FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5662, 372 aa 1>>>pF1KB5662 372 - 372 aa - 372 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.0339+/-0.000917; mu= -2.5026+/- 0.055 mean_var=304.9786+/-64.924, 0's: 0 Z-trim(116.1): 302 B-trim: 3 in 1/53 Lambda= 0.073441 statistics sampled from 16351 (16690) to 16351 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.805), E-opt: 0.2 (0.513), width: 16 Scan time: 2.850 The best scores are: opt bits E(32554) CCDS6357.1 TRIB1 gene_id:10221|Hs108|chr8 ( 372) 2529 280.8 1.3e-75 CCDS64971.1 TRIB1 gene_id:10221|Hs108|chr8 ( 206) 1378 158.6 4.4e-39 CCDS1683.1 TRIB2 gene_id:28951|Hs108|chr2 ( 343) 1266 147.0 2.4e-35 CCDS77554.1 TRIB3 gene_id:57761|Hs108|chr20 ( 385) 992 118.0 1.4e-26 CCDS12997.1 TRIB3 gene_id:57761|Hs108|chr20 ( 358) 988 117.5 1.8e-26 >>CCDS6357.1 TRIB1 gene_id:10221|Hs108|chr8 (372 aa) initn: 2529 init1: 2529 opt: 2529 Z-score: 1470.8 bits: 280.8 E(32554): 1.3e-75 Smith-Waterman score: 2529; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS63 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE 310 320 330 340 350 360 370 pF1KB5 YQEDSDISSFFC :::::::::::: CCDS63 YQEDSDISSFFC 370 >>CCDS64971.1 TRIB1 gene_id:10221|Hs108|chr8 (206 aa) initn: 1378 init1: 1378 opt: 1378 Z-score: 815.1 bits: 158.6 E(32554): 4.4e-39 Smith-Waterman score: 1378; 100.0% identity (100.0% similar) in 206 aa overlap (167-372:1-206) 140 150 160 170 180 190 pF1KB5 LPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHC :::::::::::::::::::::::::::::: CCDS64 MHSYVRSRKRLREEEAARLFKQIVSAVAHC 10 20 30 200 210 220 230 240 250 pF1KB5 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB5 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB5 SLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 SLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC 160 170 180 190 200 >>CCDS1683.1 TRIB2 gene_id:28951|Hs108|chr2 (343 aa) initn: 1283 init1: 1215 opt: 1266 Z-score: 748.0 bits: 147.0 E(32554): 2.4e-35 Smith-Waterman score: 1275; 61.9% identity (81.2% similar) in 320 aa overlap (56-371:35-342) 30 40 50 60 70 80 pF1KB5 TRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPP-GSPCSPQPPPAAPGAGGGSGS : . .:: ::: :. : . . CCDS16 RSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCV------ 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 APGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNIT : :. :::: : .:: ::. .:.:.:: :::: :. ::... : . : .::::. CCDS16 ----SCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNIN 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB5 GIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLG :.:.::::::::::::...:::::.::. :.:::::::::: ::.:::::::....:: CCDS16 QITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLR 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB5 DLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA :::::::.:. ::::...::::::..:..:.::.::::::::::::::::::.:.::::: CCDS16 DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKA 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB5 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPS ::::::::::::.::::::::: .::.:::::::::: ::: .::::.:::::.:::::: CCDS16 ADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPS 240 250 260 270 280 290 330 340 350 360 370 pF1KB5 ERLTAPEILLHPWFE---SVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC ::::. ::: :::: :: . .: .:. :::.::. . . ... :: CCDS16 ERLTSQEILDHPWFSTDFSVSNSAYGAKEV--SDQLVPDVNMEENLDPFFN 300 310 320 330 340 >>CCDS77554.1 TRIB3 gene_id:57761|Hs108|chr20 (385 aa) initn: 1019 init1: 928 opt: 992 Z-score: 590.5 bits: 118.0 E(32554): 1.4e-26 Smith-Waterman score: 992; 46.6% identity (70.1% similar) in 348 aa overlap (15-360:27-365) 10 20 30 40 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCP : :. : :: .. :. :. :: . .. : CCDS77 MVLMHLAVKNNRMSANNDHFLTPTWQQMRATPLAAPAG-SLSRKKRLELDDN--LDTERP 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 RLSECSSPPDYLSPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSR .. : :. : :: : ::.:: . . ..: ::.. :.:: : .. . CCDS77 VQKRARSGPQ---PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQ 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 ALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDM :: :: : :::.:... ..:: .:: :.... .::. : :.:: . ::: CCDS77 ALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDM 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLE :: ::::.:. : ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:: CCDS77 HSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 DTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDS :. .. : ::.: :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.:: CCDS77 DSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 DPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GY .: ::.::::: . .: .: ::::.: ::::::.::::: ::::::... : . CCDS77 EPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAP 300 310 320 330 340 350 350 360 370 pF1KB5 IDSEIGTSDQIVPEYQEDSDISSFFC :.. . :.::. CCDS77 TRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG 360 370 380 >>CCDS12997.1 TRIB3 gene_id:57761|Hs108|chr20 (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 588.6 bits: 117.5 E(32554): 1.8e-26 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. CCDS12 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : CCDS12 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : CCDS12 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: CCDS12 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: CCDS12 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: CCDS12 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. CCDS12 PDGLGLDEAREEEGDREVVLYG 340 350 372 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:53:42 2016 done: Thu Nov 3 17:53:43 2016 Total Scan time: 2.850 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]