Result of FASTA (omim) for
pF1KB5826
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5826, 475 aa
1>>>pF1KB5826 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.1161+/-0.000531; mu= 0.7188+/- 0.033
mean_var=295.6180+/-60.649, 0's: 0 Z-trim(118.0): 237 B-trim: 1361 in 1/54
Lambda= 0.074595
statistics sampled from 30153 (30458) to 30153 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.357), width: 16
Scan time: 9.190
The best scores are: opt bits E(85289)
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 3268 365.7 1.6e-100
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 1231 146.4 1.6e-34
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 1225 145.8 2.5e-34
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 1213 144.5 6e-34
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 1048 126.8 1.4e-28
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 1048 126.8 1.4e-28
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1042 126.1 2.1e-28
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 1042 126.1 2.1e-28
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1042 126.1 2.1e-28
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 1042 126.1 2.1e-28
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 1042 126.1 2.1e-28
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 962 117.5 7.9e-26
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 961 117.4 9e-26
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 942 115.4 3.7e-25
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 942 115.4 3.7e-25
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 914 112.4 3e-24
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 858 106.3 2e-22
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 858 106.3 2e-22
XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 830 103.1 1.1e-21
XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 830 103.1 1.2e-21
NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 830 103.1 1.2e-21
NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 830 103.2 1.2e-21
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 830 103.3 1.6e-21
NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 808 100.9 7.7e-21
XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 787 98.4 2.6e-20
XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 787 98.4 2.6e-20
XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 787 98.5 2.8e-20
XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 787 98.5 2.8e-20
NP_001291425 (OMIM: 613184) E3 ubiquitin-protein l ( 262) 783 98.0 3.4e-20
XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 780 97.7 4.4e-20
XP_016873949 (OMIM: 608487) PREDICTED: tripartite ( 314) 775 97.2 7e-20
NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 736 92.9 1.2e-18
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 683 87.4 7.8e-17
XP_016878725 (OMIM: 134610,249100,608107) PREDICTE ( 780) 684 87.8 1.2e-16
NP_000234 (OMIM: 134610,249100,608107) pyrin isofo ( 781) 684 87.8 1.2e-16
XP_011538873 (OMIM: 111620,111750,609017) PREDICTE ( 468) 657 84.7 6.1e-16
NP_001017922 (OMIM: 111620,111750,609017) erythroi ( 475) 657 84.7 6.2e-16
XP_011538872 (OMIM: 111620,111750,609017) PREDICTE ( 475) 657 84.7 6.2e-16
NP_061008 (OMIM: 111620,111750,609017) erythroid m ( 475) 657 84.7 6.2e-16
XP_006710376 (OMIM: 111620,111750,609017) PREDICTE ( 475) 657 84.7 6.2e-16
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 633 82.1 3.9e-15
XP_011512533 (OMIM: 613591) PREDICTED: butyrophili ( 313) 618 80.3 8.6e-15
NP_001184168 (OMIM: 613591) butyrophilin subfamily ( 313) 618 80.3 8.6e-15
XP_016865656 (OMIM: 613591) PREDICTED: butyrophili ( 407) 618 80.4 1e-14
XP_005248855 (OMIM: 613591) PREDICTED: butyrophili ( 407) 618 80.4 1e-14
NP_853509 (OMIM: 613591) butyrophilin subfamily 2 ( 407) 618 80.4 1e-14
XP_016865655 (OMIM: 613591) PREDICTED: butyrophili ( 461) 618 80.5 1.1e-14
XP_011512531 (OMIM: 613591) PREDICTED: butyrophili ( 461) 618 80.5 1.1e-14
XP_011512530 (OMIM: 613591) PREDICTED: butyrophili ( 523) 618 80.5 1.2e-14
XP_005248854 (OMIM: 613591) PREDICTED: butyrophili ( 523) 618 80.5 1.2e-14
>>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa)
initn: 3268 init1: 3268 opt: 3268 Z-score: 1925.6 bits: 365.7 E(85289): 1.6e-100
Smith-Waterman score: 3268; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 KNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKH
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 RDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 EFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 LELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 DSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSF
370 380 390 400 410 420
430 440 450 460 470
pF1KB5 YNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
430 440 450 460 470
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 1158 init1: 894 opt: 1231 Z-score: 741.0 bits: 146.4 E(85289): 1.6e-34
Smith-Waterman score: 1232; 43.8% identity (68.6% similar) in 475 aa overlap (1-473:1-464)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-GKGGGS-VCPVCRQRF
::. : . ::.:: :::: :..:: .:::.::.::: . :. : .:: ::.
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSR
.:::::: ::.:.. ... . :: : .: : : :: . . :: .: .:
NP_660 PQRNLRPNRPLAKMAEMARRL-HPPSPVPQGV-CPAHREPLAAFCGDELRLLCAACERSG
70 80 90 100 110
120 130 140 150 160 170
pF1KB5 KHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRI
.: : . ::..::.. . ::. .: .::.... : .... . :.: ::.:.. .
NP_660 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHS
.:: . . .:.::::. ::.::..: : : : : :.:.::: : :::.::. ::.
NP_660 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 SALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANP
:: :::.. .:.: .. .:. ... :::.::.:::: . :: .:::::::::
NP_660 PALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 WLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGV
::::::::.:. :: .:..: . :::: : ::: ..: ::.:::::.: . .: :::
NP_660 ELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 CRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMV
::..: :: . ::. .::: : .. . :... .:: . :: .:::::::::: .
NP_660 CRENVNRKEKGELSAGNGFW-ILVFLGSYYNSSERALAPL--RDPPRRVGIFLDYEAGHL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 SFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
:::. :: :::.. : : :.: :::.::: ... .:.:.: . :: :.:
NP_660 SFYSATD-GSLLFIFPEIPFSGTLRPLFSPL----SSSPTPMTICRPKGGS-GDTLAPQ
420 430 440 450 460
>>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa)
initn: 1218 init1: 470 opt: 1225 Z-score: 737.3 bits: 145.8 E(85289): 2.5e-34
Smith-Waterman score: 1225; 41.8% identity (69.9% similar) in 471 aa overlap (2-464:15-483)
10 20 30 40
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKG-
..:: : . :..: .::. . ::: :::::.::. ::.. .
NP_742 MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 -GGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEK
:::::. ..:::::::..::. :... :. . : : : : ::: .
NP_742 ERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQAVKRKIRDESLCPQHHEALSLFCYE
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB5 DGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRA
: .:.: .:: :. :: :..:::..:.:::.:::: : :..: . . . : .
NP_742 DQEAVCLICAISHTHRAHTVVPLDDATQEYKEKLQKCLEPLEQKLQEITRCKSSEEKKPG
130 140 150 160 170 180
170 180 190 200 210 220
pF1KB5 DWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQAL
. :. ::.....: :: . . : ::.: :..::..:.. :. : :. :.:... . :
NP_742 ELKRLVESRRQQILREFEELHRRLDEEQQVLLSRLEEEEQDILQRLRENAAHLGDKRRDL
190 200 210 220 230 240
230 240 250 260 270 280
pF1KB5 QELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVP----GLKK
.: .:.. .: .:..:.:..: .::. :. . .. .: :: .. . : .:.:
NP_742 AHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSNFPRQYFALRK
250 260 270 280 290 300
290 300 310 320 330
pF1KB5 MLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQ-QSIPGNEERFDSYPMVLGAQHFHS
.:. . .::::.::.: :.:::::..:.. .:. ...: . .:: :: ::... : :
NP_742 ILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTS
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 GKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLH
:.:::::.: : : .::::::: :::.. ..:.: . ::: .:: : : : ::::
NP_742 GRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLH
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB5 LQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAP
..: : .:::::::::: .::::.::. : ::.:.. .:: : :.: ::. : ::.::
NP_742 IKVKPKRVGIFLDYEAGTLSFYNVTDR-SHIYTFTD-TFTEKLWPLFYPGIRAGRKNAAP
430 440 450 460 470
460 470
pF1KB5 LTLCPLNIGSQGSTDY
::. :
NP_742 LTIRPPTDWE
480
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 1061 init1: 654 opt: 1213 Z-score: 730.5 bits: 144.5 E(85289): 6e-34
Smith-Waterman score: 1214; 43.6% identity (68.4% similar) in 475 aa overlap (1-473:1-463)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-GKGGGS-VCPVCRQRF
::. : . ::.:: :::: :..:: .:::.::.::: . :. : .:: ::.
XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 LLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSR
.:::::: ::.:.. ... . :: : .: : : :: . . :: .: .:
XP_016 PQRNLRPNRPLAKMAEMARRL-HPPSPVPQGV-CPAHREPLAAFCGDELRLLCAACERSG
70 80 90 100 110
120 130 140 150 160 170
pF1KB5 KHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRI
.: : . ::..::.. . ::. .: .::.... : .... . :. ::.:.. .
XP_016 EHWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQ-MVESQRQNV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 HAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHS
.:: . . .:.::::. ::.::..: : : : : :.:.::: : :::.::. ::.
XP_016 LGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB5 SALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANP
:: :::.. .:.: .. .:. ... :::.::.:::: . :: .:::::::::
XP_016 PALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANP
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB5 WLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGV
::::::::.:. :: .:..: . :::: : ::: ..: ::.:::::.: . .: :::
XP_016 ELILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB5 CRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMV
::..: :: . ::. .::: : .. . :... .:: . :: .:::::::::: .
XP_016 CRENVNRKEKGELSAGNGFW-ILVFLGSYYNSSERALAPL--RDPPRRVGIFLDYEAGHL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KB5 SFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
:::. :: :::.. : : :.: :::.::: ... .:.:.: . :: :.:
XP_016 SFYSATD-GSLLFIFPEIPFSGTLRPLFSPL----SSSPTPMTICRPKGGS-GDTLAPQ
420 430 440 450 460
>>NP_477514 (OMIM: 607564) tripartite motif-containing p (488 aa)
initn: 1371 init1: 749 opt: 1048 Z-score: 634.3 bits: 126.8 E(85289): 1.4e-28
Smith-Waterman score: 1368; 46.6% identity (71.2% similar) in 466 aa overlap (12-448:11-474)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECI------SQVGKGGGSVCPVC
:::::::::. ..::.::.::::::: :: : .:. : ::::
NP_477 MTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACITPNGRESVIGQEGERSCPVC
10 20 30 40 50
60 70 80 90 100 110
pF1KB5 RQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVC
. . ::::::.:::.: :.:. . .. :: :::.:.:::..:::..::.:
NP_477 QTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADHGEKLQLFCQEDGKVICWLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB5 AQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQ
.:..:: : .::.:::::::.: .: .:. ... :::: . : :...::. .: .
NP_477 ERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEKLTAFIREKKTSWKNQMEPE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB5 KSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDR
. ::..:: : .:.: . :::.:..::..:.. :::. : : :..:.:.:.::::.:.:
NP_477 RCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAENDLVHQTQSLRELISDLER
180 190 200 210 220 230
240 250 260 270 280
pF1KB5 RCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCA--------
::..:..::::.: : :::: :.:. . .:::. ..: ::.:::.:
NP_477 RCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRAPDLKRMLRVCRELTDVQSY
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 -VHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGN-EERFDSYPMVLGAQHFHSGKHYW
: .::.: ::: :.:...:::::. .. : :. :...: :::.::: ::::::
NP_477 WVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHYDC--SVLGSQHFSSGKHYW
300 310 320 330 340 350
350 360 370 380 390
pF1KB5 EVDVTGKEAWDLGVCRDSVRRK---GHFLLSS--------KSGFWTIWLWNKQKYEA--G
::::. : :: :::: .:. .:: . .::.:.: : ....:.:
NP_477 EVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQSGYWVIGLQHNHEYRAYED
360 370 380 390 400 410
400 410 420 430 440 450
pF1KB5 TYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFN
. :. : . ::: .::.::::::: :::::.:.:: ::.::. : : :.:.:
NP_477 SSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYTFSKYYFPTTLCPYFNPCNC
420 430 440 450 460 470
460 470
pF1KB5 DGGKNTAPLTLCPLNIGSQGSTDY
NP_477 VIPMTLRRPSS
480
>>NP_001003818 (OMIM: 607564) tripartite motif-containin (516 aa)
initn: 1371 init1: 749 opt: 1048 Z-score: 634.0 bits: 126.8 E(85289): 1.4e-28
Smith-Waterman score: 1368; 46.6% identity (71.2% similar) in 466 aa overlap (12-448:39-502)
10 20 30 40
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECI-
:::::::::. ..::.::.::::::: ::
NP_001 QAGNILEIRVGQAGARRVATMTSPVLVDIREEVTCPICLELLTEPLSIDCGHSFCQACIT
10 20 30 40 50 60
50 60 70 80 90
pF1KB5 -----SQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVH
: .:. : ::::. . ::::::.:::.: :.:. . .. :: :
NP_001 PNGRESVIGQEGERSCPVCQTSYQPGNLRPNRHLANIVRRLREVVLGPGKQLKAVLCADH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 GERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEK
::.:.:::..:::..::.: .:..:: : .::.:::::::.: .: .:. ... :::
NP_001 GEKLQLFCQEDGKVICWLCERSQEHRGHHTFLVEEVAQEYQEKFQESLKKLKNEEQEAEK
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 LEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKE
: . : :...::. .: .. ::..:: : .:.: . :::.:..::..:.. :::. : :
NP_001 LTAFIREKKTSWKNQMEPERCRIQTEFNQLRNILDRVEQRELKKLEQEEKKGLRIIEEAE
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB5 AKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHV
:..:.:.:.::::.:.:::..:..::::.: : :::: :.:. . .:::. ..
NP_001 NDLVHQTQSLRELISDLERRCQGSTMELLQDVSDVTERSEFWTLRKPEALPTKLRSMFRA
250 260 270 280 290 300
280 290 300 310 320
pF1KB5 PGLKKMLRTCA---------VHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGN-EERF
: ::.:::.: : .::.: ::: :.:...:::::. .. : :. :...
NP_001 PDLKRMLRVCRELTDVQSYWVDVTLNPHTANLNLVLAKNRRQVRFVGAKVSGPSCLEKHY
310 320 330 340 350 360
330 340 350 360 370
pF1KB5 DSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRK---GHFLLSS--------K
: :::.::: ::::::::::. : :: :::: .:. .:: . .
NP_001 DC--SVLGSQHFSSGKHYWEVDVAKKTAWILGVCSNSLGPTFSFNHFAQNHSAYSRYQPQ
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB5 SGFWTIWLWNKQKYEA--GTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYS
::.:.: : ....:.: . :. : . ::: .::.::::::: :::::.:.:: ::.
NP_001 SGYWVIGLQHNHEYRAYEDSSPSLLLSMTVPPRRVGVFLDYEAGTVSFYNVTNHGFPIYT
430 440 450 460 470 480
440 450 460 470
pF1KB5 FSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY
::. : : :.:.:
NP_001 FSKYYFPTTLCPYFNPCNCVIPMTLRRPSS
490 500 510
>>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 966 init1: 362 opt: 1042 Z-score: 631.0 bits: 126.1 E(85289): 2.1e-28
Smith-Waterman score: 1042; 38.5% identity (65.4% similar) in 462 aa overlap (10-455:10-465)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-----GKGG-----GSV
. ::.:: :::: :..:: :::.::. ::. :: : ::
XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100
pF1KB5 -CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGER-CAVHGERLHLFCEKDGK
:: ::. .:: ::: ..... :..:. . : : . : : : :.:::.:: .
XP_006 PCPECREMSPQRNLLPNR----LLTKVAEMAQQ-HPGLQKQDLCQEHHEPLKLFCQKDQS
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 ALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWK
.: :: .::.:: : ..: :::.: :. ::. . ::.. . .:... . :.:.
XP_006 PICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 KTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQEL
:. .. :: :: ... .::::::: :: :: .:.: : :. : : .:...:. :
XP_006 GKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 ISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVPGLKKMLRTCAV
. .:..: .. :..::.. : :... ... ... : :.::.::: ..::
XP_006 LLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 HITLDPDTANPWLILSEDRRQVRLGDTQQ-SIPGNEERFDSYPMVLGAQHFHSGKHYWEV
.. : .: :.:.: :.:.. ::.. . : ...:: .:: ..: : ::.:::::
XP_006 DVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB5 --DVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
..:: : ::::::.: :: . ..:::.. : . :: . ::. :. ::
XP_006 GMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPP
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
..:::::.::: ::::...: :: ....:. .: :::.::: : .:.
XP_006 SHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMW
420 430 440 450 460 470
470
pF1KB5 LNIGSQGSTDY
XP_006 VKG
>>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa)
initn: 966 init1: 362 opt: 1042 Z-score: 631.0 bits: 126.1 E(85289): 2.1e-28
Smith-Waterman score: 1042; 38.5% identity (65.4% similar) in 462 aa overlap (10-455:10-465)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-----GKGG-----GSV
. ::.:: :::: :..:: :::.::. ::. :: : ::
NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100
pF1KB5 -CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGER-CAVHGERLHLFCEKDGK
:: ::. .:: ::: ..... :..:. . : : . : : : :.:::.:: .
NP_001 PCPECREMSPQRNLLPNR----LLTKVAEMAQQ-HPGLQKQDLCQEHHEPLKLFCQKDQS
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 ALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWK
.: :: .::.:: : ..: :::.: :. ::. . ::.. . .:... . :.:.
NP_001 PICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 KTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQEL
:. .. :: :: ... .::::::: :: :: .:.: : :. : : .:...:. :
NP_001 GKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 ISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVPGLKKMLRTCAV
. .:..: .. :..::.. : :... ... ... : :.::.::: ..::
NP_001 LLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 HITLDPDTANPWLILSEDRRQVRLGDTQQ-SIPGNEERFDSYPMVLGAQHFHSGKHYWEV
.. : .: :.:.: :.:.. ::.. . : ...:: .:: ..: : ::.:::::
NP_001 DVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB5 --DVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
..:: : ::::::.: :: . ..:::.. : . :: . ::. :. ::
NP_001 GMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPP
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
..:::::.::: ::::...: :: ....:. .: :::.::: : .:.
NP_001 SHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMW
420 430 440 450 460 470
470
pF1KB5 LNIGSQGSTDY
NP_001 VKG
>>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 966 init1: 362 opt: 1042 Z-score: 631.0 bits: 126.1 E(85289): 2.1e-28
Smith-Waterman score: 1042; 38.5% identity (65.4% similar) in 462 aa overlap (10-455:10-465)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-----GKGG-----GSV
. ::.:: :::: :..:: :::.::. ::. :: : ::
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100
pF1KB5 -CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGER-CAVHGERLHLFCEKDGK
:: ::. .:: ::: ..... :..:. . : : . : : : :.:::.:: .
XP_011 PCPECREMSPQRNLLPNR----LLTKVAEMAQQ-HPGLQKQDLCQEHHEPLKLFCQKDQS
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 ALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWK
.: :: .::.:: : ..: :::.: :. ::. . ::.. . .:... . :.:.
XP_011 PICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 KTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQEL
:. .. :: :: ... .::::::: :: :: .:.: : :. : : .:...:. :
XP_011 GKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 ISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVPGLKKMLRTCAV
. .:..: .. :..::.. : :... ... ... : :.::.::: ..::
XP_011 LLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 HITLDPDTANPWLILSEDRRQVRLGDTQQ-SIPGNEERFDSYPMVLGAQHFHSGKHYWEV
.. : .: :.:.: :.:.. ::.. . : ...:: .:: ..: : ::.:::::
XP_011 DVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB5 --DVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
..:: : ::::::.: :: . ..:::.. : . :: . ::. :. ::
XP_011 GMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPP
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
..:::::.::: ::::...: :: ....:. .: :::.::: : .:.
XP_011 SHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMW
420 430 440 450 460 470
470
pF1KB5 LNIGSQGSTDY
XP_011 VKG
>>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 966 init1: 362 opt: 1042 Z-score: 631.0 bits: 126.1 E(85289): 2.1e-28
Smith-Waterman score: 1042; 38.5% identity (65.4% similar) in 462 aa overlap (10-455:10-465)
10 20 30 40 50
pF1KB5 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQV-----GKGG-----GSV
. ::.:: :::: :..:: :::.::. ::. :: : ::
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100
pF1KB5 -CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGER-CAVHGERLHLFCEKDGK
:: ::. .:: ::: ..... :..:. . : : . : : : :.:::.:: .
XP_011 PCPECREMSPQRNLLPNR----LLTKVAEMAQQ-HPGLQKQDLCQEHHEPLKLFCQKDQS
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 ALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWK
.: :: .::.:: : ..: :::.: :. ::. . ::.. . .:... . :.:.
XP_011 PICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQ
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 KTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQEL
:. .. :: :: ... .::::::: :: :: .:.: : :. : : .:...:. :
XP_011 GKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB5 ISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPEL-RSVCHVPGLKKMLRTCAV
. .:..: .. :..::.. : :... ... ... : :.::.::: ..::
XP_011 LLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330 340
pF1KB5 HITLDPDTANPWLILSEDRRQVRLGDTQQ-SIPGNEERFDSYPMVLGAQHFHSGKHYWEV
.. : .: :.:.: :.:.. ::.. . : ...:: .:: ..: : ::.:::::
XP_011 DVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEV
300 310 320 330 340 350
350 360 370 380 390 400
pF1KB5 --DVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPP
..:: : ::::::.: :: . ..:::.. : . :: . ::. :. ::
XP_011 GMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPP
360 370 380 390 400 410
410 420 430 440 450 460
pF1KB5 CQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCP
..:::::.::: ::::...: :: ....:. .: :::.::: : .:.
XP_011 SHMGIFLDFEAGEVSFYSVSD-GSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMW
420 430 440 450 460 470
470
pF1KB5 LNIGSQGSTDY
XP_011 VKG
475 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 15:02:15 2016 done: Sat Nov 5 15:02:17 2016
Total Scan time: 9.190 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]