FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5684, 562 aa 1>>>pF1KB5684 562 - 562 aa - 562 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0415+/-0.00115; mu= 15.6278+/- 0.069 mean_var=144.7618+/-27.132, 0's: 0 Z-trim(108.1): 191 B-trim: 19 in 2/49 Lambda= 0.106598 statistics sampled from 9747 (9981) to 9747 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.307), width: 16 Scan time: 3.410 The best scores are: opt bits E(32554) CCDS6126.1 PLAT gene_id:5327|Hs108|chr8 ( 562) 4071 638.6 6e-183 CCDS6127.1 PLAT gene_id:5327|Hs108|chr8 ( 516) 3459 544.4 1.2e-154 CCDS83291.1 PLAT gene_id:5327|Hs108|chr8 ( 473) 2533 402.0 8.5e-112 CCDS34302.1 F12 gene_id:2161|Hs108|chr5 ( 615) 661 114.2 4.6e-25 CCDS3709.1 PRSS12 gene_id:8492|Hs108|chr4 ( 875) 638 110.9 6.8e-24 CCDS42110.1 PRSS33 gene_id:260429|Hs108|chr16 ( 280) 509 90.4 3e-18 CCDS14101.1 ACR gene_id:49|Hs108|chr22 ( 421) 502 89.6 8.4e-18 CCDS5279.1 PLG gene_id:5340|Hs108|chr6 ( 810) 505 90.4 9.3e-18 CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 ( 655) 494 88.6 2.6e-17 CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 ( 662) 494 88.6 2.6e-17 CCDS10431.1 TPSAB1 gene_id:7177|Hs108|chr16 ( 275) 478 85.7 8.2e-17 CCDS33757.2 MST1 gene_id:4485|Hs108|chr3 ( 725) 468 84.6 4.4e-16 CCDS32993.1 HPN gene_id:3249|Hs108|chr19 ( 417) 463 83.6 5.3e-16 CCDS58452.1 PRSS36 gene_id:146547|Hs108|chr16 ( 752) 466 84.3 5.6e-16 CCDS58453.1 PRSS36 gene_id:146547|Hs108|chr16 ( 850) 466 84.4 6.1e-16 CCDS32436.1 PRSS36 gene_id:146547|Hs108|chr16 ( 855) 466 84.4 6.1e-16 CCDS10481.1 PRSS22 gene_id:64063|Hs108|chr16 ( 317) 460 83.0 6.1e-16 CCDS47145.1 PRSS48 gene_id:345062|Hs108|chr4 ( 328) 460 83.0 6.3e-16 CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16 ( 343) 456 82.4 9.9e-16 CCDS7339.1 PLAU gene_id:5328|Hs108|chr10 ( 431) 453 82.1 1.6e-15 CCDS2145.1 PROC gene_id:5624|Hs108|chr2 ( 461) 442 80.4 5.3e-15 CCDS73251.1 OVCH2 gene_id:341277|Hs108|chr11 ( 565) 442 80.5 6.1e-15 CCDS44442.1 PLAU gene_id:5328|Hs108|chr10 ( 414) 435 79.3 1e-14 CCDS10478.1 PRSS21 gene_id:10942|Hs108|chr16 ( 314) 425 77.6 2.5e-14 CCDS10476.1 PRSS27 gene_id:83886|Hs108|chr16 ( 290) 424 77.4 2.7e-14 CCDS33907.1 MASP1 gene_id:5648|Hs108|chr3 ( 699) 407 75.2 2.9e-13 CCDS73390.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 344) 378 70.4 4e-12 CCDS73393.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 388) 378 70.5 4.4e-12 CCDS73391.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 413) 378 70.5 4.5e-12 CCDS73392.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 448) 378 70.5 4.8e-12 CCDS44735.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 457) 378 70.5 4.8e-12 CCDS55788.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 532) 378 70.6 5.3e-12 CCDS58185.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 563) 378 70.7 5.5e-12 CCDS41721.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 567) 378 70.7 5.6e-12 CCDS219.1 CELA3B gene_id:23436|Hs108|chr1 ( 270) 373 69.5 5.9e-12 CCDS44881.1 TMPRSS12 gene_id:283471|Hs108|chr12 ( 348) 374 69.8 6.2e-12 CCDS8487.1 ST14 gene_id:6768|Hs108|chr11 ( 855) 379 71.0 6.5e-12 CCDS2745.1 PRSS50 gene_id:29122|Hs108|chr3 ( 385) 373 69.7 7.4e-12 CCDS3518.1 TMPRSS11D gene_id:9407|Hs108|chr4 ( 418) 368 69.0 1.3e-11 CCDS31735.1 C1S gene_id:716|Hs108|chr12 ( 688) 371 69.7 1.3e-11 >>CCDS6126.1 PLAT gene_id:5327|Hs108|chr8 (562 aa) initn: 4071 init1: 4071 opt: 4071 Z-score: 3398.0 bits: 638.6 E(32554): 6e-183 Smith-Waterman score: 4071; 100.0% identity (100.0% similar) in 562 aa overlap (1-562:1-562) 10 20 30 40 50 60 pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 490 500 510 520 530 540 550 560 pF1KB5 DVPGVYTKVTNYLDWIRDNMRP :::::::::::::::::::::: CCDS61 DVPGVYTKVTNYLDWIRDNMRP 550 560 >>CCDS6127.1 PLAT gene_id:5327|Hs108|chr8 (516 aa) initn: 3459 init1: 3459 opt: 3459 Z-score: 2889.8 bits: 544.4 E(32554): 1.2e-154 Smith-Waterman score: 3620; 91.6% identity (91.8% similar) in 562 aa overlap (1-562:1-516) 10 20 30 40 50 60 pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV :::::::::::::::::::::::::::::::::::::: CCDS61 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQ---------------------- 10 20 30 70 80 90 100 110 120 pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE .::::::::::::::::::::::::::::::::::: CCDS61 ------------------------GCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 40 50 60 70 130 140 150 160 170 180 pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 380 390 400 410 420 430 490 500 510 520 530 540 pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS61 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 440 450 460 470 480 490 550 560 pF1KB5 DVPGVYTKVTNYLDWIRDNMRP :::::::::::::::::::::: CCDS61 DVPGVYTKVTNYLDWIRDNMRP 500 510 >>CCDS83291.1 PLAT gene_id:5327|Hs108|chr8 (473 aa) initn: 3407 init1: 2517 opt: 2533 Z-score: 2120.6 bits: 402.0 E(32554): 8.5e-112 Smith-Waterman score: 3233; 84.2% identity (84.2% similar) in 562 aa overlap (1-562:1-473) 10 20 30 40 50 60 pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR : CCDS83 I----------------------------------------------------------- 190 200 210 220 230 240 pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN :::::::::::::::::::::::::::::: CCDS83 ------------------------------GNSDCYFGNGSAYRGTHSLTESGASCLPWN 130 140 150 250 260 270 280 290 300 pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH 340 350 360 370 380 390 490 500 510 520 530 540 pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS83 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK 400 410 420 430 440 450 550 560 pF1KB5 DVPGVYTKVTNYLDWIRDNMRP :::::::::::::::::::::: CCDS83 DVPGVYTKVTNYLDWIRDNMRP 460 470 >>CCDS34302.1 F12 gene_id:2161|Hs108|chr5 (615 aa) initn: 1183 init1: 232 opt: 661 Z-score: 563.4 bits: 114.2 E(32554): 4.6e-25 Smith-Waterman score: 1029; 32.6% identity (56.8% similar) in 562 aa overlap (5-559:105-612) 10 20 30 pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGA ..: :: . : . : :.. : CCDS34 TTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCP-QHL-----TGN 80 90 100 110 120 40 50 60 70 80 90 pF1KB5 RSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNG . . : . . ...... : : .. : : :.. :.:. . ..: :..: CCDS34 HCQKEKCFEPQLLRFFHKNEIWYRT--EQAAVARCQCKGPDAHCQRLASQACRTNPCLHG 130 140 150 160 170 180 100 110 120 130 140 150 pF1KB5 GTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSS : : .. . .:.:: :..: :..::.:.::. .:.:::: :. ::: : : : CCDS34 GRCLEV--EGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASE 190 200 210 220 230 240 160 170 180 190 200 210 pF1KB5 ALAQKPYSGRRPDAIR-LGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNS : : . . : :::.: .::::: : .:::.:.. . : :.:. :. CCDS34 A----TYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTP-- 250 260 270 280 290 220 230 240 250 260 270 pF1KB5 DCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGD :.. . .: : .... : :: . :.: . CCDS34 ------------TQAAPPTPVS--P--------RLHVPLMP-AQPAPPKPQPTTRTPPQS 300 310 320 330 280 290 300 310 320 330 pF1KB5 AKPWCHVLKNRRLTWEYCDVPSCSTCG--LRQYSQPQFRIKGGLFADIASHPWQAAIFAK : .: .: . .:: ::. . . :. ::: : ..::. ::.. CCDS34 QTP--GALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWG 340 350 360 370 380 390 340 350 360 370 380 390 pF1KB5 HRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEK : .:.: ::. ::.:.::::.:.: :. :::.::. : : : . :.. CCDS34 HS-------FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRS 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 YIVHKEFDDDTYDNDIALLQLKSDSS-RCAQESSVVRTVCLPPADLQLPDWTECELSGYG : .:. :. .:..:.:::.:. :.. :: : :. :::: . . . : :...:.: CCDS34 YRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWG 450 460 470 480 490 500 460 470 480 490 500 510 pF1KB5 KHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQ .. . :. :.::.: . ::.. . . .. .::::: ..: :::: CCDS34 HQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGT------DACQ 510 520 530 540 550 560 520 530 540 550 560 pF1KB5 GDSGGPLVCLNDG---RMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP ::::::::: ... :.:: :::::: :::... ::::: :. :: :::.. CCDS34 GDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS 570 580 590 600 610 >>CCDS3709.1 PRSS12 gene_id:8492|Hs108|chr4 (875 aa) initn: 510 init1: 216 opt: 638 Z-score: 542.5 bits: 110.9 E(32554): 6.8e-24 Smith-Waterman score: 638; 31.6% identity (57.3% similar) in 424 aa overlap (147-557:474-870) 120 130 140 150 160 170 pF1KB5 KCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNH .:.. .. ..: : .: .. ::.:: CCDS37 STGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYP-GG---EGHRLSLGFP 450 460 470 480 490 180 190 200 210 220 pF1KB5 NYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSD------CY-FG-NGSAYRGTHS . . .. :: :.... :..: .: : .: .: : : . CCDS37 VRLMDGENKKEGRVEVFINGQWGT------ICDDGWTDKDAAVICRQLGYKGPARARTMA 500 510 520 530 540 550 230 240 250 260 270 280 pF1KB5 LTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTW : . . ... :. . . : .:.:: ::. . :: : . ... . CCDS37 YFGEGKGPIHVDNVKCTGNERSLADCIKQ--DIGRHN-CRHSE-DAGVICDYF-GKKASG 560 570 580 590 600 290 300 310 320 330 340 pF1KB5 EYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILIS . :.:::: . : :: :: . .. :::... : .. : :.:::. :.: CCDS37 NSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDG-RLLCGATLLS 610 620 630 640 650 660 350 360 370 380 390 400 pF1KB5 SCWILSAAHCFQERF--PPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDND :::.:.:::::. :. . .: .: . .:: : :... :.. ..:.:. : : : CCDS37 SCWVLTAAHCFK-RYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYD 670 680 690 700 710 720 410 420 430 440 450 460 pF1KB5 IALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWT--ECELSGYGKHEALSPFYSERLK :::..:.. .::. :: : .::: . :. : .: ..:.: . ::. :. CCDS37 IALVRLQGPEEQCARFSSHVLPACLPLWR-ERPQKTASNCYITGWGD---TGRAYSRTLQ 730 740 750 760 770 780 470 480 490 500 510 520 pF1KB5 EAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGR .: . : :. : .. . : :::::. . . . :.:::::::::.: :. CCDS37 QAAIPLLPKRFCEERY--KGRFTGRMLCAGNLH----EHKRVDSCQGDSGGPLMCERPGE 790 800 810 820 830 530 540 550 560 pF1KB5 MTLV-GIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP .: :. ::: ::: :: :::::::. .. ::. CCDS37 SWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL 840 850 860 870 >>CCDS42110.1 PRSS33 gene_id:260429|Hs108|chr16 (280 aa) initn: 472 init1: 243 opt: 509 Z-score: 441.0 bits: 90.4 E(32554): 3e-18 Smith-Waterman score: 512; 36.0% identity (62.1% similar) in 264 aa overlap (297-557:26-275) 270 280 290 300 310 320 pF1KB5 CRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQA ..:: ..:. :: :: . . :::: CCDS42 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSS---RIVGGRDGRDGEWPWQA 10 20 30 40 50 330 340 350 360 370 380 pF1KB5 AIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQK .: .:: : . .::: ::. :.:.::::: .: : . : :: . . . CCDS42 SI--QHR---GAH-VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLS 60 70 80 90 100 390 400 410 420 430 440 pF1KB5 FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL :.. .. ....: .:.:::::. : . :. :. :::: . : : :.. CCDS42 VPVRRVLLPPDYSEDGARGDLALLQLR----RPVPLSARVQPVCLPVPGARPPPGTPCRV 110 120 130 140 150 160 450 460 470 480 490 500 pF1KB5 SGYGKHEALSPFYSER-LKEAHVRLYPSSRCTSQHLLNRTV--TDNMLCAGDTRSGGPQA .:.:. . :. : :. ..: : : : . . .. : .. .. :. .: ::. CCDS42 TGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQG 170 180 190 200 210 220 510 520 530 540 550 560 pF1KB5 NLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP . .:::::::::::.::..: .:::..::: ::. . :::::.:..: ::. CCDS42 H-KDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF 230 240 250 260 270 280 >>CCDS14101.1 ACR gene_id:49|Hs108|chr22 (421 aa) initn: 398 init1: 128 opt: 502 Z-score: 433.1 bits: 89.6 E(32554): 8.4e-18 Smith-Waterman score: 502; 35.2% identity (58.7% similar) in 281 aa overlap (291-556:25-285) 270 280 290 300 310 pF1KB5 LGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQ--FRIKGGLFAD :: : :::: ..:: :: :: :. CCDS14 MVEMLPTAILLVLAVSVVAKDNATCDGP----CGLRFRQNPQGGVRIVGGKAAQ 10 20 30 40 50 320 330 340 350 360 370 pF1KB5 IASHPWQAAI----FAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGR .. ::.... . .:: ::: :..: :.:.::::: . : ...: CCDS14 HGAWPWMVSLQIFTYNSHRY-----HTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGA 60 70 80 90 100 380 390 400 410 420 pF1KB5 ---TY---RVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRT :: . : . .... ::: :.:..... : :::::... : :.. . CCDS14 KEITYGNNKPVKAPLQERY-VEKIIIHEKYNSATEGNDIALVEITPPIS-CGR---FIGP 110 120 130 140 150 160 430 440 450 460 470 480 pF1KB5 VCLPPADLQLPDWTE-CELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVT ::: :: .. : ..:.: : .: : : ::.: : . :.: . : : CCDS14 GCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQ 170 180 190 200 210 220 490 500 510 520 530 540 pF1KB5 DNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLN--DGRMTLVGIISWGLGCGQKDVPGV . .:: : : ... :.:::::::::.: . .. ...::: :::.::.. ::. CCDS14 PTNVCA-----GYPVGKI-DTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGI 230 240 250 260 270 550 560 pF1KB5 YTKVTNYLDWIRDNMRP :: . ::.:: CCDS14 YTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRP 280 290 300 310 320 330 >>CCDS5279.1 PLG gene_id:5340|Hs108|chr6 (810 aa) initn: 752 init1: 243 opt: 505 Z-score: 432.3 bits: 90.4 E(32554): 9.3e-18 Smith-Waterman score: 926; 35.1% identity (56.3% similar) in 522 aa overlap (70-561:334-808) 40 50 60 70 80 90 pF1KB5 ICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQ ::.. .: : . :. : : .. . . CCDS52 PHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQ---VRWEYCKIPSCDSSPVSTE 310 320 330 340 350 360 100 110 120 130 140 150 pF1KB5 ALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNS-SALAQ : . :: . ::. .: ::::: ::. .: .: .:.: . . CCDS52 QLAPT----APPE-------LTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRH 370 380 390 400 160 170 180 190 200 pF1KB5 KPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACS--------- . :.: :: . ::::::: :. :::.. . :.:. :: CCDS52 QKTPENYPNA---GL-TMNYCRNPDADKGPWCFTTDPS-VRWEYCNLKKCSGTEASVVAP 410 420 430 440 450 460 210 220 230 240 250 pF1KB5 -----------EGNSDCYFGNGSAYRGTHSLTESGASCLPWNSM-ILIGKVYTAQ-NPSA .. ::.::::..::: .. : .:. : : .. ...: . :: : CCDS52 PPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRA 470 480 490 500 510 520 260 270 280 290 300 pF1KB5 QALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSCST----CGLRQYSQPQF-- :: : :::::::::. :::.. . :.: ..:::::.:.. :: : . CCDS52 ---GLEK-NYCRNPDGDVGGPWCYTTNPRKL-YDYCDVPQCAAPSFDCGKPQVEPKKCPG 530 540 550 560 570 310 320 330 340 350 360 pF1KB5 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLT :. :: : : :::... : : .: ::: ::: :.:.::::... : CCDS52 RVVGGCVAHPHSWPWQVSL----RTRFGMHF-CGGTLISPEWVLTAAHCLEKSPRPSSYK 580 590 600 610 620 630 370 380 390 400 410 420 pF1KB5 VILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTV :::: .: . :..:: . : . : .:::::.:.: : .. : . CCDS52 VILGAHQEVNLEPHVQEIEVSRL-----FLEPTR-KDIALLKLSSP----AVITDKVIPA 640 650 660 670 680 430 440 450 460 470 480 pF1KB5 CLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDN ::: . . : ::: ..:.: :. . : . ::::.. . .. :. ..:: : .. CCDS52 CLPSPNYVVADRTECFITGWG--ETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQST 690 700 710 720 730 740 490 500 510 520 530 540 pF1KB5 MLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKV :::: .:: :.:::::::::::.. .. : :. ::::::.. . ::::..: CCDS52 ELCAGHL-AGGT-----DSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRV 750 760 770 780 790 550 560 pF1KB5 TNYLDWIRDNMRP . .. ::. :: CCDS52 SRFVTWIEGVMRNN 800 810 >>CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 (655 aa) initn: 1461 init1: 474 opt: 494 Z-score: 424.2 bits: 88.6 E(32554): 2.6e-17 Smith-Waterman score: 1062; 34.5% identity (58.6% similar) in 519 aa overlap (86-562:164-647) 60 70 80 90 100 110 pF1KB5 WLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFA :. :.:::.:... ... :.::..:. CCDS33 ATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFT 140 150 160 170 180 190 120 130 140 150 160 170 pF1KB5 GKCCEIDTRATCYEDQGISY-RG--TWSTAESG--AECTNWNSSALAQKPYSGRRPDAIR :: : . :... : .: :. ...: .: ... . . : : CCDS33 GKDCGTE---KCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCE----GTR----- 200 210 220 230 240 180 190 200 210 220 pF1KB5 LGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPA------CS-EGNSDCYFGNGSAY :. : . . :... : .. :. : :. : . :..:::..: CCDS33 -----HTACLSSPCLNGGTCHLIVAT--GTTVCACPPGFAGRLCNIEPDERCFLGNGTGY 250 260 270 280 290 230 240 250 260 270 280 pF1KB5 RGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKN ::. : . :: ::: ::: .: .... . .: :::: : ::::::.: .:::.:.:. CCDS33 RGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKD 300 310 320 330 340 350 290 300 310 pF1KB5 RRLTWEYCDVPSCST------------------------CGLRQYSQPQF---RIKGGLF :.:::: . .: . :: :.... : :: :: CCDS33 SALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACG-RRHKKRTFLRPRIIGGSS 360 370 380 390 400 410 320 330 340 350 360 370 pF1KB5 ADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTY . .:::: :::. :. : :.: :. .::..::::::.. : ..:.::. . CCDS33 SLPGSHPWLAAIYI------GDSF-CAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHF 420 430 440 450 460 380 390 400 410 420 430 pF1KB5 RVVPGEEEQKFEVEKYIVHKEFDD-DTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPAD . : : .:::: . .. . :.:..:..::. ..::: .:. :. .::: CCDS33 FNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPG 470 480 490 500 510 520 440 450 460 470 480 490 pF1KB5 LQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAG- .: .:...:.:. . :: :.:: : : . .:.: .. . .. :::::: CCDS33 STFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGY 530 540 550 560 570 580 500 510 520 530 540 550 pF1KB5 -DTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYL : .: :::::::::::.: ..: : :::::: :::. :::::.:.::. CCDS33 FDCKS--------DACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYV 590 600 610 620 630 560 pF1KB5 DWIRDNMRP ::: : .:: CCDS33 DWINDRIRPPRRLVAPS 640 650 >>CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 (662 aa) initn: 1154 init1: 474 opt: 494 Z-score: 424.2 bits: 88.6 E(32554): 2.6e-17 Smith-Waterman score: 1073; 35.8% identity (55.6% similar) in 525 aa overlap (41-562:202-654) 20 30 40 50 60 70 pF1KB5 VLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCW : :: . . : : .:...:: : CCDS75 GGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWAR--VRQGHVEQCE 180 190 200 210 220 80 90 100 110 120 130 pF1KB5 CNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYED : .::. :... .: :.:::::. . . :: :: ::::. :.:. :. CCDS75 CFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLG 230 240 250 260 270 280 140 150 160 170 180 190 pF1KB5 QGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWC .: .:::. ::. :: : :::. : :. . : :::: : :::::: : .::: CCDS75 NGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWC 290 300 310 320 330 340 200 210 220 230 240 250 pF1KB5 YVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYT :: : . : :.: ::. . .: .:::. : : :.. . CCDS75 YVVKDSALSWEYCRLEACDLET-----------EGRESLTRVQLS--P----DLLATLPE 350 360 370 380 390 260 270 280 290 300 310 pF1KB5 AQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFR .:. :: : .:. : . .: : CCDS75 PASPGRQACGR-RHKK-----------------------------------RTFLRP--R 400 410 320 330 340 350 360 370 pF1KB5 IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTV : :: . .:::: :::. :. : :.: :. .::..::::::.. : ..: CCDS75 IIGGSSSLPGSHPWLAAIYI------GDSF-CAGSLVHTCWVVSAAHCFSHSPPRDSVSV 420 430 440 450 460 380 390 400 410 420 pF1KB5 ILGRTYRVVPGEEEQKFEVEKYIVHKEFDD-DTYDNDIALLQLKSDSSRCAQESSVVRTV .::. . . : : .:::: . .. . :.:..:..::. ..::: .:. :. . CCDS75 VLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPI 470 480 490 500 510 520 430 440 450 460 470 480 pF1KB5 CLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDN ::: .: .:...:.:. . :: :.:: : : . .:.: .. . .. : CCDS75 CLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPN 530 540 550 560 570 580 490 500 510 520 530 540 pF1KB5 MLCAG--DTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYT ::::: : .: :::::::::::.: ..: : :::::: :::. ::::: CCDS75 MLCAGYFDCKS--------DACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYT 590 600 610 620 630 550 560 pF1KB5 KVTNYLDWIRDNMRP .:.::.::: : .:: CCDS75 RVANYVDWINDRIRPPRRLVAPS 640 650 660 562 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:32:37 2016 done: Fri Nov 4 21:32:38 2016 Total Scan time: 3.410 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]