FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5651, 400 aa 1>>>pF1KB5651 400 - 400 aa - 400 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.0291+/-0.000311; mu= 0.3884+/- 0.019 mean_var=209.0335+/-42.027, 0's: 0 Z-trim(123.5): 79 B-trim: 47 in 1/59 Lambda= 0.088709 statistics sampled from 43427 (43563) to 43427 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.809), E-opt: 0.2 (0.511), width: 16 Scan time: 7.680 The best scores are: opt bits E(85289) XP_016861610 (OMIM: 607392) PREDICTED: WW domain-c ( 400) 2750 364.1 3.5e-100 XP_016861611 (OMIM: 607392) PREDICTED: WW domain-c ( 400) 2750 364.1 3.5e-100 NP_001161752 (OMIM: 607392) WW domain-containing t ( 400) 2750 364.1 3.5e-100 NP_056287 (OMIM: 607392) WW domain-containing tran ( 400) 2750 364.1 3.5e-100 NP_001161750 (OMIM: 607392) WW domain-containing t ( 400) 2750 364.1 3.5e-100 NP_001269027 (OMIM: 120433,606608) transcriptional ( 454) 881 124.9 3.9e-28 NP_001269026 (OMIM: 120433,606608) transcriptional ( 466) 872 123.8 8.8e-28 NP_001269028 (OMIM: 120433,606608) transcriptional ( 470) 862 122.5 2.2e-27 XP_016872582 (OMIM: 120433,606608) PREDICTED: tran ( 310) 617 91.0 4.3e-18 NP_001269029 (OMIM: 120433,606608) transcriptional ( 492) 616 91.0 6.7e-18 XP_005271438 (OMIM: 120433,606608) PREDICTED: tran ( 494) 609 90.1 1.3e-17 NP_001181974 (OMIM: 120433,606608) transcriptional ( 326) 488 74.5 4.1e-13 NP_006097 (OMIM: 120433,606608) transcriptional co ( 450) 487 74.5 5.8e-13 XP_011540858 (OMIM: 120433,606608) PREDICTED: tran ( 330) 466 71.7 2.9e-12 XP_011540857 (OMIM: 120433,606608) PREDICTED: tran ( 332) 463 71.3 3.8e-12 NP_001123617 (OMIM: 120433,606608) transcriptional ( 504) 440 68.5 4.1e-11 XP_005271440 (OMIM: 120433,606608) PREDICTED: tran ( 490) 422 66.2 2e-10 NP_001181973 (OMIM: 120433,606608) transcriptional ( 488) 420 65.9 2.4e-10 NP_001269030 (OMIM: 120433,606608) transcriptional ( 508) 419 65.8 2.7e-10 XP_005271435 (OMIM: 120433,606608) PREDICTED: tran ( 510) 419 65.8 2.7e-10 XP_005271437 (OMIM: 120433,606608) PREDICTED: tran ( 506) 414 65.2 4.2e-10 >>XP_016861610 (OMIM: 607392) PREDICTED: WW domain-conta (400 aa) initn: 2750 init1: 2750 opt: 2750 Z-score: 1919.6 bits: 364.1 E(85289): 3.5e-100 Smith-Waterman score: 2750; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF 310 320 330 340 350 360 370 380 390 400 pF1KB5 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL :::::::::::::::::::::::::::::::::::::::: XP_016 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL 370 380 390 400 >>XP_016861611 (OMIM: 607392) PREDICTED: WW domain-conta (400 aa) initn: 2750 init1: 2750 opt: 2750 Z-score: 1919.6 bits: 364.1 E(85289): 3.5e-100 Smith-Waterman score: 2750; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF 310 320 330 340 350 360 370 380 390 400 pF1KB5 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL :::::::::::::::::::::::::::::::::::::::: XP_016 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL 370 380 390 400 >>NP_001161752 (OMIM: 607392) WW domain-containing trans (400 aa) initn: 2750 init1: 2750 opt: 2750 Z-score: 1919.6 bits: 364.1 E(85289): 3.5e-100 Smith-Waterman score: 2750; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF 310 320 330 340 350 360 370 380 390 400 pF1KB5 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL :::::::::::::::::::::::::::::::::::::::: NP_001 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL 370 380 390 400 >>NP_056287 (OMIM: 607392) WW domain-containing transcri (400 aa) initn: 2750 init1: 2750 opt: 2750 Z-score: 1919.6 bits: 364.1 E(85289): 3.5e-100 Smith-Waterman score: 2750; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF 310 320 330 340 350 360 370 380 390 400 pF1KB5 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL :::::::::::::::::::::::::::::::::::::::: NP_056 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL 370 380 390 400 >>NP_001161750 (OMIM: 607392) WW domain-containing trans (400 aa) initn: 2750 init1: 2750 opt: 2750 Z-score: 1919.6 bits: 364.1 E(85289): 3.5e-100 Smith-Waterman score: 2750; 100.0% identity (100.0% similar) in 400 aa overlap (1-400:1-400) 10 20 30 40 50 60 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSRQSSTDSSGGHPGPRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQQSYDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMAVSQPNLVMNHQHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDF 310 320 330 340 350 360 370 380 390 400 pF1KB5 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL :::::::::::::::::::::::::::::::::::::::: NP_001 LDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLTWL 370 380 390 400 >>NP_001269027 (OMIM: 120433,606608) transcriptional coa (454 aa) initn: 1060 init1: 319 opt: 881 Z-score: 626.1 bits: 124.9 E(85289): 3.9e-28 Smith-Waterman score: 1196; 49.0% identity (69.2% similar) in 441 aa overlap (3-400:38-454) 10 20 30 pF1KB5 MNPAS--APPPLPPPGQQVIHVTQDLDTDLEA ::. : : :: :.:..:: : .::::: NP_001 PPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEA 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 LFNSVMNPK----PSS--WRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQH :::.::::: :.. : . ::.:::: :. :::::.:::. : : : :: NP_001 LFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDA--GTAG---ALTPQH 70 80 90 100 110 120 90 100 110 120 130 pF1KB5 VRSHSSPASLQLG---------TG--AGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMT ::.:::::::::: :: .: :..:. :: :::.:... :..::: ::::. NP_001 VRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQH--LRQSSFEIPDDVPLPAGWEMA 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB5 FTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQRSMAVSQPNLVMNH :..:::::::::.. :::::::::: :..::. : .: :: : : .. .:: NP_001 KTSSGQRYFLNHIDQTTTWQDPRKAM---LSQMNV-TAPTSPPVQQNMMNSAS---AMN- 190 200 210 220 230 200 210 220 230 240 250 pF1KB5 QHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEE :. .: :: : :.: .:.:. :. .:::..:::..:::.::.:..:.: NP_001 QRISQSAPVKQPPPLAP-QSPQGGVMGGSNS-----NQQQQMRLQQLQMEKERLRLKQQE 240 250 260 270 280 260 270 280 290 300 pF1KB5 LMRQ----EAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSRE :.:: : :: ::: : . .: :. : :. ..:..:.::::::::.: ::::. NP_001 LLRQVRPQELALRSQLPT-LEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRD 290 300 310 320 330 340 310 320 330 340 350 360 pF1KB5 QSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNV .::::::... :::: ::.:::..:::::::.. .:. . ::.::::.:. .::::: NP_001 ESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTL--PSQQNRFPDYLEAIPGTNV 350 360 370 380 390 400 370 380 390 400 pF1KB5 DLGTLES-------EDLIP---------LFNDVESALNKS----EPFLTWL ::::::. :.:.: ..::.::.: . : ::::: NP_001 DLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL 410 420 430 440 450 >>NP_001269026 (OMIM: 120433,606608) transcriptional coa (466 aa) initn: 996 init1: 264 opt: 872 Z-score: 619.7 bits: 123.8 E(85289): 8.8e-28 Smith-Waterman score: 1172; 47.7% identity (67.3% similar) in 453 aa overlap (3-400:38-466) 10 20 30 pF1KB5 MNPAS--APPPLPPPGQQVIHVTQDLDTDLEA ::. : : :: :.:..:: : .::::: NP_001 PPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEA 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 LFNSVMNPK----PSS--WRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQH :::.::::: :.. : . ::.:::: :. :::::.:::. : : : :: NP_001 LFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDA--GTAG---ALTPQH 70 80 90 100 110 120 90 100 110 120 130 pF1KB5 VRSHSSPASLQLG---------TG--AGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMT ::.:::::::::: :: .: :..:. :: :::.:... :..::: ::::. NP_001 VRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQH--LRQSSFEIPDDVPLPAGWEMA 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB5 FTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQRSMAVSQPNLVMNH :..:::::::::.. :::::::::: :..::. : .: :: : : .. .:: NP_001 KTSSGQRYFLNHIDQTTTWQDPRKAM---LSQMNV-TAPTSPPVQQNMMNSAS---AMN- 190 200 210 220 230 200 210 220 230 240 250 pF1KB5 QHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEE :. .: :: : :.: .:.:. :. .:::..:::..:::.::.:..:.: NP_001 QRISQSAPVKQPPPLAP-QSPQGGVMGGSNS-----NQQQQMRLQQLQMEKERLRLKQQE 240 250 260 270 280 260 270 280 290 pF1KB5 LMRQ----------------EAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSD :.:: : :: ::: : . .: :. : :. ..:..:.:::: NP_001 LLRQAMRNINPSTANSPKCQELALRSQLPT-LEQDGGTQNPVSSPGMSQELRTMTTNSSD 290 300 310 320 330 340 300 310 320 330 340 350 pF1KB5 PFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRF ::::.: ::::..::::::... :::: ::.:::..:::::::.. .:. . ::.:: NP_001 PFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTL--PSQQNRF 350 360 370 380 390 400 360 370 380 390 pF1KB5 PDFLDCLPGTNVDLGTLES-------EDLIP---------LFNDVESALNKS----EPFL ::.:. .:::::::::::. :.:.: ..::.::.: . : :: NP_001 PDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFL 410 420 430 440 450 460 400 pF1KB5 TWL ::: NP_001 TWL >>NP_001269028 (OMIM: 120433,606608) transcriptional coa (470 aa) initn: 1001 init1: 269 opt: 862 Z-score: 612.8 bits: 122.5 E(85289): 2.2e-27 Smith-Waterman score: 1164; 47.3% identity (66.7% similar) in 457 aa overlap (3-400:38-470) 10 20 30 pF1KB5 MNPAS--APPPLPPPGQQVIHVTQDLDTDLEA ::. : : :: :.:..:: : .::::: NP_001 PPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEA 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 LFNSVMNPK----PSS--WRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQH :::.::::: :.. : . ::.:::: :. :::::.:::. : : : :: NP_001 LFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDA--GTAG---ALTPQH 70 80 90 100 110 120 90 100 110 120 130 pF1KB5 VRSHSSPASLQLG---------TG--AGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMT ::.:::::::::: :: .: :..:. :: :::.:... :..::: ::::. NP_001 VRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQH--LRQSSFEIPDDVPLPAGWEMA 130 140 150 160 170 180 140 150 160 170 180 190 pF1KB5 FTATGQRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQRSMAVSQPNLVMNH :..:::::::::.. :::::::::: :..::. : .: :: : : .. .:: NP_001 KTSSGQRYFLNHIDQTTTWQDPRKAM---LSQMNV-TAPTSPPVQQNMMNSAS---AMN- 190 200 210 220 230 200 210 220 230 240 250 pF1KB5 QHQQQMAPSTLSQQNHPTQNPPAGLMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEE :. .: :: : :.: .:.:. :. .:::..:::..:::.::.:..:.: NP_001 QRISQSAPVKQPPPLAP-QSPQGGVMGGSNS-----NQQQQMRLQQLQMEKERLRLKQQE 240 250 260 270 280 260 270 280 290 pF1KB5 LMRQ--------------------EAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITN :.:: : :: ::: : . .: :. : :. ..:..:. NP_001 LLRQVRPQAMRNINPSTANSPKCQELALRSQLPT-LEQDGGTQNPVSSPGMSQELRTMTT 290 300 310 320 330 340 300 310 320 330 340 350 pF1KB5 NSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQ ::::::::.: ::::..::::::... :::: ::.:::..:::::::.. .:. . : NP_001 NSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTL--PSQ 350 360 370 380 390 400 360 370 380 390 pF1KB5 QTRFPDFLDCLPGTNVDLGTLES-------EDLIP---------LFNDVESALNKS---- :.::::.:. .:::::::::::. :.:.: ..::.::.: . NP_001 QNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDK 410 420 430 440 450 460 400 pF1KB5 EPFLTWL : ::::: NP_001 ESFLTWL 470 >>XP_016872582 (OMIM: 120433,606608) PREDICTED: transcri (310 aa) initn: 739 init1: 260 opt: 617 Z-score: 445.9 bits: 91.0 E(85289): 4.3e-18 Smith-Waterman score: 763; 43.8% identity (68.8% similar) in 317 aa overlap (132-400:1-310) 110 120 130 140 150 160 pF1KB5 AAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLNHIEKITTWQDPRKAMNQ :. :..:::::::::.. :::::::::: XP_016 MAKTSSGQRYFLNHIDQTTTWQDPRKAM-- 10 20 170 180 190 200 pF1KB5 PLNHMNLHPAVSSTPVPQRSM-------------AVSQPNLV--MNHQHQQ------QMA :..::. : .: :: : : :..: . . .::... .. XP_016 -LSQMNV-TAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLD 30 40 50 60 70 80 210 220 230 240 250 pF1KB5 PS-TLSQ---QNHPTQNPPAGLMSMPNALT---TQQQQQQKLRLQRIQMERERIRMRQEE : ...: :. :...:: . :.. . ....:::..:::..:::.::.:..:.: XP_016 PRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQE 90 100 110 120 130 140 260 270 280 290 300 310 pF1KB5 LMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSREQSTD :.::: :: ::: : . .: :. : :. ..:..:.::::::::.: ::::..::: XP_016 LLRQELALRSQLPT-LEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTD 150 160 170 180 190 200 320 330 340 350 360 370 pF1KB5 SGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGT :::... :::: ::.:::..:::::::.. .:. . ::.::::.:. .::::::::: XP_016 SGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLP--SQQNRFPDYLEAIPGTNVDLGT 210 220 230 240 250 260 380 390 400 pF1KB5 LES-------EDLIP---------LFNDVESALNKS----EPFLTWL ::. :.:.: ..::.::.: . : ::::: XP_016 LEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL 270 280 290 300 310 >>NP_001269029 (OMIM: 120433,606608) transcriptional coa (492 aa) initn: 1162 init1: 319 opt: 616 Z-score: 442.3 bits: 91.0 E(85289): 6.7e-18 Smith-Waterman score: 1163; 45.9% identity (67.9% similar) in 464 aa overlap (6-400:43-492) 10 20 30 pF1KB5 MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSV : : :: :.:..:: : .::::::::.: NP_001 PQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAV 20 30 40 50 60 70 40 50 60 70 80 pF1KB5 MNPK----PSS--WRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHS :::: :.. : . ::.:::: :. :::::.:::. : : : ::::.:: NP_001 MNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDA--GTAG---ALTPQHVRAHS 80 90 100 110 120 90 100 110 120 130 pF1KB5 SPASLQLG---------TG--AGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATG :::::::: :: .: :..:. :: :::.:... :..::: ::::. :..: NP_001 SPASLQLGAVSPGTLTPTGVVSGPAATPTAQH--LRQSSFEIPDDVPLPAGWEMAKTSSG 130 140 150 160 170 180 140 150 160 170 180 pF1KB5 QRYFLNHIEKITTWQDPRKAMNQPLNHMNLHPAVSSTPVPQRSM-------------AVS ::::::::.. :::::::::: :..::. : .: :: : : :.. NP_001 QRYFLNHIDQTTTWQDPRKAM---LSQMNV-TAPTSPPVQQNMMNSASGPLPDGWEQAMT 190 200 210 220 230 240 190 200 210 220 230 pF1KB5 QPNLV--MNHQHQQ------QMAPS-TLSQ---QNHPTQNPPAGLMSMPNALT---TQQQ : . . .::... .. : ...: :. :...:: . :.. . .... NP_001 QDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSN 250 260 270 280 290 300 240 250 260 270 280 pF1KB5 QQQKLRLQRIQMERERIRMRQEELMRQ----EAALCRQLPMEAETLAPVQAAVNPPTMTP :::..:::..:::.::.:..:.::.:: : :: ::: : . .: :. : :. NP_001 QQQQMRLQQLQMEKERLRLKQQELLRQVRPQELALRSQLPT-LEQDGGTQNPVSSPGMSQ 310 320 330 340 350 360 290 300 310 320 330 340 pF1KB5 DMRSITNNSSDPFLNGGPYHSREQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQT ..:..:.::::::::.: ::::..::::::... :::: ::.:::..:::::::.. .:. NP_001 ELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQS 370 380 390 400 410 420 350 360 370 380 390 pF1KB5 PMNINPQQTRFPDFLDCLPGTNVDLGTLES-------EDLIP---------LFNDVESAL . ::.::::.:. .:::::::::::. :.:.: ..::.::.: NP_001 TL--PSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVL 430 440 450 460 470 400 pF1KB5 NKS----EPFLTWL . : ::::: NP_001 AATKLDKESFLTWL 480 490 400 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Wed Nov 2 23:04:08 2016 done: Wed Nov 2 23:04:09 2016 Total Scan time: 7.680 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]