FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5840, 482 aa 1>>>pF1KB5840 482 - 482 aa - 482 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3365+/-0.000357; mu= 16.1760+/- 0.022 mean_var=155.0157+/-32.569, 0's: 0 Z-trim(119.1): 27 B-trim: 222 in 2/50 Lambda= 0.103012 statistics sampled from 32697 (32735) to 32697 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.384), width: 16 Scan time: 9.240 The best scores are: opt bits E(85289) NP_038474 (OMIM: 607754) E3 ubiquitin-protein liga ( 482) 3331 506.9 5.2e-143 XP_011514300 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 418) 2909 444.1 3.6e-124 XP_011514299 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 418) 2909 444.1 3.6e-124 XP_011514298 (OMIM: 607754) PREDICTED: E3 ubiquiti ( 439) 2610 399.7 8.9e-111 NP_001138597 (OMIM: 607754) E3 ubiquitin-protein l ( 329) 2255 346.8 5.6e-95 NP_001278592 (OMIM: 607754) E3 ubiquitin-protein l ( 265) 1833 283.9 3.7e-76 NP_005655 (OMIM: 176270,603856,615346) probable E3 ( 507) 1440 225.8 2.1e-58 NP_001258636 (OMIM: 608426) probable E3 ubiquitin- ( 373) 1038 166.0 1.7e-40 NP_054879 (OMIM: 608426) probable E3 ubiquitin-pro ( 416) 1038 166.0 1.8e-40 >>NP_038474 (OMIM: 607754) E3 ubiquitin-protein ligase m (482 aa) initn: 3331 init1: 3331 opt: 3331 Z-score: 2688.4 bits: 506.9 E(85289): 5.2e-143 Smith-Waterman score: 3331; 99.8% identity (100.0% similar) in 482 aa overlap (1-482:1-482) 10 20 30 40 50 60 pF1KB5 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_038 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL 430 440 450 460 470 480 pF1KB5 DL :: NP_038 DL >>XP_011514300 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 2909 init1: 2909 opt: 2909 Z-score: 2350.2 bits: 444.1 E(85289): 3.6e-124 Smith-Waterman score: 2909; 99.8% identity (100.0% similar) in 418 aa overlap (65-482:1-418) 40 50 60 70 80 90 pF1KB5 TAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ :::::::::::::::::::::::::::::: XP_011 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 100 110 120 130 140 150 pF1KB5 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 PYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 PYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB5 RITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPD 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB5 GRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAA 340 350 360 370 380 390 460 470 480 pF1KB5 GGDDELTDSEDEWDLFHDELEDFYDLDL :::::::::::::::::::::::::::: XP_011 GGDDELTDSEDEWDLFHDELEDFYDLDL 400 410 >>XP_011514299 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 2909 init1: 2909 opt: 2909 Z-score: 2350.2 bits: 444.1 E(85289): 3.6e-124 Smith-Waterman score: 2909; 99.8% identity (100.0% similar) in 418 aa overlap (65-482:1-418) 40 50 60 70 80 90 pF1KB5 TAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ :::::::::::::::::::::::::::::: XP_011 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 100 110 120 130 140 150 pF1KB5 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 PYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: XP_011 PYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC 220 230 240 250 260 270 340 350 360 370 380 390 pF1KB5 RITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPD 280 290 300 310 320 330 400 410 420 430 440 450 pF1KB5 GRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAA 340 350 360 370 380 390 460 470 480 pF1KB5 GGDDELTDSEDEWDLFHDELEDFYDLDL :::::::::::::::::::::::::::: XP_011 GGDDELTDSEDEWDLFHDELEDFYDLDL 400 410 >>XP_011514298 (OMIM: 607754) PREDICTED: E3 ubiquitin-pr (439 aa) initn: 2610 init1: 2610 opt: 2610 Z-score: 2109.8 bits: 399.7 E(85289): 8.9e-111 Smith-Waterman score: 2900; 90.9% identity (91.1% similar) in 482 aa overlap (1-482:1-439) 10 20 30 40 50 60 pF1KB5 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT ::: :::::::::::::: XP_011 CRY-------------------------------------------EHSKPLKQEEATAT 70 130 140 150 160 170 180 pF1KB5 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB5 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG 140 150 160 170 180 190 250 260 270 280 290 300 pF1KB5 LQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB5 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFW 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDL 380 390 400 410 420 430 pF1KB5 DL :: XP_011 DL >>NP_001138597 (OMIM: 607754) E3 ubiquitin-protein ligas (329 aa) initn: 2255 init1: 2255 opt: 2255 Z-score: 1826.1 bits: 346.8 E(85289): 5.6e-95 Smith-Waterman score: 2255; 99.7% identity (100.0% similar) in 329 aa overlap (1-329:1-329) 10 20 30 40 50 60 pF1KB5 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATAT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 LQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG ::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILK ::::::::::::::::::::::::::::: NP_001 ILSNCNHTYCLKCIRKWRSAKQFESKIIK 310 320 >>NP_001278592 (OMIM: 607754) E3 ubiquitin-protein ligas (265 aa) initn: 1833 init1: 1833 opt: 1833 Z-score: 1488.3 bits: 283.9 E(85289): 3.7e-76 Smith-Waterman score: 1833; 99.6% identity (100.0% similar) in 265 aa overlap (65-329:1-265) 40 50 60 70 80 90 pF1KB5 TAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ :::::::::::::::::::::::::::::: NP_001 MHGVCKEGDNCRYSHDLSDSPYSVVCKYFQ 10 20 30 100 110 120 130 140 150 pF1KB5 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNS 40 50 60 70 80 90 160 170 180 190 200 210 pF1KB5 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLC 100 110 120 130 140 150 220 230 240 250 260 270 pF1KB5 PYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_001 PYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQ 160 170 180 190 200 210 280 290 300 310 320 330 pF1KB5 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPEC ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIK 220 230 240 250 260 340 350 360 370 380 390 pF1KB5 RITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPD >>NP_005655 (OMIM: 176270,603856,615346) probable E3 ubi (507 aa) initn: 1419 init1: 1125 opt: 1440 Z-score: 1169.4 bits: 225.8 E(85289): 2.1e-58 Smith-Waterman score: 1618; 51.5% identity (70.9% similar) in 505 aa overlap (2-482:20-507) 10 20 30 pF1KB5 MAEAATPGTTATT------SGAGAAAATA---AAASPTPIPT :::: :... :: .:: .: :: . .:.:. NP_005 MEEPAAPSEAHEAAGAQAGAEAAREGVSGPDLPVCEPSGESAAPDSALPHAARGWAPFPV 10 20 30 40 50 60 40 50 60 70 80 pF1KB5 VTAPS-LGAGG------GGGGS------DGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHD . .:. : :: .:::. . :.: ::::. :::..:: ::::.::::::: NP_005 APVPAHLRRGGLRPAPASGGGAWPSPLPSRSSGIWTKQIICRYYIHGQCKEGENCRYSHD 70 80 90 100 110 120 90 100 110 120 130 pF1KB5 LSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLS-SIVG :: ... : : : .: :: : : :.:::: ..: NP_005 LSGRKMATEGGVSPPGASAGGGPSTAAHIEPPTQEVAEAPP--------AASSLSLPVIG 130 140 150 160 170 140 150 160 170 180 190 pF1KB5 PLVEMNTGEAESRNSNF-ATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKE .: . ::: :.. :. ::: :.:..:::::::::: :: . : :::::.: NP_005 SAAERGFFEAERDNADRGAAGGAGVESWADAIEFVPGQPYRGRWVASAPEAPLQSS---- 180 190 200 210 220 200 210 220 230 240 250 pF1KB5 ESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQHIKS :.:..: :: . ..: ::. : : ::.:.::::: ::::::: ::::::::: .:... NP_005 ETERKQMAVGSGLRFCYYASRGVCFRGESCMYLHGDICDMCGLQTLHPMDAAQREEHMRA 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB5 CIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWR :::::::::::::::::. : :::::::::::::::..:::::::::::..:..:::.:: NP_005 CIEAHEKDMELSFAVQRGMDKVCGICMEVVYEKANPNDRRFGILSNCNHSFCIRCIRRWR 290 300 310 320 330 340 320 330 340 350 360 370 pF1KB5 SAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRG ::.:::..:.::::.::.::..:::::.::::.::::::: .::::::::::::: :::: NP_005 SARQFENRIVKSCPQCRVTSELVIPSEFWVEEEEEKQKLIQQYKEAMSNKACRYFAEGRG 350 360 370 380 390 400 380 390 400 410 420 430 pF1KB5 SCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEE .:::: .::::: ::.: .:: :. : : : . : .. :.. . . ..: NP_005 NCPFGDTCFYKHEYPEGWGDEPPGPGGGSFSAYWHQ----LVEPVRMGEGNMLYKSIKKE 410 420 430 440 450 460 440 450 460 470 480 pF1KB5 VVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL .:...:. .:. . . ::: :::.:::.: :::....: : NP_005 LVVLRLASLLFKRFLSL-RDELPFSEDQWDLLHYELEEYFNLIL 470 480 490 500 >>NP_001258636 (OMIM: 608426) probable E3 ubiquitin-prot (373 aa) initn: 1016 init1: 975 opt: 1038 Z-score: 848.0 bits: 166.0 E(85289): 1.7e-40 Smith-Waterman score: 1060; 44.2% identity (71.1% similar) in 360 aa overlap (104-451:8-365) 80 90 100 110 120 130 pF1KB5 NCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEE-ATATELTTKSSLAASS :::.:..: :..: . : : : NP_001 MSTKQITCRYDHTRPSAAAGGAVGTMAHSVPSPAFHS 10 20 30 140 150 160 170 180 pF1KB5 SL--SSIVGPLVEMNTGEAESRNSNFATVG----AGSEDWVNAIEFVPGQPYCGRTAPSC : ... .:. :. : .:.. .. .: . . .: . :. :: NP_001 PHPPSEVTASIVKTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSP 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB5 TEAP---LQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQL : :.. . .. . ... ...:::::::.::::.:. ::::::. :..: ::. NP_001 EMKPHSYLDAIRSGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQV 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB5 LHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILS :::.: ::. : : :. . :..:: .:: : :.: ::.:::::. :::. ::::::::: NP_001 LHPFDPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILS 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB5 NCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKE ::::::::.:::.:: :::::. :::::::::. :.::::: ::::....:..:: .:. NP_001 NCNHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQ 220 230 240 250 260 270 370 380 390 400 410 420 pF1KB5 AMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRN--HFWE .:..:::.::..:.:.::::..:.:.::::::: ::.. . ::. .. : ..:. NP_001 GMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWD 280 290 300 310 320 330 430 440 450 460 470 480 pF1KB5 LIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLD .::.::. . .: :.: :::.... : NP_001 FIENRESRHVPNN--EDVDMTELGDLFMHLSGVESSEP 340 350 360 370 >>NP_054879 (OMIM: 608426) probable E3 ubiquitin-protein (416 aa) initn: 1285 init1: 975 opt: 1038 Z-score: 847.5 bits: 166.0 E(85289): 1.8e-40 Smith-Waterman score: 1329; 46.8% identity (73.3% similar) in 408 aa overlap (56-451:3-408) 30 40 50 60 70 80 pF1KB5 ASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSP :::.::::::::::.::..: .::::..: NP_054 MSTKQITCRYFMHGVCREGSQCLFSHDLANSK 10 20 30 90 100 110 120 130 140 pF1KB5 YSVVCKYFQRGYCIYGDRCRYEHSKPLKQEE-ATATELTTKSSLAASSSL--SSIVGPLV :..:::.:.::: :: ::::.:..: :..: . : : : : ... .: NP_054 PSTICKYYQKGYCAYGTRCRYDHTRPSAAAGGAVGTMAHSVPSPAFHSPHPPSEVTASIV 40 50 60 70 80 90 150 160 170 180 190 pF1KB5 EMNTGEAESRNSNFATVG----AGSEDWVNAIEFVPGQPYCGRTAPSCTEAP---LQGSV . :. : .:.. .. .: . . .: . :. :: : :.. NP_054 KTNSHEPGKREKRTLVLRDRNLSGMAERKTQPSMVSNPGSCSDPQPSPEMKPHSYLDAIR 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB5 TKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQLLHPMDAAQRSQH . .. . ... ...:::::::.::::.:. ::::::. :..: ::.:::.: ::. : NP_054 SGLDDVEASSSYSNEQQLCPYAAAGECRFGDACVYLHGEVCEICRLQVLHPFDPEQRKAH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB5 IKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIR : :. . :..:: .:: : :.: ::.:::::. :::. :::::::::::::::::.::: NP_054 EKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCNHTYCLSCIR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB5 KWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDE .:: :::::. :::::::::. :.::::: ::::....:..:: .:..:..:::.::.. NP_054 QWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KB5 GRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRN--HFWELIEERENSNPFD :.:.::::..:.:.::::::: ::.. . ::. .. : ..:..::.::. . . NP_054 GKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSQGTVRFFNSVRLWDFIENRESRHVPN 340 350 360 370 380 390 440 450 460 470 480 pF1KB5 NDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL : :.: :::.... : NP_054 N--EDVDMTELGDLFMHLSGVESSEP 400 410 482 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:08:20 2016 done: Sat Nov 5 15:08:22 2016 Total Scan time: 9.240 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]