FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5772, 762 aa 1>>>pF1KB5772 762 - 762 aa - 762 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.2064+/-0.00067; mu= -13.8993+/- 0.040 mean_var=701.2289+/-161.229, 0's: 0 Z-trim(114.5): 1645 B-trim: 515 in 1/53 Lambda= 0.048433 statistics sampled from 22236 (24460) to 22236 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.623), E-opt: 0.2 (0.287), width: 16 Scan time: 12.710 The best scores are: opt bits E(85289) NP_006250 (OMIM: 601591) cGMP-dependent protein ki ( 762) 5068 371.2 8.9e-102 XP_005263183 (OMIM: 601591) PREDICTED: cGMP-depend ( 762) 5068 371.2 8.9e-102 XP_016863904 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 4830 354.6 9.1e-97 XP_016863902 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 4830 354.6 9.1e-97 XP_016863903 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 4830 354.6 9.1e-97 XP_016863905 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 4830 354.6 9.1e-97 XP_016863907 (OMIM: 601591) PREDICTED: cGMP-depend ( 462) 2988 225.6 3.7e-58 NP_001269414 (OMIM: 601591) cGMP-dependent protein ( 733) 2859 216.8 2.5e-55 XP_016863906 (OMIM: 601591) PREDICTED: cGMP-depend ( 745) 2859 216.9 2.5e-55 NP_001269409 (OMIM: 601591) cGMP-dependent protein ( 342) 2338 180.0 1.5e-44 NP_001269410 (OMIM: 601591) cGMP-dependent protein ( 342) 2338 180.0 1.5e-44 NP_001269411 (OMIM: 601591) cGMP-dependent protein ( 313) 2036 158.8 3.1e-38 NP_001269412 (OMIM: 601591) cGMP-dependent protein ( 282) 1968 154.0 7.9e-37 XP_016871902 (OMIM: 176894,615436) PREDICTED: cGMP ( 585) 1492 121.2 1.3e-26 XP_016871901 (OMIM: 176894,615436) PREDICTED: cGMP ( 591) 1492 121.2 1.3e-26 NP_001091982 (OMIM: 176894,615436) cGMP-dependent ( 671) 1492 121.3 1.4e-26 NP_006249 (OMIM: 176894,615436) cGMP-dependent pro ( 686) 1492 121.3 1.4e-26 NP_005035 (OMIM: 300083) cAMP-dependent protein ki ( 358) 957 83.5 1.7e-15 NP_997401 (OMIM: 601639,615830) cAMP-dependent pro ( 343) 953 83.2 2e-15 NP_002721 (OMIM: 601639,615830) cAMP-dependent pro ( 351) 953 83.2 2e-15 NP_001291278 (OMIM: 601639,615830) cAMP-dependent ( 427) 953 83.3 2.3e-15 NP_001229791 (OMIM: 176892) cAMP-dependent protein ( 338) 931 81.7 5.7e-15 XP_005271076 (OMIM: 176892) PREDICTED: cAMP-depend ( 338) 920 80.9 9.7e-15 NP_001229787 (OMIM: 176892) cAMP-dependent protein ( 339) 920 80.9 9.8e-15 XP_005271075 (OMIM: 176892) PREDICTED: cAMP-depend ( 346) 920 80.9 9.9e-15 XP_005271074 (OMIM: 176892) PREDICTED: cAMP-depend ( 347) 920 80.9 9.9e-15 XP_005271073 (OMIM: 176892) PREDICTED: cAMP-depend ( 349) 920 80.9 9.9e-15 XP_005271072 (OMIM: 176892) PREDICTED: cAMP-depend ( 350) 920 80.9 1e-14 NP_002722 (OMIM: 176892) cAMP-dependent protein ki ( 351) 920 80.9 1e-14 XP_006710821 (OMIM: 176892) PREDICTED: cAMP-depend ( 354) 920 80.9 1e-14 NP_001229788 (OMIM: 176892) cAMP-dependent protein ( 355) 920 80.9 1e-14 NP_001229789 (OMIM: 176892) cAMP-dependent protein ( 357) 920 80.9 1e-14 NP_001229786 (OMIM: 176892) cAMP-dependent protein ( 358) 920 80.9 1e-14 NP_891993 (OMIM: 176892) cAMP-dependent protein ki ( 398) 920 81.0 1.1e-14 NP_002723 (OMIM: 176893,616176) cAMP-dependent pro ( 351) 908 80.1 1.8e-14 XP_011538254 (OMIM: 176894,615436) PREDICTED: cGMP ( 406) 779 71.2 1e-11 NP_001258972 (OMIM: 608938) ribosomal protein S6 k ( 451) 753 69.4 3.8e-11 NP_001258973 (OMIM: 608938) ribosomal protein S6 k ( 472) 753 69.4 3.9e-11 NP_003943 (OMIM: 608939) ribosomal protein S6 kina ( 482) 753 69.4 3.9e-11 NP_001258989 (OMIM: 608938) ribosomal protein S6 k ( 502) 753 69.5 4e-11 NP_003152 (OMIM: 608938) ribosomal protein S6 kina ( 525) 753 69.5 4.1e-11 XP_005274634 (OMIM: 300075,300844,303600) PREDICTE ( 710) 754 69.7 4.7e-11 XP_016885208 (OMIM: 300075,300844,303600) PREDICTE ( 711) 754 69.7 4.7e-11 XP_016885207 (OMIM: 300075,300844,303600) PREDICTE ( 711) 754 69.7 4.7e-11 XP_006724570 (OMIM: 300075,300844,303600) PREDICTE ( 711) 754 69.7 4.7e-11 XP_011543865 (OMIM: 300075,300844,303600) PREDICTE ( 712) 754 69.7 4.7e-11 XP_016885204 (OMIM: 300075,300844,303600) PREDICTE ( 712) 754 69.7 4.7e-11 XP_016885203 (OMIM: 300075,300844,303600) PREDICTE ( 712) 754 69.7 4.7e-11 XP_016885205 (OMIM: 300075,300844,303600) PREDICTE ( 712) 754 69.7 4.7e-11 XP_016885202 (OMIM: 300075,300844,303600) PREDICTE ( 712) 754 69.7 4.7e-11 >>NP_006250 (OMIM: 601591) cGMP-dependent protein kinase (762 aa) initn: 5068 init1: 5068 opt: 5068 Z-score: 1948.2 bits: 371.2 E(85289): 8.9e-102 Smith-Waterman score: 5068; 100.0% identity (100.0% similar) in 762 aa overlap (1-762:1-762) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::::::::::::::::::::::::::::::::: NP_006 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 730 740 750 760 >>XP_005263183 (OMIM: 601591) PREDICTED: cGMP-dependent (762 aa) initn: 5068 init1: 5068 opt: 5068 Z-score: 1948.2 bits: 371.2 E(85289): 8.9e-102 Smith-Waterman score: 5068; 100.0% identity (100.0% similar) in 762 aa overlap (1-762:1-762) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::::::::::::::::::::::::::::::::: XP_005 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 730 740 750 760 >>XP_016863904 (OMIM: 601591) PREDICTED: cGMP-dependent (774 aa) initn: 4905 init1: 4830 opt: 4830 Z-score: 1858.3 bits: 354.6 E(85289): 9.1e-97 Smith-Waterman score: 4830; 99.9% identity (100.0% similar) in 732 aa overlap (1-732:1-732) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::. XP_016 ARSLPSPLQREVLYLLYYFFIFFPGICFCTQILDVCMYMPITDFGCFFLKQFLF 730 740 750 760 770 >>XP_016863902 (OMIM: 601591) PREDICTED: cGMP-dependent (774 aa) initn: 4905 init1: 4830 opt: 4830 Z-score: 1858.3 bits: 354.6 E(85289): 9.1e-97 Smith-Waterman score: 4830; 99.9% identity (100.0% similar) in 732 aa overlap (1-732:1-732) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::. XP_016 ARSLPSPLQREVLYLLYYFFIFFPGICFCTQILDVCMYMPITDFGCFFLKQFLF 730 740 750 760 770 >>XP_016863903 (OMIM: 601591) PREDICTED: cGMP-dependent (774 aa) initn: 4905 init1: 4830 opt: 4830 Z-score: 1858.3 bits: 354.6 E(85289): 9.1e-97 Smith-Waterman score: 4830; 99.9% identity (100.0% similar) in 732 aa overlap (1-732:1-732) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::. XP_016 ARSLPSPLQREVLYLLYYFFIFFPGICFCTQILDVCMYMPITDFGCFFLKQFLF 730 740 750 760 770 >>XP_016863905 (OMIM: 601591) PREDICTED: cGMP-dependent (774 aa) initn: 4905 init1: 4830 opt: 4830 Z-score: 1858.3 bits: 354.6 E(85289): 9.1e-97 Smith-Waterman score: 4830; 99.9% identity (100.0% similar) in 732 aa overlap (1-732:1-732) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 670 680 690 700 710 720 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::. XP_016 ARSLPSPLQREVLYLLYYFFIFFPGICFCTQILDVCMYMPITDFGCFFLKQFLF 730 740 750 760 770 >>XP_016863907 (OMIM: 601591) PREDICTED: cGMP-dependent (462 aa) initn: 2988 init1: 2988 opt: 2988 Z-score: 1165.1 bits: 225.6 E(85289): 3.7e-58 Smith-Waterman score: 2988; 100.0% identity (100.0% similar) in 462 aa overlap (1-462:1-462) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA :::::::::::::::::::::::::::::::::::::::::: XP_016 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVG 430 440 450 460 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS >>NP_001269414 (OMIM: 601591) cGMP-dependent protein kin (733 aa) initn: 2859 init1: 2859 opt: 2859 Z-score: 1114.2 bits: 216.8 E(85289): 2.5e-55 Smith-Waterman score: 4819; 96.2% identity (96.2% similar) in 762 aa overlap (1-762:1-733) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA ::::::::::::::::::::: :::::::::: NP_001 MSNWKLSKALSLEMIQLKEKV-----------------------------KVKNENVAFA 430 440 450 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 640 650 660 670 680 690 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::::::::::::::::::::::::::::::::: NP_001 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF 700 710 720 730 >>XP_016863906 (OMIM: 601591) PREDICTED: cGMP-dependent (745 aa) initn: 4640 init1: 2859 opt: 2859 Z-score: 1114.2 bits: 216.9 E(85289): 2.5e-55 Smith-Waterman score: 4581; 95.9% identity (96.0% similar) in 732 aa overlap (1-732:1-703) 10 20 30 40 50 60 pF1KB5 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIID 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKAL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 MSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFA ::::::::::::::::::::: :::::::::: XP_016 MSNWKLSKALSLEMIQLKEKV-----------------------------KVKNENVAFA 430 440 450 490 500 510 520 530 540 pF1KB5 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWS 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB5 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKK 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB5 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYN 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB5 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLK 640 650 660 670 680 690 730 740 750 760 pF1KB5 ARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF :::::::::::. XP_016 ARSLPSPLQREVLYLLYYFFIFFPGICFCTQILDVCMYMPITDFGCFFLKQFLF 700 710 720 730 740 >>NP_001269409 (OMIM: 601591) cGMP-dependent protein kin (342 aa) initn: 2338 init1: 2338 opt: 2338 Z-score: 921.0 bits: 180.0 E(85289): 1.5e-44 Smith-Waterman score: 2338; 100.0% identity (100.0% similar) in 342 aa overlap (421-762:1-342) 400 410 420 430 440 450 pF1KB5 VGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPF :::::::::::::::::::::::::::::: NP_001 MSNWKLSKALSLEMIQLKEKVARFSSSSPF 10 20 30 460 470 480 490 500 510 pF1KB5 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCS 40 50 60 70 80 90 520 530 540 550 560 570 pF1KB5 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRL 100 110 120 130 140 150 580 590 600 610 620 630 pF1KB5 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFS 160 170 180 190 200 210 640 650 660 670 680 690 pF1KB5 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQN 220 230 240 250 260 270 700 710 720 730 740 750 pF1KB5 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGM 280 290 300 310 320 330 760 pF1KB5 PPDELSGWDKDF :::::::::::: NP_001 PPDELSGWDKDF 340 762 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 08:21:42 2016 done: Sat Nov 5 08:21:43 2016 Total Scan time: 12.710 Total Display time: 0.240 Function used was FASTA [36.3.4 Apr, 2011]