FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5633, 522 aa 1>>>pF1KB5633 522 - 522 aa - 522 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6319+/-0.000454; mu= 14.3498+/- 0.028 mean_var=205.3279+/-45.036, 0's: 0 Z-trim(115.0): 140 B-trim: 0 in 0/54 Lambda= 0.089506 statistics sampled from 24975 (25132) to 24975 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.295), width: 16 Scan time: 9.320 The best scores are: opt bits E(85289) NP_004611 (OMIM: 602355) TNF receptor-associated f ( 522) 3654 485.3 1.9e-136 NP_665802 (OMIM: 602355) TNF receptor-associated f ( 522) 3654 485.3 1.9e-136 XP_016873709 (OMIM: 602355) PREDICTED: TNF recepto ( 324) 1444 199.6 1.2e-50 NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470) 641 96.1 2.4e-19 XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF ( 485) 625 94.1 1e-18 NP_001186356 (OMIM: 601896,614849) TNF receptor-as ( 485) 625 94.1 1e-18 NP_663777 (OMIM: 601896,614849) TNF receptor-assoc ( 568) 504 78.6 5.6e-14 XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF ( 568) 504 78.6 5.6e-14 XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF ( 568) 504 78.6 5.6e-14 NP_003291 (OMIM: 601896,614849) TNF receptor-assoc ( 568) 504 78.6 5.6e-14 NP_001029082 (OMIM: 602356) TNF receptor-associate ( 557) 498 77.8 9.5e-14 XP_016857710 (OMIM: 602356) PREDICTED: TNF recepto ( 557) 498 77.8 9.5e-14 NP_665702 (OMIM: 602356) TNF receptor-associated f ( 557) 498 77.8 9.5e-14 NP_004610 (OMIM: 602356) TNF receptor-associated f ( 557) 498 77.8 9.5e-14 XP_016877109 (OMIM: 601896,614849) PREDICTED: TNF ( 292) 486 75.9 1.9e-13 NP_663778 (OMIM: 601896,614849) TNF receptor-assoc ( 543) 411 66.5 2.3e-10 XP_016877108 (OMIM: 601896,614849) PREDICTED: TNF ( 543) 411 66.5 2.3e-10 XP_011535419 (OMIM: 601896,614849) PREDICTED: TNF ( 512) 401 65.2 5.3e-10 XP_016870584 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 XP_011517280 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 XP_011517279 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 XP_011517277 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 XP_011517276 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 XP_011517278 (OMIM: 601895) PREDICTED: TNF recepto ( 501) 399 64.9 6.3e-10 NP_066961 (OMIM: 601895) TNF receptor-associated f ( 501) 399 64.9 6.3e-10 XP_016870583 (OMIM: 601895) PREDICTED: TNF recepto ( 533) 399 65.0 6.5e-10 XP_011517275 (OMIM: 601895) PREDICTED: TNF recepto ( 556) 399 65.0 6.7e-10 NP_001177876 (OMIM: 601711) TNF receptor-associate ( 294) 373 61.3 4.7e-09 NP_005649 (OMIM: 601711) TNF receptor-associated f ( 416) 373 61.5 5.8e-09 NP_001177874 (OMIM: 601711) TNF receptor-associate ( 416) 373 61.5 5.8e-09 XP_011535418 (OMIM: 601896,614849) PREDICTED: TNF ( 516) 366 60.7 1.2e-08 XP_011508261 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 290 50.9 1.2e-05 NP_001306136 (OMIM: 602356) TNF receptor-associate ( 568) 290 50.9 1.2e-05 XP_011508262 (OMIM: 602356) PREDICTED: TNF recepto ( 568) 290 50.9 1.2e-05 XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631) 284 50.2 2.1e-05 XP_011523808 (OMIM: 602464) PREDICTED: TNF recepto ( 454) 274 48.7 4.3e-05 XP_011523807 (OMIM: 602464) PREDICTED: TNF recepto ( 461) 274 48.7 4.3e-05 XP_011523806 (OMIM: 602464) PREDICTED: TNF recepto ( 477) 274 48.8 4.4e-05 XP_011523810 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 268 47.8 6.3e-05 XP_011523809 (OMIM: 602464) PREDICTED: TNF recepto ( 352) 268 47.8 6.3e-05 XP_016861431 (OMIM: 609729) PREDICTED: E3 ubiquiti (1037) 253 46.5 0.00046 NP_055824 (OMIM: 609729) E3 ubiquitin-protein liga (1066) 253 46.5 0.00047 NP_001158067 (OMIM: 609730) PDZ domain-containing (1036) 220 42.2 0.0088 >>NP_004611 (OMIM: 602355) TNF receptor-associated facto (522 aa) initn: 3654 init1: 3654 opt: 3654 Z-score: 2570.6 bits: 485.3 E(85289): 1.9e-136 Smith-Waterman score: 3654; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE 430 440 450 460 470 480 490 500 510 520 pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV :::::::::::::::::::::::::::::::::::::::::: NP_004 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV 490 500 510 520 >>NP_665802 (OMIM: 602355) TNF receptor-associated facto (522 aa) initn: 3654 init1: 3654 opt: 3654 Z-score: 2570.6 bits: 485.3 E(85289): 1.9e-136 Smith-Waterman score: 3654; 100.0% identity (100.0% similar) in 522 aa overlap (1-522:1-522) 10 20 30 40 50 60 pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 QLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 GMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_665 HLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLE 430 440 450 460 470 480 490 500 510 520 pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV :::::::::::::::::::::::::::::::::::::::::: NP_665 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV 490 500 510 520 >>XP_016873709 (OMIM: 602355) PREDICTED: TNF receptor-as (324 aa) initn: 1444 init1: 1444 opt: 1444 Z-score: 1030.5 bits: 199.6 E(85289): 1.2e-50 Smith-Waterman score: 1449; 84.7% identity (88.0% similar) in 249 aa overlap (1-249:1-232) 10 20 30 40 50 60 pF1KB5 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSLLNCENSCGSSQSESDCCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NFAKREILSLMVKCPNEGCLHKMELRHLEDHQAHCEFALMDCPQCQRPFQKFHINIHILK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 DCPRRQVSCDNCAASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPI :::::::::::::::::::::: . :. . . .::. : : XP_016 DCPRRQVSCDNCAASMAFEDKE----------------SFTLVAQAGVQWHDLSSPQ-PQ 190 200 210 220 250 260 270 280 290 300 pF1KB5 PCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIH : :. :.: XP_016 PPGFKRFSCLSLLSSWDYRHVPPCPANIFVFLVETRFLHVGQAGLELPTSGNPPALASQS 230 240 250 260 270 280 >>NP_004286 (OMIM: 602464) TNF receptor-associated facto (470 aa) initn: 749 init1: 143 opt: 641 Z-score: 468.4 bits: 96.1 E(85289): 2.4e-19 Smith-Waterman score: 746; 26.7% identity (57.8% similar) in 469 aa overlap (53-499:1-462) 30 40 50 60 70 80 pF1KB5 MASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALREAVQ . :.: .: . . ::.: .:: :: NP_004 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQ 10 20 30 90 100 110 120 130 pF1KB5 -TPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKC--PNEGC . :::::: .:. . . .. ::: :. : ...:: . ..:.: ..: .::: NP_004 VSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGC 40 50 60 70 80 90 140 150 160 170 180 190 pF1KB5 LHKMELRHLEDHQAHCEFALMDCP-QCQRPFQKFHINIHILKDCPRRQVSCDNCAASMAF . ::::. : : : .. :: .: ... . :. .:::.:...:. :. ... NP_004 RWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSG 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB5 EDKEIHDQNCPLANVICEY-CNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNH : : :. :: .: :: :.. ..:. . .: .:: :::. : ... . NP_004 EAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTY----CTKEFVFDT 160 170 180 190 200 260 270 280 290 300 pF1KB5 LARHLQENTQSHMRMLAQ-AVHSLSVIPDSGYISEVRN-------FQET--IHQLEGRLV . : . . . : .: ... :.... : :... :. .:. NP_004 IQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCP-KLA 210 220 230 240 250 260 310 320 330 340 350 360 pF1KB5 RQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQ : . . .. . ::. .. .. :. .. :. . . .:. :::::..: .:. NP_004 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGS-DGVLIWKIGSYGRRLQEA 270 280 290 300 310 320 370 380 390 400 410 420 pF1KB5 EEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQ . . . ::.::: : :::: . :. ... ....::..... : .:. : ::: NP_004 KAKPNLECFSPAFYTHKYGYKLQVSAFLN-GNGSGEGTHLSLYIRVLPGAFDNLLEWPFA 330 340 350 360 370 380 430 440 450 460 470 480 pF1KB5 GTIRLTILDQSEAPVR--QNHEEIMDAKPELLAFQRP-----TIPRNPKGFGYVTFMHLE . ...::::. . :. : . :. ::.: .. .. :::: :. . NP_004 RRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQ 390 400 410 420 430 440 490 500 510 520 pF1KB5 ALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV .:.:....::....: : NP_004 DIRKRNYVRDDAVFIRAAVELPRKILS 450 460 470 >>XP_011535420 (OMIM: 601896,614849) PREDICTED: TNF rece (485 aa) initn: 506 init1: 242 opt: 625 Z-score: 457.1 bits: 94.1 E(85289): 1e-18 Smith-Waterman score: 645; 28.7% identity (58.7% similar) in 470 aa overlap (49-501:32-479) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: XP_011 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: XP_011 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: XP_011 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEK- ... . : : : : : ..: ... :. :.: ..: XP_011 SQVPM----IALQVSLLQNESVEKNKSI---QSLHNQI----------CSFEIEIERQKE 190 200 210 220 260 270 280 290 300 pF1KB5 MQRNHLAR--HLQENTQSH---MRMLAQAVHSLSVIPD--SGYISEVRNFQETIHQLEGR : ::. .. :::. .:. .. : . .. . . ... : :...:. . .::. XP_011 MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELES- 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 LVRQDHQIRELTAKMETQ-SMYVSELK-RTIRT--LEDKVAEIEAQQCNGIYIWKIGNFG . .. :. . :. .:.: : . . :. . :: .. . .:. . ::. :::: .. XP_011 VDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 MHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSH . . : . ..: :::: :::.: :..:. . ....::: :.::::. XP_011 RRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDAL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 LPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEA :::::. . : ..::. . :.. . . :. .:..:: : . : .:. . XP_011 LPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTV 410 420 430 440 450 490 500 510 520 pF1KB5 LRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV :.. :.:::::.... :.: XP_011 LENGTYIKDDTIFIKVIVDTSDLPDP 460 470 480 >>NP_001186356 (OMIM: 601896,614849) TNF receptor-associ (485 aa) initn: 506 init1: 242 opt: 625 Z-score: 457.1 bits: 94.1 E(85289): 1e-18 Smith-Waterman score: 645; 28.7% identity (58.7% similar) in 470 aa overlap (49-501:32-479) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: NP_001 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: NP_001 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: NP_001 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEK- ... . : : : : : ..: ... :. :.: ..: NP_001 SQVPM----IALQVSLLQNESVEKNKSI---QSLHNQI----------CSFEIEIERQKE 190 200 210 220 260 270 280 290 300 pF1KB5 MQRNHLAR--HLQENTQSH---MRMLAQAVHSLSVIPD--SGYISEVRNFQETIHQLEGR : ::. .. :::. .:. .. : . .. . . ... : :...:. . .::. NP_001 MLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELES- 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 LVRQDHQIRELTAKMETQ-SMYVSELK-RTIRT--LEDKVAEIEAQQCNGIYIWKIGNFG . .. :. . :. .:.: : . . :. . :: .. . .:. . ::. :::: .. NP_001 VDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYK 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 MHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSH . . : . ..: :::: :::.: :..:. . ....::: :.::::. NP_001 RRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMRGEYDAL 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 LPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEA :::::. . : ..::. . :.. . . :. .:..:: : . : .:. . NP_001 LPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIAS-GCPVFVAQTV 410 420 430 440 450 490 500 510 520 pF1KB5 LRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV :.. :.:::::.... :.: NP_001 LENGTYIKDDTIFIKVIVDTSDLPDP 460 470 480 >>NP_663777 (OMIM: 601896,614849) TNF receptor-associate (568 aa) initn: 506 init1: 242 opt: 504 Z-score: 371.9 bits: 78.6 E(85289): 5.6e-14 Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: NP_663 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: NP_663 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: NP_663 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH ... . . : : .:: . : : . :.. :.: .. : . .: .:: :.:. .:: NP_663 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV 190 200 210 220 230 240 260 270 280 290 300 pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG . ... : .. .:. .: . .:: :.. . . .. ...... : ..: NP_663 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 250 260 270 280 290 300 310 320 330 340 pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK .. :: ...:. .:. ..:. ..:: . :: .:... NP_663 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 310 320 330 340 350 360 350 pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW :.:.: : : ::. :: NP_663 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ :: .. . . : . ..: :::: :::.: :..:. . ....::: :. NP_663 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR 430 440 450 460 470 420 430 440 450 460 470 pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT ::::. :::::. . : ..::. . :.. . . :. .:..:: NP_663 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF 480 490 500 510 520 530 480 490 500 510 520 pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV NP_663 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP 540 550 560 >>XP_016877107 (OMIM: 601896,614849) PREDICTED: TNF rece (568 aa) initn: 506 init1: 242 opt: 504 Z-score: 371.9 bits: 78.6 E(85289): 5.6e-14 Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: XP_016 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: XP_016 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: XP_016 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH ... . . : : .:: . : : . :.. :.: .. : . .: .:: :.:. .:: XP_016 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV 190 200 210 220 230 240 260 270 280 290 300 pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG . ... : .. .:. .: . .:: :.. . . .. ...... : ..: XP_016 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 250 260 270 280 290 300 310 320 330 340 pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK .. :: ...:. .:. ..:. ..:: . :: .:... XP_016 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 310 320 330 340 350 360 350 pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW :.:.: : : ::. :: XP_016 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ :: .. . . : . ..: :::: :::.: :..:. . ....::: :. XP_016 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR 430 440 450 460 470 420 430 440 450 460 470 pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT ::::. :::::. . : ..::. . :.. . . :. .:..:: XP_016 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF 480 490 500 510 520 530 480 490 500 510 520 pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV XP_016 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP 540 550 560 >>XP_016877106 (OMIM: 601896,614849) PREDICTED: TNF rece (568 aa) initn: 506 init1: 242 opt: 504 Z-score: 371.9 bits: 78.6 E(85289): 5.6e-14 Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: XP_016 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: XP_016 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: XP_016 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH ... . . : : .:: . : : . :.. :.: .. : . .: .:: :.:. .:: XP_016 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV 190 200 210 220 230 240 260 270 280 290 300 pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG . ... : .. .:. .: . .:: :.. . . .. ...... : ..: XP_016 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 250 260 270 280 290 300 310 320 330 340 pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK .. :: ...:. .:. ..:. ..:: . :: .:... XP_016 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 310 320 330 340 350 360 350 pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW :.:.: : : ::. :: XP_016 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ :: .. . . : . ..: :::: :::.: :..:. . ....::: :. XP_016 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR 430 440 450 460 470 420 430 440 450 460 470 pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT ::::. :::::. . : ..::. . :.. . . :. .:..:: XP_016 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF 480 490 500 510 520 530 480 490 500 510 520 pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV XP_016 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP 540 550 560 >>NP_003291 (OMIM: 601896,614849) TNF receptor-associate (568 aa) initn: 506 init1: 242 opt: 504 Z-score: 371.9 bits: 78.6 E(85289): 5.6e-14 Smith-Waterman score: 638; 26.3% identity (54.2% similar) in 498 aa overlap (49-463:32-525) 20 30 40 50 60 70 pF1KB5 CCVAMASSCSAVTKDDSVGGTASTGNLSSSFMEEIQGYDVEFDPPLESKYECPICLMALR :. : :: .: .:.::.: : ..: NP_003 ESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLC 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB5 EAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREILSLMVKCPNE- :: ::::::..:. . ... :: . .: ......: :: :::::.:.. : :: NP_003 SPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNES 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB5 -GCLHKMELRHLEDH-QAHCEFALMDC--PQCQRPFQKFHINIHILKDCPRRQVSCDNCA :: ... : :: : . :.: . : :.:.. . . :. : : :...:..: NP_003 RGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB5 ASMAFEDKEIH-DQNCPLANVICEY-CNT-ILIREQMPNHYDLDCPTAPIPCTFSTFGCH ... . . : : .:: . : : . :.. :.: .. : . .: .:: :.:. .:: NP_003 SQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLS-ECVNAPSTCSFKRYGCV 190 200 210 220 230 240 260 270 280 290 300 pF1KB5 EKMQRNHLARHLQENTQSHMRMLAQAVHSL----SVIPDSGYISE--VRNFQETIHQLEG . ... : .. .:. .: . .:: :.. . . .. ...... : ..: NP_003 FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEI 250 260 270 280 290 300 310 320 330 340 pF1KB5 RLVRQDHQIRELTAKM-------ETQSMYVSELKRTIR-----------------TLEDK .. :: ...:. .:. ..:. ..:: . :: .:... NP_003 EIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNR 310 320 330 340 350 360 350 pF1KB5 VAEIE-----AQQC----------------------------------------NGIYIW :.:.: : : ::. :: NP_003 VTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIW 370 380 390 400 410 420 360 370 380 390 400 410 pF1KB5 KIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQ :: .. . . : . ..: :::: :::.: :..:. . ....::: :. NP_003 KIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGK-GTHLSLFFVIMR 430 440 450 460 470 420 430 440 450 460 470 pF1KB5 GEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVT ::::. :::::. . : ..::. . :.. . . :. .:..:: NP_003 GEYDALLPWPFKQKVTLMLMDQGSS--RRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVF 480 490 500 510 520 530 480 490 500 510 520 pF1KB5 FMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV NP_003 VAQTVLENGTYIKDDTIFIKVIVDTSDLPDP 540 550 560 522 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:46:51 2016 done: Thu Nov 3 17:46:52 2016 Total Scan time: 9.320 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]