Result of FASTA (omim) for
pF1KB5684
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5684, 562 aa
1>>>pF1KB5684 562 - 562 aa - 562 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8246+/-0.000484; mu= 10.6123+/- 0.029
mean_var=150.6887+/-28.721, 0's: 0 Z-trim(114.7): 345 B-trim: 178 in 2/50
Lambda= 0.104480
statistics sampled from 24287 (24746) to 24287 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.648), E-opt: 0.2 (0.29), width: 16
Scan time: 10.190
The best scores are: opt bits E(85289)
NP_000921 (OMIM: 173370,612348) tissue-type plasmi ( 562) 4071 626.4 7.3e-179
NP_127509 (OMIM: 173370,612348) tissue-type plasmi ( 516) 3459 534.1 4e-151
NP_001306118 (OMIM: 173370,612348) tissue-type pla ( 473) 2533 394.5 3.9e-109
NP_001306120 (OMIM: 104300,191840,601709) urokinas ( 345) 982 160.6 7.5e-39
XP_011532764 (OMIM: 234000,610618,610619) PREDICTE ( 503) 661 112.4 3.6e-24
NP_000496 (OMIM: 234000,610618,610619) coagulation ( 615) 661 112.4 4.2e-24
NP_003610 (OMIM: 249500,606709) neurotrypsin precu ( 875) 638 109.1 5.9e-23
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 509 89.2 1.9e-17
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 509 89.2 1.9e-17
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 509 89.2 1.9e-17
NP_001088 (OMIM: 102480) acrosin precursor [Homo s ( 421) 502 88.3 5.2e-17
NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 505 89.0 6.1e-17
NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 494 87.3 1.6e-16
NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 494 87.3 1.7e-16
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 478 84.5 4.7e-16
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 477 84.4 5.2e-16
NP_066278 (OMIM: 142408) hepatocyte growth factor- ( 725) 468 83.4 2.7e-15
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 463 82.4 2.9e-15
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 466 83.1 3e-15
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 466 83.1 3e-15
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 466 83.1 3e-15
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 463 82.4 3e-15
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 463 82.4 3e-15
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 463 82.4 3e-15
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 463 82.4 3e-15
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 463 82.4 3e-15
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 466 83.1 3.4e-15
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 466 83.1 3.4e-15
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 460 81.9 3.4e-15
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 460 81.9 3.4e-15
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 466 83.2 3.7e-15
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 466 83.2 3.7e-15
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 456 81.3 5.5e-15
XP_011538168 (OMIM: 104300,191840,601709) PREDICTE ( 431) 453 80.9 8.9e-15
NP_002649 (OMIM: 104300,191840,601709) urokinase-t ( 431) 451 80.6 1.1e-14
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 442 79.3 2.9e-14
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 442 79.3 3e-14
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 442 79.3 3.1e-14
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 442 79.4 3.3e-14
NP_001138503 (OMIM: 104300,191840,601709) urokinas ( 414) 433 77.9 7e-14
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 431 77.5 7e-14
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 425 76.6 1.3e-13
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 424 76.4 1.4e-13
XP_016862359 (OMIM: 257920,600521) PREDICTED: mann ( 668) 407 74.2 1.5e-12
NP_001870 (OMIM: 257920,600521) mannan-binding lec ( 699) 407 74.2 1.5e-12
XP_011511292 (OMIM: 257920,600521) PREDICTED: mann ( 706) 407 74.2 1.5e-12
XP_016873855 (OMIM: 606751) PREDICTED: transmembra ( 227) 378 69.4 1.4e-11
XP_016873856 (OMIM: 606751) PREDICTED: transmembra ( 227) 378 69.4 1.4e-11
NP_001275678 (OMIM: 606751) transmembrane protease ( 344) 378 69.5 1.9e-11
NP_001275681 (OMIM: 606751) transmembrane protease ( 388) 378 69.6 2.1e-11
>>NP_000921 (OMIM: 173370,612348) tissue-type plasminoge (562 aa)
initn: 4071 init1: 4071 opt: 4071 Z-score: 3332.2 bits: 626.4 E(85289): 7.3e-179
Smith-Waterman score: 4071; 100.0% identity (100.0% similar) in 562 aa overlap (1-562:1-562)
10 20 30 40 50 60
pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
490 500 510 520 530 540
550 560
pF1KB5 DVPGVYTKVTNYLDWIRDNMRP
::::::::::::::::::::::
NP_000 DVPGVYTKVTNYLDWIRDNMRP
550 560
>>NP_127509 (OMIM: 173370,612348) tissue-type plasminoge (516 aa)
initn: 3459 init1: 3459 opt: 3459 Z-score: 2834.1 bits: 534.1 E(85289): 4e-151
Smith-Waterman score: 3620; 91.6% identity (91.8% similar) in 562 aa overlap (1-562:1-516)
10 20 30 40 50 60
pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
::::::::::::::::::::::::::::::::::::::
NP_127 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQ----------------------
10 20 30
70 80 90 100 110 120
pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
.:::::::::::::::::::::::::::::::::::
NP_127 ------------------------GCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
40 50 60 70
130 140 150 160 170 180
pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
80 90 100 110 120 130
190 200 210 220 230 240
pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
140 150 160 170 180 190
250 260 270 280 290 300
pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
200 210 220 230 240 250
310 320 330 340 350 360
pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
260 270 280 290 300 310
370 380 390 400 410 420
pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
320 330 340 350 360 370
430 440 450 460 470 480
pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
380 390 400 410 420 430
490 500 510 520 530 540
pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_127 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
440 450 460 470 480 490
550 560
pF1KB5 DVPGVYTKVTNYLDWIRDNMRP
::::::::::::::::::::::
NP_127 DVPGVYTKVTNYLDWIRDNMRP
500 510
>>NP_001306118 (OMIM: 173370,612348) tissue-type plasmin (473 aa)
initn: 3407 init1: 2517 opt: 2533 Z-score: 2080.2 bits: 394.5 E(85289): 3.9e-109
Smith-Waterman score: 3233; 84.2% identity (84.2% similar) in 562 aa overlap (1-562:1-473)
10 20 30 40 50 60
pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 IDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCR
:
NP_001 I-----------------------------------------------------------
190 200 210 220 230 240
pF1KB5 NPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWN
::::::::::::::::::::::::::::::
NP_001 ------------------------------GNSDCYFGNGSAYRGTHSLTESGASCLPWN
130 140 150
250 260 270 280 290 300
pF1KB5 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG
160 170 180 190 200 210
310 320 330 340 350 360
pF1KB5 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
220 230 240 250 260 270
370 380 390 400 410 420
pF1KB5 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCA
280 290 300 310 320 330
430 440 450 460 470 480
pF1KB5 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQH
340 350 360 370 380 390
490 500 510 520 530 540
pF1KB5 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQK
400 410 420 430 440 450
550 560
pF1KB5 DVPGVYTKVTNYLDWIRDNMRP
::::::::::::::::::::::
NP_001 DVPGVYTKVTNYLDWIRDNMRP
460 470
>>NP_001306120 (OMIM: 104300,191840,601709) urokinase-ty (345 aa)
initn: 994 init1: 272 opt: 982 Z-score: 818.5 bits: 160.6 E(85289): 7.5e-39
Smith-Waterman score: 982; 43.4% identity (66.8% similar) in 346 aa overlap (233-561:2-338)
210 220 230 240 250 260
pF1KB5 CSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLG
: :::::: .. ..: :. .: ::::
NP_001 MGRPCLPWNSATVLQQTYHAHRSDALQLGLG
10 20 30
270 280 290 300
pF1KB5 KHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST--------------CGLRQYSQPQ
:::::::::. .:::.: . . . : : .:. :: . .:.
NP_001 KHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTL-RPR
40 50 60 70 80 90
310 320 330 340 350 360
pF1KB5 FRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHL
:.: :: :. : ..:: :::. .:: . . ..::: ::: ::..::.::: . .
NP_001 FKIIGGEFTTIENQPWFAAIYRRHR-GGSVTYVCGGSLISPCWVISATHCFIDYPKKEDY
100 110 120 130 140
370 380 390 400 410 420
pF1KB5 TVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQLKSDSSRCAQESSVV
: :::. . :.:::::. :.::... :: . ::::::...: .:::: : ..
NP_001 IVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTI
150 160 170 180 190 200
430 440 450 460 470 480
pF1KB5 RTVCLPPADLQLPDW-TECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRT
.:.::: . :.. : ::..:.::... . .: :.:: . :.: .: . : .
NP_001 QTICLPSM-YNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSE
210 220 230 240 250 260
490 500 510 520 530 540
pF1KB5 VTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGV
:: .::::.: :: . :.::::::::::: .:::::.::.::: ::. :: :::
NP_001 VTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGV
270 280 290 300 310 320
550 560
pF1KB5 YTKVTNYLDWIRDNMRP
::.:...: :::.. .
NP_001 YTRVSHFLPWIRSHTKEENGLAL
330 340
>>XP_011532764 (OMIM: 234000,610618,610619) PREDICTED: c (503 aa)
initn: 1183 init1: 232 opt: 661 Z-score: 554.9 bits: 112.4 E(85289): 3.6e-24
Smith-Waterman score: 1022; 33.1% identity (57.5% similar) in 534 aa overlap (33-559:15-500)
10 20 30 40 50 60
pF1KB5 AMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLR
: . . : . . ...... : : .
XP_011 MPSGPHCLCPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYR--TE
10 20 30 40
70 80 90 100 110 120
pF1KB5 SNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEID
. : : :.. :.:. . ..: :..:: : .. . .:.:: :..: :..:
XP_011 QAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLEVE--GHRLCHCPVGYTGAFCDVD
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB5 TRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIR-LGLGNHNYCRN
:.:.::. .:.:::: :. ::: : : : : : . . : :::.: .:::
XP_011 TKASCYDGRGLSYRGLARTTLSGAPCQPWASEAT----YRNVTAEQARNWGLGGHAFCRN
110 120 130 140 150
190 200 210 220 230 240
pF1KB5 PDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNS
:: : .:::.:.. . : :.:. :. :.. . .: :
XP_011 PDNDIRPWCFVLNRDRLSWEYCDLAQCQTP--------------TQAAPPTPVS--P---
160 170 180 190
250 260 270 280 290 300
pF1KB5 MILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCG-
.... : :: . :.: . : .: .: . .::
XP_011 -----RLHVPLMP-AQPAPPKPQPTTRTPPQSQTP--GALPAKREQPPSLTRNGPLSCGQ
200 210 220 230 240
310 320 330 340 350
pF1KB5 -LRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCF
::. . . :. ::: : ..::. ::.. : .:.: ::. ::.:.::::.
XP_011 RLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHS-------FCAGSLIAPCWVLTAAHCL
250 260 270 280 290 300
360 370 380 390 400 410
pF1KB5 QERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSS-R
:.: :. :::.::. : : : . :..: .:. :. .:..:.:::.:. :..
XP_011 QDRPAPEDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGS
310 320 330 340 350 360
420 430 440 450 460 470
pF1KB5 CAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTS
:: : :. :::: . . . : :...:.:.. . :. :.::.: . ::..
XP_011 CALLSPYVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSA
370 380 390 400 410 420
480 490 500 510 520 530
pF1KB5 QHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDG---RMTLVGIISWGL
. . .. .::::: ..: ::::::::::::: ... :.:: ::::::
XP_011 PDVHGSSILPGMLCAGFLEGGT------DACQGDSGGPLVCEDQAAERRLTLQGIISWGS
430 440 450 460 470
540 550 560
pF1KB5 GCGQKDVPGVYTKVTNYLDWIRDNMRP
:::... ::::: :. :: :::..
XP_011 GCGDRNKPGVYTDVAYYLAWIREHTVS
480 490 500
>>NP_000496 (OMIM: 234000,610618,610619) coagulation fac (615 aa)
initn: 1183 init1: 232 opt: 661 Z-score: 553.8 bits: 112.4 E(85289): 4.2e-24
Smith-Waterman score: 1029; 32.6% identity (56.8% similar) in 562 aa overlap (5-559:105-612)
10 20 30
pF1KB5 MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGA
..: :: . : . : :.. :
NP_000 TTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCLCP-QHL-----TGN
80 90 100 110 120
40 50 60 70 80 90
pF1KB5 RSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNG
. . : . . ...... : : .. : : :.. :.:. . ..: :..:
NP_000 HCQKEKCFEPQLLRFFHKNEIWYRT--EQAAVARCQCKGPDAHCQRLASQACRTNPCLHG
130 140 150 160 170 180
100 110 120 130 140 150
pF1KB5 GTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSS
: : .. . .:.:: :..: :..::.:.::. .:.:::: :. ::: : : :
NP_000 GRCLEV--EGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQPWASE
190 200 210 220 230 240
160 170 180 190 200 210
pF1KB5 ALAQKPYSGRRPDAIR-LGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNS
: : . . : :::.: .::::: : .:::.:.. . : :.:. :.
NP_000 A----TYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTP--
250 260 270 280 290
220 230 240 250 260 270
pF1KB5 DCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGD
:.. . .: : .... : :: . :.: .
NP_000 ------------TQAAPPTPVS--P--------RLHVPLMP-AQPAPPKPQPTTRTPPQS
300 310 320 330
280 290 300 310 320 330
pF1KB5 AKPWCHVLKNRRLTWEYCDVPSCSTCG--LRQYSQPQFRIKGGLFADIASHPWQAAIFAK
: .: .: . .:: ::. . . :. ::: : ..::. ::..
NP_000 QTP--GALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHPYIAALYWG
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB5 HRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEK
: .:.: ::. ::.:.::::.:.: :. :::.::. : : : . :..
NP_000 HS-------FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPCQTLAVRS
400 410 420 430 440
400 410 420 430 440 450
pF1KB5 YIVHKEFDDDTYDNDIALLQLKSDSS-RCAQESSVVRTVCLPPADLQLPDWTECELSGYG
: .:. :. .:..:.:::.:. :.. :: : :. :::: . . . : :...:.:
NP_000 YRLHEAFSPVSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSETTLCQVAGWG
450 460 470 480 490 500
460 470 480 490 500 510
pF1KB5 KHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQ
.. . :. :.::.: . ::.. . . .. .::::: ..: ::::
NP_000 HQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGT------DACQ
510 520 530 540 550 560
520 530 540 550 560
pF1KB5 GDSGGPLVCLNDG---RMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
::::::::: ... :.:: :::::: :::... ::::: :. :: :::..
NP_000 GDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
570 580 590 600 610
>>NP_003610 (OMIM: 249500,606709) neurotrypsin precursor (875 aa)
initn: 510 init1: 216 opt: 638 Z-score: 533.1 bits: 109.1 E(85289): 5.9e-23
Smith-Waterman score: 638; 31.6% identity (57.3% similar) in 424 aa overlap (147-557:474-870)
120 130 140 150 160 170
pF1KB5 KCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNH
.:.. .. ..: : .: .. ::.::
NP_003 STGPIWLDDVSCSGKETRFLQCSRRQWGRHDCSHREDVSIACYP-GG---EGHRLSLGFP
450 460 470 480 490
180 190 200 210 220
pF1KB5 NYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSD------CY-FG-NGSAYRGTHS
. . .. :: :.... :..: .: : .: .: : : .
NP_003 VRLMDGENKKEGRVEVFINGQWGT------ICDDGWTDKDAAVICRQLGYKGPARARTMA
500 510 520 530 540 550
230 240 250 260 270 280
pF1KB5 LTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTW
: . . ... :. . . : .:.:: ::. . :: : . ... .
NP_003 YFGEGKGPIHVDNVKCTGNERSLADCIKQ--DIGRHN-CRHSE-DAGVICDYF-GKKASG
560 570 580 590 600
290 300 310 320 330 340
pF1KB5 EYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILIS
. :.:::: . : :: :: . .. :::... : .. : :.:::. :.:
NP_003 NSNKESLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDG-RLLCGATLLS
610 620 630 640 650 660
350 360 370 380 390 400
pF1KB5 SCWILSAAHCFQERF--PPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDND
:::.:.:::::. :. . .: .: . .:: : :... :.. ..:.:. : : :
NP_003 SCWVLTAAHCFK-RYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYD
670 680 690 700 710 720
410 420 430 440 450 460
pF1KB5 IALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWT--ECELSGYGKHEALSPFYSERLK
:::..:.. .::. :: : .::: . :. : .: ..:.: . ::. :.
NP_003 IALVRLQGPEEQCARFSSHVLPACLPLWR-ERPQKTASNCYITGWGD---TGRAYSRTLQ
730 740 750 760 770 780
470 480 490 500 510 520
pF1KB5 EAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGR
.: . : :. : .. . : :::::. . . . :.:::::::::.: :.
NP_003 QAAIPLLPKRFCEERY--KGRFTGRMLCAGNLH----EHKRVDSCQGDSGGPLMCERPGE
790 800 810 820 830
530 540 550 560
pF1KB5 MTLV-GIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
.: :. ::: ::: :: :::::::. .. ::.
NP_003 SWVVYGVTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL
840 850 860 870
>>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa)
initn: 472 init1: 243 opt: 509 Z-score: 434.3 bits: 89.2 E(85289): 1.9e-17
Smith-Waterman score: 512; 36.0% identity (62.1% similar) in 264 aa overlap (297-557:26-275)
270 280 290 300 310 320
pF1KB5 CRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQA
..:: ..:. :: :: . . ::::
NP_690 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSS---RIVGGRDGRDGEWPWQA
10 20 30 40 50
330 340 350 360 370 380
pF1KB5 AIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQK
.: .:: : . .::: ::. :.:.::::: .: : . : :: . . .
NP_690 SI--QHR---GAH-VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLS
60 70 80 90 100
390 400 410 420 430 440
pF1KB5 FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL
:.. .. ....: .:.:::::. : . :. :. :::: . : : :..
NP_690 VPVRRVLLPPDYSEDGARGDLALLQLR----RPVPLSARVQPVCLPVPGARPPPGTPCRV
110 120 130 140 150 160
450 460 470 480 490 500
pF1KB5 SGYGKHEALSPFYSER-LKEAHVRLYPSSRCTSQHLLNRTV--TDNMLCAGDTRSGGPQA
.:.:. . :. : :. ..: : : : . . .. : .. .. :. .: ::.
NP_690 TGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQG
170 180 190 200 210 220
510 520 530 540 550 560
pF1KB5 NLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
. .:::::::::::.::..: .:::..::: ::. . :::::.:..: ::.
NP_690 H-KDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
>>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 472 init1: 243 opt: 509 Z-score: 434.3 bits: 89.2 E(85289): 1.9e-17
Smith-Waterman score: 512; 36.0% identity (62.1% similar) in 264 aa overlap (297-557:26-275)
270 280 290 300 310 320
pF1KB5 CRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQA
..:: ..:. :: :: . . ::::
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSS---RIVGGRDGRDGEWPWQA
10 20 30 40 50
330 340 350 360 370 380
pF1KB5 AIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQK
.: .:: : . .::: ::. :.:.::::: .: : . : :: . . .
XP_011 SI--QHR---GAH-VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLS
60 70 80 90 100
390 400 410 420 430 440
pF1KB5 FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL
:.. .. ....: .:.:::::. : . :. :. :::: . : : :..
XP_011 VPVRRVLLPPDYSEDGARGDLALLQLR----RPVPLSARVQPVCLPVPGARPPPGTPCRV
110 120 130 140 150 160
450 460 470 480 490 500
pF1KB5 SGYGKHEALSPFYSER-LKEAHVRLYPSSRCTSQHLLNRTV--TDNMLCAGDTRSGGPQA
.:.:. . :. : :. ..: : : : . . .. : .. .. :. .: ::.
XP_011 TGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQG
170 180 190 200 210 220
510 520 530 540 550 560
pF1KB5 NLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
. .:::::::::::.::..: .:::..::: ::. . :::::.:..: ::.
XP_011 H-KDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
>>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 472 init1: 243 opt: 509 Z-score: 434.3 bits: 89.2 E(85289): 1.9e-17
Smith-Waterman score: 512; 36.0% identity (62.1% similar) in 264 aa overlap (297-557:26-275)
270 280 290 300 310 320
pF1KB5 CRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQA
..:: ..:. :: :: . . ::::
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSAACGQPRMSS---RIVGGRDGRDGEWPWQA
10 20 30 40 50
330 340 350 360 370 380
pF1KB5 AIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQK
.: .:: : . .::: ::. :.:.::::: .: : . : :: . . .
XP_011 SI--QHR---GAH-VCGGSLIAPQWVLTAAHCFPRRALPAEYRVRLGALRLGSTSPRTLS
60 70 80 90 100
390 400 410 420 430 440
pF1KB5 FEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECEL
:.. .. ....: .:.:::::. : . :. :. :::: . : : :..
XP_011 VPVRRVLLPPDYSEDGARGDLALLQLR----RPVPLSARVQPVCLPVPGARPPPGTPCRV
110 120 130 140 150 160
450 460 470 480 490 500
pF1KB5 SGYGKHEALSPFYSER-LKEAHVRLYPSSRCTSQHLLNRTV--TDNMLCAGDTRSGGPQA
.:.:. . :. : :. ..: : : : . . .. : .. .. :. .: ::.
XP_011 TGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQG
170 180 190 200 210 220
510 520 530 540 550 560
pF1KB5 NLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
. .:::::::::::.::..: .:::..::: ::. . :::::.:..: ::.
XP_011 H-KDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
230 240 250 260 270 280
562 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:32:38 2016 done: Fri Nov 4 21:32:40 2016
Total Scan time: 10.190 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]