FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5840, 482 aa 1>>>pF1KB5840 482 - 482 aa - 482 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.9573+/-0.00088; mu= 12.4880+/- 0.053 mean_var=149.7292+/-31.208, 0's: 0 Z-trim(111.9): 22 B-trim: 801 in 1/51 Lambda= 0.104814 statistics sampled from 12756 (12778) to 12756 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.735), E-opt: 0.2 (0.393), width: 16 Scan time: 3.520 The best scores are: opt bits E(32554) CCDS5860.1 MKRN1 gene_id:23608|Hs108|chr7 ( 482) 3331 515.3 5.7e-146 CCDS47725.1 MKRN1 gene_id:23608|Hs108|chr7 ( 329) 2255 352.5 4.1e-97 CCDS10013.1 MKRN3 gene_id:7681|Hs108|chr15 ( 507) 1440 229.4 7e-60 CCDS63545.1 MKRN2 gene_id:23609|Hs108|chr3 ( 373) 1038 168.5 1.1e-41 CCDS33702.1 MKRN2 gene_id:23609|Hs108|chr3 ( 416) 1038 168.5 1.2e-41 >>CCDS5860.1 MKRN1 gene_id:23608|Hs108|chr7 (482 aa) initn: 3331 init1: 3331 opt: 3331 Z-score: 2734.2 bits: 515.3 E(32554): 5.7e-146 Smith-Waterman score: 3331; 99.8% identity (100.0% similar) in 482 aa overlap (1-482:1-482) 10 20 30 40 50 60 pF1KB5 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL 430 440 450 460 470 480 pF1KB5 DL :: CCDS58 DL >>CCDS47725.1 MKRN1 gene_id:23608|Hs108|chr7 (329 aa) initn: 2255 init1: 2255 opt: 2255 Z-score: 1857.0 bits: 352.5 E(32554): 4.1e-97 Smith-Waterman score: 2255; 99.7% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KB5 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS47 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK ::::::::::::::::::::::::::::: CCDS47 ILSNCNHTYCLKCIRKWRSAKQFESKIIK 310 320 >>CCDS10013.1 MKRN3 gene_id:7681|Hs108|chr15 (507 aa) initn: 1419 init1: 1125 opt: 1440 Z-score: 1188.5 bits: 229.4 E(32554): 7e-60 Smith-Waterman score: 1618; 51.5% identity (70.9% similar) in 505 aa overlap (2-482:20-507) 10 20 30 pF1KB5 MAEAATPGTTATT------SGAGAAAATA---AAASPTPIPT :::: :... :: .:: .: :: . .:.:. CCDS10 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 VTAPS-LGAGG------GGGGS------DGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHD . .:. : :: .:::. . :.: ::::. :::..:: ::::.::::::: CCDS10 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD 70 80 90 100 110 120 90 100 110 120 130 pF1KB5 LSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVG :: ... : : : .: :: : : :.:::: ..: CCDS10 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIG 130 140 150 160 170 140 150 160 170 180 190 pF1KB5 PLVEMNTGEAESRNSNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKE .: . ::: :.. :. ::: :.:..:::::::::: :: . : :::::.: CCDS10 SAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS---- 180 190 200 210 220 200 210 220 230 240 250 pF1KB5 ESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQHIKS :.:..: :: . ..: ::. : : ::.:.::::: ::::::: ::::::::: .:... CCDS10 ETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRA 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB5 CIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWR :::::::::::::::::. : :::::::::::::::..:::::::::::..:..:::.:: CCDS10 CIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWR 290 300 310 320 330 340 320 330 340 350 360 370 pF1KB5 SAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRG ::.:::..:.::::.::.::..:::::.::::.::::::: .::::::::::::: :::: CCDS10 SARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRG 350 360 370 380 390 400 380 390 400 410 420 430 pF1KB5 SCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEE .:::: .::::: ::.: .:: :. : : : . : .. :.. . . ..: CCDS10 NCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKE 410 420 430 440 450 460 440 450 460 470 480 pF1KB5 VVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL .:...:. .:. . . ::: :::.:::.: :::....: : CCDS10 LVVLRLASLLFKRFLSL-RDELPFSEDQWDLLHYELEEYFNLIL 470 480 490 500 >>CCDS63545.1 MKRN2 gene_id:23609|Hs108|chr3 (373 aa) initn: 1016 init1: 975 opt: 1038 Z-score: 861.7 bits: 168.5 E(32554): 1.1e-41 Smith-Waterman score: 1060; 44.2% identity (71.1% similar) in 360 aa overlap (104-451:8-365) 80 90 100 110 120 130 pF1KB5 NCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEE-ATATELTTKSSLAASS :::.:..: :..: . : : : CCDS63 MSTKQITCRYDHTRPSAAAGGAVGTMAHSVPSPAFHS 10 20 30 140 150 160 170 180 pF1KB5 SL--SSIVGPLVEMNTGEAESRNSNFATVG----AGSEDWVNAIEFVPGQPYCGRTAPSC : ... .:. :. : .:.. .. .: . . .: . :. :: CCDS63 PHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 TEAP---LQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQL : :.. . .. . ... ...:::::::.::::.:. ::::::. :..: ::. CCDS63 EMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQV 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 LHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILS :::.: ::. : : :. . :..:: .:: : :.: ::.:::::. :::. ::::::::: CCDS63 LHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILS 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 NCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKE ::::::::.:::.:: :::::. :::::::::. :.::::: ::::....:..:: .:. CCDS63 NCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQ 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 AMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRN--HFWE .:..:::.::..:.:.::::..:.:.::::::: ::.. . ::. .. : ..:. CCDS63 GMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 LIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLD .::.::. . .: :.: :::.... : CCDS63 FIENRESRHVPNN--EDVDMTELGDLFMHLSGVESSEP 340 350 360 370 >>CCDS33702.1 MKRN2 gene_id:23609|Hs108|chr3 (416 aa) initn: 1285 init1: 975 opt: 1038 Z-score: 861.1 bits: 168.5 E(32554): 1.2e-41 Smith-Waterman score: 1329; 46.8% identity (73.3% similar) in 408 aa overlap (56-451:3-408) 30 40 50 60 70 80 pF1KB5 ASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSP :::.::::::::::.::..: .::::..: CCDS33 MSTKQITCRYFMHGVCREGSQCLFSHDLANSK 10 20 30 90 100 110 120 130 140 pF1KB5 YSVVCKYFQRGYCIYGDRCRYEHSKPLKQEE-ATATELTTKSSLAASSSL--SSIVGPLV :..:::.:.::: :: ::::.:..: :..: . : : : : ... .: CCDS33 PSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIV 40 50 60 70 80 90 150 160 170 180 190 pF1KB5 EMNTGEAESRNSNFATVG----AGSEDWVNAIEFVPGQPYCGRTAPSCTEAP---LQGSV . :. : .:.. .. .: . . .: . :. :: : :.. CCDS33 KTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIR 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB5 TKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQH . .. . ... ...:::::::.::::.:. ::::::. :..: ::.:::.: ::. : CCDS33 SGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB5 IKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIR : :. . :..:: .:: : :.: ::.:::::. :::. :::::::::::::::::.::: CCDS33 EKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB5 KWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDE .:: :::::. :::::::::. :.::::: ::::....:..:: .:..:..:::.::.. CCDS33 QWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB5 GRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRN--HFWELIEERENSNPFD :.:.::::..:.:.::::::: ::.. . ::. .. : ..:..::.::. . . CCDS33 GKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPN 340 350 360 370 380 390 440 450 460 470 480 pF1KB5 NDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL : :.: :::.... : CCDS33 N--EDVDMTELGDLFMHLSGVESSEP 400 410 482 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:08:19 2016 done: Sat Nov 5 15:08:20 2016 Total Scan time: 3.520 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]