FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5738, 740 aa 1>>>pF1KB5738 740 - 740 aa - 740 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2634+/-0.00104; mu= 14.5443+/- 0.061 mean_var=75.7186+/-14.920, 0's: 0 Z-trim(103.4): 80 B-trim: 3 in 1/48 Lambda= 0.147392 statistics sampled from 7315 (7399) to 7315 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.59), E-opt: 0.2 (0.227), width: 16 Scan time: 2.580 The best scores are: opt bits E(32554) CCDS1686.1 DDX1 gene_id:1653|Hs108|chr2 ( 740) 5029 1079.5 0 CCDS6951.1 DDX31 gene_id:64794|Hs108|chr9 ( 851) 374 89.7 2.1e-17 CCDS12577.1 HNRNPUL1 gene_id:11100|Hs108|chr19 ( 756) 349 84.4 7.4e-16 CCDS82351.1 HNRNPUL1 gene_id:11100|Hs108|chr19 ( 767) 349 84.4 7.5e-16 CCDS12576.1 HNRNPUL1 gene_id:11100|Hs108|chr19 ( 856) 349 84.4 8.3e-16 CCDS41659.1 HNRNPUL2 gene_id:221092|Hs108|chr11 ( 747) 330 80.3 1.2e-14 CCDS30964.1 DDX59 gene_id:83479|Hs108|chr1 ( 619) 306 75.2 3.5e-13 CCDS31081.1 HNRNPU gene_id:3192|Hs108|chr1 ( 806) 280 69.7 2e-11 CCDS41479.1 HNRNPU gene_id:3192|Hs108|chr1 ( 825) 280 69.7 2.1e-11 CCDS33758.1 RNF123 gene_id:63891|Hs108|chr3 (1314) 282 70.2 2.4e-11 CCDS4977.1 DDX43 gene_id:55510|Hs108|chr6 ( 648) 274 68.4 4e-11 CCDS55404.1 DDX3X gene_id:1654|Hs108|chrX ( 646) 270 67.5 7.3e-11 CCDS3282.1 EIF4A2 gene_id:1974|Hs108|chr3 ( 407) 267 66.9 7.4e-11 CCDS43931.1 DDX3X gene_id:1654|Hs108|chrX ( 662) 270 67.5 7.4e-11 CCDS14782.1 DDX3Y gene_id:8653|Hs108|chrY ( 660) 268 67.1 9.9e-11 >>CCDS1686.1 DDX1 gene_id:1653|Hs108|chr2 (740 aa) initn: 5029 init1: 5029 opt: 5029 Z-score: 5776.7 bits: 1079.5 E(32554): 0 Smith-Waterman score: 5029; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:1-740) 10 20 30 40 50 60 pF1KB5 MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 IQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 IQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 GCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 GCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 NYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 NYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 NFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 NFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 QTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 QTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 LSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 KIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 KIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGAN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 SPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 SPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQF 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 SCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 SCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 EIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS16 EIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEK 670 680 690 700 710 720 730 740 pF1KB5 EAQTSFLHLGYLPNQLFRTF :::::::::::::::::::: CCDS16 EAQTSFLHLGYLPNQLFRTF 730 740 >>CCDS6951.1 DDX31 gene_id:64794|Hs108|chr9 (851 aa) initn: 431 init1: 175 opt: 374 Z-score: 426.1 bits: 89.7 E(32554): 2.1e-17 Smith-Waterman score: 382; 25.0% identity (59.8% similar) in 376 aa overlap (266-626:289-640) 240 250 260 270 280 290 pF1KB5 AELKFNFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPS .:.: .. .... .. ..: ::.. :. CCDS69 KQSIPVLLEGRDALVRSQTGSGKTLAYCIPVVQSLQAMESKIQRS----DGPYALVLVPT 260 270 280 290 300 310 300 310 320 330 340 350 pF1KB5 RELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRL-DDLV :::: :........ : . . ...:: ... . :..:..:...::::: : . CCDS69 RELALQSFDTVQKLLKPFT--WIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIK 320 330 340 350 360 370 360 370 380 390 400 410 pF1KB5 STGKLNLSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFD :: ....:..:.::.:::: .:. :. :. . : :... .. : .. :::: . CCDS69 STKNIHFSRLRWLVFDEADRILDLGFEKDITVILNA---VNAECQKRQNVLLSATL-TEG 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 VKKLSEKIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGK-SHIRTDDVHAKD : .:.. .: :. . :: : : .::: . : . . :. . CCDS69 VTRLADISLHDPVSI------SVLDKSHD---QLNPKDKAVQEVCPPPAGDKLDSFAIPE 430 440 450 460 470 480 490 500 510 520 pF1KB5 NTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLE-------QYF . . .. . :. . . . .. : .. .. ..: . :. .: : . CCDS69 SLKQHVTV--VPSKLRLVCLAAFILQKCKFEEDQKMVVFFSS---CELVEFHYSLFLQTL 480 490 500 510 520 530 530 540 550 560 570 580 pF1KB5 IQQGGGP-----DKKGHQFSCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDI ....:.: . . ... . ::: . .:: ...:... :.::::::::.:. CCDS69 LSSSGAPASGQLPSASMRLKFLRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAARGLDL 540 550 560 570 580 590 590 600 610 620 630 640 pF1KB5 HGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVA-TEKEKVWYHVCSSRGKGCYN : .... . :. .:.:::::..: : .. ..: .: : : CCDS69 PQVTWIVQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKINVSEIK 600 610 620 630 640 650 650 660 670 680 690 700 pF1KB5 TRLKEDGGCTIWYNEMQLLSEIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGS CCDS69 MEDILCVLTRDDCFKGKRWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVSWAKKA 660 670 680 690 700 710 >>CCDS12577.1 HNRNPUL1 gene_id:11100|Hs108|chr19 (756 aa) initn: 350 init1: 210 opt: 349 Z-score: 398.2 bits: 84.4 E(32554): 7.4e-16 Smith-Waterman score: 385; 25.4% identity (57.7% similar) in 366 aa overlap (97-439:127-469) 70 80 90 100 110 120 pF1KB5 TLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATK ::.:.. . .:. . : : ::. CCDS12 PPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGF------AYLWSGARASY 100 110 120 130 140 150 130 140 150 160 170 pF1KB5 GLMKGKHYYEVSCH-------------DQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKK :. .:. .:.. . : . :.::: . : .:: . :..:.:::::: CCDS12 GVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKK 160 170 180 190 200 210 180 190 200 210 220 pF1KB5 SHNKQFDNYGEEFTMHDTIGCYLDIDKGH---VKFSKNGKDLGLAFEIPPH-MKNQALFP : :..:.:::..:. .:.:::. :.. :. ..:.:::: .:.::.: . . .:::.: CCDS12 STNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP 220 230 240 250 260 270 230 240 250 260 270 280 pF1KB5 ACVLKNAELKFNFGEEEFKF-PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPK ..:: ..::::.. . ::. ... : . ... : . .. ..: CCDS12 HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGT-VGPKSKAECEIL----- 280 290 300 310 320 290 300 310 320 330 340 pF1KB5 ALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPG .. :. : .: ::. .::. .. :.: : :.. :. :. . : CCDS12 MMVGLPA---AGKTTWAIKH---AASNPS-KKYNILGTNAIMDKMRVM--GLRRQRNYAG 330 340 350 360 370 350 360 370 380 390 400 pF1KB5 RLDDLVSTGKLNLSQ-VRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCS : : :.. . :.. ... . . . .:.: .. . . . . .: ...: CCDS12 RWDVLIQQATQCLNRLIQIAARKKRNYILDQ--TNVYGSAQRRKMRPFEGFQRKAIVICP 380 390 400 410 420 430 410 420 430 440 450 460 pF1KB5 AT--LHSFDVKKLSEKIMHFP--TWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSH . :.. .:. .:. : . ...:.. ..:: CCDS12 TDEDLKDRTIKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREEADKLVRQ 440 450 460 470 480 490 470 480 490 500 510 520 pF1KB5 IRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLE CCDS12 YNEEGRKAGPPPEKRFDNRGGGGFRGRGGGGGFQRYENRGPPGGNRGGFQNRGGGSGGGG 500 510 520 530 540 550 >>CCDS82351.1 HNRNPUL1 gene_id:11100|Hs108|chr19 (767 aa) initn: 350 init1: 210 opt: 349 Z-score: 398.1 bits: 84.4 E(32554): 7.5e-16 Smith-Waterman score: 385; 25.4% identity (57.7% similar) in 366 aa overlap (97-439:138-480) 70 80 90 100 110 120 pF1KB5 TLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATK ::.:.. . .:. . : : ::. CCDS82 PPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGF------AYLWSGARASY 110 120 130 140 150 160 130 140 150 160 170 pF1KB5 GLMKGKHYYEVSCH-------------DQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKK :. .:. .:.. . : . :.::: . : .:: . :..:.:::::: CCDS82 GVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKK 170 180 190 200 210 220 180 190 200 210 220 pF1KB5 SHNKQFDNYGEEFTMHDTIGCYLDIDKGH---VKFSKNGKDLGLAFEIPPH-MKNQALFP : :..:.:::..:. .:.:::. :.. :. ..:.:::: .:.::.: . . .:::.: CCDS82 STNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP 230 240 250 260 270 280 230 240 250 260 270 280 pF1KB5 ACVLKNAELKFNFGEEEFKF-PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPK ..:: ..::::.. . ::. ... : . ... : . .. ..: CCDS82 HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGT-VGPKSKAECEIL----- 290 300 310 320 330 290 300 310 320 330 340 pF1KB5 ALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPG .. :. : .: ::. .::. .. :.: : :.. :. :. . : CCDS82 MMVGLPA---AGKTTWAIKH---AASNPS-KKYNILGTNAIMDKMRVM--GLRRQRNYAG 340 350 360 370 380 350 360 370 380 390 400 pF1KB5 RLDDLVSTGKLNLSQ-VRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCS : : :.. . :.. ... . . . .:.: .. . . . . .: ...: CCDS82 RWDVLIQQATQCLNRLIQIAARKKRNYILDQ--TNVYGSAQRRKMRPFEGFQRKAIVICP 390 400 410 420 430 440 410 420 430 440 450 460 pF1KB5 AT--LHSFDVKKLSEKIMHFP--TWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSH . :.. .:. .:. : . ...:.. ..:: CCDS82 TDEDLKDRTIKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREEADKLVRQ 450 460 470 480 490 500 470 480 490 500 510 520 pF1KB5 IRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLE CCDS82 YNEEGRKAGPPPEKRFDNRGGGGFRGRGGGGGFQRYENRGPPGGNRGGFQNRGGGSGGGG 510 520 530 540 550 560 >>CCDS12576.1 HNRNPUL1 gene_id:11100|Hs108|chr19 (856 aa) initn: 350 init1: 210 opt: 349 Z-score: 397.3 bits: 84.4 E(32554): 8.3e-16 Smith-Waterman score: 385; 25.4% identity (57.7% similar) in 366 aa overlap (97-439:227-569) 70 80 90 100 110 120 pF1KB5 TLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATK ::.:.. . .:. . : : ::. CCDS12 PPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGF------AYLWSGARASY 200 210 220 230 240 250 130 140 150 160 170 pF1KB5 GLMKGKHYYEVSCH-------------DQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKK :. .:. .:.. . : . :.::: . : .:: . :..:.:::::: CCDS12 GVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKK 260 270 280 290 300 310 180 190 200 210 220 pF1KB5 SHNKQFDNYGEEFTMHDTIGCYLDIDKGH---VKFSKNGKDLGLAFEIPPH-MKNQALFP : :..:.:::..:. .:.:::. :.. :. ..:.:::: .:.::.: . . .:::.: CCDS12 STNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP 320 330 340 350 360 370 230 240 250 260 270 280 pF1KB5 ACVLKNAELKFNFGEEEFKF-PPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPK ..:: ..::::.. . ::. ... : . ... : . .. ..: CCDS12 HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGT-VGPKSKAECEIL----- 380 390 400 410 420 290 300 310 320 330 340 pF1KB5 ALIVEPSRELAEQTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPG .. :. : .: ::. .::. .. :.: : :.. :. :. . : CCDS12 MMVGLPA---AGKTTWAIKH---AASNPS-KKYNILGTNAIMDKMRVM--GLRRQRNYAG 430 440 450 460 470 350 360 370 380 390 400 pF1KB5 RLDDLVSTGKLNLSQ-VRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCS : : :.. . :.. ... . . . .:.: .. . . . . .: ...: CCDS12 RWDVLIQQATQCLNRLIQIAARKKRNYILDQ--TNVYGSAQRRKMRPFEGFQRKAIVICP 480 490 500 510 520 530 410 420 430 440 450 460 pF1KB5 AT--LHSFDVKKLSEKIMHFP--TWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSH . :.. .:. .:. : . ...:.. ..:: CCDS12 TDEDLKDRTIKRTDEEGKDVPDHAVLEMKANFTLPDVGDFLDEVLFIELQREEADKLVRQ 540 550 560 570 580 590 470 480 490 500 510 520 pF1KB5 IRTDDVHAKDNTRPGANSPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLE CCDS12 YNEEGRKAGPPPEKRFDNRGGGGFRGRGGGGGFQRYENRGPPGGNRGGFQNRGGGSGGGG 600 610 620 630 640 650 >>CCDS41659.1 HNRNPUL2 gene_id:221092|Hs108|chr11 (747 aa) initn: 309 init1: 183 opt: 330 Z-score: 376.5 bits: 80.3 E(32554): 1.2e-14 Smith-Waterman score: 363; 39.2% identity (65.2% similar) in 158 aa overlap (119-262:278-435) 90 100 110 120 130 pF1KB5 NKWQMNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVS---------- : : :.: :. ::: .:.. CCDS41 LDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEG 250 260 270 280 290 300 140 150 160 170 180 190 pF1KB5 CHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDI : . .: :::::. . .:: :.:..:: : : :..: ::...:. : .:.:::. .. CCDS41 CTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANF 310 320 330 340 350 360 200 210 220 230 240 250 pF1KB5 DKGHVK--FSKNGKDLGLAFEIPPH-MKNQALFPACVLKNAELKFNFGE-EEFKFPPKDG . .:. :::::.:::.:: : . ..::.: . :: ...:::. :: ::: . CCDS41 ETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEE 370 380 390 400 410 420 260 270 280 290 300 310 pF1KB5 FVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAEQTLNNIKQFKKYID :: . .: CCDS41 FVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAE 430 440 450 460 470 480 >>CCDS30964.1 DDX59 gene_id:83479|Hs108|chr1 (619 aa) initn: 514 init1: 183 opt: 306 Z-score: 350.2 bits: 75.2 E(32554): 3.5e-13 Smith-Waterman score: 409; 24.0% identity (57.2% similar) in 416 aa overlap (228-630:205-560) 200 210 220 230 240 250 pF1KB5 IDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKFNFGEEEFKFPPKDGFVA : : : .. :. :. . .. : . CCDS30 LNLQEDQIENLKQQLGILVQGQEVTRPIIDFEHCSLPEV-LNHNLKKSGYEVPTP---IQ 180 190 200 210 220 230 260 270 280 290 300 pF1KB5 LSKAPDGY----IVKSQHSGNAQ--------VTQTKFLPNAPKALIVEPSRELAEQTLNN .. : : :. : .:... . .. : ..:.:::. :.:::: : . CCDS30 MQMIPVGLLGRDILASADTGSGKTAAFLLPVIMRALFESKTPSALILTPTRELAIQIERQ 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB5 IKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVR :.. . . :... .:..::. :: :.. : ....::::: :... ....: :. CCDS30 AKELMSGL--PRMKTVLLVGGLPLPPQLYRLQQHVKVIIATPGRLLDIIKQSSVELCGVK 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 FLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSEKIMHF ..:.:::: .:..:... . . ..:: .: :.:. :::. . ....:. ...: CCDS30 IVVVDEADTMLKMGFQQQVLDILENIP---ND---CQTILVSATIPT-SIEQLASQLLHN 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 PTWVDLKGEDSVP-DTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGANSPEM :. . . :: ..: .:.... :: ..: : . :. .. CCDS30 PVRI-ITGEKNLPCANVRQII---------LW---------VEDPAKKKKLFEILNDKKL 410 420 430 440 490 500 510 520 530 540 pF1KB5 WSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQFSCVC .. . ..: :. : : . .:. : .. . CCDS30 FKPPV--------------------LVFVDCKLGADLLSEA-VQKITG-------LKSIS 450 460 470 550 560 570 580 590 600 pF1KB5 LHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYVHRIG .:.... :::. :. . .:: . .. : : .::.:. .: :.: .:. ..:::.:: CCDS30 IHSEKSQIERKNILKGLLEGDYEVVVSTGVLGRGLDLISVRLVVNFDMPSSMDEYVHQIG 480 490 500 510 520 530 610 620 630 640 650 660 pF1KB5 RVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLSEIEE :::: . : ::... ........ . CCDS30 RVGRLGQNGTAITFINNNSKRLFWDIAKRVKPTGSILPPQLLNSPYLHDQKRKEQQKDKQ 540 550 560 570 580 590 >>CCDS31081.1 HNRNPU gene_id:3192|Hs108|chr1 (806 aa) initn: 230 init1: 147 opt: 280 Z-score: 318.4 bits: 69.7 E(32554): 2e-11 Smith-Waterman score: 307; 28.5% identity (57.7% similar) in 267 aa overlap (93-322:271-537) 70 80 90 100 110 pF1KB5 IVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKE---- .. :. : :. : : .: .. CCDS31 YIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFL 250 260 270 280 290 300 120 130 140 150 160 pF1KB5 WHGCRATKGLMKGKHYYEVSC-------H------DQGLCRVGWSTMQASLDLGTDKFGF : : ::. :. ::: .:.. : : :.::: ... :: ..:.. CCDS31 WAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSY 310 320 330 340 350 360 170 180 190 200 210 220 pF1KB5 GFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFS--KNGKDLGLAFEIPPH-M :.. : :. : . ..:::.: .:.: :. .... .:..: :::.:::.::.: . . CCDS31 GYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVL 370 380 390 400 410 420 230 240 250 260 270 pF1KB5 KNQALFPACVLKNAELKFNFGEEEFK-FPPKDGFVALSKAPDGYIVKS----QHSGNAQV .. ::: . .: ..::::..: :: . .. ....: :.. ... . .: CCDS31 AGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEV 430 440 450 460 470 480 280 290 300 310 320 pF1KB5 TQTKFLPNAPKALIV------EPSRE--LAEQTLNN---IKQFKKYI-DNPKLRELLIIG .. ::.: :. : .:.. :. .:. . . ::: . :. :: :: CCDS31 VMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRA 490 500 510 520 530 540 330 340 350 360 370 380 pF1KB5 GVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFIN CCDS31 PQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQK 550 560 570 580 590 600 >>CCDS41479.1 HNRNPU gene_id:3192|Hs108|chr1 (825 aa) initn: 228 init1: 147 opt: 280 Z-score: 318.3 bits: 69.7 E(32554): 2.1e-11 Smith-Waterman score: 307; 28.5% identity (57.7% similar) in 267 aa overlap (93-322:290-556) 70 80 90 100 110 pF1KB5 IVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKE---- .. :. : :. : : .: .. CCDS41 YIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFL 260 270 280 290 300 310 120 130 140 150 160 pF1KB5 WHGCRATKGLMKGKHYYEVSC-------H------DQGLCRVGWSTMQASLDLGTDKFGF : : ::. :. ::: .:.. : : :.::: ... :: ..:.. CCDS41 WAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSY 320 330 340 350 360 370 170 180 190 200 210 220 pF1KB5 GFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFS--KNGKDLGLAFEIPPH-M :.. : :. : . ..:::.: .:.: :. .... .:..: :::.:::.::.: . . CCDS41 GYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVL 380 390 400 410 420 430 230 240 250 260 270 pF1KB5 KNQALFPACVLKNAELKFNFGEEEFK-FPPKDGFVALSKAPDGYIVKS----QHSGNAQV .. ::: . .: ..::::..: :: . .. ....: :.. ... . .: CCDS41 AGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEV 440 450 460 470 480 490 280 290 300 310 320 pF1KB5 TQTKFLPNAPKALIV------EPSRE--LAEQTLNN---IKQFKKYI-DNPKLRELLIIG .. ::.: :. : .:.. :. .:. . . ::: . :. :: :: CCDS41 VMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRA 500 510 520 530 540 550 330 340 350 360 370 380 pF1KB5 GVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQGYSDFIN CCDS41 PQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQK 560 570 580 590 600 610 >>CCDS33758.1 RNF123 gene_id:63891|Hs108|chr3 (1314 aa) initn: 213 init1: 135 opt: 282 Z-score: 317.2 bits: 70.2 E(32554): 2.4e-11 Smith-Waterman score: 282; 29.1% identity (58.3% similar) in 230 aa overlap (123-339:125-349) 100 110 120 130 140 150 pF1KB5 MNPYDRGSAFAIGSDGLCCQSREVKEWHGCRATKGLMKGKHYYEVSCHDQGLCRVGWSTM :.: ..::: ::: .::: ..:: :. CCDS33 VLDHTGGFEGLLLVDDDLLGVIGHSNFGTIRSTTCVYKGKWLYEVLISSQGLMQIGWCTI 100 110 120 130 140 150 160 170 180 190 200 pF1KB5 QASLD----LGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYLDIDKGHVKFSKN . .. .: . .... :. .. : :::. .. : ..: .:.: : ..: : CCDS33 SCRFNQEEGVGDTHNSYAYDGNRVRKWNVTTTNYGKAWAAGDIVSCLIDLDDGTLSFCLN 160 170 180 190 200 210 210 220 230 240 250 260 pF1KB5 GKDLGLAFEIPPHMKNQALFPACVLKNAE-LKFNFGEEEFKFPPKDGFVALSKAPDGYIV : .:: ::: . ..: ::: :. : . :::: . ...: :. :. :.. .: CCDS33 GVSLGTAFENLSRGLGMAYFPAISLSFKESVAFNFGSRPLRYPVA-GYRPLQDPPSADLV 220 230 240 250 260 270 270 280 290 300 310 pF1KB5 KSQHSGNA--QVTQTKFLPNAPKALIVEPSR-ELAEQ-----TLNNIKQFKKYIDNPKLR ..:. . : .... : . : : :. .: : :: .: :... : :: CCDS33 RAQRLLGCFRAVLSVELDPVEGRLLDKESSKWRLRGQPTVLLTLAHI--FHHF--APLLR 280 290 300 310 320 320 330 340 350 360 370 pF1KB5 ELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLNLSQVRFLVLDEADGLLSQG .. .. .: :...:.: CCDS33 KVYLVEAVLMSFLLGIVEKGTPTQAQSVVHQVLDLLWLFMEDYEVQDCLKQLMMSLLRLY 330 340 350 360 370 380 740 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:24:10 2016 done: Sat Nov 5 15:24:11 2016 Total Scan time: 2.580 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]