Result of FASTA (omim) for
pF1KB5682
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5682, 552 aa
1>>>pF1KB5682 552 - 552 aa - 552 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6257+/-0.000387; mu= 3.8017+/- 0.024
mean_var=201.0393+/-42.050, 0's: 0 Z-trim(119.5): 41 B-trim: 1178 in 1/56
Lambda= 0.090455
statistics sampled from 33563 (33604) to 33563 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.737), E-opt: 0.2 (0.394), width: 16
Scan time: 10.030
The best scores are: opt bits E(85289)
NP_005350 (OMIM: 139210,174900,175050,260350,60099 ( 552) 3833 513.0 9.7e-145
NP_005896 (OMIM: 603295,615342) mothers against de ( 430) 493 77.0 1.3e-13
XP_005266458 (OMIM: 603295,615342) PREDICTED: moth ( 442) 493 77.1 1.3e-13
NP_001120689 (OMIM: 603295,615342) mothers against ( 467) 493 77.1 1.4e-13
XP_006719890 (OMIM: 603295,615342) PREDICTED: moth ( 479) 493 77.1 1.4e-13
NP_005894 (OMIM: 603110) mothers against decapenta ( 465) 485 76.0 2.8e-13
NP_001001419 (OMIM: 603110) mothers against decape ( 465) 485 76.0 2.8e-13
XP_016864959 (OMIM: 603110) PREDICTED: mothers aga ( 465) 485 76.0 2.8e-13
NP_001001420 (OMIM: 603110) mothers against decape ( 465) 485 76.0 2.8e-13
NP_001129409 (OMIM: 601366) mothers against decape ( 437) 482 75.6 3.6e-13
XP_016881235 (OMIM: 601366) PREDICTED: mothers aga ( 437) 482 75.6 3.6e-13
NP_005893 (OMIM: 603109,613795) mothers against de ( 425) 472 74.3 8.6e-13
XP_011519861 (OMIM: 603109,613795) PREDICTED: moth ( 381) 471 74.1 8.6e-13
XP_005263049 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
NP_005891 (OMIM: 601595) mothers against decapenta ( 465) 471 74.2 1e-12
XP_011530264 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
XP_006714280 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
XP_011530266 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
XP_011530263 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
NP_001003688 (OMIM: 601595) mothers against decape ( 465) 471 74.2 1e-12
XP_011530265 (OMIM: 601595) PREDICTED: mothers aga ( 465) 471 74.2 1e-12
XP_005266460 (OMIM: 603295,615342) PREDICTED: moth ( 393) 463 73.1 1.8e-12
XP_005266461 (OMIM: 603295,615342) PREDICTED: moth ( 356) 459 72.6 2.4e-12
XP_016881238 (OMIM: 601366) PREDICTED: mothers aga ( 263) 359 59.4 1.6e-08
XP_016881239 (OMIM: 601366) PREDICTED: mothers aga ( 227) 231 42.7 0.0015
NP_001138576 (OMIM: 603109,613795) mothers against ( 230) 231 42.7 0.0016
NP_001138574 (OMIM: 603109,613795) mothers against ( 320) 231 42.8 0.002
XP_011519862 (OMIM: 603109,613795) PREDICTED: moth ( 376) 231 42.8 0.0023
NP_001138575 (OMIM: 603109,613795) mothers against ( 381) 231 42.8 0.0023
XP_011524287 (OMIM: 601366) PREDICTED: mothers aga ( 414) 231 42.8 0.0025
XP_016881237 (OMIM: 601366) PREDICTED: mothers aga ( 414) 231 42.8 0.0025
XP_016881236 (OMIM: 601366) PREDICTED: mothers aga ( 418) 231 42.8 0.0025
XP_011524286 (OMIM: 601366) PREDICTED: mothers aga ( 425) 231 42.9 0.0025
XP_006722514 (OMIM: 601366) PREDICTED: mothers aga ( 467) 231 42.9 0.0027
NP_001003652 (OMIM: 601366) mothers against decape ( 467) 231 42.9 0.0027
XP_005258316 (OMIM: 601366) PREDICTED: mothers aga ( 467) 231 42.9 0.0027
NP_005892 (OMIM: 601366) mothers against decapenta ( 467) 231 42.9 0.0027
XP_016881234 (OMIM: 601366) PREDICTED: mothers aga ( 467) 231 42.9 0.0027
>>NP_005350 (OMIM: 139210,174900,175050,260350,600993) m (552 aa)
initn: 3833 init1: 3833 opt: 3833 Z-score: 2719.5 bits: 513.0 E(85289): 9.7e-145
Smith-Waterman score: 3833; 100.0% identity (100.0% similar) in 552 aa overlap (1-552:1-552)
10 20 30 40 50 60
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL
490 500 510 520 530 540
550
pF1KB5 HTMPIADPQPLD
::::::::::::
NP_005 HTMPIADPQPLD
550
>>NP_005896 (OMIM: 603295,615342) mothers against decape (430 aa)
initn: 860 init1: 231 opt: 493 Z-score: 365.4 bits: 77.0 E(85289): 1.3e-13
Smith-Waterman score: 887; 35.4% identity (55.2% similar) in 542 aa overlap (7-543:3-419)
10 20 30 40 50
pF1KB5 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
..:: :. .. :. :. .:: : : .:..:..:::::::.:: .: :
NP_005 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
:.. : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
NP_005 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
: : ::.:::::.:: .: .
NP_005 PFGSKQKEVCINPYHYRRVETPVL------------------------------------
120 130
180 190 200 210 220 230
pF1KB5 SIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGL
:: .:.: .:. . :.. . . . ::. ::: :
NP_005 -------PP-------------VLVPRHSEYN-----PQLSLLAKFRSASL----HSEPL
140 150 160 170
240 250 260 270 280 290
pF1KB5 L-QIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
. . :. :. :: . :. : : . :.: :..:. : . .. ::
NP_005 MPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASY--PHSPGSPSEPESPYQH------
180 190 200 210 220
300 310 320 330 340 350
pF1KB5 HPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDP
. . :: : :..:::.::.:.. .:::::.. : : .::..::
NP_005 --SDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--VLIDGFTDP
230 240 250 260
360 370 380 390 400 410
pF1KB5 SGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLD
:.. .::::: ::::.:. .:: .: ::::::.: : :.:...:.:: ..:::: .
NP_005 SNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSIFVQSRNCN
270 280 290 300 310 320
420 430 440 450 460 470
pF1KB5 REAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSV
. : :. .: :: . .:::. .: : : .. .. :
NP_005 YQHGFHPA-TVCKIPSGCSLKVFN--------NQLFAQLLAQSVHHGFEV----------
330 340 350 360
480 490 500 510 520 530
pF1KB5 GGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQL
: .: ..: .::::::::: .: ::.. :::::::::: ::
NP_005 ----------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQW
370 380 390 400 410
540 550
pF1KB5 LDEVLHTMPIADPQPLD
::.:: :
NP_005 LDKVLTQMGSPHNPISSVS
420 430
>>XP_005266458 (OMIM: 603295,615342) PREDICTED: mothers (442 aa)
initn: 716 init1: 231 opt: 493 Z-score: 365.2 bits: 77.1 E(85289): 1.3e-13
Smith-Waterman score: 734; 36.1% identity (57.5% similar) in 449 aa overlap (7-451:3-360)
10 20 30 40 50
pF1KB5 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
..:: :. .. :. :. .:: : : .:..:..:::::::.:: .: :
XP_005 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
:.. : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
XP_005 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
: : ::.:::::.:: .: . : .. . :. : .:.::
XP_005 PFGSKQKEVCINPYHYRRVETPVL-----------PPVLVPR----HS-EYNPQLSLL--
120 130 140 150
180 190 200 210 220 230
pF1KB5 SIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGL
.. :. .: : : : ::: .:. : .::
XP_005 ---------AKFRSASLHSEP--LMP--HNAT----YPD----SFQQPPCS---------
160 170 180
240 250 260 270 280 290
pF1KB5 LQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPH
: :.:.. .:. .: : . :..:. : . : : .
XP_005 ---ALPPSPSH---AFSQSPCTASY------------PHSPGSPSE--------PESPYQ
190 200 210 220
300 310 320 330 340 350
pF1KB5 PGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPS
. . :: : :..:::.::.:.. .:::::.. : : .::..:::
XP_005 HSDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--VLIDGFTDPS
230 240 250 260
360 370 380 390 400 410
pF1KB5 GG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDR
.. .::::: ::::.:. .:: .: ::::::.: : :.:...:.:: ..:::: .
XP_005 NNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSIFVQSRNCNY
270 280 290 300 310 320
420 430 440 450 460 470
pF1KB5 EAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVG
. : :. .: :: . .:::. : :. :.
XP_005 QHGFHPA-TVCKIPSGCSLKVFN-NQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKVA
330 340 350 360 370 380
480 490 500 510 520 530
pF1KB5 GIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLL
XP_005 MKAGEPRKFLSGKERQLGLYMEVKAFSFITCYFVCCKVLANESSISKYGLIKVSGYV
390 400 410 420 430 440
>>NP_001120689 (OMIM: 603295,615342) mothers against dec (467 aa)
initn: 741 init1: 231 opt: 493 Z-score: 364.9 bits: 77.1 E(85289): 1.4e-13
Smith-Waterman score: 947; 36.4% identity (57.8% similar) in 550 aa overlap (7-543:3-456)
10 20 30 40 50
pF1KB5 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
..:: :. .. :. :. .:: : : .:..:..:::::::.:: .: :
NP_001 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
:.. : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
NP_001 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
: : ::.:::::.:: .: . : .. . ... : :: .. .
NP_001 PFGSKQKEVCINPYHYRRVETPVL-----------PPVLVPRHS---EYNPQLSLLAKFR
120 130 140 150 160
180 190 200 210 220
pF1KB5 SIQTIQHP--PSNRASTETYSTP--ALLAPSESNATS----TANFPNIPVASTSQPASIL
: . ..: : : . .... : . : :: :.: : ::..:. : .: :.: :
NP_001 SASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSP-GSPSEPESPY
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB5 GGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHN-STTTWTGSRTAPYTPNLPHHQNGHL
.:: . . : : :: . .. : .:. : ..
NP_001 --QHS-----VDTPPLP-------------YHATEASETQSGQ---PV--------DATA
230 240
290 300 310 320 330 340
pF1KB5 QHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIV
..: . : . :: : :..:::.::.:.. .:::::.. : :
NP_001 DRHVVLSIPNGDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--V
250 260 270 280 290
350 360 370 380 390 400
pF1KB5 TVDGYVDPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAV
.::..:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:.:: ..
NP_001 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSI
300 310 320 330 340 350
410 420 430 440 450 460
pF1KB5 FVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAG
:::: . . : :. .: :: . .:::. .: : : .. .. :
NP_001 FVQSRNCNYQHGFHPA-TVCKIPSGCSLKVFN--------NQLFAQLLAQSVHHGFEV--
360 370 380 390 400
470 480 490 500 510 520
pF1KB5 NIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEI
: .: ..: .::::::::: .: ::.. :::::::
NP_001 ------------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEI
410 420 430 440
530 540 550
pF1KB5 HLHRALQLLDEVLHTMPIADPQPLD
::: :: ::.:: :
NP_001 HLHGPLQWLDKVLTQMGSPHNPISSVS
450 460
>>XP_006719890 (OMIM: 603295,615342) PREDICTED: mothers (479 aa)
initn: 597 init1: 231 opt: 493 Z-score: 364.7 bits: 77.1 E(85289): 1.4e-13
Smith-Waterman score: 794; 36.7% identity (59.8% similar) in 458 aa overlap (7-451:3-397)
10 20 30 40 50
pF1KB5 MDNMSITNTPTSNDACLS--IVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLI
..:: :. .. :. :. .:: : : .:..:..:::::::.:: .: :
XP_006 MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELE
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 TAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQY
:.. : .::::::: :.:::::::. :::.::::: :.::::::... ::: .. :..
XP_006 RALSCPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGH
: : ::.:::::.:: .: . : .. . ... : :: .. .
XP_006 PFGSKQKEVCINPYHYRRVETPVL-----------PPVLVPRHS---EYNPQLSLLAKFR
120 130 140 150 160
180 190 200 210 220
pF1KB5 SIQTIQHP--PSNRASTETYSTP--ALLAPSESNATS----TANFPNIPVASTSQPASIL
: . ..: : : . .... : . : :: :.: : ::..:. : .: :.: :
XP_006 SASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYPHSP-GSPSEPESPY
170 180 190 200 210 220
230 240 250 260 270 280
pF1KB5 GGSHSEGLLQIASGPQPGQQQNGFTGQPATYHHN-STTTWTGSRTAPYTPNLPHHQNGHL
.:: . . : : :: . .. : .:. : . .: .
XP_006 --QHS-----VDTPPLP-------------YHATEASETQSGQ---PVDATADRHVVLSI
230 240 250
290 300 310 320 330 340
pF1KB5 QHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIV
:. : . :: : :..:::.::.:.. .:::::.. : :
XP_006 -------PN-GDFRPVCYE-----------EPQHWCSVAYYELNNRVGETFQASSRS--V
260 270 280 290
350 360 370 380 390 400
pF1KB5 TVDGYVDPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAV
.::..:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:.:: ..
XP_006 LIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECVSDSSI
300 310 320 330 340 350
410 420 430 440 450 460
pF1KB5 FVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAG
:::: . . : :. .: :: . .:::. : :. :.
XP_006 FVQSRNCNYQHGFHPA-TVCKIPSGCSLKVFN-NQLFAQLLAQSVHHGFEVVYELTKMCT
360 370 380 390 400 410
470 480 490 500 510 520
pF1KB5 NIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEI
XP_006 IRMSFVKVAMKAGEPRKFLSGKERQLGLYMEVKAFSFITCYFVCCKVLANESSISKYGLI
420 430 440 450 460 470
>>NP_005894 (OMIM: 603110) mothers against decapentapleg (465 aa)
initn: 701 init1: 232 opt: 485 Z-score: 359.3 bits: 76.0 E(85289): 2.8e-13
Smith-Waterman score: 937; 36.9% identity (56.5% similar) in 531 aa overlap (20-543:15-454)
10 20 30 40 50 60
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
:. :. .:: : : .:..:...::::::.:: .. : :
NP_005 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
10 20 30 40 50
70 80 90 100 110
pF1KB5 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
... : .::::::: :.:::::::. :::.::::: :.::::::... ::: . :.. :
NP_005 LSSPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 DLKCDSVCVNPYHYERVVSPGID--LSGLTLQSNAPSSMMVK-DEYVHDFEGQPSLSTEG
: ::.:::::.:: :: . : . : :..:. . :. .:. .:
NP_005 GSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
:. : :.: :: :.:. . .: : ::.. : :
NP_005 DSF----HQPNN--------TPFPLSPN-------SPYPPSP-ASSTYPNS---------
180 190 200
240 250 260 270 280 290
pF1KB5 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
.::: : . : :: : : : : :. .. ::
NP_005 --PASSGPGSPFQLPADTPPPA-----------------YMP--PDDQMGQ-DNSQPMDT
210 220 230 240
300 310 320 330 340 350
pF1KB5 HPGHYWPVHNELAFQP--PISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYV
. . .. . :.. . :..::::.:.:.. .:::.:.. :. : :::..
NP_005 SNNMIPQIMPSISSRDVQPVA-YEEPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFT
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 DPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYY
:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:::: ..::::
NP_005 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRN
310 320 330 340 350
420 430 440 450 460 470
pF1KB5 LDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPG
. . : : .: :: : .:.:. : :. :... :
NP_005 CNFHHGFHP-TTVCKIPSSCSLKIFN-NQEFAQLLAQSVNHGFEA---------------
360 370 380 390 400
480 490 500 510 520 530
pF1KB5 SVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRAL
: .: ..: .::::::::: .: ::.. :::::::::: :
NP_005 ------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL
410 420 430 440
540 550
pF1KB5 QLLDEVLHTMPIADPQPLD
: ::.:: :
NP_005 QWLDKVLTQMGSPLNPISSVS
450 460
>>NP_001001419 (OMIM: 603110) mothers against decapentap (465 aa)
initn: 701 init1: 232 opt: 485 Z-score: 359.3 bits: 76.0 E(85289): 2.8e-13
Smith-Waterman score: 937; 36.9% identity (56.5% similar) in 531 aa overlap (20-543:15-454)
10 20 30 40 50 60
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
:. :. .:: : : .:..:...::::::.:: .. : :
NP_001 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
10 20 30 40 50
70 80 90 100 110
pF1KB5 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
... : .::::::: :.:::::::. :::.::::: :.::::::... ::: . :.. :
NP_001 LSSPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 DLKCDSVCVNPYHYERVVSPGID--LSGLTLQSNAPSSMMVK-DEYVHDFEGQPSLSTEG
: ::.:::::.:: :: . : . : :..:. . :. .:. .:
NP_001 GSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
:. : :.: :: :.:. . .: : ::.. : :
NP_001 DSF----HQPNN--------TPFPLSPN-------SPYPPSP-ASSTYPNS---------
180 190 200
240 250 260 270 280 290
pF1KB5 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
.::: : . : :: : : : : :. .. ::
NP_001 --PASSGPGSPFQLPADTPPPA-----------------YMP--PDDQMGQ-DNSQPMDT
210 220 230 240
300 310 320 330 340 350
pF1KB5 HPGHYWPVHNELAFQP--PISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYV
. . .. . :.. . :..::::.:.:.. .:::.:.. :. : :::..
NP_001 SNNMIPQIMPSISSRDVQPVA-YEEPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFT
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 DPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYY
:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:::: ..::::
NP_001 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRN
310 320 330 340 350
420 430 440 450 460 470
pF1KB5 LDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPG
. . : : .: :: : .:.:. : :. :... :
NP_001 CNFHHGFHP-TTVCKIPSSCSLKIFN-NQEFAQLLAQSVNHGFEA---------------
360 370 380 390 400
480 490 500 510 520 530
pF1KB5 SVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRAL
: .: ..: .::::::::: .: ::.. :::::::::: :
NP_001 ------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL
410 420 430 440
540 550
pF1KB5 QLLDEVLHTMPIADPQPLD
: ::.:: :
NP_001 QWLDKVLTQMGSPLNPISSVS
450 460
>>XP_016864959 (OMIM: 603110) PREDICTED: mothers against (465 aa)
initn: 701 init1: 232 opt: 485 Z-score: 359.3 bits: 76.0 E(85289): 2.8e-13
Smith-Waterman score: 937; 36.9% identity (56.5% similar) in 531 aa overlap (20-543:15-454)
10 20 30 40 50 60
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
:. :. .:: : : .:..:...::::::.:: .. : :
XP_016 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
10 20 30 40 50
70 80 90 100 110
pF1KB5 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
... : .::::::: :.:::::::. :::.::::: :.::::::... ::: . :.. :
XP_016 LSSPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 DLKCDSVCVNPYHYERVVSPGID--LSGLTLQSNAPSSMMVK-DEYVHDFEGQPSLSTEG
: ::.:::::.:: :: . : . : :..:. . :. .:. .:
XP_016 GSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
:. : :.: :: :.:. . .: : ::.. : :
XP_016 DSF----HQPNN--------TPFPLSPN-------SPYPPSP-ASSTYPNS---------
180 190 200
240 250 260 270 280 290
pF1KB5 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
.::: : . : :: : : : : :. .. ::
XP_016 --PASSGPGSPFQLPADTPPPA-----------------YMP--PDDQMGQ-DNSQPMDT
210 220 230 240
300 310 320 330 340 350
pF1KB5 HPGHYWPVHNELAFQP--PISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYV
. . .. . :.. . :..::::.:.:.. .:::.:.. :. : :::..
XP_016 SNNMIPQIMPSISSRDVQPVA-YEEPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFT
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 DPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYY
:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:::: ..::::
XP_016 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRN
310 320 330 340 350
420 430 440 450 460 470
pF1KB5 LDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPG
. . : : .: :: : .:.:. : :. :... :
XP_016 CNFHHGFHP-TTVCKIPSSCSLKIFN-NQEFAQLLAQSVNHGFEA---------------
360 370 380 390 400
480 490 500 510 520 530
pF1KB5 SVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRAL
: .: ..: .::::::::: .: ::.. :::::::::: :
XP_016 ------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL
410 420 430 440
540 550
pF1KB5 QLLDEVLHTMPIADPQPLD
: ::.:: :
XP_016 QWLDKVLTQMGSPLNPISSVS
450 460
>>NP_001001420 (OMIM: 603110) mothers against decapentap (465 aa)
initn: 701 init1: 232 opt: 485 Z-score: 359.3 bits: 76.0 E(85289): 2.8e-13
Smith-Waterman score: 937; 36.9% identity (56.5% similar) in 531 aa overlap (20-543:15-454)
10 20 30 40 50 60
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
:. :. .:: : : .:..:...::::::.:: .. : :
NP_001 MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKA
10 20 30 40 50
70 80 90 100 110
pF1KB5 ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQYAF
... : .::::::: :.:::::::. :::.::::: :.::::::... ::: . :.. :
NP_001 LSSPG-QPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 DLKCDSVCVNPYHYERVVSPGID--LSGLTLQSNAPSSMMVK-DEYVHDFEGQPSLSTEG
: ::.:::::.:: :: . : . : :..:. . :. .:. .:
NP_001 GSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
:. : :.: :: :.:. . .: : ::.. : :
NP_001 DSF----HQPNN--------TPFPLSPN-------SPYPPSP-ASSTYPNS---------
180 190 200
240 250 260 270 280 290
pF1KB5 LLQIASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPP
.::: : . : :: : : : : :. .. ::
NP_001 --PASSGPGSPFQLPADTPPPA-----------------YMP--PDDQMGQ-DNSQPMDT
210 220 230 240
300 310 320 330 340 350
pF1KB5 HPGHYWPVHNELAFQP--PISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYV
. . .. . :.. . :..::::.:.:.. .:::.:.. :. : :::..
NP_001 SNNMIPQIMPSISSRDVQPVA-YEEPKHWCSIVYYELNNRVGEAFHASSTS--VLVDGFT
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 DPSGG-DRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYY
:::.. .::::: ::::.:. .:: .: ::::::.: : :.:...:::: ..::::
NP_001 DPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVG-GEVYAECLSDSSIFVQSRN
310 320 330 340 350
420 430 440 450 460 470
pF1KB5 LDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPG
. . : : .: :: : .:.:. : :. :... :
NP_001 CNFHHGFHP-TTVCKIPSSCSLKIFN-NQEFAQLLAQSVNHGFEA---------------
360 370 380 390 400
480 490 500 510 520 530
pF1KB5 SVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRAL
: .: ..: .::::::::: .: ::.. :::::::::: :
NP_001 ------------------VYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPL
410 420 430 440
540 550
pF1KB5 QLLDEVLHTMPIADPQPLD
: ::.:: :
NP_001 QWLDKVLTQMGSPLNPISSVS
450 460
>>NP_001129409 (OMIM: 601366) mothers against decapentap (437 aa)
initn: 914 init1: 230 opt: 482 Z-score: 357.5 bits: 75.6 E(85289): 3.6e-13
Smith-Waterman score: 922; 38.9% identity (57.0% similar) in 519 aa overlap (28-543:33-426)
10 20 30 40 50
pF1KB5 MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSL
:.:. : . ..:..::::::: : .:: :
NP_001 SILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLK-KTGRLDEL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 ITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKN-ELKHVKYCQ
::::.. . .::::: :.:::::::. :::.::::: :::::::::.. ::: .. :.
NP_001 EKAITTQNCN-TKCVTIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB5 YAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEG
:::.:: : ::::::::.:: .: . : .. . . . : :.
NP_001 YAFNLKKDEVCVNPYHYQRVETPVL-----------PPVLVPRHTEI--LTELPPLDDYT
130 140 150 160
180 190 200 210 220 230
pF1KB5 HSIQTIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEG
::: : : . :: . : .:: .:. : :. : ::
NP_001 HSI------PENT------NFPAGIEP-QSNY-----IPETP-----PPGYI-----SE-
170 180 190
240 250 260 270 280 290
pF1KB5 LLQIASGPQPGQQQNGF--TGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPM
.: :: : ::.:: : :: .
NP_001 -----DGETSDQQLNQSMDTGSPAEL---SPTTLS-------------------------
200 210 220
300 310 320 330 340 350
pF1KB5 PPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYV
::.. : .:: ..:: .::::::.:.. .:::::. .: : .::::..
NP_001 --------PVNHSLDLQPVTYSEPA--FWCSIAYYELNQRVGETFH--ASQPSLTVDGFT
230 240 250 260 270
360 370 380 390 400 410
pF1KB5 DPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYL
:::...::::: ::::.:. ..: .: :::.::.: : :.:...:::: :.::::
NP_001 DPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIG-GEVFAECLSDSAIFVQSPNC
280 290 300 310 320 330
420 430 440 450 460 470
pF1KB5 DREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGS
... : :. .: :: :. .:.:. .:. :. : .. :
NP_001 NQRYGWHPA-TVCKIPPGCNLKIFN--------NQEFAALLAQSVNQ-------------
340 350 360 370
480 490 500 510 520 530
pF1KB5 VGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQ
:. .: .: :.: .::::::::: .: ::.. ::::::.::. ::
NP_001 --GFE-----------AVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
380 390 400 410
540 550
pF1KB5 LLDEVLHTMPIADPQPLD
::.:: :
NP_001 WLDKVLTQMGSPSVRCSSMS
420 430
552 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 17:59:40 2016 done: Thu Nov 3 17:59:41 2016
Total Scan time: 10.030 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]