FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5662, 372 aa 1>>>pF1KB5662 372 - 372 aa - 372 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.3808+/-0.000364; mu= 1.4572+/- 0.023 mean_var=369.3764+/-78.452, 0's: 0 Z-trim(124.0): 916 B-trim: 2412 in 1/61 Lambda= 0.066733 statistics sampled from 43536 (44740) to 43536 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.806), E-opt: 0.2 (0.525), width: 16 Scan time: 9.250 The best scores are: opt bits E(85289) NP_079471 (OMIM: 609461) tribbles homolog 1 isofor ( 372) 2529 256.8 5.7e-68 NP_001269914 (OMIM: 609461) tribbles homolog 1 iso ( 206) 1378 145.7 9e-35 NP_067675 (OMIM: 609462) tribbles homolog 2 [Homo ( 343) 1266 135.2 2.2e-31 XP_016883478 (OMIM: 607898) PREDICTED: tribbles ho ( 385) 992 108.9 2e-23 NP_001288130 (OMIM: 607898) tribbles homolog 3 iso ( 385) 992 108.9 2e-23 NP_001288122 (OMIM: 607898) tribbles homolog 3 iso ( 358) 988 108.5 2.6e-23 NP_001288125 (OMIM: 607898) tribbles homolog 3 iso ( 358) 988 108.5 2.6e-23 NP_001288119 (OMIM: 607898) tribbles homolog 3 iso ( 358) 988 108.5 2.6e-23 NP_001288117 (OMIM: 607898) tribbles homolog 3 iso ( 358) 988 108.5 2.6e-23 NP_066981 (OMIM: 607898) tribbles homolog 3 isofor ( 358) 988 108.5 2.6e-23 NP_001269476 (OMIM: 609437) serine/threonine-prote ( 435) 421 54.0 7.8e-07 NP_114406 (OMIM: 609437) serine/threonine-protein ( 435) 421 54.0 7.8e-07 NP_001269475 (OMIM: 609437) serine/threonine-prote ( 440) 421 54.0 7.9e-07 NP_115806 (OMIM: 609235) serine/threonine-protein ( 778) 422 54.4 1.1e-06 XP_011516388 (OMIM: 607025) PREDICTED: maternal em ( 373) 407 52.5 1.8e-06 NP_001094064 (OMIM: 612760) SNF-related serine/thr ( 765) 413 53.5 1.9e-06 XP_005265302 (OMIM: 612760) PREDICTED: SNF-related ( 765) 413 53.5 1.9e-06 NP_060189 (OMIM: 612760) SNF-related serine/threon ( 765) 413 53.5 1.9e-06 NP_006243 (OMIM: 600497) 5'-AMP-activated protein ( 552) 409 52.9 2e-06 NP_001243614 (OMIM: 607025) maternal embryonic leu ( 610) 407 52.8 2.5e-06 NP_001243618 (OMIM: 607025) maternal embryonic leu ( 619) 407 52.8 2.5e-06 XP_011516385 (OMIM: 607025) PREDICTED: maternal em ( 619) 407 52.8 2.5e-06 XP_011516386 (OMIM: 607025) PREDICTED: maternal em ( 619) 407 52.8 2.5e-06 XP_011516384 (OMIM: 607025) PREDICTED: maternal em ( 619) 407 52.8 2.5e-06 XP_011516383 (OMIM: 607025) PREDICTED: maternal em ( 619) 407 52.8 2.5e-06 XP_011516382 (OMIM: 607025) PREDICTED: maternal em ( 622) 407 52.8 2.5e-06 XP_011516381 (OMIM: 607025) PREDICTED: maternal em ( 651) 407 52.8 2.6e-06 XP_011516378 (OMIM: 607025) PREDICTED: maternal em ( 651) 407 52.8 2.6e-06 NP_055606 (OMIM: 607025) maternal embryonic leucin ( 651) 407 52.8 2.6e-06 XP_011516380 (OMIM: 607025) PREDICTED: maternal em ( 651) 407 52.8 2.6e-06 XP_011516379 (OMIM: 607025) PREDICTED: maternal em ( 651) 407 52.8 2.6e-06 XP_011541028 (OMIM: 614776) PREDICTED: serine/thre ( 660) 402 52.4 3.6e-06 XP_005259384 (OMIM: 609235) PREDICTED: serine/thre ( 688) 402 52.4 3.7e-06 XP_005267700 (OMIM: 602678) PREDICTED: MAP/microtu ( 643) 400 52.2 4.1e-06 NP_742081 (OMIM: 607707) calcium/calmodulin-depend ( 449) 396 51.6 4.2e-06 XP_016876782 (OMIM: 602678) PREDICTED: MAP/microtu ( 708) 400 52.2 4.3e-06 NP_001122392 (OMIM: 602678) MAP/microtubule affini ( 713) 400 52.2 4.3e-06 XP_016876781 (OMIM: 602678) PREDICTED: MAP/microtu ( 722) 400 52.2 4.4e-06 XP_016876780 (OMIM: 602678) PREDICTED: MAP/microtu ( 728) 400 52.2 4.4e-06 NP_002367 (OMIM: 602678) MAP/microtubule affinity- ( 729) 400 52.2 4.4e-06 NP_742080 (OMIM: 607707) calcium/calmodulin-depend ( 479) 396 51.6 4.4e-06 XP_005267699 (OMIM: 602678) PREDICTED: MAP/microtu ( 737) 400 52.2 4.4e-06 XP_005267698 (OMIM: 602678) PREDICTED: MAP/microtu ( 738) 400 52.2 4.4e-06 XP_006720209 (OMIM: 602678) PREDICTED: MAP/microtu ( 739) 400 52.2 4.4e-06 NP_001122391 (OMIM: 602678) MAP/microtubule affini ( 744) 400 52.2 4.4e-06 NP_001122390 (OMIM: 602678) MAP/microtubule affini ( 753) 400 52.2 4.5e-06 NP_742079 (OMIM: 607707) calcium/calmodulin-depend ( 492) 396 51.6 4.5e-06 XP_016868154 (OMIM: 607707) PREDICTED: calcium/cal ( 493) 396 51.6 4.5e-06 XP_005249921 (OMIM: 607707) PREDICTED: calcium/cal ( 494) 396 51.6 4.5e-06 XP_016868153 (OMIM: 607707) PREDICTED: calcium/cal ( 502) 396 51.6 4.5e-06 >>NP_079471 (OMIM: 609461) tribbles homolog 1 isoform 1 (372 aa) initn: 2529 init1: 2529 opt: 2529 Z-score: 1341.3 bits: 256.8 E(85289): 5.7e-68 Smith-Waterman score: 2529; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 FCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPE 310 320 330 340 350 360 370 pF1KB5 YQEDSDISSFFC :::::::::::: NP_079 YQEDSDISSFFC 370 >>NP_001269914 (OMIM: 609461) tribbles homolog 1 isoform (206 aa) initn: 1378 init1: 1378 opt: 1378 Z-score: 745.3 bits: 145.7 E(85289): 9e-35 Smith-Waterman score: 1378; 100.0% identity (100.0% similar) in 206 aa overlap (167-372:1-206) 140 150 160 170 180 190 pF1KB5 LPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHC :::::::::::::::::::::::::::::: NP_001 MHSYVRSRKRLREEEAARLFKQIVSAVAHC 10 20 30 200 210 220 230 240 250 pF1KB5 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNT 40 50 60 70 80 90 260 270 280 290 300 310 pF1KB5 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIR 100 110 120 130 140 150 320 330 340 350 360 370 pF1KB5 SLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC 160 170 180 190 200 >>NP_067675 (OMIM: 609462) tribbles homolog 2 [Homo sapi (343 aa) initn: 1283 init1: 1215 opt: 1266 Z-score: 684.5 bits: 135.2 E(85289): 2.2e-31 Smith-Waterman score: 1275; 61.9% identity (81.2% similar) in 320 aa overlap (56-371:35-342) 30 40 50 60 70 80 pF1KB5 TRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPP-GSPCSPQPPPAAPGAGGGSGS : . .:: ::: :. : . . NP_067 RSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLGSPSPPETPNLSHCV------ 10 20 30 40 50 90 100 110 120 130 140 pF1KB5 APGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNIT : :. :::: : .:: ::. .:.:.:: :::: :. ::... : . : .::::. NP_067 ----SCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNIN 60 70 80 90 100 110 150 160 170 180 190 200 pF1KB5 GIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLG :.:.::::::::::::...:::::.::. :.:::::::::: ::.:::::::....:: NP_067 QITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLR 120 130 140 150 160 170 210 220 230 240 250 260 pF1KB5 DLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA :::::::.:. ::::...::::::..:..:.::.::::::::::::::::::.:.::::: NP_067 DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKA 180 190 200 210 220 230 270 280 290 300 310 320 pF1KB5 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPS ::::::::::::.::::::::: .::.:::::::::: ::: .::::.:::::.:::::: NP_067 ADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPS 240 250 260 270 280 290 330 340 350 360 370 pF1KB5 ERLTAPEILLHPWFE---SVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC ::::. ::: :::: :: . .: .:. :::.::. . . ... :: NP_067 ERLTSQEILDHPWFSTDFSVSNSAYGAKEV--SDQLVPDVNMEENLDPFFN 300 310 320 330 340 >>XP_016883478 (OMIM: 607898) PREDICTED: tribbles homolo (385 aa) initn: 1019 init1: 928 opt: 992 Z-score: 541.4 bits: 108.9 E(85289): 2e-23 Smith-Waterman score: 992; 46.6% identity (70.1% similar) in 348 aa overlap (15-360:27-365) 10 20 30 40 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCP : :. : :: .. :. :. :: . .. : XP_016 MVLMHLAVKNNRMSANNDHFLTPTWQQMRATPLAAPAG-SLSRKKRLELDDN--LDTERP 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 RLSECSSPPDYLSPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSR .. : :. : :: : ::.:: . . ..: ::.. :.:: : .. . XP_016 VQKRARSGPQ---PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQ 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 ALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDM :: :: : :::.:... ..:: .:: :.... .::. : :.:: . ::: XP_016 ALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDM 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLE :: ::::.:. : ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:: XP_016 HSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 DTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDS :. .. : ::.: :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.:: XP_016 DSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 DPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GY .: ::.::::: . .: .: ::::.: ::::::.::::: ::::::... : . XP_016 EPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAP 300 310 320 330 340 350 350 360 370 pF1KB5 IDSEIGTSDQIVPEYQEDSDISSFFC :.. . :.::. XP_016 TRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG 360 370 380 >>NP_001288130 (OMIM: 607898) tribbles homolog 3 isoform (385 aa) initn: 1019 init1: 928 opt: 992 Z-score: 541.4 bits: 108.9 E(85289): 2e-23 Smith-Waterman score: 992; 46.6% identity (70.1% similar) in 348 aa overlap (15-360:27-365) 10 20 30 40 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCP : :. : :: .. :. :. :: . .. : NP_001 MVLMHLAVKNNRMSANNDHFLTPTWQQMRATPLAAPAG-SLSRKKRLELDDN--LDTERP 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 RLSECSSPPDYLSPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSR .. : :. : :: : ::.:: . . ..: ::.. :.:: : .. . NP_001 VQKRARSGPQ---PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQ 60 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 ALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDM :: :: : :::.:... ..:: .:: :.... .::. : :.:: . ::: NP_001 ALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDM 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 HSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLE :: ::::.:. : ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:: NP_001 HSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLE 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB5 DTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDS :. .. : ::.: :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.:: NP_001 DSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB5 DPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GY .: ::.::::: . .: .: ::::.: ::::::.::::: ::::::... : . NP_001 EPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAP 300 310 320 330 340 350 350 360 370 pF1KB5 IDSEIGTSDQIVPEYQEDSDISSFFC :.. . :.::. NP_001 TRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG 360 370 380 >>NP_001288122 (OMIM: 607898) tribbles homolog 3 isoform (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 539.6 bits: 108.5 E(85289): 2.6e-23 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. NP_001 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : NP_001 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : NP_001 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: NP_001 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: NP_001 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: NP_001 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. NP_001 PDGLGLDEAREEEGDREVVLYG 340 350 >>NP_001288125 (OMIM: 607898) tribbles homolog 3 isoform (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 539.6 bits: 108.5 E(85289): 2.6e-23 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. NP_001 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : NP_001 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : NP_001 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: NP_001 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: NP_001 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: NP_001 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. NP_001 PDGLGLDEAREEEGDREVVLYG 340 350 >>NP_001288119 (OMIM: 607898) tribbles homolog 3 isoform (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 539.6 bits: 108.5 E(85289): 2.6e-23 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. NP_001 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : NP_001 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : NP_001 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: NP_001 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: NP_001 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: NP_001 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. NP_001 PDGLGLDEAREEEGDREVVLYG 340 350 >>NP_001288117 (OMIM: 607898) tribbles homolog 3 isoform (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 539.6 bits: 108.5 E(85289): 2.6e-23 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. NP_001 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : NP_001 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : NP_001 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: NP_001 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: NP_001 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: NP_001 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. NP_001 PDGLGLDEAREEEGDREVVLYG 340 350 >>NP_066981 (OMIM: 607898) tribbles homolog 3 isoform 1 (358 aa) initn: 1019 init1: 928 opt: 988 Z-score: 539.6 bits: 108.5 E(85289): 2.6e-23 Smith-Waterman score: 988; 46.5% identity (70.2% similar) in 346 aa overlap (17-360:2-338) 10 20 30 40 50 60 pF1KB5 MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYL :. : :: .. :. :. :: . .. : .. : :. NP_066 MRATPLAAPAG-SLSRKKRLELDDN--LDTERPVQKRARSGPQ-- 10 20 30 40 70 80 90 100 110 pF1KB5 SPPGSPCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRC : :: : ::.:: . . ..: ::.. :.:: : .. .:: :: : : NP_066 -PRLPPCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTC 50 60 70 80 90 120 130 140 150 160 170 pF1KB5 KVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLRE ::.:... ..:: .:: :.... .::. : :.:: . ::::: ::::.:. : NP_066 KVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPE 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB5 EEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDAL ::: ::.:...:.::::: ..:: :::: .:::. .:: .: ::.:::. .. : ::.: NP_066 PEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 SDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRG :::.:::::.::::.. ..::::::::::::: :.:.:.:.:::.::.: ::.::::: NP_066 WDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 QFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIV . .: .: ::::.: ::::::.::::: ::::::... : . :.. . :.: NP_066 AYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVV 280 290 300 310 320 330 360 370 pF1KB5 PEYQEDSDISSFFC :. NP_066 PDGLGLDEAREEEGDREVVLYG 340 350 372 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 17:53:43 2016 done: Thu Nov 3 17:53:45 2016 Total Scan time: 9.250 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]