FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5702, 906 aa 1>>>pF1KB5702 906 - 906 aa - 906 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2972+/-0.00051; mu= 16.3570+/- 0.032 mean_var=95.8058+/-19.575, 0's: 0 Z-trim(110.4): 79 B-trim: 1321 in 2/53 Lambda= 0.131032 statistics sampled from 18645 (18724) to 18645 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.554), E-opt: 0.2 (0.22), width: 16 Scan time: 11.140 The best scores are: opt bits E(85289) NP_001310912 (OMIM: 116805,608970) catenin alpha-1 ( 906) 5735 1095.6 0 NP_001310911 (OMIM: 116805,608970) catenin alpha-1 ( 906) 5735 1095.6 0 NP_001310913 (OMIM: 116805,608970) catenin alpha-1 ( 906) 5735 1095.6 0 NP_001894 (OMIM: 116805,608970) catenin alpha-1 is ( 906) 5735 1095.6 0 NP_001310914 (OMIM: 116805,608970) catenin alpha-1 ( 897) 5180 990.7 0 NP_001277236 (OMIM: 116805,608970) catenin alpha-1 ( 841) 5149 984.8 0 NP_001277238 (OMIM: 116805,608970) catenin alpha-1 ( 803) 5095 974.6 0 NP_001277239 (OMIM: 116805,608970) catenin alpha-1 ( 783) 4958 948.7 0 NP_004380 (OMIM: 114025) catenin alpha-2 isoform 1 ( 905) 4756 910.5 0 XP_016858892 (OMIM: 114025) PREDICTED: catenin alp ( 905) 4756 910.5 0 NP_001269527 (OMIM: 114025) catenin alpha-2 isofor ( 939) 4756 910.6 0 XP_016858894 (OMIM: 114025) PREDICTED: catenin alp ( 876) 4278 820.2 0 XP_016858893 (OMIM: 114025) PREDICTED: catenin alp ( 891) 4278 820.2 0 XP_011530858 (OMIM: 114025) PREDICTED: catenin alp ( 953) 4278 820.2 0 NP_001269526 (OMIM: 114025) catenin alpha-2 isofor ( 953) 4278 820.2 0 XP_011530857 (OMIM: 114025) PREDICTED: catenin alp ( 953) 4278 820.2 0 NP_001158355 (OMIM: 114025) catenin alpha-2 isofor ( 860) 3976 763.1 0 NP_037398 (OMIM: 607667,615616) catenin alpha-3 is ( 895) 3492 671.6 4.7e-192 NP_001120856 (OMIM: 607667,615616) catenin alpha-3 ( 895) 3492 671.6 4.7e-192 XP_016871642 (OMIM: 607667,615616) PREDICTED: cate ( 907) 3492 671.6 4.7e-192 NP_001310927 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310925 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310924 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310919 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310922 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310926 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310929 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310921 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310928 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001277241 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310923 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310917 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310916 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310920 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001310918 (OMIM: 116805,608970) catenin alpha-1 ( 536) 3396 653.3 8.9e-187 NP_001269528 (OMIM: 114025) catenin alpha-2 isofor ( 584) 3105 598.3 3.5e-170 NP_001269529 (OMIM: 114025) catenin alpha-2 isofor ( 537) 3035 585.1 3.1e-166 XP_016871640 (OMIM: 607667,615616) PREDICTED: cate ( 918) 2906 560.8 1.1e-158 NP_001310941 (OMIM: 116805,608970) catenin alpha-1 ( 455) 2893 558.2 3.3e-158 NP_001310942 (OMIM: 116805,608970) catenin alpha-1 ( 455) 2893 558.2 3.3e-158 NP_001310940 (OMIM: 116805,608970) catenin alpha-1 ( 505) 2817 543.8 7.5e-154 NP_001310915 (OMIM: 116805,608970) catenin alpha-1 ( 875) 2817 544.0 1.2e-153 NP_001310931 (OMIM: 116805,608970) catenin alpha-1 ( 471) 2810 542.5 1.8e-153 NP_001310932 (OMIM: 116805,608970) catenin alpha-1 ( 471) 2810 542.5 1.8e-153 NP_001310934 (OMIM: 116805,608970) catenin alpha-1 ( 471) 2810 542.5 1.8e-153 NP_001310933 (OMIM: 116805,608970) catenin alpha-1 ( 471) 2810 542.5 1.8e-153 XP_016871644 (OMIM: 607667,615616) PREDICTED: cate ( 634) 2732 527.8 6.2e-149 XP_016871643 (OMIM: 607667,615616) PREDICTED: cate ( 634) 2732 527.8 6.2e-149 XP_016871645 (OMIM: 607667,615616) PREDICTED: cate ( 634) 2732 527.8 6.2e-149 NP_001310939 (OMIM: 116805,608970) catenin alpha-1 ( 423) 2697 521.1 4.4e-147 >>NP_001310912 (OMIM: 116805,608970) catenin alpha-1 iso (906 aa) initn: 5735 init1: 5735 opt: 5735 Z-score: 5860.5 bits: 1095.6 E(85289): 0 Smith-Waterman score: 5735; 100.0% identity (100.0% similar) in 906 aa overlap (1-906:1-906) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF 850 860 870 880 890 900 pF1KB5 KAMDSI :::::: NP_001 KAMDSI >>NP_001310911 (OMIM: 116805,608970) catenin alpha-1 iso (906 aa) initn: 5735 init1: 5735 opt: 5735 Z-score: 5860.5 bits: 1095.6 E(85289): 0 Smith-Waterman score: 5735; 100.0% identity (100.0% similar) in 906 aa overlap (1-906:1-906) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF 850 860 870 880 890 900 pF1KB5 KAMDSI :::::: NP_001 KAMDSI >>NP_001310913 (OMIM: 116805,608970) catenin alpha-1 iso (906 aa) initn: 5735 init1: 5735 opt: 5735 Z-score: 5860.5 bits: 1095.6 E(85289): 0 Smith-Waterman score: 5735; 100.0% identity (100.0% similar) in 906 aa overlap (1-906:1-906) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF 850 860 870 880 890 900 pF1KB5 KAMDSI :::::: NP_001 KAMDSI >>NP_001894 (OMIM: 116805,608970) catenin alpha-1 isofor (906 aa) initn: 5735 init1: 5735 opt: 5735 Z-score: 5860.5 bits: 1095.6 E(85289): 0 Smith-Waterman score: 5735; 100.0% identity (100.0% similar) in 906 aa overlap (1-906:1-906) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF 850 860 870 880 890 900 pF1KB5 KAMDSI :::::: NP_001 KAMDSI >>NP_001310914 (OMIM: 116805,608970) catenin alpha-1 iso (897 aa) initn: 5669 init1: 5147 opt: 5180 Z-score: 5293.5 bits: 990.7 E(85289): 0 Smith-Waterman score: 5655; 99.0% identity (99.0% similar) in 906 aa overlap (1-906:1-897) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS ::::::::::::::::::::::::::::::: :::::::::::::::::::: NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSG---------AAKNLMNAVVQTVKASYVAS 790 800 810 820 830 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF 840 850 860 870 880 890 pF1KB5 KAMDSI :::::: NP_001 KAMDSI >>NP_001277236 (OMIM: 116805,608970) catenin alpha-1 iso (841 aa) initn: 5147 init1: 5147 opt: 5149 Z-score: 5262.3 bits: 984.8 E(85289): 0 Smith-Waterman score: 5149; 98.8% identity (99.4% similar) in 823 aa overlap (1-823:1-823) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKER 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDR 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTED 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 QRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVAS ::::::::::::::::::::::::::::::: .. . .:. : NP_001 QRIALYCHQLNICSKVKAEVQNLGGELVVSGNCDTCGALQGLKGWPPPLCWPLTGWTAPC 790 800 810 820 830 840 850 860 870 880 890 900 pF1KB5 TKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEF NP_001 P >>NP_001277238 (OMIM: 116805,608970) catenin alpha-1 iso (803 aa) initn: 5095 init1: 5095 opt: 5095 Z-score: 5207.4 bits: 974.6 E(85289): 0 Smith-Waterman score: 5095; 100.0% identity (100.0% similar) in 803 aa overlap (104-906:1-803) 80 90 100 110 120 130 pF1KB5 EKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLS :::::::::::::::::::::::::::::: NP_001 MKAAAGEFADDPCSSVKRGNMVRAARALLS 10 20 30 140 150 160 170 180 190 pF1KB5 AVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAK 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB5 RQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVT 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB5 GISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GISNAAQATASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESII 160 170 180 190 200 210 320 330 340 350 360 370 pF1KB5 SGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTK 220 230 240 250 260 270 380 390 400 410 420 430 pF1KB5 KTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEV 280 290 300 310 320 330 440 450 460 470 480 490 pF1KB5 ANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEK 340 350 360 370 380 390 500 510 520 530 540 550 pF1KB5 QVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVI 400 410 420 430 440 450 560 570 580 590 600 610 pF1KB5 HVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFID 460 470 480 490 500 510 620 630 640 650 660 670 pF1KB5 ASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIM 520 530 540 550 560 570 680 690 700 710 720 730 pF1KB5 AQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGK 580 590 600 610 620 630 740 750 760 770 780 790 pF1KB5 GPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNIC 640 650 660 670 680 690 800 810 820 830 840 850 pF1KB5 SKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLN 700 710 720 730 740 750 860 870 880 890 900 pF1KB5 LPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI 760 770 780 790 800 >>NP_001277239 (OMIM: 116805,608970) catenin alpha-1 iso (783 aa) initn: 4958 init1: 4958 opt: 4958 Z-score: 5067.6 bits: 948.7 E(85289): 0 Smith-Waterman score: 4958; 100.0% identity (100.0% similar) in 783 aa overlap (124-906:1-783) 100 110 120 130 140 150 pF1KB5 VEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQ :::::::::::::::::::::::::::::: NP_001 MVRAARALLSAVTRLLILADMADVYKLLVQ 10 20 30 160 170 180 190 200 210 pF1KB5 LKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGI 40 50 60 70 80 90 220 230 240 250 260 270 pF1KB5 LQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGG 100 110 120 130 140 150 280 290 300 310 320 330 pF1KB5 GGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERI 160 170 180 190 200 210 340 350 360 370 380 390 pF1KB5 VAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDS 220 230 240 250 260 270 400 410 420 430 440 450 pF1KB5 FLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMS 280 290 300 310 320 330 460 470 480 490 500 510 pF1KB5 ASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLA 340 350 360 370 380 390 520 530 540 550 560 570 pF1KB5 VSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVL 400 410 420 430 440 450 580 590 600 610 620 630 pF1KB5 EATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIR 460 470 480 490 500 510 640 650 660 670 680 690 pF1KB5 TPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQE 520 530 540 550 560 570 700 710 720 730 740 750 pF1KB5 EKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAG 580 590 600 610 620 630 760 770 780 790 800 810 pF1KB5 SRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVD 640 650 660 670 680 690 820 830 840 850 860 870 pF1KB5 SAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKRE 700 710 720 730 740 750 880 890 900 pF1KB5 KQDETQTKIKRASQKKHVNPVQALSEFKAMDSI ::::::::::::::::::::::::::::::::: NP_001 KQDETQTKIKRASQKKHVNPVQALSEFKAMDSI 760 770 780 >>NP_004380 (OMIM: 114025) catenin alpha-2 isoform 1 [Ho (905 aa) initn: 2419 init1: 2419 opt: 4756 Z-score: 4860.3 bits: 910.5 E(85289): 0 Smith-Waterman score: 4756; 82.4% identity (94.5% similar) in 899 aa overlap (9-905:8-904) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV : .::::::::::::.::::::::::::::::::..::::.::.:::::::: NP_004 MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHV 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::.::::::..:::::: ::::::::::::::::. :. :..::::::::::: NP_004 LAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL ::.::::::::::::::::::::::::..:: .::.::... ..:: :::::. ..: . NP_004 RGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :. ::: .::.::::::: ::.:::::: :.::. .::::::: :.:::::: .:: NP_004 GKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRAN 180 190 200 210 220 230 250 260 270 280 290 pF1KB5 RDLIYKQLQQAVTGISNAAQATA-SDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEE :: ..::.:.:..:::::::::. .:.:. : : : ::: :::.::..::.::..::: NP_004 RDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIG--ELAAALNEFDNKIILDPMTFSEA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 RFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKE :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: NP_004 RFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 RSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEY ..: :: :::::::::::::::::::::::.:::::::::::::::::::.::::::::: NP_004 KGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEY 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 AQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKL :::::::::::.:::::::::::::::::::::.:.:...::::::::::.:::.::::. NP_004 AQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKV 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 AQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLD ::.:::.::.::::::::::.:::::::.::::.::::::::::::::::::: ::: :: NP_004 AQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 RTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALS :::::::::::::::....::.::: :::::::::::::::.::::::.::::.:.:::: NP_004 RTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALS 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 SDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEEL-DDSDFETEDFDVRSRTSVQT .. ::..::::::::::::::.:::::::::::::::: :::::: ::.:::::::::: NP_004 ANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB5 EDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQ :::::::::::::::::::::.:::::::: :..:::::::::.::::::::::::::: NP_004 EDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQ 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB5 MCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLA :::::::::::::::::::::::::.:::::::::::::::.:..::.:::::::::::: NP_004 MCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLA 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB5 YLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYV :::::::::::::::::::::::::::::.:::.::: :::::::::::::: ::::::: NP_004 YLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYV 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB5 ASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALS ::::::: : :..: :.:::::::::::::::::: .: ::...:.:::::..:::::: NP_004 ASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALS 840 850 860 870 880 890 900 pF1KB5 EFKAMDSI ::::::: NP_004 EFKAMDSF 900 >>XP_016858892 (OMIM: 114025) PREDICTED: catenin alpha-2 (905 aa) initn: 2419 init1: 2419 opt: 4756 Z-score: 4860.3 bits: 910.5 E(85289): 0 Smith-Waterman score: 4756; 82.4% identity (94.5% similar) in 899 aa overlap (9-905:8-904) 10 20 30 40 50 60 pF1KB5 MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHV : .::::::::::::.::::::::::::::::::..::::.::.:::::::: XP_016 MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHV 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 LAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVK :::::::::.::::::..:::::: ::::::::::::::::. :. :..::::::::::: XP_016 LAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 RGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKAL ::.::::::::::::::::::::::::..:: .::.::... ..:: :::::. ..: . XP_016 RGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB5 KPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKAN :. ::: .::.::::::: ::.:::::: :.::. .::::::: :.:::::: .:: XP_016 GKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRAN 180 190 200 210 220 230 250 260 270 280 290 pF1KB5 RDLIYKQLQQAVTGISNAAQATA-SDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEE :: ..::.:.:..:::::::::. .:.:. : : : ::: :::.::..::.::..::: XP_016 RDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIG--ELAAALNEFDNKIILDPMTFSEA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 RFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKE :::::::::::::::::::::::::::::::::::::::::::::::::::::.:.:::: XP_016 RFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKE 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 RSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEY ..: :: :::::::::::::::::::::::.:::::::::::::::::::.::::::::: XP_016 KGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEY 360 370 380 390 400 410 420 430 440 450 460 470 pF1KB5 AQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKL :::::::::::.:::::::::::::::::::::.:.:...::::::::::.:::.::::. XP_016 AQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKV 420 430 440 450 460 470 480 490 500 510 520 530 pF1KB5 AQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLD ::.:::.::.::::::::::.:::::::.::::.::::::::::::::::::: ::: :: XP_016 AQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLD 480 490 500 510 520 530 540 550 560 570 580 590 pF1KB5 RTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALS :::::::::::::::....::.::: :::::::::::::::.::::::.::::.:.:::: XP_016 RTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALS 540 550 560 570 580 590 600 610 620 630 640 650 pF1KB5 SDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEEL-DDSDFETEDFDVRSRTSVQT .. ::..::::::::::::::.:::::::::::::::: :::::: ::.:::::::::: XP_016 ANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQT 600 610 620 630 640 650 660 670 680 690 700 710 pF1KB5 EDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQ :::::::::::::::::::::.:::::::: :..:::::::::.::::::::::::::: XP_016 EDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQ 660 670 680 690 700 710 720 730 740 750 760 770 pF1KB5 MCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLA :::::::::::::::::::::::::.:::::::::::::::.:..::.:::::::::::: XP_016 MCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLA 720 730 740 750 760 770 780 790 800 810 820 830 pF1KB5 YLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYV :::::::::::::::::::::::::::::.:::.::: :::::::::::::: ::::::: XP_016 YLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYV 780 790 800 810 820 830 840 850 860 870 880 890 pF1KB5 ASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALS ::::::: : :..: :.:::::::::::::::::: .: ::...:.:::::..:::::: XP_016 ASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALS 840 850 860 870 880 890 900 pF1KB5 EFKAMDSI ::::::: XP_016 EFKAMDSF 900 906 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Nov 3 18:03:38 2016 done: Thu Nov 3 18:03:39 2016 Total Scan time: 11.140 Total Display time: 0.390 Function used was FASTA [36.3.4 Apr, 2011]