FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5863, 461 aa 1>>>pF1KB5863 461 - 461 aa - 461 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5765+/-0.00115; mu= 11.6605+/- 0.067 mean_var=172.4834+/-32.605, 0's: 0 Z-trim(108.6): 238 B-trim: 6 in 1/50 Lambda= 0.097656 statistics sampled from 10062 (10343) to 10062 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.318), width: 16 Scan time: 2.970 The best scores are: opt bits E(32554) CCDS2145.1 PROC gene_id:5624|Hs108|chr2 ( 461) 3287 476.0 3.6e-134 CCDS14666.1 F9 gene_id:2158|Hs108|chrX ( 461) 790 124.2 2.9e-28 CCDS73602.1 F7 gene_id:2155|Hs108|chr13 ( 382) 690 110.0 4.5e-24 CCDS9529.1 F7 gene_id:2155|Hs108|chr13 ( 444) 687 109.6 6.6e-24 CCDS9528.1 F7 gene_id:2155|Hs108|chr13 ( 466) 687 109.7 6.8e-24 CCDS9530.1 F10 gene_id:2159|Hs108|chr13 ( 488) 639 102.9 7.7e-22 CCDS83495.1 F9 gene_id:2158|Hs108|chrX ( 423) 579 94.4 2.4e-19 CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 ( 638) 568 93.1 9.3e-19 CCDS10431.1 TPSAB1 gene_id:7177|Hs108|chr16 ( 275) 541 88.8 7.6e-18 CCDS3847.1 F11 gene_id:2160|Hs108|chr4 ( 625) 545 89.8 8.7e-18 CCDS3709.1 PRSS12 gene_id:8492|Hs108|chr4 ( 875) 542 89.6 1.4e-17 CCDS33564.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 492) 535 88.3 2e-17 CCDS54486.1 TMPRSS2 gene_id:7113|Hs108|chr21 ( 529) 535 88.3 2.1e-17 CCDS3369.1 HGFAC gene_id:3083|Hs108|chr4 ( 655) 536 88.6 2.2e-17 CCDS75098.1 HGFAC gene_id:3083|Hs108|chr4 ( 662) 533 88.1 2.9e-17 CCDS32993.1 HPN gene_id:3249|Hs108|chr19 ( 417) 509 84.5 2.3e-16 CCDS10430.1 TPSG1 gene_id:25823|Hs108|chr16 ( 321) 506 84.0 2.6e-16 CCDS45469.1 PRSS8 gene_id:5652|Hs108|chr16 ( 343) 504 83.7 3.2e-16 CCDS62766.1 KLK15 gene_id:55554|Hs108|chr19 ( 255) 502 83.3 3.3e-16 CCDS12805.1 KLK15 gene_id:55554|Hs108|chr19 ( 256) 502 83.3 3.3e-16 CCDS13686.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 454) 505 84.0 3.5e-16 CCDS12088.1 TMPRSS9 gene_id:360200|Hs108|chr19 (1059) 509 85.0 4.1e-16 CCDS73391.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 413) 500 83.2 5.4e-16 CCDS73392.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 448) 500 83.3 5.7e-16 CCDS44735.1 TMPRSS5 gene_id:80975|Hs108|chr11 ( 457) 500 83.3 5.8e-16 CCDS74856.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 802) 503 84.0 6.2e-16 CCDS13941.1 TMPRSS6 gene_id:164656|Hs108|chr22 ( 811) 503 84.0 6.2e-16 CCDS58790.1 TMPRSS3 gene_id:64699|Hs108|chr21 ( 453) 497 82.9 7.7e-16 CCDS10476.1 PRSS27 gene_id:83886|Hs108|chr16 ( 290) 493 82.1 8.5e-16 CCDS82946.1 CFI gene_id:3426|Hs108|chr4 ( 591) 497 83.0 9.1e-16 CCDS12822.1 KLK13 gene_id:26085|Hs108|chr19 ( 277) 491 81.8 1e-15 CCDS3520.1 TMPRSS11F gene_id:389208|Hs108|chr4 ( 438) 493 82.3 1.1e-15 CCDS55788.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 532) 494 82.5 1.1e-15 CCDS41721.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 567) 494 82.6 1.2e-15 CCDS58185.1 TMPRSS13 gene_id:84000|Hs108|chr11 ( 563) 490 82.0 1.8e-15 CCDS42110.1 PRSS33 gene_id:260429|Hs108|chr16 ( 280) 484 80.8 2e-15 CCDS3518.1 TMPRSS11D gene_id:9407|Hs108|chr4 ( 418) 484 81.0 2.6e-15 CCDS13571.1 TMPRSS15 gene_id:5651|Hs108|chr21 (1019) 489 82.2 2.8e-15 CCDS123.1 MASP2 gene_id:10747|Hs108|chr1 ( 686) 483 81.1 3.9e-15 CCDS82945.1 CFI gene_id:3426|Hs108|chr4 ( 576) 481 80.7 4.3e-15 CCDS44442.1 PLAU gene_id:5328|Hs108|chr10 ( 414) 477 80.0 5.1e-15 CCDS7339.1 PLAU gene_id:5328|Hs108|chr10 ( 431) 477 80.0 5.2e-15 CCDS34049.1 CFI gene_id:3426|Hs108|chr4 ( 583) 475 79.9 7.7e-15 CCDS3521.1 TMPRSS11B gene_id:132724|Hs108|chr4 ( 416) 469 78.9 1.1e-14 CCDS73251.1 OVCH2 gene_id:341277|Hs108|chr11 ( 565) 469 79.0 1.4e-14 CCDS53579.1 HABP2 gene_id:3026|Hs108|chr10 ( 534) 468 78.9 1.5e-14 CCDS7577.1 HABP2 gene_id:3026|Hs108|chr10 ( 560) 468 78.9 1.5e-14 CCDS43129.2 TMPRSS7 gene_id:344805|Hs108|chr3 ( 717) 465 78.6 2.3e-14 CCDS157.1 CELA2A gene_id:63036|Hs108|chr1 ( 269) 455 76.7 3.3e-14 CCDS33993.1 TMPRSS11E gene_id:28983|Hs108|chr4 ( 423) 453 76.6 5.4e-14 >>CCDS2145.1 PROC gene_id:5624|Hs108|chr2 (461 aa) initn: 3287 init1: 3287 opt: 3287 Z-score: 2522.1 bits: 476.0 E(32554): 3.6e-134 Smith-Waterman score: 3287; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS21 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV 370 380 390 400 410 420 430 440 450 460 pF1KB5 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP ::::::::::::::::::::::::::::::::::::::::: CCDS21 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP 430 440 450 460 >>CCDS14666.1 F9 gene_id:2158|Hs108|chrX (461 aa) initn: 870 init1: 272 opt: 790 Z-score: 620.9 bits: 124.2 E(32554): 2.9e-28 Smith-Waterman score: 993; 35.8% identity (65.3% similar) in 447 aa overlap (25-445:29-454) 10 20 30 40 50 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF-LEELRHSSL .:: . : :...: :: :: :::. ...: CCDS14 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGI ::::.:: :.::::.:.:.:.. : ::...:::::: : : . :.: : : CCDS14 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNP--------CLNGGSCKDDI 70 80 90 100 110 120 130 140 150 160 170 pF1KB5 GSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQ .:. : : :.::. :. .:. :.. :: : ..: . . . :::. ::.:... . CCDS14 NSYECWCPFGFEGKNCELDVT---CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKS 120 130 140 150 160 180 190 200 210 pF1KB5 CHPAVKFPCGRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRLID :.::: ::::: . .: .. . .. . : .: :.. CCDS14 CEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVG 170 180 190 200 210 220 220 230 240 250 260 270 pF1KB5 GKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWE :. .. :. :::::: ..: ::. ... .:..:::::.. . :. : ::..... : CCDS14 GEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETE 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB5 KWELDLDIKEVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQ . : .. ... : ::. . . ..:::::.: .: .:.. ..:::. :. .. : . CCDS14 HTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL-K 290 300 310 320 330 340 340 350 360 370 380 390 pF1KB5 AGQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI :. :.::: .:..: ..::.....:.: . : . . . .::.:::. CCDS14 FGS-GYVSGWGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF 350 360 370 380 390 400 410 420 430 440 450 pF1KB5 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR .:.:.:::::: :. .:: ::.:..:::: :.. .::.:::::::..:: CCDS14 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 400 410 420 430 440 450 460 pF1KB5 DKEAPQKSWAP CCDS14 LT 460 >>CCDS73602.1 F7 gene_id:2155|Hs108|chr13 (382 aa) initn: 685 init1: 290 opt: 690 Z-score: 545.7 bits: 110.0 E(32554): 4.5e-24 Smith-Waterman score: 869; 37.2% identity (65.4% similar) in 379 aa overlap (88-455:22-373) 60 70 80 90 100 110 pF1KB5 ECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGS ::::: : : . :.: : . : CCDS73 MVSQALRLLCLLLGLQGCLAADGDQCASSP--------CQNGGSCKDQLQS 10 20 30 40 120 130 140 150 160 170 pF1KB5 FSCDCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQC . : : ..::: :. .. . : : .:::: .:: ...: .: : : ::.: : ..: CCDS73 YICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSC 50 60 70 80 90 100 180 190 200 210 220 230 pF1KB5 HPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKK :.:..:::. : .::. . .. : :.. ::. .:. ::::.:: . CCDS73 TPTVEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQVLLLVNGA 110 120 130 140 150 240 250 260 270 280 290 pF1KB5 KLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNY .: ::..::. ::..::::.:. :. :.. :::.:: . . : . . .:.. .: CCDS73 QL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY 160 170 180 190 200 210 300 310 320 330 340 350 pF1KB5 SKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKE .::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::: .: CCDS73 VPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGAT 220 230 240 250 260 360 370 380 390 400 pF1KB5 AKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDACEGDSGGPM : . .::: .: . ..: . : ..: :.::: .:.:.:::::: CCDS73 ALE--LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPH 270 280 290 300 310 320 410 420 430 440 450 460 pF1KB5 VASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP .. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. : CCDS73 ATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 330 340 350 360 370 380 >>CCDS9529.1 F7 gene_id:2155|Hs108|chr13 (444 aa) initn: 924 init1: 290 opt: 687 Z-score: 542.6 bits: 109.6 E(32554): 6.6e-24 Smith-Waterman score: 1112; 39.5% identity (67.0% similar) in 461 aa overlap (6-455:5-435) 10 20 30 40 50 60 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI .: :. :..: : .:: ..:.:: ::. :.:::.:::::: .:::::: CCDS95 MVSQALRLLCLLLGLQGC---LAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECK 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC :: :.::::.:::.... : :: .. ::::: : : . :.: : . :. : CCDS95 EEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQNGGSCKDQLQSYIC 60 70 80 90 100 130 140 150 160 170 pF1KB5 DCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPA : ..::: :. .. . : : .:::: .:: ...: .: : : ::.: : ..: :. CCDS95 FCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPT 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB5 VKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLA :..:::. : .::. . .. : :.. ::. .:. ::::.:: . .: CCDS95 VEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQVLLLVNGAQL- 170 180 190 200 210 240 250 260 270 280 290 pF1KB5 CGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKS ::..::. ::..::::.:. :. :.. :::.:: . . : . . .:.. .: . CCDS95 CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPG 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB5 TTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKR ::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::: .: : . CCDS95 TTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGATALE 280 290 300 310 320 330 360 370 380 390 400 pF1KB5 NRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDACEGDSGGPMVAS .::: .: . ..: . : ..: :.::: .:.:.:::::: .. CCDS95 --LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH 340 350 360 370 380 410 420 430 440 450 460 pF1KB5 FHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. : CCDS95 YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP 390 400 410 420 430 440 >>CCDS9528.1 F7 gene_id:2155|Hs108|chr13 (466 aa) initn: 920 init1: 290 opt: 687 Z-score: 542.4 bits: 109.7 E(32554): 6.8e-24 Smith-Waterman score: 1110; 40.0% identity (67.6% similar) in 447 aa overlap (20-455:39-457) 10 20 30 40 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEE :.: :: ..:.:: ::. :.:::.:::: CCDS95 LCLLLGLQGCLAAGGVAKASGGETRDMPWKPGP-HRVFVTQEEAHGVLHRRRRANAFLEE 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB5 LRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHG :: .:::::: :: :.::::.:::.... : :: .. ::::: : : . : CCDS95 LRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQNGG 70 80 90 100 110 110 120 130 140 150 160 pF1KB5 TCIDGIGSFSCDCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYK .: : . :. : : ..::: :. .. . : : .:::: .:: ...: .: : : ::. CCDS95 SCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYS 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB5 LGDDLLQCHPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQ : : ..: :.:..:::. : .::. . .. : :.. ::. .:. ::: CCDS95 LLADGVSCTPTVEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQ 180 190 200 210 220 230 240 250 260 270 280 pF1KB5 VVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIK :.:: . .: ::..::. ::..::::.:. :. :.. :::.:: . . : . . CCDS95 VLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVA 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB5 EVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG .:.. .: .::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::: CCDS95 QVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWG 290 300 310 320 330 340 350 360 370 380 390 pF1KB5 YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDAC .: : . .::: .: . ..: . : ..: :.::: .:.: CCDS95 QLLDRGATAL--ELMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSC 350 360 370 380 390 400 400 410 420 430 440 450 pF1KB5 EGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKS .:::::: .. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. : CCDS95 KGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVL 410 420 430 440 450 460 460 pF1KB5 WAP CCDS95 LRAPFP >>CCDS9530.1 F10 gene_id:2159|Hs108|chr13 (488 aa) initn: 944 init1: 282 opt: 639 Z-score: 505.6 bits: 102.9 E(32554): 7.7e-22 Smith-Waterman score: 1080; 36.0% identity (63.2% similar) in 475 aa overlap (24-461:22-479) 10 20 30 40 50 60 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI .:.: :.:...: ::::::::.... :::::. CCDS95 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECM 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC :: :..:::.:.:.. : : ::.:. ::::: . : : ..: : ::.: ..: CCDS95 EETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSP--------CQNQGKCKDGLGEYTC 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB5 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK : :.::. :. . : :::::: : ..: :: . :::: :: :.:. : :. CCDS95 TCLEGFEGKNCELFTRKL-CSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGP 120 130 140 150 160 190 200 210 pF1KB5 FPCGRPWKRMEKKRSHLKR-----------------DTEDQE-----------DQVDP-- .:::. . .:... . . :. : . .:..: CCDS95 YPCGK--QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPER 170 180 190 200 210 220 220 230 240 250 260 pF1KB5 ------RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVR :.. :. . :. :::..:.. ... ::.... ..::::::. ..:.. :: CCDS95 GDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVR 230 240 250 260 270 280 270 280 290 300 310 320 pF1KB5 LGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSG .:. . .. : : ... :. : ..: : : :::.:.: : :. ....: :::. CCDS95 VGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERD 290 300 310 320 330 340 330 340 350 360 370 380 pF1KB5 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN :: : .. . .:.:.: : .: :. : :.....: : .: :. : ....: CCDS95 WAESTL-MTQKTGIVSGFG----RTHEKGRQSTR-LKMLEVPYVDRNSCKLSSSFIITQN 350 360 370 380 390 400 390 400 410 420 430 440 pF1KB5 MLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDW :.::: ..:::.:::::: :. :. :.:..:.:::::::. .::.::::. .: : CCDS95 MFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKW 410 420 430 440 450 460 450 460 pF1KB5 IHGHIRDKEAPQ-KSWAP : .. . :. :: :: CCDS95 IDRSMKTRGLPKAKSHAPEVITSSPLK 470 480 >>CCDS83495.1 F9 gene_id:2158|Hs108|chrX (423 aa) initn: 834 init1: 272 opt: 579 Z-score: 460.6 bits: 94.4 E(32554): 2.4e-19 Smith-Waterman score: 784; 31.8% identity (59.7% similar) in 447 aa overlap (25-445:29-416) 10 20 30 40 50 pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF-LEELRHSSL .:: . : :...: :: :: :::. ...: CCDS83 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 ERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGI ::::.:: :.::::.:.:.:.. : ::...:: CCDS83 ERECMEEKCSFEEAREVFENTERTTEFWKQYVD--------------------------- 70 80 90 120 130 140 150 160 170 pF1KB5 GSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQ ..:.. :: : ..: . . . :::. ::.:... . CCDS83 ----------------------VTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKS 100 110 120 130 180 190 200 210 pF1KB5 CHPAVKFPCGRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRLID :.::: ::::: . .: .. . .. . : .: :.. CCDS83 CEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVG 140 150 160 170 180 190 220 230 240 250 260 270 pF1KB5 GKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWE :. .. :. :::::: ..: ::. ... .:..:::::.. . :. : ::..... : CCDS83 GEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETE 200 210 220 230 240 250 280 290 300 310 320 330 pF1KB5 KWELDLDIKEVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQ . : .. ... : ::. . . ..:::::.: .: .:.. ..:::. :. .. : . CCDS83 HTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL-K 260 270 280 290 300 340 350 360 370 380 390 pF1KB5 AGQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI :. :.::: .:..: ..::.....:.: . : . . . .::.:::. CCDS83 FGS-GYVSGWGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF 310 320 330 340 350 360 400 410 420 430 440 450 pF1KB5 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR .:.:.:::::: :. .:: ::.:..:::: :.. .::.:::::::..:: CCDS83 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 370 380 390 400 410 420 460 pF1KB5 DKEAPQKSWAP CCDS83 LT >>CCDS34120.1 KLKB1 gene_id:3818|Hs108|chr4 (638 aa) initn: 561 init1: 275 opt: 568 Z-score: 450.2 bits: 93.1 E(32554): 9.3e-19 Smith-Waterman score: 568; 37.4% identity (65.6% similar) in 262 aa overlap (207-461:386-637) 180 190 200 210 220 230 pF1KB5 PAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVL---LDSK ... :.. : . :. :::: : : .. CCDS34 SPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQ 360 370 380 390 400 410 240 250 260 270 280 290 pF1KB5 KKLACGAVLIHPSWVLTAAHCMDESKKLLV-RL--GEYDLRRWEKWELDLDIKEVFVHPN ..: ::. :: .::::::::.: : :. : .: : .:::...: : CCDS34 RHL-CGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQN 420 430 440 450 460 470 300 310 320 330 340 350 pF1KB5 YSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK :. : ..::::..: : . .. :::::..: . . . :::::. :.:: CCDS34 YKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG----DTSTIYTNCWVTGWGF--SKEK 480 490 500 510 520 360 370 380 390 400 pF1KB5 EAKRNRTFVLNFIKIPVVPHNECSEVMSNM-VSENMLCAGILGDRQDACEGDSGGPMVAS .: .:. ..::.: ..::.. .... ... :.::: .:::.::::::.: . CCDS34 GEIQN---ILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCK 530 540 550 560 570 580 410 420 430 440 450 460 pF1KB5 FHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP .: : :::..::::::. .. ::::::..:.::: . ..... . .: CCDS34 HNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA 590 600 610 620 630 >>CCDS10431.1 TPSAB1 gene_id:7177|Hs108|chr16 (275 aa) initn: 454 init1: 264 opt: 541 Z-score: 433.9 bits: 88.8 E(32554): 7.6e-18 Smith-Waterman score: 541; 36.2% identity (63.4% similar) in 254 aa overlap (212-452:31-274) 190 200 210 220 230 pF1KB5 PCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVL-LDSKKKLA-CG .. :. . :. :::: : . . . :: CCDS10 MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG 10 20 30 40 50 60 240 250 260 270 280 290 pF1KB5 AVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELD--LDIKEVFVHPNYSKSTTD . ::::.::::::::. . : :. : . .::. . . : : .....:::.. . CCDS10 GSLIHPQWVLTAAHCVGPDVKDLAAL-RVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIG 70 80 90 100 110 300 310 320 330 340 350 pF1KB5 NDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRT :::::.: .:...:. . . :: .. : :. ::::: .. :. CCDS10 ADIALLELEEPVNVSSHVHTVTLPPAS----ETFPPGMPCWVTGWGDVDNDERLPP---P 120 130 140 150 160 170 360 370 380 390 400 pF1KB5 FVLNFIKIPVVPHNECSEVMS---------NMVSENMLCAGILGDRQDACEGDSGGPMVA : :. .:.:.. .. :. . .: ..::::: . :.:.:.::::::.: CCDS10 FPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAG--NTRRDSCQGDSGGPLVC 180 190 200 210 220 230 410 420 430 440 450 460 pF1KB5 SFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP . .:::. .:.:::::::. . :.::.:. :::::: .. : CCDS10 KVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP 240 250 260 270 >>CCDS3847.1 F11 gene_id:2160|Hs108|chr4 (625 aa) initn: 565 init1: 249 opt: 545 Z-score: 432.8 bits: 89.8 E(32554): 8.7e-18 Smith-Waterman score: 558; 30.8% identity (59.1% similar) in 389 aa overlap (83-445:246-618) 60 70 80 90 100 110 pF1KB5 SSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCI : :. . . ::. : : .. . CCDS38 DSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKAL 220 230 240 250 260 270 120 130 140 150 160 pF1KB5 DGIGSFSCDCRSGWEGRFCQ----REVSFLNCSLD------NGGCTHYCLEEVGWRRC-- .:.. : :: . ::. ....::. :: . .: . : . : :: CCDS38 SGFSLQS--CRHSIP-VFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAV---RCQF 280 290 300 310 320 170 180 190 200 210 pF1KB5 -SCAPGY-KLGDDLLQCHPAVKFPCGRPWKRMEKKRS----HLKRDTEDQE--DQVDPRL . .:. . .. .:. .. : : : .. . . :. :.: .. ::. CCDS38 FTYTPAQASCNEGKGKCYLKLS-SNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRI 330 340 350 360 370 380 220 230 240 250 260 pF1KB5 IDGKMTRRGDSPWQVVLLDSK--KKLACGAVLIHPSWVLTAAHCMD--ESKKLL-VRLGE . : . ::. ::::.: .. .. ::. .: .:.::::::. :: :.: : : CCDS38 VGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYSGI 390 400 410 420 430 440 270 280 290 300 310 320 pF1KB5 YDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE . . .. . ..:...: .:. . . :::::.: .. ... :::::..: . CCDS38 LNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKG--D 450 460 470 480 490 500 330 340 350 360 370 380 pF1KB5 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-SNMVSENML : : . ::::::.. :.: .: .:. :::.: ..::.. . .. ....:. CCDS38 R--NVIYTDCWVTGWGYRKLRDK--IQN---TLQKAKIPLVTNEECQKRYRGHKITHKMI 510 520 530 540 550 390 400 410 420 430 440 pF1KB5 CAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH ::: .:::.::::::. . . .: :::..::::::. . ::::.: .:.::: CCDS38 CAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWIL 560 570 580 590 600 610 450 460 pF1KB5 GHIRDKEAPQKSWAP CCDS38 EKTQAV 620 461 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 10:32:35 2016 done: Sat Nov 5 10:32:36 2016 Total Scan time: 2.970 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]