Result of FASTA (omim) for
pF1KB5796
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5796, 780 aa
1>>>pF1KB5796 780 - 780 aa - 780 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4866+/-0.00048; mu= 5.2289+/- 0.030
mean_var=199.0126+/-41.886, 0's: 0 Z-trim(115.1): 219 B-trim: 186 in 1/50
Lambda= 0.090915
statistics sampled from 25008 (25269) to 25008 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.296), width: 16
Scan time: 10.920
The best scores are: opt bits E(85289)
NP_444282 (OMIM: 606389,612997) cation channel spe ( 780) 5371 718.2 3.3e-206
NP_821138 (OMIM: 609120) cation channel sperm-asso ( 398) 262 47.8 0.0001
NP_066919 (OMIM: 608230) voltage-dependent T-type (2223) 272 49.7 0.00016
NP_001009931 (OMIM: 616293) hornerin [Homo sapiens (2850) 269 49.4 0.00025
XP_016882222 (OMIM: 142705) PREDICTED: sarcoplasmi ( 613) 250 46.4 0.00043
NP_002143 (OMIM: 142705) sarcoplasmic reticulum hi ( 699) 250 46.5 0.00048
NP_937770 (OMIM: 609121) cation channel sperm-asso ( 472) 242 45.3 0.00074
XP_011539734 (OMIM: 609121) PREDICTED: cation chan ( 386) 235 44.3 0.0012
NP_000325 (OMIM: 168300,170400,170500,603967,60839 (1836) 248 46.5 0.0012
XP_016861142 (OMIM: 604385,615548,615552) PREDICTE (1259) 243 45.7 0.0014
XP_016862506 (OMIM: 113900,272120,600163,601144,60 (1962) 246 46.3 0.0015
NP_001153633 (OMIM: 113900,272120,600163,601144,60 (1962) 246 46.3 0.0015
NP_001092875 (OMIM: 113900,272120,600163,601144,60 (1998) 246 46.3 0.0016
XP_011532293 (OMIM: 113900,272120,600163,601144,60 (2015) 246 46.3 0.0016
NP_000326 (OMIM: 113900,272120,600163,601144,60115 (2015) 246 46.3 0.0016
NP_001092874 (OMIM: 113900,272120,600163,601144,60 (2016) 246 46.3 0.0016
NP_932173 (OMIM: 113900,272120,600163,601144,60115 (2016) 246 46.3 0.0016
XP_016870608 (OMIM: 601012,614860) PREDICTED: volt (1745) 237 45.1 0.0032
NP_001192223 (OMIM: 601013) voltage-dependent R-ty (2251) 237 45.1 0.0039
NP_000712 (OMIM: 601013) voltage-dependent R-type (2270) 237 45.1 0.0039
NP_001192222 (OMIM: 601013) voltage-dependent R-ty (2313) 237 45.1 0.0039
XP_011517295 (OMIM: 601012,614860) PREDICTED: volt (2341) 237 45.2 0.004
XP_016870605 (OMIM: 601012,614860) PREDICTED: volt (2342) 237 45.2 0.004
XP_011517294 (OMIM: 601012,614860) PREDICTED: volt (2343) 237 45.2 0.004
XP_016870604 (OMIM: 601012,614860) PREDICTED: volt (2343) 237 45.2 0.004
XP_011517293 (OMIM: 601012,614860) PREDICTED: volt (2344) 237 45.2 0.004
XP_016857739 (OMIM: 601013) PREDICTED: voltage-dep (2396) 237 45.2 0.0041
XP_016857738 (OMIM: 601013) PREDICTED: voltage-dep (2415) 237 45.2 0.0041
XP_016857737 (OMIM: 601013) PREDICTED: voltage-dep (2436) 237 45.2 0.0041
XP_016857736 (OMIM: 601013) PREDICTED: voltage-dep (2439) 237 45.2 0.0041
XP_016857740 (OMIM: 601013) PREDICTED: voltage-dep (2458) 237 45.2 0.0041
XP_016857733 (OMIM: 601013) PREDICTED: voltage-dep (2458) 237 45.2 0.0041
XP_016857732 (OMIM: 601013) PREDICTED: voltage-dep (2458) 237 45.2 0.0041
NP_001003406 (OMIM: 608230) voltage-dependent T-ty (2188) 234 44.7 0.005
NP_001120693 (OMIM: 108500,141500,183086,601011,61 (2261) 230 44.2 0.0073
NP_001167551 (OMIM: 108500,141500,183086,601011,61 (2263) 230 44.2 0.0073
NP_000059 (OMIM: 108500,141500,183086,601011,61710 (2266) 230 44.2 0.0073
NP_001120694 (OMIM: 108500,141500,183086,601011,61 (2506) 230 44.3 0.0079
NP_075461 (OMIM: 108500,141500,183086,601011,61710 (2512) 230 44.3 0.008
>>NP_444282 (OMIM: 606389,612997) cation channel sperm-a (780 aa)
initn: 5371 init1: 5371 opt: 5371 Z-score: 3823.0 bits: 718.2 E(85289): 3.3e-206
Smith-Waterman score: 5371; 99.7% identity (100.0% similar) in 780 aa overlap (1-780:1-780)
10 20 30 40 50 60
pF1KB5 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELHHHGVPHQRGESHHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 PEFQDFHDQALSSHVHQSHHHSEARNHGRAHGPTGFGLAPSQGAVPSHRSYGEDYHDELQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RDGRRHHDGSQYSGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_444 RDGRRHHDGSQYGGFHQQSDSHYHRGSHHGRPQYLGENLSHYSSGVPHHGEASHHGGSYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 PHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 PHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDYH
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 QHQDHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 HSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRKKGHSTN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 LFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB5 MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 MALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB5 LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 LFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB5 LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILIIYIIIQYF
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_444 LRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSLIYMDSRAQGAWYIIPILVIYIIIQYF
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB5 IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 IFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTML
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB5 KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_444 KRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAAVIDEIVDTTFEAGEEDFRN
730 740 750 760 770 780
>>NP_821138 (OMIM: 609120) cation channel sperm-associat (398 aa)
initn: 132 init1: 101 opt: 262 Z-score: 205.5 bits: 47.8 E(85289): 0.0001
Smith-Waterman score: 262; 21.8% identity (57.6% similar) in 316 aa overlap (437-746:40-338)
410 420 430 440 450 460
pF1KB5 GRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVA
: ... . .: :. ... .: :. ...
NP_821 SRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMAL
10 20 30 40 50 60
470 480 490 500 510 520
pF1KB5 QTFAEVEIRGEWYFMALDSIFFC-IYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLD
: ... : . .. .. ::: : . : .:. . ..:. . .: :: .:. . :
NP_821 WTSYDIRYR-LFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLP
70 80 90 100 110 120
530 540 550 560 570 580
pF1KB5 FLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAA
. : : . . : : . ....:: .:. ... ... . ..::.. ..:.
NP_821 YALRQLMG------KQFTYLYIADGMQSLR---ILKLIGYSQGIRTLITAVGQTVYTVAS
130 140 150 160 170
590 600 610 620 630 640
pF1KB5 ILILMFTCLFLFSAVLRALF---RKSDPKRFQNIFTTIFTLFTLLTLDDWSLIY--MDSR
.:.:.: ...:. . :: ..: . :. ...::::.: :.: :. . .:.:
NP_821 VLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNR
180 190 200 210 220 230
650 660 670 680 690 700
pF1KB5 AQGAWYIIPILIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLED
. . : :.:.. :::::. . :.. . .. .: ..: . :: :. .
NP_821 EFALSRAFTI--IFILLASFIFLNMFVGVMIMHTEDSI----RKFERELMLEQQEMLMGE
240 250 260 270 280 290
710 720 730 740 750 760
pF1KB5 SLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQA
. . :. . .:.. . : .:. ..:. .. : : .:
NP_821 KQVILQRQQ-EEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIY
300 310 320 330 340 350
770 780
pF1KB5 AVIDEIVDTTFEAGEEDFRN
NP_821 FSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
360 370 380 390
>>NP_066919 (OMIM: 608230) voltage-dependent T-type calc (2223 aa)
initn: 186 init1: 127 opt: 272 Z-score: 202.2 bits: 49.7 E(85289): 0.00016
Smith-Waterman score: 277; 21.0% identity (55.9% similar) in 424 aa overlap (270-675:468-866)
240 250 260 270 280 290
pF1KB5 SPHHGETISPHSSVGSYQRGISDYHSEYHQGDHHPSEYHHGDHPHHTQHHYHQTHRHRDY
: . :. . : : .. .:.. .:. . :
NP_066 IFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDE
440 450 460 470 480 490
300 310 320 330 340 350
pF1KB5 HQHQDHHGAYHSSYLHGDYV----QSTSQLSIPH-----TSRSLIHDAPGPAASRTGVFP
.: :. : . ::: .: .: : : ..:.. :. :: . :
NP_066 GRHL---GSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQPIPATLASDPASCP
500 510 520 530 540 550
360 370 380 390 400
pF1KB5 --YHVAHPRGSAHSMTRSSSTIRSRVTQMSKKVHTQDISTKHSEDWGKEEGQFQKRKTGR
: : :. . : :.. . .. . . ... ... ::: .. : :.
NP_066 CCQHEDGRRPSGLGSTDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSE-------LGK
560 570 580 590 600
410 420 430 440 450 460
pF1KB5 LQRTRKKGHSTNLFQWL----WEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVML
.. .... .. :: :.. : .:....: :. :.... .::: .
NP_066 EEEEEEQADGAV---WLCGDVWRET-------RAKLRGIVDSKYFNRGIMMAILVNTVSM
610 620 630 640 650
470 480 490 500 510 520
pF1KB5 VAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGL-SYFFDFWNNLDFFIMAMAV
. . : . . . .: ....: .::. :.:: .:. . .: .: .:. ...
NP_066 GIEHHEQPE-ELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISI
660 670 680 690 700 710
530 540 550 560 570 580
pF1KB5 LDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSI
... . .... . ::.:.:.: .: . :.: :.: : .... ..:. . : .
NP_066 WEIVGQADGGLSVLR--TFRLLRVLKLVRFMPALR--RQLVVLMKTMDNVATFCMLLMLF
720 730 740 750 760 770
590 600 610 620 630 640
pF1KB5 AAILILMFTCLFLFSAVLRALFRKSDPKR--FQNIFTTIFTLFTLLTLDDWSLIYMDSRA
:. .. .: . ::. . : : :.... .: :.: .:: .::... ... :
NP_066 IFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMA
780 790 800 810 820 830
650 660 670 680 690 700
pF1KB5 QGAWYIIPILIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDS
. . . .. . . ....::....::..::
NP_066 STSPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNIEEFDKLQ
840 850 860 870 880 890
710 720 730 740 750 760
pF1KB5 LTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASVEQEQQKFRSQAA
NP_066 EGLDSSGDPKLCPIPMTPNGHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKS
900 910 920 930 940 950
>>NP_001009931 (OMIM: 616293) hornerin [Homo sapiens] (2850 aa)
initn: 85 init1: 85 opt: 269 Z-score: 198.6 bits: 49.4 E(85289): 0.00025
Smith-Waterman score: 296; 26.4% identity (48.8% similar) in 455 aa overlap (25-419:1239-1683)
10 20 30 40 50
pF1KB5 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGHSRALHHYELH-HHGVPHQ
: :: . : :. .: : : .::
NP_001 HGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGR--HGSGLGHSSSHGQHGSGSG
1210 1220 1230 1240 1250 1260
60 70 80 90
pF1KB5 RGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRA---------HGPTG-----F---
:. :. : : .. :......: : : : .:: . :: :. :
NP_001 RSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQE
1270 1280 1290 1300 1310 1320
100 110 120 130 140
pF1KB5 GLAPSQGAVPSHRSYGEDYHDELQRDGR---------RHHDGSQYSGFHQQ-------SD
: . .:.. .::. : . . : : :: .:: .:. . : :.
NP_001 GSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSS
1330 1340 1350 1360 1370 1380
150 160 170 180 190
pF1KB5 SHYHRGSHHGRPQYLG--ENLSHYSSGVPHHGEASHHGGSYLPHGPNPYSESFHHSEASH
: ..:: :. . .: :. : ::: .:: .: :..:: :: . : . ..:
NP_001 SSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSS
1390 1400 1410 1420 1430 1440
200 210 220 230 240 250
pF1KB5 LSGLQHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSPHHGETISPHSSVGSYQR
:: . . .:: . ... : .. :.: .::.. .. . ::..: ::
NP_001 -SGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGS-GS---
1450 1460 1470 1480 1490 1500
260 270 280 290 300 310
pF1KB5 GISDYHSEYHQGDHHPSEYHH-----GDHPHHTQHHYHQTHRHRDYHQHQDHHGAYHSSY
: :. .. :..:. : : : :. . :: . : . :: . : :
NP_001 GWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSST-HGQHGSTSGQSSSCG
1510 1520 1530 1540 1550 1560
320 330 340 350 360
pF1KB5 LHGDYV-QSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMT--------
:: ::.:. . : : : .. : .: .: : : . :: .: .
NP_001 QHGASSGQSSSHGQ--HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGS
1570 1580 1590 1600 1610
370 380 390 400 410
pF1KB5 -RSSSTIR--SRVTQMSKKVHTQDIS------TKHSEDWGKEEGQFQK-RKTGRLQRTRK
::::. . : . . : : .. : ..:. :. : :. ..:. .: ..
NP_001 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGER
1620 1630 1640 1650 1660 1670
420 430 440 450 460 470
pF1KB5 KGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEI
.: :.
NP_001 HGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRS
1680 1690 1700 1710 1720 1730
>--
initn: 85 init1: 85 opt: 285 Z-score: 209.9 bits: 51.5 E(85289): 5.9e-05
Smith-Waterman score: 306; 25.3% identity (49.8% similar) in 454 aa overlap (3-419:539-977)
10 20
pF1KB5 MDQNSVPEKAQNEADTNNADRFF-------RS
:. : ....:. . ... . ::
NP_001 SSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRS
510 520 530 540 550 560
30 40 50 60 70 80
pF1KB5 HSSPPHHR-PGHSRALHHYELHHHGVPHQRGESHHPPEFQDFHDQALSSHVHQSH--HHS
: :.. ::: .: : : . : :. .. : : :. ..: .:.
NP_001 SSRGPYESGSGHSSGLGHQE-SRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHG
570 580 590 600 610 620
90 100 110 120 130
pF1KB5 EARNHGRAHGPTGFGLAPSQ---------GAVPSHRSYGEDYHDELQRDGRRHHDGSQYS
. ... .:: : : . :. : ::. .: :. :. :.. :
NP_001 ATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDF-------GHSSSYGQHGS
630 640 650 660 670 680
140 150 160 170 180 190
pF1KB5 GFHQQSDSHYHRGSHHGRPQYLG-ENLSHYSSGVPHHGEASHHGGSYLPHGP--NPYSES
: .:.. : :: :. . .: .. : ::: .:: .: :...: :: . :.:
NP_001 GSGWSSSNGPH-GSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRS
690 700 710 720 730
200 210 220 230 240
pF1KB5 FHHSEASHLSGL--QHDESQHHQVPHRGWPHHHQVHHHGRSRHHEAHQHGKSP-HHGETI
.:. .: ::. :: ..:.. : : . : .: :: . :..: .::
NP_001 EQHGSSSGLSSSYGQHGSGSHQSSGH-GRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGT
740 750 760 770 780 790
250 260 270 280 290 300
pF1KB5 SPHSSVGSYQRGISDYHSEY--HQGDHHPSEYHHGDHPHH--TQHHYHQTHRHRDYHQHQ
: :: : :. : : : . :.. . .::. : .: .. .: . . ..
NP_001 SCSSSCGHYESG-SGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQH
800 810 820 830 840 850
310 320 330 340 350 360
pF1KB5 DHHGAYHSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSM
: .. ::: . . .. .. : : : . : .: .: : . : ::.
NP_001 DSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSG---
860 870 880 890 900 910
370 380 390 400 410
pF1KB5 TRSSSTIR--SRVTQMSKKVHTQDIS-----TKHSEDWGKEEGQFQK-RKTGRLQRTRKK
::::. : : : : : .. . :.:. :. . :. ..:. .:....
NP_001 -RSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQH
920 930 940 950 960 970
420 430 440 450 460 470
pF1KB5 GHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIR
: :.
NP_001 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGW
980 990 1000 1010 1020 1030
>>XP_016882222 (OMIM: 142705) PREDICTED: sarcoplasmic re (613 aa)
initn: 311 init1: 119 opt: 250 Z-score: 194.4 bits: 46.4 E(85289): 0.00043
Smith-Waterman score: 272; 21.8% identity (52.4% similar) in 435 aa overlap (18-423:119-532)
10 20 30 40
pF1KB5 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGH-SRALHHYELH
.... : :.. . . :: :. . :
XP_016 EKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEH
90 100 110 120 130 140
50 60 70 80 90 100
pF1KB5 HHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAH-GPTGFGLAPSQGAV
.: .: .:..::. . .:...::. ::: :. :.: : : .
XP_016 RHHLPSHRSHSHQDED----EDEVVSSE----HHHHILRHGHRGHDGEDDEGEEEEEEEE
150 160 170 180 190 200
110 120 130 140 150 160
pF1KB5 PSHRSYGEDYHDELQRDGRRHHDGSQYS-GFHQQSDSHYHRGSHHGRPQYLGENLSHYSS
... : :. .. :. .. . : : :... :: :.: .. . .. . ..
XP_016 EEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDD
210 220 230 240 250 260
170 180 190 200 210 220
pF1KB5 GVP--HHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQ
: .. .: .: : . . . :.. :: . :: .:.:... . . . ::
XP_016 DVSIEYRHQAHRHQGHGIEEDED-VSDGHHHRDPSH-RHRSHEEDDNDD-DDVSTEYGHQ
270 280 290 300 310
230 240 250 260 270
pF1KB5 VHHHGRSRHHEAHQ-HGKSPHHGETISPHSSVGSY-QRGISDYHSE-YHQGDHHPSEYHH
.:.: :..:.. :. :: . : : .. : .: .::: .: ::
XP_016 AHRHQDHRKEEVEAVSGEHHHH---VPDHRHQGHRDEEEDEDVSTERWHQGPQH---VHH
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB5 G--DHPHHTQH------HYHQTHRHRDYHQ-HQDHHGAYHSSYLHGDYVQSTSQLSIPHT
: :. .. .. :: .:. : ... ..: . :.. : . . . . ..
XP_016 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHH-HRVPREEDEEV
380 390 400 410 420 430
340 350 360 370 380
pF1KB5 SRSLIHDAPGPAAS---------RTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKV
: : :.::. : . : . :: : :..... : .:. .. :.
XP_016 SAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPG--HTVVKDRSHLRKDDSEEEKE-
440 450 460 470 480
390 400 410 420 430
pF1KB5 HTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRK---KGHSTNLFQWLWEKLTFLIQGFRE
. .: .... .: ..:.:. .. .: :. .. .::. .: :
XP_016 KEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEE
490 500 510 520 530 540
440 450 460 470 480 490
pF1KB5 MIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLK
XP_016 DEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESG
550 560 570 580 590 600
>>NP_002143 (OMIM: 142705) sarcoplasmic reticulum histid (699 aa)
initn: 311 init1: 119 opt: 250 Z-score: 193.6 bits: 46.5 E(85289): 0.00048
Smith-Waterman score: 272; 21.8% identity (52.4% similar) in 435 aa overlap (18-423:119-532)
10 20 30 40
pF1KB5 MDQNSVPEKAQNEADTNNADRFFRSHSSPPHHRPGH-SRALHHYELH
.... : :.. . . :: :. . :
NP_002 EKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEH
90 100 110 120 130 140
50 60 70 80 90 100
pF1KB5 HHGVPHQRGESHHPPEFQDFHDQALSSHVHQSHHHSEARNHGRAH-GPTGFGLAPSQGAV
.: .: .:..::. . .:...::. ::: :. :.: : : .
NP_002 RHHLPSHRSHSHQDED----EDEVVSSE----HHHHILRHGHRGHDGEDDEGEEEEEEEE
150 160 170 180 190 200
110 120 130 140 150 160
pF1KB5 PSHRSYGEDYHDELQRDGRRHHDGSQYS-GFHQQSDSHYHRGSHHGRPQYLGENLSHYSS
... : :. .. :. .. . : : :... :: :.: .. . .. . ..
NP_002 EEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDD
210 220 230 240 250 260
170 180 190 200 210 220
pF1KB5 GVP--HHGEASHHGGSYLPHGPNPYSESFHHSEASHLSGLQHDESQHHQVPHRGWPHHHQ
: .. .: .: : . . . :.. :: . :: .:.:... . . . ::
NP_002 DVSIEYRHQAHRHQGHGIEEDED-VSDGHHHRDPSH-RHRSHEEDDNDD-DDVSTEYGHQ
270 280 290 300 310
230 240 250 260 270
pF1KB5 VHHHGRSRHHEAHQ-HGKSPHHGETISPHSSVGSY-QRGISDYHSE-YHQGDHHPSEYHH
.:.: :..:.. :. :: . : : .. : .: .::: .: ::
NP_002 AHRHQDHRKEEVEAVSGEHHHH---VPDHRHQGHRDEEEDEDVSTERWHQGPQH---VHH
320 330 340 350 360 370
280 290 300 310 320 330
pF1KB5 G--DHPHHTQH------HYHQTHRHRDYHQ-HQDHHGAYHSSYLHGDYVQSTSQLSIPHT
: :. .. .. :: .:. : ... ..: . :.. : . . . . ..
NP_002 GLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHH-HRVPREEDEEV
380 390 400 410 420 430
340 350 360 370 380
pF1KB5 SRSLIHDAPGPAAS---------RTGVFPYHVAHPRGSAHSMTRSSSTIRSRVTQMSKKV
: : :.::. : . : . :: : :..... : .:. .. :.
NP_002 SAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPG--HTVVKDRSHLRKDDSEEEKE-
440 450 460 470 480
390 400 410 420 430
pF1KB5 HTQDISTKHSEDWGKEEGQFQKRKTGRLQRTRK---KGHSTNLFQWLWEKLTFLIQGFRE
. .: .... .: ..:.:. .. .: :. .. .::. .: :
NP_002 KEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEE
490 500 510 520 530 540
440 450 460 470 480 490
pF1KB5 MIRNLTQSLAFETFIFFVVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLK
NP_002 DEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESG
550 560 570 580 590 600
>>NP_937770 (OMIM: 609121) cation channel sperm-associat (472 aa)
initn: 178 init1: 178 opt: 242 Z-score: 190.3 bits: 45.3 E(85289): 0.00074
Smith-Waterman score: 323; 23.5% identity (57.5% similar) in 362 aa overlap (426-776:74-415)
400 410 420 430 440 450
pF1KB5 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF
:. :. . . :..: . ::. .. .
NP_937 PLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMY---IKQLLRHPAFQLLLAL
50 60 70 80 90 100
460 470 480 490 500 510
pF1KB5 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL
.. .:.. .. .: . .. . : ..:.: . : . :.:: . :. :. : :: :
NP_937 LLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN-GFWIFWKDGWNIL
110 120 130 140 150
520 530 540 550 560 570
pF1KB5 DFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTG
.:.:. . .: :.. . . .: . .::::: ..: . :. . .:
NP_937 NFIIVFILLLRFFINEINIPSINY-----------TLRALRLVHVCMAVEPLARIIRV--
160 170 180 190 200
580 590 600 610 620 630
pF1KB5 TLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSL
. ::.:..: :..:.. ...::. .:: ::.:::: ....::: .: : :
NP_937 -ILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVD
210 220 230 240 250 260
640 650 660 670 680
pF1KB5 IYMDSRAQGAWYIIPI-----LIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQER
:: : ... : . : . :.: : :: .:: . :.. ... ..:. :...:.:
NP_937 IYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQ-MMKAGEQGQQQR
270 280 290 300 310 320
690 700 710 720 730 740
pF1KB5 AAR----IQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQL
. .:. .:.: .. . . : : . . : .....:. . . :.
NP_937 ITFSETGAEEEEENDQLPLVHCVVARSEKS-GLLQEPLAGGPLSNLSENTCDNFCLVLEA
330 340 350 360 370 380
750 760 770 780
pF1KB5 VASVEQEQQKFRSQ-AAVIDEIVDTTFEAGEEDFRN
. .. ...:.. ...:. :. .:
NP_937 IQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQ
390 400 410 420 430 440
NP_937 QDLLSALVSMEKVHDSSSQILLKKHKSSH
450 460 470
>>XP_011539734 (OMIM: 609121) PREDICTED: cation channel (386 aa)
initn: 178 init1: 178 opt: 235 Z-score: 186.5 bits: 44.3 E(85289): 0.0012
Smith-Waterman score: 316; 27.0% identity (60.0% similar) in 270 aa overlap (426-689:74-324)
400 410 420 430 440 450
pF1KB5 KEEGQFQKRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFF
:. :. . . :..: . ::. .. .
XP_011 PLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMY---IKQLLRHPAFQLLLAL
50 60 70 80 90 100
460 470 480 490 500 510
pF1KB5 VVCLNTVMLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFF-DFWNNL
.. .:.. .. .: . .. . : ..:.: . : . :.:: . :. :. : :: :
XP_011 LLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLN-GFWIFWKDGWNIL
110 120 130 140 150
520 530 540 550 560 570
pF1KB5 DFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTG
.:.:. . .: :.. . . .: . .::::: ..: . :. . .:
XP_011 NFIIVFILLLRFFINEINIPSINY-----------TLRALRLVHVCMAVEPLARIIRV--
160 170 180 190 200
580 590 600 610 620 630
pF1KB5 TLGQSLPSIAAILILMFTCLFLFSAVLRALFRKSDPKRFQNIFTTIFTLFTLLTLDDWSL
. ::.:..: :..:.. ...::. .:: ::.:::: ....::: .: : :
XP_011 -ILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVD
210 220 230 240 250 260
640 650 660 670 680
pF1KB5 IYMDSRAQGAWYIIPI-----LIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQER
:: : ... : . : . :.: : :: .:: . :.. ... ..:. :...:.:
XP_011 IYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQ-MMKAGEQGQQQR
270 280 290 300 310 320
690 700 710 720 730 740
pF1KB5 AARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVASV
XP_011 ITFSEAQRKRRRMTSCHWCIVWSPARRNLVSSRNPLREAPCRTSQKTRVTTFAWCLRQYR
330 340 350 360 370 380
>>NP_000325 (OMIM: 168300,170400,170500,603967,608390,61 (1836 aa)
initn: 137 init1: 137 opt: 248 Z-score: 186.4 bits: 46.5 E(85289): 0.0012
Smith-Waterman score: 254; 24.2% identity (55.7% similar) in 273 aa overlap (433-677:1342-1604)
410 420 430 440 450 460
pF1KB5 KRKTGRLQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTV
::: :. .:. . ::. :....::: :
NP_000 MTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQG---MVYDLVTKQAFDITIMILICLNMV
1320 1330 1340 1350 1360
470 480 490 500 510 520
pF1KB5 MLVAQTFAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMA
....: . ... . .. .. ::. :.. : .::..:: :: :: .:: .. ..
NP_000 TMMVETDNQSQLKVD-ILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVVVILS
1370 1380 1390 1400 1410 1420
530 540 550 560 570 580
pF1KB5 VLDFLLMQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPS
.. . : . . . .:::.... . :.:: :: . ... . .: .:::.
NP_000 IVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAK------GIRTLLFALMMSLPA
1430 1440 1450 1460 1470 1480
590 600 610 620 630
pF1KB5 IAAILILMFTCLFLFSAVLRALF---RK----SDPKRFQNIFTTIFTLFTLLTLDDWSLI
. : .:.: .:..: . : .: .: :... ..:. :: . : :. .
NP_000 LFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGL
1490 1500 1510 1520 1530 1540
640 650 660 670
pF1KB5 YMDSRAQGAWYIIPIL---------------------IIYIIIQYFIFLNLVITVLVDSF
.: : : ::::...: .:. :......:
NP_000 LNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENF
1550 1560 1570 1580 1590 1600
680 690 700 710 720 730
pF1KB5 QTALFKGLEKAKQERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEK
..:
NP_000 NVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL
1610 1620 1630 1640 1650 1660
>>XP_016861142 (OMIM: 604385,615548,615552) PREDICTED: s (1259 aa)
initn: 210 init1: 100 opt: 243 Z-score: 185.1 bits: 45.7 E(85289): 0.0014
Smith-Waterman score: 272; 23.5% identity (60.0% similar) in 260 aa overlap (439-677:826-1078)
410 420 430 440 450 460
pF1KB5 LQRTRKKGHSTNLFQWLWEKLTFLIQGFREMIRNLTQSLAFETFIFFVVCLNTVMLVAQT
.. ... : :. .:. .. :: . ..:..
XP_016 EQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAES
800 810 820 830 840 850
470 480 490 500 510 520
pF1KB5 FAEVEIRGEWYFMALDSIFFCIYVVEALLKIIALGLSYFFDFWNNLDFFIMAMAVLDFLL
. . . . . :. .: :...: :.::.:: :: . :: .: .. ..... ..
XP_016 YNQPKAM-KSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMI
860 870 880 890 900 910
530 540 550 560 570 580
pF1KB5 --MQTHSFAIYHQSLFRILKVFKSLRALRAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAI
.... . .::::... . : :: .:. : ... . .: .::::. :
XP_016 STLENQEHIPFPPTLFRIVRLARIGRILRLVRAAR------GIRTLLFALMMSLPSLFNI
920 930 940 950 960
590 600 610 620 630
pF1KB5 LILMFTCLFLFSAVLRALFRKSDPKR-------FQNIFTTIFTLFTLLTLDDW-SLI--Y
.:.: .:... . : : .:. :... .... :: . : : ::. .
XP_016 GLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPM
970 980 990 1000 1010 1020
640 650 660 670 680
pF1KB5 MDSR----AQGAWYIIP-----ILIIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQ
. :. ... .: .. ::::...: .:. :.:....:.::
XP_016 LRSKESCNSSSENCHLPGIATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGE
1030 1040 1050 1060 1070 1080
690 700 710 720 730 740
pF1KB5 ERAARIQEKLLEDSLTELRAAEPKEVASEGTMLKRLIEKKFGTMTEKQQELLFHYLQLVA
XP_016 DDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRL
1090 1100 1110 1120 1130 1140
780 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 18:22:36 2016 done: Sat Nov 5 18:22:38 2016
Total Scan time: 10.920 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]