FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5623, 979 aa 1>>>pF1KB5623 979 - 979 aa - 979 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7928+/-0.000455; mu= 19.0568+/- 0.028 mean_var=92.5355+/-18.500, 0's: 0 Z-trim(110.4): 142 B-trim: 418 in 3/54 Lambda= 0.133328 statistics sampled from 18602 (18750) to 18602 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.575), E-opt: 0.2 (0.22), width: 16 Scan time: 13.720 The best scores are: opt bits E(85289) NP_003990 (OMIM: 105250,601743) oncostatin-M-speci ( 979) 6656 1291.8 0 NP_001310434 (OMIM: 105250,601743) oncostatin-M-sp ( 979) 6656 1291.8 0 XP_005248441 (OMIM: 105250,601743) PREDICTED: onco ( 980) 6644 1289.5 0 NP_001310435 (OMIM: 105250,601743) oncostatin-M-sp ( 980) 6644 1289.5 0 XP_016865508 (OMIM: 105250,601743) PREDICTED: onco ( 799) 5377 1045.8 0 XP_011512463 (OMIM: 105250,601743) PREDICTED: onco ( 800) 5365 1043.4 0 XP_016865509 (OMIM: 105250,601743) PREDICTED: onco ( 647) 4379 853.7 0 XP_005248444 (OMIM: 105250,601743) PREDICTED: onco ( 581) 3587 701.3 3.6e-201 NP_001310436 (OMIM: 105250,601743) oncostatin-M-sp ( 581) 3587 701.3 3.6e-201 XP_005248443 (OMIM: 105250,601743) PREDICTED: onco ( 582) 3575 699.0 1.8e-200 NP_001310433 (OMIM: 105250,601743) oncostatin-M-sp ( 342) 2247 443.4 9.4e-124 NP_001161827 (OMIM: 105250,601743) oncostatin-M-sp ( 342) 2247 443.4 9.4e-124 XP_016864952 (OMIM: 151443,601559) PREDICTED: leuk (1097) 1200 242.4 9.8e-63 NP_002301 (OMIM: 151443,601559) leukemia inhibitor (1097) 1200 242.4 9.8e-63 XP_011512344 (OMIM: 151443,601559) PREDICTED: leuk (1097) 1200 242.4 9.8e-63 XP_011512342 (OMIM: 151443,601559) PREDICTED: leuk (1097) 1200 242.4 9.8e-63 NP_001121143 (OMIM: 151443,601559) leukemia inhibi (1097) 1200 242.4 9.8e-63 XP_016864951 (OMIM: 151443,601559) PREDICTED: leuk (1115) 1200 242.4 9.9e-63 XP_016856691 (OMIM: 601642) PREDICTED: interleukin ( 700) 433 94.7 1.8e-18 XP_011539685 (OMIM: 601642) PREDICTED: interleukin ( 862) 433 94.8 2.1e-18 XP_005270885 (OMIM: 601642) PREDICTED: interleukin ( 862) 433 94.8 2.1e-18 XP_005270882 (OMIM: 601642) PREDICTED: interleukin ( 862) 433 94.8 2.1e-18 NP_001550 (OMIM: 601642) interleukin-12 receptor s ( 862) 433 94.8 2.1e-18 XP_005270884 (OMIM: 601642) PREDICTED: interleukin ( 862) 433 94.8 2.1e-18 NP_001245145 (OMIM: 601642) interleukin-12 recepto ( 635) 430 94.1 2.5e-18 NP_001245143 (OMIM: 601642) interleukin-12 recepto ( 659) 430 94.1 2.5e-18 XP_016856692 (OMIM: 601642) PREDICTED: interleukin ( 659) 430 94.1 2.5e-18 NP_001306162 (OMIM: 601642) interleukin-12 recepto ( 659) 430 94.1 2.5e-18 XP_011539686 (OMIM: 601642) PREDICTED: interleukin ( 809) 397 87.9 2.4e-16 NP_001245144 (OMIM: 601642) interleukin-12 recepto ( 776) 368 82.3 1.1e-14 XP_006710680 (OMIM: 601642) PREDICTED: interleukin ( 776) 368 82.3 1.1e-14 XP_016856693 (OMIM: 601642) PREDICTED: interleukin ( 498) 363 81.2 1.5e-14 XP_011541447 (OMIM: 609510,613955) PREDICTED: inte ( 594) 340 76.8 3.8e-13 NP_001229568 (OMIM: 609510,613955) interleukin-31 ( 622) 340 76.8 3.9e-13 XP_011541446 (OMIM: 609510,613955) PREDICTED: inte ( 622) 340 76.8 3.9e-13 NP_001284501 (OMIM: 609510,613955) interleukin-31 ( 440) 333 75.3 7.7e-13 XP_011539052 (OMIM: 138971,162830,617014) PREDICTE ( 639) 263 62.0 1.2e-08 NP_758519 (OMIM: 138971,162830,617014) granulocyte ( 783) 263 62.1 1.4e-08 XP_005270550 (OMIM: 138971,162830,617014) PREDICTE ( 835) 263 62.1 1.4e-08 NP_000751 (OMIM: 138971,162830,617014) granulocyte ( 836) 263 62.1 1.4e-08 XP_011539051 (OMIM: 138971,162830,617014) PREDICTE ( 862) 263 62.1 1.5e-08 XP_016855859 (OMIM: 138971,162830,617014) PREDICTE ( 863) 263 62.1 1.5e-08 XP_011539050 (OMIM: 138971,162830,617014) PREDICTE ( 863) 263 62.1 1.5e-08 NP_724781 (OMIM: 138971,162830,617014) granulocyte ( 863) 263 62.1 1.5e-08 NP_004834 (OMIM: 605350) interleukin-27 receptor s ( 636) 227 55.1 1.4e-06 NP_786943 (OMIM: 600694) interleukin-6 receptor su ( 329) 200 49.7 3.1e-05 NP_002175 (OMIM: 600694) interleukin-6 receptor su ( 918) 167 43.7 0.0055 XP_016877727 (OMIM: 601907) PREDICTED: neogenin is (1381) 168 44.0 0.0067 XP_016877720 (OMIM: 601907) PREDICTED: neogenin is (1434) 168 44.0 0.0069 >>NP_003990 (OMIM: 105250,601743) oncostatin-M-specific (979 aa) initn: 6656 init1: 6656 opt: 6656 Z-score: 6919.8 bits: 1291.8 E(85289): 0 Smith-Waterman score: 6656; 100.0% identity (100.0% similar) in 979 aa overlap (1-979:1-979) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 LPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKN 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB5 YMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPP 910 920 930 940 950 960 970 pF1KB5 TENSSLSSITLLDPGEHYC ::::::::::::::::::: NP_003 TENSSLSSITLLDPGEHYC 970 >>NP_001310434 (OMIM: 105250,601743) oncostatin-M-specif (979 aa) initn: 6656 init1: 6656 opt: 6656 Z-score: 6919.8 bits: 1291.8 E(85289): 0 Smith-Waterman score: 6656; 100.0% identity (100.0% similar) in 979 aa overlap (1-979:1-979) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 LPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKN 850 860 870 880 890 900 910 920 930 940 950 960 pF1KB5 YMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPP 910 920 930 940 950 960 970 pF1KB5 TENSSLSSITLLDPGEHYC ::::::::::::::::::: NP_001 TENSSLSSITLLDPGEHYC 970 >>XP_005248441 (OMIM: 105250,601743) PREDICTED: oncostat (980 aa) initn: 4096 init1: 4096 opt: 6644 Z-score: 6907.3 bits: 1289.5 E(85289): 0 Smith-Waterman score: 6644; 99.9% identity (99.9% similar) in 980 aa overlap (1-979:1-980) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 NFTYLCQIELHGEGKMMQ-YNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_005 NFTYLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 SSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLY 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB5 LLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEK 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB5 NYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPP 910 920 930 940 950 960 960 970 pF1KB5 PTENSSLSSITLLDPGEHYC :::::::::::::::::::: XP_005 PTENSSLSSITLLDPGEHYC 970 980 >>NP_001310435 (OMIM: 105250,601743) oncostatin-M-specif (980 aa) initn: 4096 init1: 4096 opt: 6644 Z-score: 6907.3 bits: 1289.5 E(85289): 0 Smith-Waterman score: 6644; 99.9% identity (99.9% similar) in 980 aa overlap (1-979:1-980) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 NFTYLCQIELHGEGKMMQ-YNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: NP_001 NFTYLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 SSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLY 790 800 810 820 830 840 840 850 860 870 880 890 pF1KB5 LLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPTEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEK 850 860 870 880 890 900 900 910 920 930 940 950 pF1KB5 NYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NYMNSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPP 910 920 930 940 950 960 960 970 pF1KB5 PTENSSLSSITLLDPGEHYC :::::::::::::::::::: NP_001 PTENSSLSSITLLDPGEHYC 970 980 >>XP_016865508 (OMIM: 105250,601743) PREDICTED: oncostat (799 aa) initn: 5377 init1: 5377 opt: 5377 Z-score: 5591.4 bits: 1045.8 E(85289): 0 Smith-Waterman score: 5377; 100.0% identity (100.0% similar) in 789 aa overlap (1-789:1-789) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFR 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGY 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKS 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 SILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYL ::::::::: XP_016 SILSLIKFKISSKVWLNRR 790 >>XP_011512463 (OMIM: 105250,601743) PREDICTED: oncostat (800 aa) initn: 2817 init1: 2817 opt: 5365 Z-score: 5578.9 bits: 1043.4 E(85289): 0 Smith-Waterman score: 5365; 99.9% identity (99.9% similar) in 790 aa overlap (1-789:1-790) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 NFTYLCQIELHGEGKMMQ-YNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 NFTYLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGGFSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDF 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQG 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YHVYLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTS 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AGEGPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYK 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 SSILSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLY :::::::::: XP_011 SSILSLIKFKISSKVWLNRR 790 800 >>XP_016865509 (OMIM: 105250,601743) PREDICTED: oncostat (647 aa) initn: 4096 init1: 4096 opt: 4379 Z-score: 4555.2 bits: 853.7 E(85289): 0 Smith-Waterman score: 4379; 99.8% identity (99.8% similar) in 647 aa overlap (334-979:1-647) 310 320 330 340 350 360 pF1KB5 ETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFT :::::::::::::::::::::::::::::: XP_016 MNPFSVNFENVNATNAIMTWKVHSIRNNFT 10 20 30 370 380 390 400 410 420 pF1KB5 YLCQIELHGEGKMMQ-YNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQN ::::::::::::::: :::::::::::::::::::::::::::::::::::::::::::: XP_016 YLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSGQN 40 50 60 70 80 90 430 440 450 460 470 480 pF1KB5 FTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSE 100 110 120 130 140 150 490 500 510 520 530 540 pF1KB5 LHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGG 160 170 180 190 200 210 550 560 570 580 590 600 pF1KB5 FSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSLSWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIY 220 230 240 250 260 270 610 620 630 640 650 660 pF1KB5 GLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHV 280 290 300 310 320 330 670 680 690 700 710 720 pF1KB5 YLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLKSKARQCHPRFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGE 340 350 360 370 380 390 730 740 750 760 770 780 pF1KB5 GPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPSATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSI 400 410 420 430 440 450 790 800 810 820 830 840 pF1KB5 LSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LSLIKFKENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLP 460 470 480 490 500 510 850 860 870 880 890 900 pF1KB5 TEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TEKNHSGPGPCICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYM 520 530 540 550 560 570 910 920 930 940 950 960 pF1KB5 NSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NSLGEIPAGETSLNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTE 580 590 600 610 620 630 970 pF1KB5 NSSLSSITLLDPGEHYC ::::::::::::::::: XP_016 NSSLSSITLLDPGEHYC 640 >>XP_005248444 (OMIM: 105250,601743) PREDICTED: oncostat (581 aa) initn: 3582 init1: 3582 opt: 3587 Z-score: 3732.5 bits: 701.3 E(85289): 3.6e-201 Smith-Waterman score: 3587; 94.2% identity (95.5% similar) in 573 aa overlap (1-566:1-571) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT- ::::::::::::::::::::::::::::::::::::::::::::::::. ..:: XP_005 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENSV--STCFSGTV 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 -----EGGFSL-SWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRP :: :: : . ::: :. .. : XP_005 PSVWGEGDFSHGSGHFCPGDSSTYMGNYLKFIQVTATLTNSHH 540 550 560 570 580 600 610 620 630 640 650 pF1KB5 GVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQ >>NP_001310436 (OMIM: 105250,601743) oncostatin-M-specif (581 aa) initn: 3582 init1: 3582 opt: 3587 Z-score: 3732.5 bits: 701.3 E(85289): 3.6e-201 Smith-Waterman score: 3587; 94.2% identity (95.5% similar) in 573 aa overlap (1-566:1-571) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWSG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSS 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT- ::::::::::::::::::::::::::::::::::::::::::::::::. ..:: NP_001 SELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENSV--STCFSGTV 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 -----EGGFSL-SWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRP :: :: : . ::: :. .. : NP_001 PSVWGEGDFSHGSGHFCPGDSSTYMGNYLKFIQVTATLTNSHH 540 550 560 570 580 600 610 620 630 640 650 pF1KB5 GVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQ >>XP_005248443 (OMIM: 105250,601743) PREDICTED: oncostat (582 aa) initn: 2574 init1: 2574 opt: 3575 Z-score: 3720.1 bits: 699.0 E(85289): 1.8e-200 Smith-Waterman score: 3575; 94.1% identity (95.3% similar) in 574 aa overlap (1-566:1-572) 10 20 30 40 50 60 pF1KB5 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNSTRQSLHLQWTVHNLPYH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESELPLECATHFVRIKSLVDD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEEGTNVTICYVSRNIQNNVSCY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYTLFESFSGEKKLCTHKNWCNWQITQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRN 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 NFTYLCQIELHGEGKMMQ-YNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_005 NFTYLCQIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWKWSEWS 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GQNFTTLEAAPSEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGT :::::::::::::::::::::::::::::::::::::::::::::::::. ..:: XP_005 SSELHSIPAPANSTKLILDRCSYQICVIANNSVGASPASVIVISADPENSV--STCFSGT 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 ------EGGFSL-SWKPQPGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFR :: :: : . ::: :. .. : XP_005 VPSVWGEGDFSHGSGHFCPGDSSTYMGNYLKFIQVTATLTNSHH 540 550 560 570 580 600 610 620 630 640 650 pF1KB5 PGVRYDFRIYGLSTKRIACLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTES 979 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:19:06 2016 done: Sat Nov 5 07:19:08 2016 Total Scan time: 13.720 Total Display time: 0.330 Function used was FASTA [36.3.4 Apr, 2011]