FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5858, 490 aa 1>>>pF1KB5858 490 - 490 aa - 490 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0651+/-0.000464; mu= 14.4359+/- 0.029 mean_var=86.1957+/-18.036, 0's: 0 Z-trim(111.7): 90 B-trim: 484 in 1/50 Lambda= 0.138144 statistics sampled from 20285 (20375) to 20285 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.239), width: 16 Scan time: 8.200 The best scores are: opt bits E(85289) NP_938015 (OMIM: 606846) histone-lysine N-methyltr ( 490) 3359 679.9 4.5e-195 NP_001317293 (OMIM: 606846) histone-lysine N-methy ( 477) 1716 352.4 1.6e-96 NP_064582 (OMIM: 610663) N-lysine methyltransferas ( 433) 464 102.9 2e-21 NP_001161212 (OMIM: 608783) histone-lysine N-methy ( 428) 453 100.7 8.9e-21 XP_011542555 (OMIM: 608783) PREDICTED: histone-lys ( 391) 451 100.2 1.1e-20 XP_016857584 (OMIM: 608783) PREDICTED: histone-lys ( 236) 213 52.7 1.4e-06 XP_011542562 (OMIM: 608783) PREDICTED: histone-lys ( 239) 209 51.9 2.4e-06 XP_011542563 (OMIM: 608783) PREDICTED: histone-lys ( 239) 209 51.9 2.4e-06 XP_016857583 (OMIM: 608783) PREDICTED: histone-lys ( 239) 209 51.9 2.4e-06 XP_011542561 (OMIM: 608783) PREDICTED: histone-lys ( 239) 209 51.9 2.4e-06 XP_011542560 (OMIM: 608783) PREDICTED: histone-lys ( 239) 209 51.9 2.4e-06 XP_011542559 (OMIM: 608783) PREDICTED: histone-lys ( 258) 209 51.9 2.5e-06 XP_011542556 (OMIM: 608783) PREDICTED: histone-lys ( 286) 209 51.9 2.8e-06 NP_073580 (OMIM: 608783) histone-lysine N-methyltr ( 369) 209 52.0 3.4e-06 >>NP_938015 (OMIM: 606846) histone-lysine N-methyltransf (490 aa) initn: 3359 init1: 3359 opt: 3359 Z-score: 3623.1 bits: 679.9 E(85289): 4.5e-195 Smith-Waterman score: 3359; 100.0% identity (100.0% similar) in 490 aa overlap (1-490:1-490) 10 20 30 40 50 60 pF1KB5 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 LTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 KISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 KISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 LSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 LSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAY 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_938 AILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNE 430 440 450 460 470 480 490 pF1KB5 PSPALFHKKQ :::::::::: NP_938 PSPALFHKKQ 490 >>NP_001317293 (OMIM: 606846) histone-lysine N-methyltra (477 aa) initn: 1716 init1: 1716 opt: 1716 Z-score: 1853.6 bits: 352.4 E(85289): 1.6e-96 Smith-Waterman score: 3231; 97.1% identity (97.3% similar) in 490 aa overlap (1-490:1-477) 10 20 30 40 50 60 pF1KB5 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKVPNENIRLAARIMWRVEREGTG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALG ::::::::::::::::::::::::::::::::::::::: .::::::: NP_001 GFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNG-------------KIELRALG 190 200 210 220 250 260 270 280 290 300 pF1KB5 KISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQE 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEV 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 LSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LSYLQAFEEASFYARRMVDGYMKLYHPNNAQLGMAVMRAGLTNWHAGNIEVGHGMICKAY 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 AILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNE 410 420 430 440 450 460 490 pF1KB5 PSPALFHKKQ :::::::::: NP_001 PSPALFHKKQ 470 >>NP_064582 (OMIM: 610663) N-lysine methyltransferase SM (433 aa) initn: 665 init1: 254 opt: 464 Z-score: 505.7 bits: 102.9 E(85289): 2e-21 Smith-Waterman score: 808; 31.4% identity (63.8% similar) in 437 aa overlap (9-438:9-427) 10 20 30 40 50 60 pF1KB5 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE .: : . ::::::.: . : ..:..:. ::. :. . . :. :: :.: NP_064 MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKV--PNENIRLAARIMWRVEREG : .::.:: : ::. :::. : :: ::: . .:. :.:..::.:::. . . . NP_064 GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 TGLTEGCLVSVDDLQNHVEHFGEEEQKDL-RVDVDTFLQYWPPQSQQFSMQYISHIFGVI :..: ....:.... ..:.::: . :. .. ... . . . . .:. . NP_064 ERTPSEKLLAVKEFESHLDKL-DNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQV 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 NCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELR ::::::. :.. :. .: .:::...:.::.: :: : ... :.: NP_064 NCNGFTIEDEE-LSHLGSAIFPDVALMNHSCCPNVIVTYKG-------------TLAEVR 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 ALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKD-NPK :. .:. :::. .::::.: .:.:. .:. .:.: : :..: : :: . .. . NP_064 AVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDP 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB5 PSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSI :. :....:........:.. .:. :....:. ::. :: :.:.:::.:. NP_064 PKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQ 290 300 310 320 330 340 360 370 380 390 400 410 pF1KB5 VSEVLSYLQAFEEASFYARRMVDGYMK---LYHPNNAQLGMAVMRAGLTNWHAGNIEVGH . : :.: .: : :..... : : :: : :.. . . : . : . .:. NP_064 AMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKA---AGE 350 360 370 380 390 400 420 430 440 450 460 470 pF1KB5 GMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQV . :: ::. :.:: .:: .... NP_064 KALKKAIAIMEVAHGKDHPYISEIKQEIESH 410 420 430 >>NP_001161212 (OMIM: 608783) histone-lysine N-methyltra (428 aa) initn: 708 init1: 239 opt: 453 Z-score: 494.0 bits: 100.7 E(85289): 8.9e-21 Smith-Waterman score: 787; 31.0% identity (62.3% similar) in 448 aa overlap (9-449:6-426) 10 20 30 40 50 60 pF1KB5 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE :: :.. .: ::.:. . ....: . .: . . :: :. .: NP_001 MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE 10 20 30 40 50 70 80 90 100 110 pF1KB5 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-YGKVPNENIRLAARIMWRVEREGT :: ::.::. :.::. ::: :: .:: ::. .: . : ...:: .:..... .:. NP_001 KLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLM-DGA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 GLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQY----ISHIFG : : ::....... :.... :: : :: .. . :. :. . . :. NP_001 PSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 VINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIE . ::.::. . . .: ::::..:...:.::.: :::...:: : : . NP_001 KVICNSFTICNAE-MQEVGVGLYPSISLLNHSCDPNCSIVFN-GPH------------LL 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 LRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKD-DLFLGVKDN :::. : :::::. :.:.: .::::..::. :: :.: : .:: . :: :.. : NP_001 LRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTG---- 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 PKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRML ...: ::. ...:.::.. ... ...:. .:. . .. . : :::.:..: NP_001 ---DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVL 280 290 300 310 320 330 360 370 380 390 400 410 pF1KB5 SIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVMRAGLTNWHAGNIEVGH . . .. : .::: ::. : .. : ... :.. . :. ::..: . : : . . NP_001 DCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAM 340 350 360 370 380 390 420 430 440 450 460 470 pF1KB5 GMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQV . :. :. :::: : . .:: . . . ..: NP_001 KNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 400 410 420 480 490 pF1KB5 MAEPSNEPSPALFHKKQ >>XP_011542555 (OMIM: 608783) PREDICTED: histone-lysine (391 aa) initn: 561 init1: 242 opt: 451 Z-score: 492.4 bits: 100.2 E(85289): 1.1e-20 Smith-Waterman score: 561; 26.6% identity (55.7% similar) in 447 aa overlap (9-449:6-389) 10 20 30 40 50 60 pF1KB5 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE :: :.. .: ::.:. . ....: . .: . . :: :. .: XP_011 MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE 10 20 30 40 50 70 80 90 100 110 pF1KB5 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-YGKVPNENIRLAARIMWRVEREGT :: ::.::. :.::. ::: :: .:: ::. .: . : ...:: .:..... .:. XP_011 KLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLM-DGA 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 GLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQY----ISHIFG : : ::....... :.... :: : :: .. . :. :. . . :. XP_011 PSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB5 VINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIE . ::.::. . . .: ::::..:...:.::.: :::...:: : : . XP_011 KVICNSFTICNAE-MQEVGVGLYPSISLLNHSCDPNCSIVFN-GPH------------LL 180 190 200 210 220 240 250 260 270 280 290 pF1KB5 LRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKDDLFLGVKDNP :::. : ::: :.. : XP_011 LRAVRDIEVGEE------------------------------------DADMLTG----- 230 240 300 310 320 330 340 350 pF1KB5 KPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLS ...: ::. ...:.::.. ... ...:. .:. . .. . : :::.:..:. XP_011 --DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLD 250 260 270 280 290 360 370 380 390 400 410 pF1KB5 IVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVMRAGLTNWHAGNIEVGHG . .. : .::: ::. : .. : ... :.. . :. ::..: . : : . . XP_011 CAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMK 300 310 320 330 340 350 420 430 440 450 460 470 pF1KB5 MICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVM . :. :. :::: : . .:: . . . ..: XP_011 NLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 360 370 380 390 480 490 pF1KB5 AEPSNEPSPALFHKKQ >>XP_016857584 (OMIM: 608783) PREDICTED: histone-lysine (236 aa) initn: 403 init1: 188 opt: 213 Z-score: 239.3 bits: 52.7 E(85289): 1.4e-06 Smith-Waterman score: 432; 31.9% identity (61.9% similar) in 257 aa overlap (197-449:3-234) 170 180 190 200 210 220 pF1KB5 MQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNL--GLVNHDCWPNCTVIFNNGNHEAV : :.: .:.::.: :::...:: : : XP_016 MLISPDLPISLLNHSCDPNCSIVFN-GPH--- 10 20 230 240 250 260 270 280 pF1KB5 KSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLK . :::. : :::::. :.:.: .::::..::. :: :.: : .:: . : XP_016 ---------LLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDK 30 40 50 60 70 290 300 310 320 330 340 pF1KB5 D-DLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVF : :.. : ...: ::. ...:.::.. ... ...:. .:. . .. . XP_016 DADMLTG-------DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISSNSERL 80 90 100 110 120 350 360 370 380 390 400 pF1KB5 ADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVMRAGLT : :::.:..:. . .. : .::: ::. : .. : ... :.. . :. ::..: XP_016 PDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVMKVGKL 130 140 150 160 170 180 410 420 430 440 450 460 pF1KB5 NWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMR . : : . . . :. :. :::: : . .:: . . . ..: XP_016 QLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 190 200 210 220 230 470 480 490 pF1KB5 EAALNNQPMQVMAEPSNEPSPALFHKKQ >>XP_011542562 (OMIM: 608783) PREDICTED: histone-lysine (239 aa) initn: 455 init1: 188 opt: 209 Z-score: 235.0 bits: 51.9 E(85289): 2.4e-06 Smith-Waterman score: 481; 32.4% identity (63.4% similar) in 262 aa overlap (190-449:1-237) 160 170 180 190 200 210 pF1KB5 PQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNG .: ::::..:...:.::.: :::...:: : XP_011 MQEVGVGLYPSISLLNHSCDPNCSIVFN-G 10 20 220 230 240 250 260 270 pF1KB5 NHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHC : . :::. : :::::. :.:.: .::::..::. :: :.: : .: XP_011 PH------------LLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRC 30 40 50 60 70 280 290 300 310 320 330 pF1KB5 QKKLKD-DLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEK : . :: :.. : ...: ::. ...:.::.. ... ...:. .:. . . XP_011 QTQDKDADMLTG-------DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISS 80 90 100 110 120 340 350 360 370 380 390 pF1KB5 QEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVM . . : :::.:..:. . .. : .::: ::. : .. : ... :.. . :. :: XP_011 NSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVM 130 140 150 160 170 180 400 410 420 430 440 450 pF1KB5 RAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFM ..: . : : . . . :. :. :::: : . .:: . . . ..: XP_011 KVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 190 200 210 220 230 460 470 480 490 pF1KB5 YYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ >>XP_011542563 (OMIM: 608783) PREDICTED: histone-lysine (239 aa) initn: 455 init1: 188 opt: 209 Z-score: 235.0 bits: 51.9 E(85289): 2.4e-06 Smith-Waterman score: 481; 32.4% identity (63.4% similar) in 262 aa overlap (190-449:1-237) 160 170 180 190 200 210 pF1KB5 PQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNG .: ::::..:...:.::.: :::...:: : XP_011 MQEVGVGLYPSISLLNHSCDPNCSIVFN-G 10 20 220 230 240 250 260 270 pF1KB5 NHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHC : . :::. : :::::. :.:.: .::::..::. :: :.: : .: XP_011 PH------------LLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRC 30 40 50 60 70 280 290 300 310 320 330 pF1KB5 QKKLKD-DLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEK : . :: :.. : ...: ::. ...:.::.. ... ...:. .:. . . XP_011 QTQDKDADMLTG-------DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISS 80 90 100 110 120 340 350 360 370 380 390 pF1KB5 QEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVM . . : :::.:..:. . .. : .::: ::. : .. : ... :.. . :. :: XP_011 NSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVM 130 140 150 160 170 180 400 410 420 430 440 450 pF1KB5 RAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFM ..: . : : . . . :. :. :::: : . .:: . . . ..: XP_011 KVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 190 200 210 220 230 460 470 480 490 pF1KB5 YYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ >>XP_016857583 (OMIM: 608783) PREDICTED: histone-lysine (239 aa) initn: 455 init1: 188 opt: 209 Z-score: 235.0 bits: 51.9 E(85289): 2.4e-06 Smith-Waterman score: 481; 32.4% identity (63.4% similar) in 262 aa overlap (190-449:1-237) 160 170 180 190 200 210 pF1KB5 PQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNG .: ::::..:...:.::.: :::...:: : XP_016 MQEVGVGLYPSISLLNHSCDPNCSIVFN-G 10 20 220 230 240 250 260 270 pF1KB5 NHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHC : . :::. : :::::. :.:.: .::::..::. :: :.: : .: XP_016 PH------------LLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRC 30 40 50 60 70 280 290 300 310 320 330 pF1KB5 QKKLKD-DLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEK : . :: :.. : ...: ::. ...:.::.. ... ...:. .:. . . XP_016 QTQDKDADMLTG-------DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISS 80 90 100 110 120 340 350 360 370 380 390 pF1KB5 QEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVM . . : :::.:..:. . .. : .::: ::. : .. : ... :.. . :. :: XP_016 NSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVM 130 140 150 160 170 180 400 410 420 430 440 450 pF1KB5 RAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFM ..: . : : . . . :. :. :::: : . .:: . . . ..: XP_016 KVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 190 200 210 220 230 460 470 480 490 pF1KB5 YYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ >>XP_011542561 (OMIM: 608783) PREDICTED: histone-lysine (239 aa) initn: 455 init1: 188 opt: 209 Z-score: 235.0 bits: 51.9 E(85289): 2.4e-06 Smith-Waterman score: 481; 32.4% identity (63.4% similar) in 262 aa overlap (190-449:1-237) 160 170 180 190 200 210 pF1KB5 PQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNG .: ::::..:...:.::.: :::...:: : XP_011 MQEVGVGLYPSISLLNHSCDPNCSIVFN-G 10 20 220 230 240 250 260 270 pF1KB5 NHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHC : . :::. : :::::. :.:.: .::::..::. :: :.: : .: XP_011 PH------------LLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRC 30 40 50 60 70 280 290 300 310 320 330 pF1KB5 QKKLKD-DLFLGVKDNPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEK : . :: :.. : ...: ::. ...:.::.. ... ...:. .:. . . XP_011 QTQDKDADMLTG-------DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISS 80 90 100 110 120 340 350 360 370 380 390 pF1KB5 QEPVFADTNIYMLRMLSIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVM . . : :::.:..:. . .. : .::: ::. : .. : ... :.. . :. :: XP_011 NSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVM 130 140 150 160 170 180 400 410 420 430 440 450 pF1KB5 RAGLTNWHAGNIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFM ..: . : : . . . :. :. :::: : . .:: . . . ..: XP_011 KVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 190 200 210 220 230 460 470 480 490 pF1KB5 YYKMREAALNNQPMQVMAEPSNEPSPALFHKKQ 490 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:30:51 2016 done: Sat Nov 5 16:30:52 2016 Total Scan time: 8.200 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]