FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5816, 875 aa 1>>>pF1KB5816 875 - 875 aa - 875 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.7915+/-0.000411; mu= -2.5315+/- 0.026 mean_var=373.7247+/-73.052, 0's: 0 Z-trim(123.3): 10 B-trim: 0 in 0/57 Lambda= 0.066343 statistics sampled from 42807 (42820) to 42807 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.502), width: 16 Scan time: 15.500 The best scores are: opt bits E(85289) NP_001122324 (OMIM: 614469) serrate RNA effector m ( 875) 6065 595.1 4.6e-169 XP_005250463 (OMIM: 614469) PREDICTED: serrate RNA ( 882) 6065 595.1 4.7e-169 NP_056992 (OMIM: 614469) serrate RNA effector mole ( 876) 6053 594.0 1e-168 XP_005250462 (OMIM: 614469) PREDICTED: serrate RNA ( 883) 6053 594.0 1e-168 NP_001122326 (OMIM: 614469) serrate RNA effector m ( 871) 6009 589.8 1.9e-167 XP_005250465 (OMIM: 614469) PREDICTED: serrate RNA ( 878) 6009 589.8 1.9e-167 NP_001122325 (OMIM: 614469) serrate RNA effector m ( 872) 5997 588.6 4.2e-167 XP_005250464 (OMIM: 614469) PREDICTED: serrate RNA ( 879) 5997 588.6 4.2e-167 XP_016867780 (OMIM: 614469) PREDICTED: serrate RNA ( 792) 5426 533.9 1.1e-150 XP_016867779 (OMIM: 614469) PREDICTED: serrate RNA ( 793) 5414 532.8 2.5e-150 >>NP_001122324 (OMIM: 614469) serrate RNA effector molec (875 aa) initn: 6065 init1: 6065 opt: 6065 Z-score: 3156.2 bits: 595.1 E(85289): 4.6e-169 Smith-Waterman score: 6065; 100.0% identity (100.0% similar) in 875 aa overlap (1-875:1-875) 10 20 30 40 50 60 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL 730 740 750 760 770 780 790 800 810 820 830 840 pF1KB5 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 790 800 810 820 830 840 850 860 870 pF1KB5 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF ::::::::::::::::::::::::::::::::::: NP_001 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 850 860 870 >>XP_005250463 (OMIM: 614469) PREDICTED: serrate RNA eff (882 aa) initn: 6065 init1: 6065 opt: 6065 Z-score: 3156.1 bits: 595.1 E(85289): 4.7e-169 Smith-Waterman score: 6065; 100.0% identity (100.0% similar) in 875 aa overlap (1-875:8-882) 10 20 30 40 50 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPSDRAMGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 RPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVN 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 IKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 TQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 AEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRI 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 SHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWL 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 CPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 QILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRG 790 800 810 820 830 840 840 850 860 870 pF1KB5 NYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF :::::::::::::::::::::::::::::::::::::::::: XP_005 NYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 850 860 870 880 >>NP_056992 (OMIM: 614469) serrate RNA effector molecule (876 aa) initn: 3419 init1: 3419 opt: 6053 Z-score: 3149.9 bits: 594.0 E(85289): 1e-168 Smith-Waterman score: 6053; 99.9% identity (99.9% similar) in 876 aa overlap (1-875:1-876) 10 20 30 40 50 60 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 SFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_056 SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 790 800 810 820 830 840 840 850 860 870 pF1KB5 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF :::::::::::::::::::::::::::::::::::: NP_056 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 850 860 870 >>XP_005250462 (OMIM: 614469) PREDICTED: serrate RNA eff (883 aa) initn: 3419 init1: 3419 opt: 6053 Z-score: 3149.9 bits: 594.0 E(85289): 1e-168 Smith-Waterman score: 6053; 99.9% identity (99.9% similar) in 876 aa overlap (1-875:8-883) 10 20 30 40 50 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPSDRAMGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECK :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::: XP_005 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 PRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 NIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDD 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 RTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGN 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 PAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNR 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 ISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKW 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 LCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGP 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 AQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGR 790 800 810 820 830 840 840 850 860 870 pF1KB5 GNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF ::::::::::::::::::::::::::::::::::::::::::: XP_005 GNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 850 860 870 880 >>NP_001122326 (OMIM: 614469) serrate RNA effector molec (871 aa) initn: 5333 init1: 5333 opt: 6009 Z-score: 3127.2 bits: 589.8 E(85289): 1.9e-167 Smith-Waterman score: 6009; 99.4% identity (99.5% similar) in 875 aa overlap (1-875:1-871) 10 20 30 40 50 60 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB5 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL :::::::::::::::::::::::::::::::::::::::::::::::::::::: .: NP_001 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ----SL 730 740 750 760 770 790 800 810 820 830 840 pF1KB5 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 780 790 800 810 820 830 850 860 870 pF1KB5 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF ::::::::::::::::::::::::::::::::::: NP_001 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 840 850 860 870 >>XP_005250465 (OMIM: 614469) PREDICTED: serrate RNA eff (878 aa) initn: 5333 init1: 5333 opt: 6009 Z-score: 3127.2 bits: 589.8 E(85289): 1.9e-167 Smith-Waterman score: 6009; 99.4% identity (99.5% similar) in 875 aa overlap (1-875:8-878) 10 20 30 40 50 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPSDRAMGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 RPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVN 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 IKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDR 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 TQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNP 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 AEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRI 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 SHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWL 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 CPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPA 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 QILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRG : .:::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 Q----SLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRG 790 800 810 820 830 840 850 860 870 pF1KB5 NYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF :::::::::::::::::::::::::::::::::::::::::: XP_005 NYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 840 850 860 870 >>NP_001122325 (OMIM: 614469) serrate RNA effector molec (872 aa) initn: 3383 init1: 2687 opt: 5997 Z-score: 3121.0 bits: 588.6 E(85289): 4.2e-167 Smith-Waterman score: 5997; 99.3% identity (99.4% similar) in 876 aa overlap (1-875:1-872) 10 20 30 40 50 60 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 310 320 330 340 350 360 370 380 390 400 410 pF1KB5 SFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT ::::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_001 SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG ::::::::::::::::::::::::::::::::::::::::::::::::::::::: . NP_001 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ----S 730 740 750 760 770 780 790 800 810 820 830 pF1KB5 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 780 790 800 810 820 830 840 850 860 870 pF1KB5 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF :::::::::::::::::::::::::::::::::::: NP_001 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 840 850 860 870 >>XP_005250464 (OMIM: 614469) PREDICTED: serrate RNA eff (879 aa) initn: 3383 init1: 2687 opt: 5997 Z-score: 3121.0 bits: 588.6 E(85289): 4.2e-167 Smith-Waterman score: 5997; 99.3% identity (99.4% similar) in 876 aa overlap (1-875:8-879) 10 20 30 40 50 pF1KB5 MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPSDRAMGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYN 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB5 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB5 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB5 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECK :::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::: XP_005 RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECK 370 380 390 400 410 420 420 430 440 450 460 470 pF1KB5 PRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSV 430 440 450 460 470 480 480 490 500 510 520 530 pF1KB5 NIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDD 490 500 510 520 530 540 540 550 560 570 580 590 pF1KB5 RTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGN 550 560 570 580 590 600 600 610 620 630 640 650 pF1KB5 PAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNR 610 620 630 640 650 660 660 670 680 690 700 710 pF1KB5 ISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKW 670 680 690 700 710 720 720 730 740 750 760 770 pF1KB5 LCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGP 730 740 750 760 770 780 780 790 800 810 820 830 pF1KB5 AQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGR :: .::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AQ----SLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGR 790 800 810 820 830 840 850 860 870 pF1KB5 GNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF ::::::::::::::::::::::::::::::::::::::::::: XP_005 GNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 840 850 860 870 >>XP_016867780 (OMIM: 614469) PREDICTED: serrate RNA eff (792 aa) initn: 4750 init1: 4750 opt: 5426 Z-score: 2826.2 bits: 533.9 E(85289): 1.1e-150 Smith-Waterman score: 5426; 99.4% identity (99.5% similar) in 796 aa overlap (80-875:1-792) 50 60 70 80 90 100 pF1KB5 RSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTY :::::::::::::::::::::::::::::: XP_016 MRRDWDEHSSDPYHSGYEMPYAGGGGGPTY 10 20 30 110 120 130 140 150 160 pF1KB5 GPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 KRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLME 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 TGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 RAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSS 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 KKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGL 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 ECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFD 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 RSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHT 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB5 LDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPK 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB5 EGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMP 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB5 PNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGK 580 590 600 610 620 630 710 720 730 740 750 760 pF1KB5 DKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQP 640 650 660 670 680 690 770 780 790 800 810 820 pF1KB5 PGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYG ::::: .:::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PGPAQ----SLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYG 700 710 720 730 740 830 840 850 860 870 pF1KB5 AGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF :::::::::::::::::::::::::::::::::::::::::::::: XP_016 AGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 750 760 770 780 790 >>XP_016867779 (OMIM: 614469) PREDICTED: serrate RNA eff (793 aa) initn: 2800 init1: 2687 opt: 5414 Z-score: 2820.0 bits: 532.8 E(85289): 2.5e-150 Smith-Waterman score: 5414; 99.2% identity (99.4% similar) in 797 aa overlap (80-875:1-793) 50 60 70 80 90 100 pF1KB5 RSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTY :::::::::::::::::::::::::::::: XP_016 MRRDWDEHSSDPYHSGYEMPYAGGGGGPTY 10 20 30 110 120 130 140 150 160 pF1KB5 GPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPPQPWGHPDVHIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAV 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB5 KRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLME :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLME 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB5 TGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB5 RAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSS 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB5 KKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAG :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: XP_016 KKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAG 280 290 300 310 320 330 410 420 430 440 450 460 pF1KB5 LECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LECKPRPLHKTCSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTF 340 350 360 370 380 390 470 480 490 500 510 520 pF1KB5 DRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DRSVNIKEICWNLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIH 400 410 420 430 440 450 530 540 550 560 570 580 pF1KB5 TLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TLDDRTQLWASEPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPP 460 470 480 490 500 510 590 600 610 620 630 640 pF1KB5 KEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEGNPAEINVERDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPM 520 530 540 550 560 570 650 660 670 680 690 700 pF1KB5 PPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPNRISHGEVLEWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELG 580 590 600 610 620 630 710 720 730 740 750 760 pF1KB5 KDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDKWLCPLSGKKFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQ 640 650 660 670 680 690 770 780 790 800 810 820 pF1KB5 PPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPY :::::: .::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPGPAQ----SLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPY 700 710 720 730 740 830 840 850 860 870 pF1KB5 GAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF ::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAGRGNYDAFRGQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 750 760 770 780 790 875 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 22:20:38 2016 done: Sat Nov 5 22:20:40 2016 Total Scan time: 15.500 Total Display time: 0.340 Function used was FASTA [36.3.4 Apr, 2011]