FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5842, 483 aa 1>>>pF1KB5842 483 - 483 aa - 483 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1347+/-0.000397; mu= 14.2278+/- 0.025 mean_var=75.8665+/-15.389, 0's: 0 Z-trim(112.8): 161 B-trim: 730 in 2/49 Lambda= 0.147248 statistics sampled from 21632 (21815) to 21632 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.256), width: 16 Scan time: 8.660 The best scores are: opt bits E(85289) NP_004388 (OMIM: 600326) probable ATP-dependent RN ( 483) 3164 681.7 1.2e-195 NP_001244120 (OMIM: 600326) probable ATP-dependent ( 483) 3164 681.7 1.2e-195 XP_005271474 (OMIM: 600326) PREDICTED: probable AT ( 483) 3164 681.7 1.2e-195 XP_016872740 (OMIM: 600326) PREDICTED: probable AT ( 440) 1873 407.4 4.1e-113 XP_011540946 (OMIM: 600326) PREDICTED: probable AT ( 440) 1873 407.4 4.1e-113 XP_011540947 (OMIM: 600326) PREDICTED: probable AT ( 434) 1760 383.4 6.8e-106 NP_055555 (OMIM: 268305,608546) eukaryotic initiat ( 411) 948 210.9 5.4e-54 NP_001407 (OMIM: 602641) eukaryotic initiation fac ( 406) 943 209.9 1.1e-53 NP_001958 (OMIM: 601102) eukaryotic initiation fac ( 407) 930 207.1 7.6e-53 NP_542165 (OMIM: 142560) spliceosome RNA helicase ( 428) 838 187.6 6.1e-47 NP_004631 (OMIM: 142560) spliceosome RNA helicase ( 428) 838 187.6 6.1e-47 NP_057439 (OMIM: 615428) probable ATP-dependent RN ( 455) 744 167.6 6.6e-41 XP_011541093 (OMIM: 607663) PREDICTED: ATP-depende ( 482) 734 165.5 3e-40 NP_037396 (OMIM: 607663) ATP-dependent RNA helicas ( 483) 734 165.5 3e-40 XP_011541092 (OMIM: 607663) PREDICTED: ATP-depende ( 486) 734 165.5 3.1e-40 NP_009173 (OMIM: 605812) ATP-dependent RNA helicas ( 479) 719 162.3 2.8e-39 XP_011521136 (OMIM: 605812) PREDICTED: ATP-depende ( 484) 719 162.3 2.8e-39 XP_011521134 (OMIM: 605812) PREDICTED: ATP-depende ( 539) 719 162.3 3.1e-39 XP_011523824 (OMIM: 268305,608546) PREDICTED: euka ( 390) 699 158.0 4.3e-38 NP_001191439 (OMIM: 602641) eukaryotic initiation ( 347) 697 157.6 5.3e-38 XP_016857920 (OMIM: 174300,615464) PREDICTED: prob ( 619) 686 155.3 4.5e-37 XP_016857921 (OMIM: 174300,615464) PREDICTED: prob ( 619) 686 155.3 4.5e-37 XP_011508337 (OMIM: 174300,615464) PREDICTED: prob ( 619) 686 155.3 4.5e-37 NP_001026895 (OMIM: 174300,615464) probable ATP-de ( 619) 686 155.3 4.5e-37 NP_001317367 (OMIM: 607663) ATP-dependent RNA heli ( 369) 681 154.2 5.9e-37 XP_011534229 (OMIM: 606286) PREDICTED: probable AT ( 529) 683 154.7 6e-37 XP_011534230 (OMIM: 606286) PREDICTED: probable AT ( 529) 683 154.7 6e-37 XP_011534228 (OMIM: 606286) PREDICTED: probable AT ( 604) 683 154.7 6.8e-37 NP_061135 (OMIM: 606286) probable ATP-dependent RN ( 648) 683 154.7 7.3e-37 XP_016866492 (OMIM: 606286) PREDICTED: probable AT ( 439) 679 153.8 9.2e-37 NP_076977 (OMIM: 611665) ATP-dependent RNA helicas ( 881) 681 154.3 1.3e-36 NP_001104792 (OMIM: 611665) ATP-dependent RNA heli ( 882) 681 154.3 1.3e-36 NP_001244102 (OMIM: 605812) ATP-dependent RNA heli ( 370) 671 152.1 2.6e-36 NP_001014449 (OMIM: 605812) ATP-dependent RNA heli ( 370) 671 152.1 2.6e-36 XP_016878379 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 671 152.1 2.6e-36 NP_001244103 (OMIM: 605812) ATP-dependent RNA heli ( 370) 671 152.1 2.6e-36 XP_006721190 (OMIM: 605812) PREDICTED: ATP-depende ( 370) 671 152.1 2.6e-36 NP_004389 (OMIM: 601235) probable ATP-dependent RN ( 875) 667 151.3 1e-35 NP_060365 (OMIM: 616621) probable ATP-dependent RN ( 796) 636 144.7 8.8e-34 XP_016879601 (OMIM: 613369) PREDICTED: ATP-depende ( 775) 621 141.5 7.9e-33 NP_987095 (OMIM: 613369) ATP-dependent RNA helicas ( 938) 621 141.6 9.3e-33 XP_016879600 (OMIM: 613369) PREDICTED: ATP-depende ( 938) 621 141.6 9.3e-33 NP_031398 (OMIM: 613369) ATP-dependent RNA helicas ( 938) 621 141.6 9.3e-33 XP_006721720 (OMIM: 613369) PREDICTED: ATP-depende ( 938) 621 141.6 9.3e-33 NP_001014451 (OMIM: 605812) ATP-dependent RNA heli ( 448) 616 140.4 1e-32 NP_001244101 (OMIM: 605812) ATP-dependent RNA heli ( 453) 616 140.4 1e-32 XP_011521135 (OMIM: 605812) PREDICTED: ATP-depende ( 508) 616 140.4 1.1e-32 NP_001307110 (OMIM: 174300,615464) probable ATP-de ( 567) 610 139.2 3e-32 XP_006711625 (OMIM: 174300,615464) PREDICTED: prob ( 557) 607 138.5 4.6e-32 XP_011522561 (OMIM: 613369) PREDICTED: ATP-depende ( 674) 599 136.8 1.8e-31 >>NP_004388 (OMIM: 600326) probable ATP-dependent RNA he (483 aa) initn: 3164 init1: 3164 opt: 3164 Z-score: 3633.3 bits: 681.7 E(85289): 1.2e-195 Smith-Waterman score: 3164; 100.0% identity (100.0% similar) in 483 aa overlap (1-483:1-483) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 430 440 450 460 470 480 pF1KB5 EKP ::: NP_004 EKP >>NP_001244120 (OMIM: 600326) probable ATP-dependent RNA (483 aa) initn: 3164 init1: 3164 opt: 3164 Z-score: 3633.3 bits: 681.7 E(85289): 1.2e-195 Smith-Waterman score: 3164; 100.0% identity (100.0% similar) in 483 aa overlap (1-483:1-483) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 430 440 450 460 470 480 pF1KB5 EKP ::: NP_001 EKP >>XP_005271474 (OMIM: 600326) PREDICTED: probable ATP-de (483 aa) initn: 3164 init1: 3164 opt: 3164 Z-score: 3633.3 bits: 681.7 E(85289): 1.2e-195 Smith-Waterman score: 3164; 100.0% identity (100.0% similar) in 483 aa overlap (1-483:1-483) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 430 440 450 460 470 480 pF1KB5 EKP ::: XP_005 EKP >>XP_016872740 (OMIM: 600326) PREDICTED: probable ATP-de (440 aa) initn: 2869 init1: 1867 opt: 1873 Z-score: 2151.8 bits: 407.4 E(85289): 4.1e-113 Smith-Waterman score: 2787; 91.1% identity (91.1% similar) in 483 aa overlap (1-483:1-440) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFM------------ 250 260 270 280 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS ::::::::::::::::::::::::::::: XP_016 -------------------------------LQINQSIIFCNSSQRVELLAKKISQLGYS 290 300 310 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 380 390 400 410 420 430 pF1KB5 EKP ::: XP_016 EKP 440 >>XP_011540946 (OMIM: 600326) PREDICTED: probable ATP-de (440 aa) initn: 2869 init1: 1867 opt: 1873 Z-score: 2151.8 bits: 407.4 E(85289): 4.1e-113 Smith-Waterman score: 2787; 91.1% identity (91.1% similar) in 483 aa overlap (1-483:1-440) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFM------------ 250 260 270 280 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS ::::::::::::::::::::::::::::: XP_011 -------------------------------LQINQSIIFCNSSQRVELLAKKISQLGYS 290 300 310 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 380 390 400 410 420 430 pF1KB5 EKP ::: XP_011 EKP 440 >>XP_011540947 (OMIM: 600326) PREDICTED: probable ATP-de (434 aa) initn: 1753 init1: 1753 opt: 1760 Z-score: 2022.2 bits: 383.4 E(85289): 6.8e-106 Smith-Waterman score: 2744; 89.9% identity (89.9% similar) in 483 aa overlap (1-483:1-434) 10 20 30 40 50 60 pF1KB5 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSTARTENPVIMGLSSQNGQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQV :::::::::::::::::::::::::::::::::::::::::::::: XP_011 PIQEESIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQ-------------- 130 140 150 160 190 200 210 220 230 240 pF1KB5 SQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHV ::::::::::::::::::::::::: XP_011 -----------------------------------VHVVIATPGRILDLIKKGVAKVDHV 170 180 190 250 260 270 280 290 300 pF1KB5 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINL 200 210 220 230 240 250 310 320 330 340 350 360 pF1KB5 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEELTLKGVTQYYAYVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYS 260 270 280 290 300 310 370 380 390 400 410 420 pF1KB5 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLH 320 330 340 350 360 370 430 440 450 460 470 480 pF1KB5 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVED 380 390 400 410 420 430 pF1KB5 EKP ::: XP_011 EKP >>NP_055555 (OMIM: 268305,608546) eukaryotic initiation (411 aa) initn: 865 init1: 372 opt: 948 Z-score: 1090.3 bits: 210.9 E(85289): 5.4e-54 Smith-Waterman score: 948; 36.8% identity (71.7% similar) in 410 aa overlap (63-464:4-407) 40 50 60 70 80 pF1KB5 GGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDL---RIKTS- :.:. . . .: : : .:. ...:: NP_055 MATTATMATSGSARKRL-LKEEDMTKVEFETSE 10 20 30 90 100 110 120 130 140 pF1KB5 --DVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILARAKNGTGK ::: : :. . :...:: ::. .:.:::: ::...: ..:::..:....:::: NP_055 EVDVTPT----FDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGK 40 50 60 70 80 150 160 170 180 190 200 pF1KB5 SGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLR .... : .:. ::.. . ::....::::::.:... . .. .:. .. : ::::. NP_055 TATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMN-VQCHACIGGTNVG 90 100 110 120 130 140 210 220 230 240 250 260 pF1KB5 DDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILT .:: .:: ::: .::::..:.:.. .. ..:.::::::..:.. : . . :. NP_055 EDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRY 150 160 170 180 190 200 270 280 290 300 310 320 pF1KB5 LPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EELTLKGVTQYYAYVT-ERQKVHC :: :..: :::.: . .. :. . : .: . .::::.:. :... : :. : NP_055 LPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDT 210 220 230 240 250 260 330 340 350 360 370 380 pF1KB5 LNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGL : :.. : :.:..::::....:. :..:. . ... .:. : :..:. ....::.: NP_055 LCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGA 270 280 290 300 310 320 390 400 410 420 430 440 pF1KB5 CRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRF : :. ::...::.:. :...::.:.:. : :.::::::::.:. :.:::.. :: NP_055 SRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIR 330 340 350 360 370 380 450 460 470 480 pF1KB5 NLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP :..::. .:.: .: :. NP_055 ILRDIEQYYSTQIDEMPMNVADLI 390 400 410 >>NP_001407 (OMIM: 602641) eukaryotic initiation factor (406 aa) initn: 790 init1: 446 opt: 943 Z-score: 1084.6 bits: 209.9 E(85289): 1.1e-53 Smith-Waterman score: 943; 38.7% identity (74.2% similar) in 372 aa overlap (96-464:32-402) 70 80 90 100 110 120 pF1KB5 IKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEE . :.:. :.. :: ::. .:.:::: ::.. NP_001 SASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQR 10 20 30 40 50 60 130 140 150 160 170 180 pF1KB5 SIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICI .: ..: :..:.:..::::.... : .:....: ::.:..:::::: :.... . NP_001 AILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVM 70 80 90 100 110 120 190 200 210 220 230 240 pF1KB5 QVSKHMGGAKVMATTGGTNLRDDIMRLD-DTVHVVIATPGRILDLIKKGVAKVDHVQMIV .. .:: :. : ::::.: ....:. .. :....::::..:.... . ...:.: NP_001 ALGDYMG-ASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB5 LDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EE :::::..::. : . . ::. : .: :..: :::.: .: . .. .. : .: . :: NP_001 LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB5 LTLKGVTQYYAYVT-ERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCF :::.:. :.: : :. :. : :. : :.:..:: :. ..:. :..:. .. NP_001 LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS 250 260 270 280 290 300 370 380 390 400 410 420 pF1KB5 YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRI .:. : :..:. ....::.: : :. :::..::::.: :..:::.:.: :.:.::: NP_001 AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 310 320 330 340 350 360 430 440 450 460 470 480 pF1KB5 GRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK ::.::::. :.:::..: .:. .:..:: .: :. .: :. NP_001 GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 370 380 390 400 pF1KB5 P >>NP_001958 (OMIM: 601102) eukaryotic initiation factor (407 aa) initn: 778 init1: 439 opt: 930 Z-score: 1069.7 bits: 207.1 E(85289): 7.6e-53 Smith-Waterman score: 930; 38.4% identity (74.2% similar) in 372 aa overlap (96-464:33-403) 70 80 90 100 110 120 pF1KB5 IKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEE ..:.:. ::. :: ::. .:.:::: ::.. NP_001 GGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQR 10 20 30 40 50 60 130 140 150 160 170 180 pF1KB5 SIPIALSGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICI .: ..: :..:.:..::::.... : .:..:... . ::.:..:::::: :.... . NP_001 AIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVIL 70 80 90 100 110 120 190 200 210 220 230 240 pF1KB5 QVSKHMGGAKVMATTGGTNLRDDIMRLD-DTVHVVIATPGRILDLIKKGVAKVDHVQMIV .. .:: : : ::::.:.....:. .. :.:..::::..:.... . ..:.: NP_001 ALGDYMG-ATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFV 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB5 LDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLM-EE :::::..::. : . . .:. : . :..: :::.: .: . .. .. : .: . :: NP_001 LDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEE 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB5 LTLKGVTQYYAYVT-ERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCF :::.:. :.: : :. :. : :. : :.:..:: :. ..:. :..:. .. NP_001 LTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVS 250 260 270 280 290 300 370 380 390 400 410 420 pF1KB5 YIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRI .:. : :..:. ....::.: : :. :::..::::.: :..:::.:.: :.:.::: NP_001 ALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI 310 320 330 340 350 360 430 440 450 460 470 480 pF1KB5 GRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEK ::.::::. :.:::..: .:. :..:: .: .. .: :. NP_001 GRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI 370 380 390 400 pF1KB5 P >>NP_542165 (OMIM: 142560) spliceosome RNA helicase DDX3 (428 aa) initn: 723 init1: 349 opt: 838 Z-score: 963.7 bits: 187.6 E(85289): 6.1e-47 Smith-Waterman score: 838; 34.7% identity (67.8% similar) in 429 aa overlap (49-472:4-426) 20 30 40 50 60 70 pF1KB5 GQLRGPVKPTGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKL : ..: . .. . : :: . : NP_542 MAENDVDNELLDYEDDEVETAAGGDGAEAPAK- 10 20 30 80 90 100 110 120 130 pF1KB5 PPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALSGRDILA :: .: : : : ... :.:. :: ::: .: . :.:.:: .:.: :: :. : :.: NP_542 --KD--VKGSYV-SIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLC 40 50 60 70 80 140 150 160 170 180 190 pF1KB5 RAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMA .::.: ::...... :..:. .....:. :::::.:.:. . ::.: ..:: . NP_542 QAKSGMGKTAVFVLATLQQLEPVTGQVSVLVMCHTRELAFQISKEYERFSKYMPNVKVAV 90 100 110 120 130 140 200 210 220 230 240 250 pF1KB5 TTGGTNLRDDIMRLDDTV-HVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQ-DF :: ... : : . :.:..:::::: : .. .. :.. ..::: ::.: : :. NP_542 FFGGLSIKKDEEVLKKNCPHIVVGTPGRILALARNKSLNLKHIKHFILDECDKMLEQLDM 150 160 170 180 190 200 260 270 280 290 300 310 pF1KB5 VQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEE--LTLKGVTQYYA . ...:. :...:....:::. .. . .: :.:: . .: :::.:. :::. NP_542 RRDVQEIFRMTPHEKQVMMFSATLSKEIRPVCRKFMQDPMEIFVDDETKLTLHGLQQYYV 210 220 230 240 250 260 320 330 340 350 360 370 pF1KB5 YVTERQKVHCLNTLFSRLQINQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRN . . .: . : :.. :..:: .:: .: :: ::. . . .. . :: : ::.: NP_542 KLKDNEKNRKLFDLLDVLEFNQVVIFVKSVQRCIALAQLLVEQNFPAIAIHRGMPQEERL 270 280 290 300 310 320 380 390 400 410 420 430 pF1KB5 RVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLA ...:.. : :: :.:: ::.::. ::...:.:.:. ..:::::..:.:::: ::: NP_542 SRYQQFKDFQRRILVATNLFGRGMDIERVNIAFNYDMPEDSDTYLHRVARAGRFGTKGLA 330 340 350 360 370 380 440 450 460 470 480 pF1KB5 INLIT-YDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP :.... .: :....... ..:. .:..:: : :. . NP_542 ITFVSDENDAKILNDVQDRFEVNISELPDEIDISSYIEQTR 390 400 410 420 483 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:28:47 2016 done: Sat Nov 5 10:28:49 2016 Total Scan time: 8.660 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]