FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5607, 465 aa 1>>>pF1KB5607 465 - 465 aa - 465 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7861+/-0.000378; mu= 15.6080+/- 0.023 mean_var=92.0468+/-17.742, 0's: 0 Z-trim(115.5): 136 B-trim: 0 in 0/52 Lambda= 0.133681 statistics sampled from 25888 (26050) to 25888 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.305), width: 16 Scan time: 8.950 The best scores are: opt bits E(85289) NP_055282 (OMIM: 300642,300643) sushi repeat-conta ( 465) 3280 643.0 5.1e-184 NP_006298 (OMIM: 300187) sushi repeat-containing p ( 464) 1542 307.8 4.1e-83 NP_001164221 (OMIM: 300187) sushi repeat-containin ( 444) 1523 304.1 5e-82 XP_016885382 (OMIM: 300187) PREDICTED: sushi repea ( 419) 1401 280.6 5.8e-75 NP_001164223 (OMIM: 300187) sushi repeat-containin ( 379) 1269 255.1 2.5e-67 NP_001164222 (OMIM: 300187) sushi repeat-containin ( 405) 1209 243.5 7.9e-64 NP_000441 (OMIM: 131210,145500) E-selectin precurs ( 610) 247 58.1 7.7e-08 NP_000646 (OMIM: 153240) L-selectin precursor [Hom ( 385) 227 54.1 7.8e-07 XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 229 55.1 2.3e-06 XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 229 55.1 2.6e-06 XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 229 55.2 3.2e-06 XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 229 55.2 3.3e-06 NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 229 55.2 3.3e-06 NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 224 54.3 6.5e-06 XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 220 53.3 7.6e-06 XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 220 53.5 1.1e-05 XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 220 53.5 1.1e-05 XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 220 53.5 1.1e-05 XP_011515118 (OMIM: 608399) PREDICTED: CUB and sus (3603) 220 53.5 1.1e-05 NP_001701 (OMIM: 138470,612924,615489,615561) comp ( 764) 211 51.3 1.1e-05 XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 220 53.5 1.1e-05 NP_937757 (OMIM: 608399) CUB and sushi domain-cont (3667) 220 53.5 1.1e-05 XP_016868497 (OMIM: 608399) PREDICTED: CUB and sus (3681) 220 53.5 1.1e-05 NP_937756 (OMIM: 608399) CUB and sushi domain-cont (3707) 220 53.5 1.1e-05 NP_001269388 (OMIM: 217000,613927,615489) compleme ( 328) 203 49.4 1.7e-05 XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 212 51.9 3.1e-05 XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 212 51.9 3.2e-05 NP_000054 (OMIM: 217000,613927,615489) complement ( 752) 203 49.7 3.2e-05 XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 212 52.0 3.2e-05 XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 212 52.0 3.2e-05 XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 212 52.0 3.3e-05 XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 212 52.0 3.3e-05 XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 212 52.0 3.3e-05 NP_001269387 (OMIM: 217000,613927,615489) compleme ( 723) 201 49.3 4.1e-05 XP_011507508 (OMIM: 120650,240500,610927,614699) P ( 969) 202 49.6 4.5e-05 NP_001006659 (OMIM: 120650,240500,610927,614699) c (1092) 202 49.6 4.9e-05 NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 208 51.2 5.4e-05 NP_000565 (OMIM: 125240,613793) complement decay-a ( 381) 194 47.8 6.4e-05 NP_001287833 (OMIM: 125240,613793) complement deca ( 384) 194 47.8 6.4e-05 XP_016855956 (OMIM: 125240,613793) PREDICTED: comp ( 412) 194 47.8 6.8e-05 NP_001287832 (OMIM: 125240,613793) complement deca ( 439) 194 47.8 7.1e-05 NP_001108224 (OMIM: 125240,613793) complement deca ( 440) 194 47.8 7.1e-05 NP_001287831 (OMIM: 125240,613793) complement deca ( 444) 194 47.8 7.2e-05 XP_016855680 (OMIM: 608398) PREDICTED: CUB and sus (2973) 202 50.0 0.00011 NP_699197 (OMIM: 611691) sushi, von Willebrand fac (3571) 202 50.0 0.00012 XP_005245497 (OMIM: 147050,173610) PREDICTED: P-se ( 768) 181 45.5 0.00062 XP_005245495 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 181 45.5 0.00064 XP_005245496 (OMIM: 147050,173610) PREDICTED: P-se ( 790) 181 45.5 0.00064 XP_005245493 (OMIM: 147050,173610) PREDICTED: P-se ( 830) 181 45.5 0.00066 NP_002996 (OMIM: 147050,173610) P-selectin precurs ( 830) 181 45.5 0.00066 >>NP_055282 (OMIM: 300642,300643) sushi repeat-containin (465 aa) initn: 3280 init1: 3280 opt: 3280 Z-score: 3424.7 bits: 643.0 E(85289): 5.1e-184 Smith-Waterman score: 3280; 100.0% identity (100.0% similar) in 465 aa overlap (1-465:1-465) 10 20 30 40 50 60 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 TLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 RCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDID 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 PPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 YTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 TPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 TPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 ISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVL 370 380 390 400 410 420 430 440 450 460 pF1KB5 IDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE ::::::::::::::::::::::::::::::::::::::::::::: NP_055 IDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE 430 440 450 460 >>NP_006298 (OMIM: 300187) sushi repeat-containing prote (464 aa) initn: 1780 init1: 1521 opt: 1542 Z-score: 1613.2 bits: 307.8 E(85289): 4.1e-83 Smith-Waterman score: 1542; 45.9% identity (73.1% similar) in 453 aa overlap (13-464:17-462) 10 20 30 40 50 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTW-YAGSGYYPDESYNEVYAEEVPQAPALDYRV ::..: : :. . ::: : :. . :.. :. :. NP_006 MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSH--PR-----YKD 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 PRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA :: .... :.. : .:.:: :...:::::.. :..:..: : . : ..::: . NP_006 TPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 YCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPV :.: :: .: . ..: . :..:. ..:::.: :: :: :.:.:. ::.. ::: NP_006 ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 CVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEG :::..::.:.:: .:..:::.:::.:: :. : .:.::: .: : :.: :::.:::: NP_006 CVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 EHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGG .: :.::.:::: :...::: :::.:.:: :. :..::. :.: :::::::::. : :: NP_006 DHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 YDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNR :. ::.:.:::::. :::. : :: :..::.: .::.::::::::.::::.:.: : NP_006 YELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 YYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSY :..:..::::. :::::::.:..:::: : .::: . . . .:: . :. NP_006 LYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYS 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 FNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE :.:::.::.:.:..::. : : .:..:: . : ..:.. . :. . : NP_006 FSMVLVDKHGMDKERYVSLVMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT 420 430 440 450 460 >>NP_001164221 (OMIM: 300187) sushi repeat-containing pr (444 aa) initn: 1795 init1: 1521 opt: 1523 Z-score: 1593.7 bits: 304.1 E(85289): 5e-82 Smith-Waterman score: 1523; 47.1% identity (74.8% similar) in 420 aa overlap (45-464:25-442) 20 30 40 50 60 70 pF1KB5 FFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATCYSP :: :. .. :: .... :.. : .: NP_001 MGSPAHRPALLLLLPPLLLLLLLRVP--PSRSFPDTPWCSPIKVKYGDVYCRAP 10 20 30 40 50 80 90 100 110 120 130 pF1KB5 KGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYT .:: :...:::::.. :..:..: : . : ..::: . :.: :: .: . ..: . NP_001 QGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKVICKQKRCPTLAMPANGGFK 60 70 80 90 100 110 140 150 160 170 180 190 pF1KB5 CTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMA :..:. ..:::.: :: :: :.:.:. ::.. ::: :::..::.:.:: .:..: NP_001 CVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPASCVDMEPPRIKCPSVKERIA 120 130 140 150 160 170 200 210 220 230 240 250 pF1KB5 EPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCK ::.:::.:: :. : .:.::: .: : :.: :::.::::.: :.::.:::: :...:: NP_001 EPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCK 180 190 200 210 220 230 260 270 280 290 300 310 pF1KB5 FIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSG : :::.:.:: :. :..::. :.: :::::::::. : :::. ::.:.:::::. ::: NP_001 FRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSG 240 250 260 270 280 290 320 330 340 350 360 370 pF1KB5 SPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLR . : :: :..::.: .::.::::::::.::::.:.: : :..:..::::. :::::: NP_001 TEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLR 300 310 320 330 340 350 380 390 400 410 420 430 pF1KB5 HVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRYMEP :.:..:::: : .::: . . . .:: . :. :.:::.::.:.:..::. NP_001 HITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSL 360 370 380 390 400 410 440 450 460 pF1KB5 VTPEEIFTFIDDYLLSNQELTQRREQRDICE : : .:..:: . : ..:.. . :. . : NP_001 VMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT 420 430 440 >>XP_016885382 (OMIM: 300187) PREDICTED: sushi repeat-co (419 aa) initn: 1375 init1: 1375 opt: 1401 Z-score: 1466.8 bits: 280.6 E(85289): 5.8e-75 Smith-Waterman score: 1401; 47.3% identity (73.4% similar) in 402 aa overlap (13-413:17-410) 10 20 30 40 50 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTW-YAGSGYYPDESYNEVYAEEVPQAPALDYRV ::..: : :. . ::: : :. . :.. :. :. XP_016 MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSH--PR-----YKD 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 PRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA :: .... :.. : .:.:: :...:::::.. :..:..: : . : ..::: . XP_016 TPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 YCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPV :.: :: .: . ..: . :..:. ..:::.: :: :: :.:.:. ::.. ::: XP_016 ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 CVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEG :::..::.:.:: .:..:::.:::.:: :. : .:.::: .: : :.: :::.:::: XP_016 CVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 EHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGG .: :.::.:::: :...::: :::.:.:: :. :..::. :.: :::::::::. : :: XP_016 DHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 YDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNR :. ::.:.:::::. :::. : :: :..::.: .::.::::::::.::::.:.: : XP_016 YELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 YYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSY :..:..::::. :::::::.:..:::: : .::: . . . .: .: ::. XP_016 LYRLQLGMLQQAQCGLDLRHITVVELVGVFPTLIGRIGAKIMPPALALQL-SFITLTKLE 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 FNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE XP_016 PWILVSE >>NP_001164223 (OMIM: 300187) sushi repeat-containing pr (379 aa) initn: 1248 init1: 1248 opt: 1269 Z-score: 1329.9 bits: 255.1 E(85289): 2.5e-67 Smith-Waterman score: 1269; 47.7% identity (74.3% similar) in 354 aa overlap (13-365:17-363) 10 20 30 40 50 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTW-YAGSGYYPDESYNEVYAEEVPQAPALDYRV ::..: : :. . ::: : :. . :.. :. :. NP_001 MGSPAHRPALLLLLPPLLLLLLLRVPPSRSFPGSGDSPLEDDEVGYSH--PR-----YKD 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 PRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTA :: .... :.. : .:.:: :...:::::.. :..:..: : . : ..::: . NP_001 TPWCSPIKVKYGDVYCRAPQGGYYKTALGTRCDIRCQKGYELHGSSLLICQSNKRWSDKV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 YCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPV :.: :: .: . ..: . :..:. ..:::.: :: :: :.:.:. ::.. ::: NP_001 ICKQKRCPTLAMPANGGFKCVDGAYFNSRCEYYCSPGYTLKGERTVTCMDNKAWSGRPAS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 CVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEG :::..::.:.:: .:..:::.:::.:: :. : .:.::: .: : :.: :::.:::: NP_001 CVDMEPPRIKCPSVKERIAEPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEG 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 EHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGG .: :.::.:::: :...::: :::.:.:: :. :..::. :.: :::::::::. : :: NP_001 DHKIQYTVYDRAENKGTCKFRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 YDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNR :. ::.:.:::::. :::. : :: :..::.: .::.::::::::.::::.:.: : NP_001 YELQGSPARVCQSNLAWSGTEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNL 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 YYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSY :..:..::: NP_001 LYRLQLGMLQAVAANPTLLLQYGASG 360 370 >>NP_001164222 (OMIM: 300187) sushi repeat-containing pr (405 aa) initn: 1425 init1: 1093 opt: 1209 Z-score: 1266.9 bits: 243.5 E(85289): 7.9e-64 Smith-Waterman score: 1221; 47.8% identity (72.2% similar) in 360 aa overlap (105-464:57-403) 80 90 100 110 120 130 pF1KB5 KGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYT : : . : .::: : .: : NP_001 PSRSFPGSGDSPLEDDEVGYSHPRYKDTPWCSPIKVKYGDVYCRA------P---QGGYY 30 40 50 60 70 140 150 160 170 180 190 pF1KB5 CTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMA : : .::: :..::.:.:. ::. . ::: . .: ..::.:.:: .:..: NP_001 KTA---LGTRCDIRCQKGYELHGSSLLICQSNKRWSD-KVICKHMEPPRIKCPSVKERIA 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB5 EPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCK ::.:::.:: :. : .:.::: .: : :.: :::.::::.: :.::.:::: :...:: NP_001 EPNKLTVRVSWETPEGRDTADGILTDVILKGLPPGSNFPEGDHKIQYTVYDRAENKGTCK 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB5 FIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSG : :::.:.:: :. :..::. :.: :::::::::. : :::. ::.:.:::::. ::: NP_001 FRVKVRVKRCGKLNAPENGYMKCSSDGDNYGATCEFSCIGGYELQGSPARVCQSNLAWSG 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB5 SPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLR . : :: :..::.: .::.::::::::.::::.:.: : :..:..::::. :::::: NP_001 TEPTCAAMNVNVGVRTAAALLDQFYEKRRLLIVSTPTARNLLYRLQLGMLQQAQCGLDLR 260 270 280 290 300 310 380 390 400 410 420 430 pF1KB5 HVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRYMEP :.:..:::: : .::: . . . .:: . :. :.:::.::.:.:..::. NP_001 HITVVELVGVFPTLIGRIGAKIMPPALALQLRLLLRIPLYSFSMVLVDKHGMDKERYVSL 320 330 340 350 360 370 440 450 460 pF1KB5 VTPEEIFTFIDDYLLSNQELTQRREQRDICE : : .:..:: . : ..:.. . :. . : NP_001 VMPVALFNLIDTFPLRKEEMVLQAEMSQTCNT 380 390 400 >>NP_000441 (OMIM: 131210,145500) E-selectin precursor [ (610 aa) initn: 167 init1: 115 opt: 247 Z-score: 261.8 bits: 58.1 E(85289): 7.7e-08 Smith-Waterman score: 345; 26.1% identity (53.2% similar) in 280 aa overlap (65-334:311-566) 40 50 60 70 80 90 pF1KB5 ESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATC-YSPKGGNYHSSLGTRCELSCDR :.: . : .:: : . .. . :...:.. NP_000 AQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAG---EFTFKSSCNFTCEE 290 300 310 320 330 100 110 120 130 140 pF1KB5 GFRLIGRRSVQCLPSRRWSGTA-YCRQMRCHALPFITSGTYTC---TNGVL-LDSRCDYS :: : : .:.: . .:. :. ..: :: : ..: ..: . : :..: NP_000 GFMLQGPAQVECTTQGQWTQQIPVCEAFQCTALSNPERGYMNCLPSASGSFRYGSSCEFS 340 350 360 370 380 390 150 160 170 180 190 200 pF1KB5 CSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPP : .:. :.:.. : :.:.. .:.: .:: . . .: : .: .: NP_000 CEQGFVLKGSKRLQCGPTGEWDNEKPTC-----EAVRC----DAVHQPPKGLVRCAHSP- 400 410 420 430 440 210 220 230 240 250 260 pF1KB5 LVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLK : . : .. : :: .. : . . . . . . :: .: .: NP_000 ---------IGEFTYKSSCAFS-CEEGFELHGSTQLECTSQGQWTEEVPSCQVVKCSSLA 450 460 470 480 490 270 280 290 300 310 320 pF1KB5 PPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPIC-APMKINVN : . ..: :. .:..:.. : :. .:. .:.: .. .::: : : :: . :. NP_000 VPGKINMSC-SGEPVFGTVCKFACPEGWTLNGSAARTCGATGHWSGLLPTCEAPTESNIP 500 510 520 530 540 550 330 340 350 360 370 380 pF1KB5 VN---SAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQ . ::::: NP_000 LVAGLSAAGLSLLTLAPFLLWLRKCLRKAKKFVPASSCQSLESDGSYQKPSYIL 560 570 580 590 600 610 >-- initn: 167 init1: 99 opt: 231 Z-score: 245.1 bits: 55.0 E(85289): 6.5e-07 Smith-Waterman score: 231; 27.2% identity (51.7% similar) in 180 aa overlap (13-187:135-310) 10 20 30 40 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYA : . : : : : .: : :. :. NP_000 RQKDEDCVEIYIKREKDVGMWNDERCSKKKLALCYTAACTNTSCSGHGECV-ETINNYTC 110 120 130 140 150 160 50 60 70 80 90 100 pF1KB5 EEVPQAPALDYRVPRWCYTL-NIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRR . : .: . : .: . . : .: : : :. : .. : .:::::. . . NP_000 KCDPGFSGLKCEQIVNCTALESPEHGSLVCSHPLG-NF--SYNSSCSISCDRGYLPSSME 170 180 190 200 210 220 110 120 130 140 150 pF1KB5 SVQCLPSRRWSGTA-YCRQMRCHALPFITSGTYTCTN--GVL-LDSRCDYSCSSGYHLEG ..::. : .::. : ..: :. ..: : . : . .. : ..: :..: : NP_000 TMQCMSSGEWSAPIPACNVVECDAVTNPANGFVECFQNPGSFPWNTTCTFDCEEGFELMG 230 240 250 260 270 280 160 170 180 190 200 210 pF1KB5 DRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGT .: : .: :.. .:.: . .: : NP_000 AQSLQCTSSGNWDNEKPTCKAVTCRAVRQPQNGSVRCSHSPAGEFTFKSSCNFTCEEGFM 290 300 310 320 330 340 >>NP_000646 (OMIM: 153240) L-selectin precursor [Homo sa (385 aa) initn: 180 init1: 102 opt: 227 Z-score: 243.7 bits: 54.1 E(85289): 7.8e-07 Smith-Waterman score: 227; 29.9% identity (54.3% similar) in 127 aa overlap (59-180:210-333) 30 40 50 60 70 80 pF1KB5 SGYYPDESYNEVYAEEVPQAPALDYRVPRWCYTLNIQD-GEATCYSPKGGNYHSSLGTRC : :. . : : : : :. :....: NP_000 GHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLG-NF--SFSSQC 180 190 200 210 220 230 90 100 110 120 130 140 pF1KB5 ELSCDRGFRLIGRRSVQCLPSRRWSGTA-YCRQMRCHALPFITSGTYTCTNGVL---LDS .::..: : : . . : : ::. :. ..:. : : ..:.. . . : NP_000 AFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTS 240 250 260 270 280 290 150 160 170 180 190 200 pF1KB5 RCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARV : . :: : .: : .. :: .: ::. :.: .: NP_000 ACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVT 300 310 320 330 340 350 210 220 230 240 250 260 pF1KB5 YWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRR NP_000 AFSGLAFIIWLARRLKKGKKSKRSMNDPY 360 370 380 >>XP_011533056 (OMIM: 608397) PREDICTED: CUB and sushi d (2238 aa) initn: 363 init1: 148 opt: 229 Z-score: 235.1 bits: 55.1 E(85289): 2.3e-06 Smith-Waterman score: 288; 25.4% identity (45.5% similar) in 354 aa overlap (25-319:1244-1586) 10 20 30 40 50 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYR : :: : :: :. .: . . : XP_011 DGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSG-----SLNE-YGAQVLLSCSPGYY 1220 1230 1240 1250 1260 60 70 80 90 pF1KB5 VPRW----CY---TLNIQDGEATCYS--------PKGGNYHSSL---GTRCELSCDRGFR . : : : :: : . .: : .:: ..: :. ..:. :. XP_011 LEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYT 1270 1280 1290 1300 1310 1320 100 110 120 130 140 150 pF1KB5 LIGRRSVQCLPSRRWSGT-AYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHL :.: . .:: . :::. . : .: . :..: . .: . :.:. :..: XP_011 LVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNG-HISGDGFSYRDTVVYQCNPGFRL 1330 1340 1350 1360 1370 1380 160 170 180 190 200 pF1KB5 EGDRSRICMEDGRWSGGEPVCVDI------DPPKIRCPHSREKMAEPEKLTARV------ : :::..: .::: :::: : .: . :. .. . ..: . XP_011 VGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 1390 1400 1410 1420 1430 1440 210 220 230 pF1KB5 ----------YWDPPL-----VKDSADGTITRVTLRGPE--PGS---------HFPEGEH :. :: :. : : . . .: . : : : .: . XP_011 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFY 1450 1460 1470 1480 1490 1500 240 250 260 270 280 290 pF1KB5 VIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGD--NYGATCEYHCDGG .. .: : . . : . : : .. :: :. .:::. .: : :. XP_011 LLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT----GELFTYGAVVHYSCRGS 1510 1520 1530 1540 1550 1560 300 310 320 330 340 350 pF1KB5 YDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNR . :. .:::: . .:::. : : XP_011 ESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEM 1570 1580 1590 1600 1610 1620 >>XP_011533055 (OMIM: 608397) PREDICTED: CUB and sushi d (2595 aa) initn: 375 init1: 148 opt: 229 Z-score: 234.3 bits: 55.1 E(85289): 2.6e-06 Smith-Waterman score: 288; 25.4% identity (45.5% similar) in 354 aa overlap (25-319:1601-1943) 10 20 30 40 50 pF1KB5 MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYR : :: : :: :. .: . . : XP_011 DGLWSNKGKPPTCKPVACPSIEAQLSEHVIWRLVSG-----SLNE-YGAQVLLSCSPGYY 1580 1590 1600 1610 1620 60 70 80 90 pF1KB5 VPRW----CY---TLNIQDGEATCYS--------PKGGNYHSSL---GTRCELSCDRGFR . : : : :: : . .: : .:: ..: :. ..:. :. XP_011 LEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTLTVYGATAIFTCNTGYT 1630 1640 1650 1660 1670 1680 100 110 120 130 140 150 pF1KB5 LIGRRSVQCLPSRRWSGT-AYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHL :.: . .:: . :::. . : .: . :..: . .: . :.:. :..: XP_011 LVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNG-HISGDGFSYRDTVVYQCNPGFRL 1690 1700 1710 1720 1730 1740 160 170 180 190 200 pF1KB5 EGDRSRICMEDGRWSGGEPVCVDI------DPPKIRCPHSREKMAEPEKLTARV------ : :::..: .::: :::: : .: . :. .. . ..: . XP_011 VGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVNFTCNTGYLLQG 1750 1760 1770 1780 1790 1800 210 220 230 pF1KB5 ----------YWDPPL-----VKDSADGTITRVTLRGPE--PGS---------HFPEGEH :. :: :. : : . . .: . : : : .: . XP_011 VSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGMSILYHCKKGFY 1810 1820 1830 1840 1850 1860 240 250 260 270 280 290 pF1KB5 VIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGD--NYGATCEYHCDGG .. .: : . . : . : : .. :: :. .:::. .: : :. XP_011 LLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLT----GELFTYGAVVHYSCRGS 1870 1880 1890 1900 1910 300 310 320 330 340 350 pF1KB5 YDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNR . :. .:::: . .:::. : : XP_011 ESLIGNDTRVCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEM 1920 1930 1940 1950 1960 1970 465 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:07:50 2016 done: Sat Nov 5 13:07:52 2016 Total Scan time: 8.950 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]