500 2510 270 280 290 300 310 320 pF1KB5 PAGAALQADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHR--CE : : .:: ::..: . :. . :. .:: . :...: : :. ::. : CCDS34 PRGYVLQEDGKTCKDLDECQTKQHNCQFLCV---NTLGGFTCKCPPGFT----QHHTACI 2520 2530 2540 2550 2560 2570 330 340 350 360 370 380 pF1KB5 DVDDCILEPSPCPQR--CVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN-CEYQCQP : ..: .:: : . : :: :.: :.: ...: . : : :: : . :.. :: CCDS34 DNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQN 2580 2590 2600 2610 2620 2630 390 400 410 420 430 pF1KB5 LNQTSYLCVCAEGFAPIPH-EPHRC--QMFC-NQTAC-PADCDPNTQAS--CECPEGYIL . .: : : .:. : : . ..: . : : .:: :.: :: .: : :: :. . CCDS34 I-LGGYRCGCPQGY--IQHYQWNQCVDENECSNPNACGSASCY-NTLGSYKCACPSGFSF 2640 2650 2660 2670 2680 440 450 460 470 480 490 pF1KB5 DD-GFICTDIDECENG-GFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSG :. . : :..:: .. . :. : : : . : : : CCDS34 DQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLS 2690 2700 2710 2720 2730 2740 500 510 520 530 540 550 pF1KB5 SGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKME CCDS34 LDTEVDEENALSPEACYECKINGYSKKDSRQKRSIHEPDPTAVEQISLESVDMDSPVNMK 2750 2760 2770 2780 2790 2800 >>CCDS46762.1 FBLN2 gene_id:2199|Hs108|chr3 (1184 aa) initn: 198 init1: 131 opt: 393 Z-score: 309.7 bits: 68.3 E(32554): 6.3e-11 Smith-Waterman score: 438; 33.3% identity (48.3% similar) in 288 aa overlap (244-466:607-886) 220 230 240 250 260 270 pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGG-CEHACNAIPGAPRCQCPAGAA .: . : :.: : :. .: : : . CCDS46 VSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGELCQHLCINTVGSYHCACFPGFS 580 590 600 610 620 630 280 290 pF1KB5 LQADGRSC-----------------------TASAT--------QSCNDL--CEHFCVPN :: :::.: .:: : ..:.: :.. : CCDS46 LQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPLPQPNTCKDNGPCKQVC--- 640 650 660 670 680 690 300 310 320 330 340 350 pF1KB5 PDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCP--QRCVNTQGGFECH----CYP :: : : :: . :: :::...:. . : ..:::: :.:.:. : : CCDS46 STVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEP 700 710 720 730 740 750 360 370 380 390 400 pF1KB5 NYDLVDGECVEPVDPCFRANCEYQCQP--LNQT---SYLCV----CAEGFAPIPHEPHRC .: : :::: : :: : : . ::: : :. :. : : .:: :. : CCDS46 GYALKDGEC-EDVDEC--AMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPE--GNC 760 770 780 790 800 410 420 430 440 450 pF1KB5 QMFCNQTACPADCDP-----NTQAS--CE-----CPEGY-ILDDGFICTDIDECENGGFC . . :. : : :: .: :. : .:: ::: :.:..:::.: CCDS46 VDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHR 810 820 830 840 850 860 460 470 480 490 500 pF1KB5 SG---VCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPP : :::::::...: : CCDS46 CGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSC 870 880 890 900 910 920 575 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 21:09:13 2016 done: Sat Nov 5 21:09:14 2016 Total Scan time: 4.070 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]