FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5635, 474 aa 1>>>pF1KB5635 474 - 474 aa - 474 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9915+/-0.000503; mu= 15.2209+/- 0.031 mean_var=132.4603+/-28.313, 0's: 0 Z-trim(111.0): 192 B-trim: 59 in 1/54 Lambda= 0.111438 statistics sampled from 19169 (19433) to 19169 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.586), E-opt: 0.2 (0.228), width: 16 Scan time: 6.850 The best scores are: opt bits E(85289) XP_016874611 (OMIM: 605269) PREDICTED: coronin-1C ( 474) 3208 528.1 2e-149 XP_016874612 (OMIM: 605269) PREDICTED: coronin-1C ( 474) 3208 528.1 2e-149 NP_055140 (OMIM: 605269) coronin-1C isoform b [Hom ( 474) 3208 528.1 2e-149 NP_001263400 (OMIM: 605269) coronin-1C isoform b [ ( 474) 3208 528.1 2e-149 NP_001098707 (OMIM: 605269) coronin-1C isoform a [ ( 527) 3208 528.2 2.2e-149 XP_016874610 (OMIM: 605269) PREDICTED: coronin-1C ( 527) 3208 528.2 2.2e-149 NP_001018080 (OMIM: 609849) coronin-1B [Homo sapie ( 489) 2474 410.1 6.9e-114 NP_065174 (OMIM: 609849) coronin-1B [Homo sapiens] ( 489) 2474 410.1 6.9e-114 XP_011544016 (OMIM: 605000,615401) PREDICTED: coro ( 461) 2155 358.8 1.8e-98 NP_001180262 (OMIM: 605000,615401) coronin-1A [Hom ( 461) 2155 358.8 1.8e-98 NP_009005 (OMIM: 605000,615401) coronin-1A [Homo s ( 461) 2155 358.8 1.8e-98 XP_016878374 (OMIM: 605000,615401) PREDICTED: coro ( 463) 2150 358.0 3.2e-98 XP_016878375 (OMIM: 605000,615401) PREDICTED: coro ( 463) 2150 358.0 3.2e-98 XP_011536427 (OMIM: 605269) PREDICTED: coronin-1C ( 286) 1764 295.7 1.1e-79 NP_001177385 (OMIM: 605002) coronin-2B isoform 2 [ ( 475) 1429 242.1 2.5e-63 NP_001310944 (OMIM: 605002) coronin-2B isoform 2 [ ( 475) 1429 242.1 2.5e-63 NP_001177386 (OMIM: 605002) coronin-2B isoform 2 [ ( 475) 1429 242.1 2.5e-63 NP_001310943 (OMIM: 605002) coronin-2B isoform 2 [ ( 475) 1429 242.1 2.5e-63 NP_006082 (OMIM: 605002) coronin-2B isoform 1 [Hom ( 480) 1429 242.1 2.5e-63 NP_438171 (OMIM: 602159) coronin-2A [Homo sapiens] ( 525) 1385 235.1 3.6e-61 XP_011517288 (OMIM: 602159) PREDICTED: coronin-2A ( 525) 1385 235.1 3.6e-61 NP_003380 (OMIM: 602159) coronin-2A [Homo sapiens] ( 525) 1385 235.1 3.6e-61 NP_078811 (OMIM: 611668) coronin-7 isoform 1 [Homo ( 925) 719 128.3 9.1e-29 NP_001188401 (OMIM: 611668) coronin-7 isoform 2 [H ( 907) 619 112.2 6.2e-24 NP_001188402 (OMIM: 611668) coronin-7 isoform 3 [H ( 840) 506 94.0 1.7e-18 NP_599027 (OMIM: 610091) WD repeat and SOCS box-co ( 275) 255 53.1 1.2e-06 NP_056441 (OMIM: 610091) WD repeat and SOCS box-co ( 421) 254 53.1 1.7e-06 XP_016879923 (OMIM: 610091) PREDICTED: WD repeat a ( 216) 193 43.0 0.00098 XP_005258020 (OMIM: 610091) PREDICTED: WD repeat a ( 216) 193 43.0 0.00098 NP_115737 (OMIM: 606929) THO complex subunit 3 [Ho ( 351) 194 43.4 0.0012 NP_004805 (OMIM: 607797) U5 small nuclear ribonucl ( 357) 191 42.9 0.0017 NP_001333155 (OMIM: 612167) WD repeat-containing p ( 620) 192 43.4 0.0022 NP_065890 (OMIM: 612167) WD repeat-containing prot ( 677) 192 43.4 0.0024 XP_005265403 (OMIM: 612167) PREDICTED: WD repeat-c ( 707) 192 43.4 0.0024 NP_001333157 (OMIM: 612167) WD repeat-containing p ( 607) 191 43.2 0.0024 XP_011532273 (OMIM: 612167) PREDICTED: WD repeat-c ( 637) 191 43.2 0.0025 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 186 42.0 0.0025 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 186 42.0 0.0025 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 186 42.3 0.0039 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 186 42.3 0.0039 XP_005262782 (OMIM: 609005) PREDICTED: WD repeat-c (1216) 184 42.4 0.0085 NP_001246 (OMIM: 603618) cell division cycle prote ( 499) 178 41.0 0.0091 >>XP_016874611 (OMIM: 605269) PREDICTED: coronin-1C isof (474 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.6 bits: 528.1 E(85289): 2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA 430 440 450 460 470 >>XP_016874612 (OMIM: 605269) PREDICTED: coronin-1C isof (474 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.6 bits: 528.1 E(85289): 2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA 430 440 450 460 470 >>NP_055140 (OMIM: 605269) coronin-1C isoform b [Homo sa (474 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.6 bits: 528.1 E(85289): 2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA 430 440 450 460 470 >>NP_001263400 (OMIM: 605269) coronin-1C isoform b [Homo (474 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.6 bits: 528.1 E(85289): 2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA 430 440 450 460 470 >>NP_001098707 (OMIM: 605269) coronin-1C isoform a [Homo (527 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.0 bits: 528.2 E(85289): 2.2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:54-527) 10 20 30 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVS :::::::::::::::::::::::::::::: NP_001 IACQGSLTSARLHAPSIGERPLSHMRWKDTMRRVVRQSKFRHVFGQAVKNDQCYDDIRVS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB5 RVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCP 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB5 HNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAG 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB5 CDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVA 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB5 EKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLL 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB5 PFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKC 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB5 EIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISL 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 KHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKS 450 460 470 480 490 500 460 470 pF1KB5 IKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::: NP_001 IKDTICNQDERISKLEQQMAKIAA 510 520 >>XP_016874610 (OMIM: 605269) PREDICTED: coronin-1C isof (527 aa) initn: 3208 init1: 3208 opt: 3208 Z-score: 2803.0 bits: 528.2 E(85289): 2.2e-149 Smith-Waterman score: 3208; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:54-527) 10 20 30 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVS :::::::::::::::::::::::::::::: XP_016 IACQGSLTSARLHAPSIGERPLSHMRWKDTMRRVVRQSKFRHVFGQAVKNDQCYDDIRVS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB5 RVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCP 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB5 HNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAG 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB5 CDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVA 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB5 EKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLL 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB5 PFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKC 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB5 EIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISL 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 KHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKS 450 460 470 480 490 500 460 470 pF1KB5 IKDTICNQDERISKLEQQMAKIAA :::::::::::::::::::::::: XP_016 IKDTICNQDERISKLEQQMAKIAA 510 520 >>NP_001018080 (OMIM: 609849) coronin-1B [Homo sapiens] (489 aa) initn: 2445 init1: 2445 opt: 2474 Z-score: 2165.7 bits: 410.1 E(85289): 6.9e-114 Smith-Waterman score: 2538; 73.2% identity (91.5% similar) in 481 aa overlap (2-472:4-484) 10 20 30 40 50 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAF :.::::::::::::: :::::::.:::::::::::.::::::.:.:.:.:::::::: NP_001 MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 LVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLS ::::: :::::::.:::::::::::::::::::::.:::::::::::::::::::::: NP_001 LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIY ::::::.::::.:::::.:::::::::::::::::...::::::.: : ::..: :.:: NP_001 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 NVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFS :::::.::::.:.: :::.::.::::. .:::.::::::::::::::::::.::::::: NP_001 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 RMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE ::::::::::.:.:..::.::.:.:.:::.::::::::::..:.::::::::::::::.: NP_001 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 SPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQ ::.:.::::.::::::::: ::::::.:.:::::::.::::::::::.::::::::::: NP_001 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNIL-DSKPTAN ::::::::::::::::::: :..::::::::...:.:.:.::::. ..:.: ::.:. NP_001 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 370 380 390 400 410 420 420 430 440 450 460 pF1KB5 KKCDLISIPKKTTDTASVQ--------NEA-KLDEILKEIKSIKDTICNQDERISKLEQQ . .. : .:: .:.. .:: ::.:...:..... . .: .:: .::.: NP_001 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 430 440 450 460 470 480 470 pF1KB5 MAKIAA .... NP_001 LGRMENGDA >>NP_065174 (OMIM: 609849) coronin-1B [Homo sapiens] (489 aa) initn: 2445 init1: 2445 opt: 2474 Z-score: 2165.7 bits: 410.1 E(85289): 6.9e-114 Smith-Waterman score: 2538; 73.2% identity (91.5% similar) in 481 aa overlap (2-472:4-484) 10 20 30 40 50 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAF :.::::::::::::: :::::::.:::::::::::.::::::.:.:.:.:::::::: NP_065 MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 LVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLS ::::: :::::::.:::::::::::::::::::::.:::::::::::::::::::::: NP_065 LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIY ::::::.::::.:::::.:::::::::::::::::...::::::.: : ::..: :.:: NP_065 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 NVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFS :::::.::::.:.: :::.::.::::. .:::.::::::::::::::::::.::::::: NP_065 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 RMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE ::::::::::.:.:..::.::.:.:.:::.::::::::::..:.::::::::::::::.: NP_065 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 SPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQ ::.:.::::.::::::::: ::::::.:.:::::::.::::::::::.::::::::::: NP_065 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNIL-DSKPTAN ::::::::::::::::::: :..::::::::...:.:.:.::::. ..:.: ::.:. NP_065 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 370 380 390 400 410 420 420 430 440 450 460 pF1KB5 KKCDLISIPKKTTDTASVQ--------NEA-KLDEILKEIKSIKDTICNQDERISKLEQQ . .. : .:: .:.. .:: ::.:...:..... . .: .:: .::.: NP_065 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 430 440 450 460 470 480 470 pF1KB5 MAKIAA .... NP_065 LGRMENGDA >>XP_011544016 (OMIM: 605000,615401) PREDICTED: coronin- (461 aa) initn: 2122 init1: 1198 opt: 2155 Z-score: 1888.8 bits: 358.8 E(85289): 1.8e-98 Smith-Waterman score: 2170; 65.3% identity (88.0% similar) in 467 aa overlap (2-467:3-456) 10 20 30 40 50 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFL :.:::.::::::::: .: ::::.:.:::..::::.::::::.:::.: ::::::::: XP_011 MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 VLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSL :::: ::::.::. :::::::.::::: ::::::.::::::::::::::.::..:: : : XP_011 VLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLD-DMHSDMIY :::: ::::.::::::::: ::.::::::::::.:..:.:::: :...: ..: : :: XP_011 REPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 NVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFS .:.:.:.:.::::. .::.::.:.::: .::::.. :::.::.::.:...:...::::: XP_011 SVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 RMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE ::::::.:::. :...::..:.:.:::.::::::.::::.:.::::::::::::::::.: XP_011 RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 SPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQ .:..:::. ::::: ::::::::::::.:::::::::.:::::.:::: ::::::::::: XP_011 APFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANK .:::: ::::. :: ::::. :..: :.::::: ::.: :.:.:.: . :: :. . XP_011 EDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRG--LD---TGRR 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 KCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA . . :. .. : : . ..:.: :..... :. . ..:...::. XP_011 R----AAPE-ASGTPSSDAVSRLEE---EMRKLQATVQELQKRLDRLEETVQAK 420 430 440 450 460 >>NP_001180262 (OMIM: 605000,615401) coronin-1A [Homo sa (461 aa) initn: 2122 init1: 1198 opt: 2155 Z-score: 1888.8 bits: 358.8 E(85289): 1.8e-98 Smith-Waterman score: 2170; 65.3% identity (88.0% similar) in 467 aa overlap (2-467:3-456) 10 20 30 40 50 pF1KB5 MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFL :.:::.::::::::: .: ::::.:.:::..::::.::::::.:::.: ::::::::: NP_001 MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 VLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSL :::: ::::.::. :::::::.::::: ::::::.::::::::::::::.::..:: : : NP_001 VLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLD-DMHSDMIY :::: ::::.::::::::: ::.::::::::::.:..:.:::: :...: ..: : :: NP_001 REPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIY 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 NVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFS .:.:.:.:.::::. .::.::.:.::: .::::.. :::.::.::.:...:...::::: NP_001 SVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 RMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDE ::::::.:::. :...::..:.:.:::.::::::.::::.:.::::::::::::::::.: NP_001 RMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 SPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQ .:..:::. ::::: ::::::::::::.:::::::::.:::::.:::: ::::::::::: NP_001 APFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQ 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 DDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANK .:::: ::::. :: ::::. :..: :.::::: ::.: :.:.:.: . :: :. . NP_001 EDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRG--LD---TGRR 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 KCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA . . :. .. : : . ..:.: :..... :. . ..:...::. NP_001 R----AAPE-ASGTPSSDAVSRLEE---EMRKLQATVQELQKRLDRLEETVQAK 420 430 440 450 460 474 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:09:05 2016 done: Sat Nov 5 13:09:06 2016 Total Scan time: 6.850 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]