Result of FASTA (omim) for
pF1KB5605
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5605, 575 aa
1>>>pF1KB5605 575 - 575 aa - 575 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.9428+/-0.000344; mu= 13.0412+/- 0.021
mean_var=181.2238+/-36.131, 0's: 0 Z-trim(121.4): 380 B-trim: 0 in 0/53
Lambda= 0.095272
statistics sampled from 37558 (38034) to 37558 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.446), width: 16
Scan time: 11.680
The best scores are: opt bits E(85289)
NP_000352 (OMIM: 188040,612926,614486) thrombomodu ( 575) 4208 590.9 3.8e-168
XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 ( 896) 472 77.6 2e-13
NP_001304677 (OMIM: 602108) matrilin-2 isoform c p ( 915) 472 77.6 2e-13
XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 ( 799) 447 74.1 2e-12
XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 ( 818) 447 74.1 2e-12
NP_085072 (OMIM: 602108) matrilin-2 isoform b prec ( 937) 447 74.2 2.2e-12
NP_002371 (OMIM: 602108) matrilin-2 isoform a prec ( 956) 447 74.2 2.2e-12
NP_001290065 (OMIM: 614708) signal peptide, CUB an ( 992) 439 73.1 4.9e-12
NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871) 432 72.6 1.9e-11
NP_001157738 (OMIM: 601216,602090,613097) latent-t (1139) 418 70.3 3.9e-11
NP_066548 (OMIM: 601216,602090,613097) latent-tran (1256) 418 70.3 4.2e-11
XP_011543335 (OMIM: 601216,602090,613097) PREDICTE (1265) 418 70.3 4.2e-11
NP_001123616 (OMIM: 601216,602090,613097) latent-t (1303) 418 70.3 4.3e-11
XP_011543334 (OMIM: 601216,602090,613097) PREDICTE (1312) 418 70.3 4.3e-11
XP_011539190 (OMIM: 604266) PREDICTED: multiple ep (1364) 415 69.9 5.9e-11
XP_006710469 (OMIM: 604266) PREDICTED: multiple ep (1436) 415 70.0 6.1e-11
NP_001400 (OMIM: 604266) multiple epidermal growth (1541) 415 70.0 6.4e-11
XP_016856022 (OMIM: 604266) PREDICTED: multiple ep (1559) 415 70.0 6.5e-11
XP_011539188 (OMIM: 604266) PREDICTED: multiple ep (1560) 415 70.0 6.5e-11
XP_011539187 (OMIM: 604266) PREDICTED: multiple ep (1603) 415 70.0 6.6e-11
XP_011539189 (OMIM: 604266) PREDICTED: multiple ep (1395) 409 69.1 1.1e-10
XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 413 70.0 1.2e-10
NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 413 70.0 1.2e-10
NP_001989 (OMIM: 135821) fibulin-2 isoform b precu (1184) 393 66.8 4.4e-10
NP_001158507 (OMIM: 135821) fibulin-2 isoform a pr (1231) 393 66.9 4.5e-10
NP_001004019 (OMIM: 135821) fibulin-2 isoform a pr (1231) 393 66.9 4.5e-10
NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 388 66.2 7.7e-10
NP_000618 (OMIM: 150390) latent-transforming growt (1395) 388 66.2 7.9e-10
NP_001987 (OMIM: 135820,608180) fibulin-1 isoform ( 683) 383 65.2 7.9e-10
NP_001159738 (OMIM: 150390) latent-transforming gr (1300) 387 66.1 8.2e-10
NP_001159736 (OMIM: 150390) latent-transforming gr (1353) 387 66.1 8.5e-10
XP_011531162 (OMIM: 150390) PREDICTED: latent-tran (1666) 388 66.3 8.8e-10
XP_005264374 (OMIM: 150390) PREDICTED: latent-tran (1668) 388 66.3 8.8e-10
XP_011531161 (OMIM: 150390) PREDICTED: latent-tran (1669) 388 66.3 8.8e-10
XP_011531160 (OMIM: 150390) PREDICTED: latent-tran (1680) 388 66.3 8.9e-10
XP_011531157 (OMIM: 150390) PREDICTED: latent-tran (1720) 388 66.3 9e-10
NP_996826 (OMIM: 150390) latent-transforming growt (1721) 388 66.3 9e-10
XP_011531155 (OMIM: 150390) PREDICTED: latent-tran (1722) 388 66.3 9e-10
XP_005264375 (OMIM: 150390) PREDICTED: latent-tran (1626) 387 66.2 9.6e-10
XP_016859598 (OMIM: 150390) PREDICTED: latent-tran (1679) 387 66.2 9.8e-10
XP_011531159 (OMIM: 150390) PREDICTED: latent-tran (1680) 387 66.2 9.8e-10
XP_011512706 (OMIM: 614708) PREDICTED: signal pept (1001) 382 65.3 1.1e-09
XP_011518550 (OMIM: 611747) PREDICTED: signal pept ( 695) 378 64.5 1.3e-09
NP_001164161 (OMIM: 611747) signal peptide, CUB an ( 807) 378 64.6 1.4e-09
XP_016873571 (OMIM: 611747) PREDICTED: signal pept ( 844) 378 64.6 1.5e-09
XP_005253094 (OMIM: 611747) PREDICTED: signal pept ( 873) 378 64.6 1.5e-09
XP_016873570 (OMIM: 611747) PREDICTED: signal pept ( 892) 378 64.6 1.5e-09
XP_005253093 (OMIM: 611747) PREDICTED: signal pept ( 919) 378 64.7 1.5e-09
XP_005253092 (OMIM: 611747) PREDICTED: signal pept ( 953) 378 64.7 1.6e-09
XP_016873569 (OMIM: 611747) PREDICTED: signal pept ( 958) 378 64.7 1.6e-09
>>NP_000352 (OMIM: 188040,612926,614486) thrombomodulin (575 aa)
initn: 4208 init1: 4208 opt: 4208 Z-score: 3139.7 bits: 590.9 E(85289): 3.8e-168
Smith-Waterman score: 4208; 100.0% identity (100.0% similar) in 575 aa overlap (1-575:1-575)
10 20 30 40 50 60
pF1KB5 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLGVLVLGALALAGLGFPAPAEPQPGGSQCVEHDCFALYPGPATFLNASQICDGLRGHLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TVRSSVAADVISLLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDNNTSYS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RWARLDLNGAPLCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EPGAAAAAVSITYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEHFCVPNP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRCVNTQGGFECHCYPNYDLVDG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ECVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIPHEPHRCQMFCNQTACPADCDPN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TQASCECPEGYILDDGFICTDIDECENGGFCSGVCHNLPGTFECICGPDSALARHIGTDC
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DSGKVDGGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLR
490 500 510 520 530 540
550 560 570
pF1KB5 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
:::::::::::::::::::::::::::::::::::
NP_000 KKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
550 560 570
>>XP_016868906 (OMIM: 602108) PREDICTED: matrilin-2 isof (896 aa)
initn: 346 init1: 209 opt: 472 Z-score: 362.2 bits: 77.6 E(85289): 2e-13
Smith-Waterman score: 530; 34.7% identity (57.7% similar) in 248 aa overlap (245-480:283-523)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
XP_016 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .. : :.
XP_016 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTRINYCALNK
320 330 340 350 360
340 350 360 370 380
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN--CEYQCQPLN-QTSYLCV
: ..::: . .. :.:. .: : .:. :: : . . :: : :: . :..:
XP_016 PGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC--LNTEDSFVCQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB5 CAEGFAPIPHEPHRCQM--FC--NQTACPADC-DPNTQASCECPEGYIL-DDGFICTDID
:.::: : .. . :. .: .. .: .: . . . .:.::::..: .:: :. .:
XP_016 CSEGFL-INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB5 ECENGGF-CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPG
: : : : . .: : : : :. : :
XP_016 SCALGDHGCEHSCVSSEDSFVCQCFEGYIL-REDGKTCRRKDVCQAIDHGCEHICVNSDD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB5 STLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVV
XP_016 SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC
550 560 570 580 590 600
>>NP_001304677 (OMIM: 602108) matrilin-2 isoform c precu (915 aa)
initn: 346 init1: 209 opt: 472 Z-score: 362.1 bits: 77.6 E(85289): 2e-13
Smith-Waterman score: 530; 34.7% identity (57.7% similar) in 248 aa overlap (245-480:283-523)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
NP_001 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .. : :.
NP_001 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTRINYCALNK
320 330 340 350 360
340 350 360 370 380
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDL-VDGECVEPVDPCFRAN--CEYQCQPLN-QTSYLCV
: ..::: . .. :.:. .: : .:. :: : . . :: : :: . :..:
NP_001 PGCEHECVNMEESYYCRCHRGYTLDPNGKTCSRVDHCAQQDHGCEQLC--LNTEDSFVCQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB5 CAEGFAPIPHEPHRCQM--FC--NQTACPADC-DPNTQASCECPEGYIL-DDGFICTDID
:.::: : .. . :. .: .. .: .: . . . .:.::::..: .:: :. .:
NP_001 CSEGFL-INEDLKTCSRVDYCLLSDHGCEYSCVNMDRSFACQCPEGHVLRSDGKTCAKLD
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB5 ECENGGF-CSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPG
: : : : . .: : : : :. : :
NP_001 SCALGDHGCEHSCVSSEDSFVCQCFEGYIL-REDGKTCRRKDVCQAIDHGCEHICVNSDD
490 500 510 520 530 540
510 520 530 540 550 560
pF1KB5 STLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVV
NP_001 SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHICVNNGNSYICKCSEGFVLAEDGRRC
550 560 570 580 590 600
>>XP_016868907 (OMIM: 602108) PREDICTED: matrilin-2 isof (799 aa)
initn: 261 init1: 209 opt: 447 Z-score: 344.2 bits: 74.1 E(85289): 2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
XP_016 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: :
XP_016 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
320 330 340 350 360
340 350 360 370 380 390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
: ..::::. .. ::: .. : : . . .. : . .::..: ... :: : :
XP_016 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
370 380 390 400 410 420
400 410 420 430 440
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
.:.. :. . :. : : .: : ::. : :.: ::..... . :. .:
XP_016 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
430 440 450 460 470 480
450 460 470 480 490
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
: ..: : : :. .: : : :.. . : : : .:.:. :: :
XP_016 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
XP_016 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
550 560 570 580 590 600
>--
initn: 243 init1: 151 opt: 281 Z-score: 220.9 bits: 51.3 E(85289): 1.5e-05
Smith-Waterman score: 281; 36.8% identity (59.6% similar) in 114 aa overlap (252-362:536-646)
230 240 250 260 270 280
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
:::.: . . ::: : :. ::..:
XP_016 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
510 520 530 540 550 560
290 300 310 320 330 340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
.. :. . :::.:: . : ::.: : :.::: : .::. : : : . :
XP_016 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
570 580 590 600 610 620
350 360 370 380 390
pF1KB5 VNTQGGFECHCYPNYDLV-DGE-CVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIP
::. ... :.: .. :. ::. :
XP_016 VNNGNSYICKCSEGFVLAEDGRRCKSITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDF
630 640 650 660 670 680
>>XP_005250977 (OMIM: 602108) PREDICTED: matrilin-2 isof (818 aa)
initn: 261 init1: 209 opt: 447 Z-score: 344.1 bits: 74.1 E(85289): 2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
XP_005 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: :
XP_005 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
320 330 340 350 360
340 350 360 370 380 390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
: ..::::. .. ::: .. : : . . .. : . .::..: ... :: : :
XP_005 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
370 380 390 400 410 420
400 410 420 430 440
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
.:.. :. . :. : : .: : ::. : :.: ::..... . :. .:
XP_005 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
430 440 450 460 470 480
450 460 470 480 490
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
: ..: : : :. .: : : :.. . : : : .:.:. :: :
XP_005 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
XP_005 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
550 560 570 580 590 600
>--
initn: 243 init1: 151 opt: 281 Z-score: 220.8 bits: 51.3 E(85289): 1.5e-05
Smith-Waterman score: 281; 36.8% identity (59.6% similar) in 114 aa overlap (252-362:536-646)
230 240 250 260 270 280
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
:::.: . . ::: : :. ::..:
XP_005 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
510 520 530 540 550 560
290 300 310 320 330 340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
.. :. . :::.:: . : ::.: : :.::: : .::. : : : . :
XP_005 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
570 580 590 600 610 620
350 360 370 380 390
pF1KB5 VNTQGGFECHCYPNYDLV-DGE-CVEPVDPCFRANCEYQCQPLNQTSYLCVCAEGFAPIP
::. ... :.: .. :. ::. :
XP_005 VNNGNSYICKCSEGFVLAEDGRRCKSITMYAVGVGKAIEEELQEIASEPTNKHLFYAEDF
630 640 650 660 670 680
>>NP_085072 (OMIM: 602108) matrilin-2 isoform b precurso (937 aa)
initn: 261 init1: 209 opt: 447 Z-score: 343.4 bits: 74.2 E(85289): 2.2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
NP_085 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: :
NP_085 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
320 330 340 350 360
340 350 360 370 380 390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
: ..::::. .. ::: .. : : . . .. : . .::..: ... :: : :
NP_085 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
370 380 390 400 410 420
400 410 420 430 440
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
.:.. :. . :. : : .: : ::. : :.: ::..... . :. .:
NP_085 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
430 440 450 460 470 480
450 460 470 480 490
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
: ..: : : :. .: : : :.. . : : : .:.:. :: :
NP_085 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
NP_085 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
550 560 570 580 590 600
>--
initn: 272 init1: 151 opt: 295 Z-score: 230.5 bits: 53.3 E(85289): 4.3e-06
Smith-Waterman score: 295; 36.5% identity (58.7% similar) in 126 aa overlap (252-370:536-658)
230 240 250 260 270 280
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
:::.: . . ::: : :. ::..:
NP_085 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
510 520 530 540 550 560
290 300 310 320 330 340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
.. :. . :::.:: . : ::.: : :.::: : .::. : : : . :
NP_085 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
570 580 590 600 610 620
350 360 370 380 390
pF1KB5 VNTQGGFECHCYPNYDLV-DG----ECVE-PVDPCFRANCEYQCQPLNQTSYLCVCAEGF
::. ... :.: .. :. :: .:.: :.: :
NP_085 VNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGII
630 640 650 660 670 680
400 410 420 430 440 450
pF1KB5 APIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGV
NP_085 DSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMF
690 700 710 720 730 740
>>NP_002371 (OMIM: 602108) matrilin-2 isoform a precurso (956 aa)
initn: 261 init1: 209 opt: 447 Z-score: 343.3 bits: 74.2 E(85289): 2.2e-12
Smith-Waterman score: 529; 33.3% identity (56.8% similar) in 264 aa overlap (245-491:283-535)
220 230 240 250 260 270
pF1KB5 VAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQ
:..:. .::. : .::. ::: .: ::
NP_002 CINIPGSYVCRCKQGYILNSDQTTCRIQDLCAMEDHNCEQLCVNVPGSFVCQCYSGYALA
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB5 ADGRSCTA-SATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEP
::. :.: . : : ::: :: : : ::: :.:. :. : :.. : .: :
NP_002 EDGKRCVAVDYCASENHGCEHECV-NAD--GSYLCQCHEGFALNPDKKTCTKIDYCASSN
320 330 340 350 360
340 350 360 370 380 390
pF1KB5 SPCPQRCVNTQGGFECHCYPNYDLV-DGECVEPVDPCF--RANCEYQCQPLNQTSYLCVC
: ..::::. .. ::: .. : : . . .. : . .::..: ... :: : :
NP_002 HGCQHECVNTDDSYSCHCLKGFTLNPDKKTCRRINYCALNKPGCEHECVNMEE-SYYCRC
370 380 390 400 410 420
400 410 420 430 440
pF1KB5 AEGFAPIPHEPHRCQMF--CNQT--ACPADCDPNTQAS--CECPEGYILDDGF-ICTDID
.:.. :. . :. : : .: : ::. : :.: ::..... . :. .:
NP_002 HRGYTLDPN-GKTCSRVDHCAQQDHGCEQLCL-NTEDSFVCQCSEGFLINEDLKTCSRVD
430 440 450 460 470 480
450 460 470 480 490
pF1KB5 EC---ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDG---GDSGSGEPPP
: ..: : : :. .: : : :.. . : : : .:.:. :: :
NP_002 YCLLSDHG--CEYSCVNMDRSFACQC-PEGHVLRSDGKTC--AKLDSCALGDHGCEHSCV
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB5 SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAP
NP_002 SSEDSFVCQCFEGYILREDGKTCRRKDVCQAIDHGCEHICVNSDDSYTCECLEGFRLAED
550 560 570 580 590 600
>--
initn: 272 init1: 151 opt: 295 Z-score: 230.4 bits: 53.3 E(85289): 4.3e-06
Smith-Waterman score: 295; 36.5% identity (58.7% similar) in 126 aa overlap (252-370:536-658)
230 240 250 260 270 280
pF1KB5 LMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAALQADGRSCT
:::.: . . ::: : :. ::..:
NP_002 FACQCPEGHVLRSDGKTCAKLDSCALGDHGCEHSCVSSEDSFVCQCFEGYILREDGKTCR
510 520 530 540 550 560
290 300 310 320 330 340
pF1KB5 -ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQRC
.. :. . :::.:: . : ::.: : :.::: : .::. : : : . :
NP_002 RKDVCQAIDHGCEHICVNSDD---SYTCECLEGFRLAEDGKRCRRKDVCKSTHHGCEHIC
570 580 590 600 610 620
350 360 370 380 390
pF1KB5 VNTQGGFECHCYPNYDLV-DG----ECVE-PVDPCFRANCEYQCQPLNQTSYLCVCAEGF
::. ... :.: .. :. :: .:.: :.: :
NP_002 VNNGNSYICKCSEGFVLAEDGRRCKKCTEGPIDLVFVIDGSKSLGEENFEVVKQFVTGII
630 640 650 660 670 680
400 410 420 430 440 450
pF1KB5 APIPHEPHRCQMFCNQTACPADCDPNTQASCECPEGYILDDGFICTDIDECENGGFCSGV
NP_002 DSLTISPKAARVGLLQYSTQVHTEFTLRNFNSAKDMKKAVAHMKYMGKGSMTGLALKHMF
690 700 710 720 730 740
>>NP_001290065 (OMIM: 614708) signal peptide, CUB and EG (992 aa)
initn: 421 init1: 216 opt: 439 Z-score: 337.1 bits: 73.1 E(85289): 4.9e-12
Smith-Waterman score: 475; 33.6% identity (55.0% similar) in 238 aa overlap (244-466:73-302)
220 230 240 250 260 270
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVE-NGGCEHACNAIPGAPRCQCPAGAA
.: : :.:: : : ::: :: : :
NP_001 DAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFH
50 60 70 80 90 100
280 290 300 310 320
pF1KB5 LQADGRSCT-ASATQSCNDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRC---EDVDD
: ::..: .. : :.. :: .. ::: : :. :. :. .:: : . .
NP_001 LAHDGHNCLDVDECAEGNGGCQQSCV---NMMGSYECHCREGFFLSDNQHTCIQRPEGMN
110 120 130 140 150
330 340 350 360 370 380
pF1KB5 CILEPSPCPQRCVNT-QGGFECHCYPNYDLVDGE--CVEPVDPCFRAN--CEYQCQPLNQ
:. . : . : .: .::. :.: :...:. .. : : .: :.. :. .:
NP_001 CMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLT---CNYGNGGCQHTCDDTEQ
160 170 180 190 200 210
390 400 410 420 430
pF1KB5 TSYLCVCAEGFAPIPHEPHRCQMFC--NQTACPADC-DPNTQASCECPEGYILD-DGFIC
: : :. . . . : : :. .: . : : : . : :: :..:. : :
NP_001 GPR-CGCHIKFV-LHTDGKTCIETCAVNNGGCDSKCHDAATGVHCTCPVGFMLQPDRKTC
220 230 240 250 260 270
440 450 460 470 480 490
pF1KB5 TDIDECE-NGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPS
:::::. :.: :. .:.: :.::: :
NP_001 KDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERNCQDIDECSFDRTCDHICVNT
280 290 300 310 320 330
>>NP_000129 (OMIM: 102370,129600,134797,154700,184900,60 (2871 aa)
initn: 784 init1: 198 opt: 432 Z-score: 326.4 bits: 72.6 E(85289): 1.9e-11
Smith-Waterman score: 438; 28.9% identity (53.3% similar) in 304 aa overlap (244-520:2405-2693)
220 230 240 250 260 270
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHA-CNAIPGAPRCQCPAGAA
.:.: . :... : :. .: : .: .
NP_000 CEICPFQGTVAFKKLCPHGRGFMTNGADIDECKVIHDVCRNGECVNDRGSYHCICKTGYT
2380 2390 2400 2410 2420 2430
280 290 300 310 320
pF1KB5 LQADGRSCTASATQSCNDL---CEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDC
. : ::. . ::. :. .: . :::.: : :: : : . :.:.:.:
NP_000 PDITGTSCV--DLNECNQAPKPCNFIC---KNTEGSYQCSCPKGYILQEDGRSCKDLDEC
2440 2450 2460 2470 2480
330 340 350 360 370 380
pF1KB5 ILEPSPCPQRCVNTQGGFECHCYPNY-----DLVDG-ECVEPVDPCFRANCEYQCQPLNQ
. : :::: ::: :.: :.. . .:. ::. .. : . . :: .
NP_000 ATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDINLC---GSKGICQN-TP
2490 2500 2510 2520 2530 2540
390 400 410 420 430
pF1KB5 TSYLCVCAEGFAPIPHEPHRCQMF--CNQTA-CPADCDPNTQA-SCECPEGYILDDGFI-
:. : : .::. . . :. :. . : :. . : ::.::. .
NP_000 GSFTCECQRGFS-LDQTGSSCEDVDECEGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQ
2550 2560 2570 2580 2590 2600
440 450 460 470 480 490
pF1KB5 CTDIDECENGGFCSGV-CHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPP
:.: .:: .. .:.:. ::: :...:.: : . .... :. : .. ::.. :
NP_000 CVDENECLSAHICGGASCHNTLGSYKCMC-PAGFQYEQFSGGCQ----DINECGSAQAPC
2610 2620 2630 2640 2650
500 510 520 530 540
pF1KB5 S----PTPGSTLT--PPA---VGLVH--SGLLIGISIASLCLVVALLALLCHLRKKQGAA
: : :. : ::. .: : ::. .:
NP_000 SYGCSNTEGGYLCGCPPGYFRIGQGHCVSGMGMGRGNPEPPVSGEMDDNSLSPEACYECK
2660 2670 2680 2690 2700 2710
550 560 570
pF1KB5 RAKMEYKCAAPSKEVVLQHVRTERTPQRL
NP_000 INGYPKRGRKRRSTNETDASNIEDQSETEANVSLASWDVEKTAIFAFNISHVSNKVRILE
2720 2730 2740 2750 2760 2770
>--
initn: 400 init1: 171 opt: 377 Z-score: 285.6 bits: 65.1 E(85289): 3.6e-09
Smith-Waterman score: 500; 36.4% identity (56.9% similar) in 239 aa overlap (244-466:1200-1431)
220 230 240 250 260 270
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAAL
.::. ::::: :. :. .:.: : ::
NP_000 RCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFAL
1170 1180 1190 1200 1210 1220
280 290 300 310 320 330
pF1KB5 QADGRSCTASATQSCND---LCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCI
. : :::: . :.: .:. : :: : :.: :. . :.. : ::..:
NP_000 MPDQRSCTD--IDECEDNPNICDGGQCTN--IPGEYRCLCYDGFMASEDMKTCVDVNECD
1230 1240 1250 1260 1270 1280
340 350 360 370 380
pF1KB5 LEPSPC-PQRCVNTQGGFECHCYPNYDLVDGE--CVEPVDPCFRA--NCEYQCQPLNQT-
:.:. : : ::.:.: ::: .:. :. :.. .. : . :: . : .
NP_000 LNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTD-INECEIGAHNCGKHAVCTNTAG
1290 1300 1310 1320 1330 1340
390 400 410 420 430
pF1KB5 SYLCVCAEGFAPIP---HEPHRCQMFCNQTACPADCDPNTQAS--CECPEGYILDDGFIC
:. : :. :. . .:. .. . ::: ::..: : : ::: ::: :
NP_000 SFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCK-NTMGSYRCLCKEGYT-GDGFTC
1350 1360 1370 1380 1390 1400
440 450 460 470 480 490
pF1KB5 TDIDEC-ENGGFC-SGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPP
::.::: :: ..: .: : : :: ..: :
NP_000 TDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCH
1410 1420 1430 1440 1450 1460
>--
initn: 266 init1: 136 opt: 349 Z-score: 264.8 bits: 61.2 E(85289): 5.2e-08
Smith-Waterman score: 426; 30.8% identity (50.0% similar) in 302 aa overlap (224-480:1998-2289)
200 210 220 230 240 250
pF1KB5 GTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPG-AVQGHWAREAPGAWDCSVENGGC
: ::: ..:.. .. .: : :
NP_000 GRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDID---ECVEEPEIC
1970 1980 1990 2000 2010 2020
260 270 280
pF1KB5 E-HACNAIPGAPRCQCPAGAALQADGRSCT----------------------ASATQSC-
.:. :. .: :: : .:...:: : . : :
NP_000 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC
2030 2040 2050 2060 2070 2080
290 300 310 320 330
pF1KB5 --------NDLCEHFCVPNPDQPGSYSCMCETGYRLAADQHRCEDVDDCILEPSPCPQ-R
.: :: .: .::. : .: .. :. :.:.: ::. : . .
NP_000 CALKGEGWGDPCE-LCPTEPDEAFRQICPYGSGIIVGPDDSAV-DMDECK-EPDVCKHGQ
2090 2100 2110 2120 2130 2140
340 350 360 370 380 390
pF1KB5 CVNTQGGFECHCYPNYDLVDGECVEPVDPCFRAN-C-EYQCQPLNQTSYLCVCAEGFAPI
:.::.:...:.: .: :. .:::. .: : .: : . :. . .. :.: ::: :
NP_000 CINTDGSYRCECPFGYILAGNECVD-TDECSVGNPCGNGTCKNVIG-GFECTCEEGFEPG
2150 2160 2170 2180 2190
400 410 420 430 440 450
pF1KB5 PHEPHRCQMFCNQTA--CPADCDPNTQAS--CECPEGYIL-DDGFICTDIDECENGGF-C
: . : :. : : :: .: :.:: ::.: .: .: : ::::.: :
NP_000 PMMTCEDINECAQNPLLCAFRC-VNTYGSYECKCPVGYVLREDRRMCKDEDECEEGKHDC
2200 2210 2220 2230 2240 2250
460 470 480 490 500
pF1KB5 SGV---CHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPSPTPGSTLTPP
. :.:: ::. ::::: : : :
NP_000 TEKQMECKNLIGTYMCICGPGYQ-RRPDGEGCVDENECQTKPGICENGRCLNTRGSYTCE
2260 2270 2280 2290 2300 2310
510 520 530 540 550 560
pF1KB5 AVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPSKEVVLQHVRT
NP_000 CNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEI
2320 2330 2340 2350 2360 2370
>--
initn: 320 init1: 171 opt: 314 Z-score: 238.8 bits: 56.4 E(85289): 1.5e-06
Smith-Waterman score: 394; 30.6% identity (51.2% similar) in 252 aa overlap (244-480:1449-1687)
220 230 240 250 260 270
pF1KB5 AVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQCPAGAAL
.::. : .:. .:: ::.: : :
NP_000 QCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYEL
1420 1430 1440 1450 1460 1470
280 290 300 310 320
pF1KB5 QADGRSCTASATQSCNDLCEHFCVPNP--DQPGSYSCMCETGYRLAADQHRCEDV--DDC
. .: .:: .. : : :. . . :::: : : ..: . : :. .:
NP_000 DRSGGNCT--DVNECLD--PTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNC
1480 1490 1500 1510 1520 1530
330 340 350 360 370 380
pF1KB5 ILEPSPCPQRCVNTQGGFECHCYPNYDLVDGECVEPVDPCFRANCEYQCQPLNQTSY--L
:. : : : : : . . . : . . . ::. : .: . : :
NP_000 YLDIRP---RGDN--GDTACSNEIGVGVSKASCCCSLGKAWGTPCEM-CPAVNTSEYKIL
1540 1550 1560 1570 1580
390 400 410 420 430
pF1KB5 CVCAEGFAPIP-----HEPHRCQMFCNQTACPADCDPNTQAS--CECPEGYILD-DGFIC
: .::: : : .. .:: . : . :: .: :.:: :: :. : .:
NP_000 CPGGEGFRPNPITVILEDIDECQEL--PGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVC
1590 1600 1610 1620 1630 1640
440 450 460 470 480 490
pF1KB5 TDIDECENGGFCS-GVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDSGSGEPPPS
:..:::. :.:. :.:.: :.. ::: :: . . :..:
NP_000 DDVNECETPGICGPGTCYNTVGNYTCICPPDY-MQVNGGNNCMDMRRSLCYRNYYADNQT
1650 1660 1670 1680 1690 1700
500 510 520 530 540 550
pF1KB5 PTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKMEYKCAAPS
NP_000 CDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPV
1710 1720 1730 1740 1750 1760
>--
initn: 208 init1: 142 opt: 297 Z-score: 226.2 bits: 54.1 E(85289): 7.4e-06
Smith-Waterman score: 380; 34.2% identity (59.7% similar) in 196 aa overlap (291-472:459-645)
270 280 290 300 310
pF1KB5 GAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSCMCETGYRLAAD
::.. :.:.: ::: : :. :..:
NP_000 RPPVEYLYPSREPPRVLPVNVTDYCQLVRYLCQNGRCIPTP---GSYRCECNKGFQLDL-
430 440 450 460 470 480
320 330 340 350 360 370
pF1KB5 QHRCEDVDDCILEPSPCPQ-RCVNTQGGFECHCYPNYD--LVDGECVEPVDPCFRAN--C
. .: :::.: : .:: .:.:.::.. :.: .:. :. :: . .: :.. . :
NP_000 RGECIDVDEC--EKNPCAGGECINNQGSYTCQCRAGYQSTLTRTEC-RDIDECLQNGRIC
490 500 510 520 530 540
380 390 400 410 420
pF1KB5 EY-QCQPLNQTSYLCVCAEGFAPIPHEPHRCQMF--CN-QTACPADCDPNTQAS--CECP
. .: . :. ::: :: . .. . :. . :. .. : : ..: : :
NP_000 NNGRCINTDG-SFHCVCNAGFH-VTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICK
550 560 570 580 590
430 440 450 460 470 480
pF1KB5 EGYIL-DDGFICTDIDECENGGFC-SGVCHNLPGTFECICGPDSALARHIGTDCDSGKVD
:. : .:: : ::.:::. :.: .: : : :...: : : :.
NP_000 PGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRS
600 610 620 630 640 650
490 500 510 520 530 540
pF1KB5 GGDSGSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAA
NP_000 TCYGGYKRGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTS
660 670 680 690 700 710
>--
initn: 216 init1: 124 opt: 296 Z-score: 225.4 bits: 53.9 E(85289): 8.1e-06
Smith-Waterman score: 360; 30.6% identity (52.9% similar) in 242 aa overlap (237-462:1771-1996)
210 220 230 240 250 260
pF1KB5 LPVGSSAAVAPLGLQLMCTAPPGAVQGHWAREAPGAWDCSVENGGCEHACNAIPGAPRCQ
:: ::. : ::: .: . :. ::.
NP_000 TDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGV--C--ENG----VCINMVGSFRCE
1750 1760 1770 1780 1790
270 280 290 300 310 320
pF1KB5 CPAGAALQADGRSCTASATQSCNDLCEH--FCVPNPDQPGSYSCMCETGYRLAADQHRCE
::.: . : . . .:.. :. . ::: : :. :::... . :.
NP_000 CPVGFFYNDKLLVCEDIDECQNGPVCQRNAECI---NTAGSYRCDCKPGYRFTSTGQ-CN
1800 1810 1820 1830 1840
330 340 350 360 370 380
pF1KB5 DVDDCILEPSPCPQ-RCVNTQGGFECHCYPNYDLVDGE--CVEPVDPCFRANC-EYQCQP
: ..: :. : . .:..: :.: : :. .. : . :.. .. : : : . :.
NP_000 DRNECQEIPNICSHGQCIDTVGSFYCLCHTGFKTNDDQTMCLD-INECERDACGNGTCRN
1850 1860 1870 1880 1890 1900
390 400 410 420 430
pF1KB5 LNQTSYLCVCAEGFAPIPHEPHRCQMF--C---NQTACPADCDPNTQAS--CECPEGY-I
. :. : : .:: . :. . : : : . : :: .: :.: ::: .
NP_000 -TIGSFNCRCNHGFI-LSHN-NDCIDVDECASGNGNLCRNGQCINTVGSFQCQCNEGYEV
1910 1920 1930 1940 1950 1960
440 450 460 470 480 490
pF1KB5 LDDGFICTDIDEC--ENGGFCSGVCHNLPGTFECICGPDSALARHIGTDCDSGKVDGGDS
:: :.::.:: : :.:.:: :..
NP_000 APDGRTCVDINECLLEPRKCAPGTCQNLDGSYRCICPPGYSLQNEKCEDIDECVEEPEIC
1970 1980 1990 2000 2010 2020
500 510 520 530 540 550
pF1KB5 GSGEPPPSPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALLCHLRKKQGAARAKM
NP_000 ALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECC
2030 2040 2050 2060 2070 2080
>>NP_001157738 (OMIM: 601216,602090,613097) latent-trans (1139 aa)
initn: 375 init1: 216 opt: 418 Z-score: 320.8 bits: 70.3 E(85289): 3.9e-11
Smith-Waterman score: 463; 27.9% identity (47.0% similar) in 481 aa overlap (103-507:509-961)
80 90 100 110 120 130
pF1KB5 LLLNGDGGVGRRRLWIGLQLPPGCGDPKRLGPLRGFQWVTGDN-NTSYSRWARLDLNGAP
:: ::. :: . : .: :: . ::
NP_001 DYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRLHV-GAG
480 490 500 510 520 530
140 150 160 170 180 190
pF1KB5 LCGPLCVAVSAAEATVPSEPIWEEQQCEVKADGFLCEFHFPATCRPLAVEPGAAAAAVSI
: :: .. : . : . : .:: .: ..::. . :: :
NP_001 --GRSCVDLN--ECAKP-------HLC---GDGGFC-INFPGHYK-CNCYPGYRLKASRP
540 550 560 570 580
200 210 220 230 240 250
pF1KB5 TYGTPFAARGADFQALPVGSSAAVAPLGLQLMCTAPPGAVQGHWA-REAPGAWDCSVENG
. . : .. : :. : ... . : :: : :.. .:. :..
NP_001 PVCEDID-ECRDPSSCPDGKCEN-KPGSFKCIACQPGYRSQGGGACRDVN---ECA-EGS
590 600 610 620 630
260 270 280 290 300
pF1KB5 GCEHA-CNAIPGAPRCQCPAGAALQADGRSCTASATQSCNDLCEH-FCVPNPDQPGSYSC
: . :. .::. :: : : : ::::: .:.:.. .: . :::..:
NP_001 PCSPGWCENLPGSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGIC---SNTPGSFQC
640 650 660 670 680 690
310 320 330 340 350 360
pF1KB5 MCETGYRLAADQHRCEDVDDCILEPSPC-PQRCVNTQGGFECHCYPNYDLVDGECVEPVD
.: .::.:. :. .:::.:.: . :. : :.::.:...: : .. :: :. . .:
NP_001 QCLSGYHLSRDRSHCEDIDECDF-PAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDID
700 710 720 730 740 750
370 380 390 400
pF1KB5 PCFR--ANC--EYQCQPLNQTSYLCVCAEGFAPI-----------PHEPHRCQM------
: . . : . :. : : ::.::: :::.: ::. ..: .
NP_001 ECSQDPSLCLPHGACKNL-QGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTV
760 770 780 790 800 810
410 420 430
pF1KB5 FCN--------QTACPADCDPNTQASCE---------------CPEG--YILDDGFIC--
::. : : . . :: ::.: : :....
NP_001 FCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYG
820 830 840 850 860 870
440 450 460 470 480
pF1KB5 ----TDIDECENGG--FCS-GVCHNLPGTFECICGP----DSALARHIGTD-------CD
::::: : .:. : : : .:: : :. : . . .: :
NP_001 IPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDECLDESNCR
880 890 900 910 920 930
490 500 510 520 530
pF1KB5 SGKVD---GGDSGSGEPPP--SPTPGSTLTPPAVGLVHSGLLIGISIASLCLVVALLALL
.: . :: . :: ::. . :.:
NP_001 NGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMERAPERRDVCWSQRGEDGMCAGPLAG
940 950 960 970 980 990
540 550 560 570
pF1KB5 CHLRKKQGAARAKMEYKCAAPSKEVVLQHVRTERTPQRL
NP_001 PALTFDDCCCRQGRGWGAQCRPCPPRGAGSHCPTSQSESNSFWDTSPLLLGKPPRDEDSS
1000 1010 1020 1030 1040 1050
575 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 21:09:14 2016 done: Sat Nov 5 21:09:16 2016
Total Scan time: 11.680 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]