Result of FASTA (omim) for
pF1KB5863
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5863, 461 aa
1>>>pF1KB5863 461 - 461 aa - 461 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.8733+/-0.000488; mu= 9.9533+/- 0.029
mean_var=212.9257+/-43.756, 0's: 0 Z-trim(115.5): 431 B-trim: 93 in 1/54
Lambda= 0.087894
statistics sampled from 25493 (26053) to 25493 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.305), width: 16
Scan time: 8.960
The best scores are: opt bits E(85289)
NP_000303 (OMIM: 176860,612283,612304) vitamin K-d ( 461) 3287 430.4 4.8e-120
XP_005263774 (OMIM: 176860,612283,612304) PREDICTE ( 482) 3287 430.5 5e-120
XP_016859994 (OMIM: 176860,612283,612304) PREDICTE ( 542) 3059 401.6 2.7e-111
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 2334 309.6 1.2e-83
NP_000124 (OMIM: 122700,300746,300807,306900) coag ( 461) 790 113.8 1e-24
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 690 101.0 5.8e-21
NP_062562 (OMIM: 227500,608446,613878) coagulation ( 444) 687 100.7 8.3e-21
NP_000122 (OMIM: 227500,608446,613878) coagulation ( 466) 687 100.8 8.6e-21
XP_006720026 (OMIM: 227500,608446,613878) PREDICTE ( 412) 649 95.9 2.2e-19
NP_000495 (OMIM: 227600,613872) coagulation factor ( 488) 639 94.7 6e-19
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 634 93.9 7.8e-19
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 634 94.0 8.6e-19
XP_011535776 (OMIM: 227500,608446,613878) PREDICTE ( 495) 634 94.1 9.4e-19
NP_001299603 (OMIM: 227600,613872) coagulation fac ( 444) 625 92.9 1.9e-18
NP_001300842 (OMIM: 122700,300746,300807,306900) c ( 423) 579 87.0 1.1e-16
XP_005262454 (OMIM: 122700,300746,300807,306900) P ( 418) 571 86.0 2.2e-16
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 568 85.6 2.9e-16
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 568 85.6 2.9e-16
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 568 85.8 3.6e-16
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 568 85.9 3.7e-16
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 568 85.9 3.7e-16
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 547 82.7 1.4e-15
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 548 83.3 2e-15
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 541 81.9 2.3e-15
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 545 82.8 2.5e-15
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 545 82.9 2.7e-15
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 545 82.9 2.7e-15
NP_003610 (OMIM: 249500,606709) neurotrypsin precu ( 875) 542 82.7 4.3e-15
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 535 81.4 4.8e-15
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 535 81.5 5.3e-15
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 535 81.5 5.6e-15
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 535 81.5 5.6e-15
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 535 81.6 5.9e-15
NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 536 81.8 6.1e-15
NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 533 81.4 8e-15
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 518 79.2 2.2e-14
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 509 78.0 4.3e-14
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 509 78.1 5e-14
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 509 78.1 5e-14
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 509 78.1 5e-14
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 509 78.1 5e-14
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 509 78.1 5e-14
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 506 77.6 5.8e-14
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 506 77.6 5.8e-14
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 509 78.3 6e-14
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 505 77.5 6.1e-14
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 509 78.4 6.8e-14
NP_001264010 (OMIM: 610601) kallikrein-15 isoform ( 255) 502 77.0 6.9e-14
XP_011525387 (OMIM: 610601) PREDICTED: kallikrein- ( 255) 502 77.0 6.9e-14
XP_006723328 (OMIM: 610601) PREDICTED: kallikrein- ( 256) 502 77.0 6.9e-14
>>NP_000303 (OMIM: 176860,612283,612304) vitamin K-depen (461 aa)
initn: 3287 init1: 3287 opt: 3287 Z-score: 2276.1 bits: 430.4 E(85289): 4.8e-120
Smith-Waterman score: 3287; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461)
10 20 30 40 50 60
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
370 380 390 400 410 420
430 440 450 460
pF1KB5 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
:::::::::::::::::::::::::::::::::::::::::
NP_000 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
430 440 450 460
>>XP_005263774 (OMIM: 176860,612283,612304) PREDICTED: v (482 aa)
initn: 3287 init1: 3287 opt: 3287 Z-score: 2275.9 bits: 430.5 E(85289): 5e-120
Smith-Waterman score: 3287; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:22-482)
10 20 30
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRI
:::::::::::::::::::::::::::::::::::::::
XP_005 MAAGRRTCSISTTRPCASASRMWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRI
10 20 30 40 50 60
40 50 60 70 80 90
pF1KB5 RKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEH
70 80 90 100 110 120
100 110 120 130 140 150
pF1KB5 PCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR
130 140 150 160 170 180
160 170 180 190 200 210
pF1KB5 CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTR
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB5 RGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELD
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB5 LDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLV
310 320 330 340 350 360
340 350 360 370 380 390
pF1KB5 TGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACE
370 380 390 400 410 420
400 410 420 430 440 450
pF1KB5 GDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW
430 440 450 460 470 480
460
pF1KB5 AP
::
XP_005 AP
>>XP_016859994 (OMIM: 176860,612283,612304) PREDICTED: v (542 aa)
initn: 3053 init1: 3053 opt: 3059 Z-score: 2119.1 bits: 401.6 E(85289): 2.7e-111
Smith-Waterman score: 3059; 99.3% identity (99.3% similar) in 432 aa overlap (33-461:111-542)
10 20 30 40 50
pF1KB5 QLTSLLLFVATWGISGTPAPLDSVFSSSERAHQ---VLRIRKRANSFLEELRHSSLEREC
::: ::::::::::::::::::::::::
XP_016 LHDPPLQVPVPPECGSSQASCCSWPPGEFPAHQLLLVLRIRKRANSFLEELRHSSLEREC
90 100 110 120 130 140
60 70 80 90 100 110
pF1KB5 IEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFS
150 160 170 180 190 200
120 130 140 150 160 170
pF1KB5 CDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAV
210 220 230 240 250 260
180 190 200 210 220 230
pF1KB5 KFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACG
270 280 290 300 310 320
240 250 260 270 280 290
pF1KB5 AVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDND
330 340 350 360 370 380
300 310 320 330 340 350
pF1KB5 IALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFV
390 400 410 420 430 440
360 370 380 390 400 410
pF1KB5 LNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGL
450 460 470 480 490 500
420 430 440 450 460
pF1KB5 VSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
::::::::::::::::::::::::::::::::::::::::::
XP_016 VSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
510 520 530 540
>>XP_016859995 (OMIM: 176860,612283,612304) PREDICTED: v (495 aa)
initn: 3273 init1: 2333 opt: 2334 Z-score: 1622.7 bits: 309.6 E(85289): 1.2e-83
Smith-Waterman score: 3187; 93.1% identity (93.1% similar) in 493 aa overlap (3-461:3-495)
10 20 30 40 50 60
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
70 80 90 100 110 120
130 140
pF1KB5 DCRSGWEGRFCQR----------------------------------EVSFLNCSLDNGG
::::::::::::: :::::::::::::
XP_016 DCRSGWEGRFCQRGEGERWMLAGGGAGLGPGWGRGTSTSCPRPPLPAEVSFLNCSLDNGG
130 140 150 160 170 180
150 160 170 180 190 200
pF1KB5 CTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQED
190 200 210 220 230 240
210 220 230 240 250 260
pF1KB5 QVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KB5 EYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLA
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB5 ERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENML
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB5 CAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH
430 440 450 460 470 480
450 460
pF1KB5 GHIRDKEAPQKSWAP
:::::::::::::::
XP_016 GHIRDKEAPQKSWAP
490
>>NP_000124 (OMIM: 122700,300746,300807,306900) coagulat (461 aa)
initn: 870 init1: 272 opt: 790 Z-score: 564.9 bits: 113.8 E(85289): 1e-24
Smith-Waterman score: 993; 35.8% identity (65.3% similar) in 447 aa overlap (25-445:29-454)
10 20 30 40 50
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF-LEELRHSSL
.:: . : :...: :: :: :::. ...:
NP_000 MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB5 ERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGI
::::.:: :.::::.:.:.:.. : ::...:::::: : : . :.: : :
NP_000 ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNP--------CLNGGSCKDDI
70 80 90 100 110
120 130 140 150 160 170
pF1KB5 GSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQ
.:. : : :.::. :. .:. :.. :: : ..: . . . :::. ::.:... .
NP_000 NSYECWCPFGFEGKNCELDVT---CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKS
120 130 140 150 160
180 190 200 210
pF1KB5 CHPAVKFPCGRPWKRMEKKRSHLKR--------DTEDQEDQVD------------PRLID
:.::: ::::: . .: .. . .. . : .: :..
NP_000 CEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVG
170 180 190 200 210 220
220 230 240 250 260 270
pF1KB5 GKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWE
:. .. :. :::::: ..: ::. ... .:..:::::.. . :. : ::..... :
NP_000 GEDAKPGQFPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETE
230 240 250 260 270 280
280 290 300 310 320 330
pF1KB5 KWELDLDIKEVFVHPNYSKSTT--DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQ
. : .. ... : ::. . . ..:::::.: .: .:.. ..:::. :. .. : .
NP_000 HTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFL-K
290 300 310 320 330 340
340 350 360 370 380 390
pF1KB5 AGQETLVTGWG--YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI
:. :.::: .:..: ..::.....:.: . : . . . .::.:::.
NP_000 FGS-GYVSGWGRVFHKGRS-------ALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF
350 360 370 380 390
400 410 420 430 440 450
pF1KB5 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIR
.:.:.:::::: :. .:: ::.:..:::: :.. .::.:::::::..::
NP_000 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK
400 410 420 430 440 450
460
pF1KB5 DKEAPQKSWAP
NP_000 LT
460
>>NP_001254483 (OMIM: 227500,608446,613878) coagulation (382 aa)
initn: 685 init1: 290 opt: 690 Z-score: 497.3 bits: 101.0 E(85289): 5.8e-21
Smith-Waterman score: 869; 37.2% identity (65.4% similar) in 379 aa overlap (88-455:22-373)
60 70 80 90 100 110
pF1KB5 ECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGS
::::: : : . :.: : . :
NP_001 MVSQALRLLCLLLGLQGCLAADGDQCASSP--------CQNGGSCKDQLQS
10 20 30 40
120 130 140 150 160 170
pF1KB5 FSCDCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQC
. : : ..::: :. .. . : : .:::: .:: ...: .: : : ::.: : ..:
NP_001 YICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSC
50 60 70 80 90 100
180 190 200 210 220 230
pF1KB5 HPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKK
:.:..:::. : .::. . .. : :.. ::. .:. ::::.:: .
NP_001 TPTVEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQVLLLVNGA
110 120 130 140 150
240 250 260 270 280 290
pF1KB5 KLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNY
.: ::..::. ::..::::.:. :. :.. :::.:: . . : . . .:.. .:
NP_001 QL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTY
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB5 SKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKE
.::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::: .:
NP_001 VPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGAT
220 230 240 250 260
360 370 380 390 400
pF1KB5 AKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDACEGDSGGPM
: . .::: .: . ..: . : ..: :.::: .:.:.::::::
NP_001 ALE--LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPH
270 280 290 300 310 320
410 420 430 440 450 460
pF1KB5 VASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
.. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. :
NP_001 ATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
330 340 350 360 370 380
>>NP_062562 (OMIM: 227500,608446,613878) coagulation fac (444 aa)
initn: 924 init1: 290 opt: 687 Z-score: 494.5 bits: 100.7 E(85289): 8.3e-21
Smith-Waterman score: 1112; 39.5% identity (67.0% similar) in 461 aa overlap (6-455:5-435)
10 20 30 40 50 60
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
.: :. :..: : .:: ..:.:: ::. :.:::.:::::: .::::::
NP_062 MVSQALRLLCLLLGLQGC---LAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECK
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
:: :.::::.:::.... : :: .. ::::: : : . :.: : . :. :
NP_062 EEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQNGGSCKDQLQSYIC
60 70 80 90 100
130 140 150 160 170
pF1KB5 DCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPA
: ..::: :. .. . : : .:::: .:: ...: .: : : ::.: : ..: :.
NP_062 FCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPT
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB5 VKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLA
:..:::. : .::. . .. : :.. ::. .:. ::::.:: . .:
NP_062 VEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQVLLLVNGAQL-
170 180 190 200 210
240 250 260 270 280 290
pF1KB5 CGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKS
::..::. ::..::::.:. :. :.. :::.:: . . : . . .:.. .: .
NP_062 CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPG
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB5 TTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKR
::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::: .: : .
NP_062 TTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGATALE
280 290 300 310 320 330
360 370 380 390 400
pF1KB5 NRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDACEGDSGGPMVAS
.::: .: . ..: . : ..: :.::: .:.:.:::::: ..
NP_062 --LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATH
340 350 360 370 380
410 420 430 440 450 460
pF1KB5 FHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. :
NP_062 YRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
390 400 410 420 430 440
>>NP_000122 (OMIM: 227500,608446,613878) coagulation fac (466 aa)
initn: 920 init1: 290 opt: 687 Z-score: 494.3 bits: 100.8 E(85289): 8.6e-21
Smith-Waterman score: 1110; 40.0% identity (67.6% similar) in 447 aa overlap (20-455:39-457)
10 20 30 40
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEE
:.: :: ..:.:: ::. :.:::.::::
NP_000 LCLLLGLQGCLAAGGVAKASGGETRDMPWKPGP-HRVFVTQEEAHGVLHRRRRANAFLEE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KB5 LRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHG
:: .:::::: :: :.::::.:::.... : :: .. ::::: : : . :
NP_000 LRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQNGG
70 80 90 100 110
110 120 130 140 150 160
pF1KB5 TCIDGIGSFSCDCRSGWEGRFCQ-REVSFLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYK
.: : . :. : : ..::: :. .. . : : .:::: .:: ...: .: : : ::.
NP_000 SCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYS
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB5 LGDDLLQCHPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQ
: : ..: :.:..:::. : .::. . .. : :.. ::. .:. :::
NP_000 LLADGVSCTPTVEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPWQ
180 190 200 210 220
230 240 250 260 270 280
pF1KB5 VVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDIK
:.:: . .: ::..::. ::..::::.:. :. :.. :::.:: . . : . .
NP_000 VLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVA
230 240 250 260 270 280
290 300 310 320 330 340
pF1KB5 EVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG
.:.. .: .::..:::::.: ::..:.. .::.:::. ..:: : . . .::.:::
NP_000 QVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGWG
290 300 310 320 330 340
350 360 370 380 390
pF1KB5 YHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDAC
.: : . .::: .: . ..: . : ..: :.::: .:.:
NP_000 QLLDRGATAL--ELMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSC
350 360 370 380 390 400
400 410 420 430 440 450
pF1KB5 EGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKS
.:::::: .. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. :
NP_000 KGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVL
410 420 430 440 450 460
460
pF1KB5 WAP
NP_000 LRAPFP
>>XP_006720026 (OMIM: 227500,608446,613878) PREDICTED: c (412 aa)
initn: 822 init1: 290 opt: 649 Z-score: 468.8 bits: 95.9 E(85289): 2.2e-19
Smith-Waterman score: 894; 35.5% identity (60.8% similar) in 459 aa overlap (6-455:20-403)
10 20 30 40
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSF
.: :. :..: : .:: ..:.:: ::. :.:::.:
XP_006 MGNVNRQGQHCRDFIMVSQALRLLCLLLGLQGC---LAAVFVTQEEAHGVLHRRRRANAF
10 20 30 40 50
50 60 70 80 90 100
pF1KB5 LEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCC
::::: .:::::: :: :.::::.:::.... : :: .. ::::: : :
XP_006 LEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSP--------CQ
60 70 80 90 100
110 120 130 140 150 160
pF1KB5 GHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGY
. :.: : . :. : : ..::: :.
XP_006 NGGSCKDQLQSYICFCLPAFEGRNCE----------------------------------
110 120 130
170 180 190 200 210 220
pF1KB5 KLGDDLLQCHPAVKFPCGR-PWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPW
....:::. : .::. . .. : :.. ::. .:. ::
XP_006 -----------TLEYPCGKIPI--LEKRNA-----SKPQ-----GRIVGGKVCPKGECPW
140 150 160 170
230 240 250 260 270 280
pF1KB5 QVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK---LLVRLGEYDLRRWEKWELDLDI
::.:: . .: ::..::. ::..::::.:. :. :.. :::.:: . . : . .
XP_006 QVLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRV
180 190 200 210 220 230
290 300 310 320 330 340
pF1KB5 KEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGW
.:.. .: .::..:::::.: ::..:.. .::.:::. ..:: : . . .::.::
XP_006 AQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFV-RFSLVSGW
240 250 260 270 280 290
350 360 370 380 390
pF1KB5 GYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCAGILGDRQDA
: .: : . .::: .: . ..: . : ..: :.::: .:.
XP_006 GQLLDRGATALE--LMVLN---VPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDS
300 310 320 330 340
400 410 420 430 440 450
pF1KB5 CEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQK
:.:::::: .. ..:::.:.:.::::.::. . ..::::.::.:..:.. .:.. :
XP_006 CKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGV
350 360 370 380 390 400
460
pF1KB5 SWAP
XP_006 LLRAPFP
410
>>NP_000495 (OMIM: 227600,613872) coagulation factor X i (488 aa)
initn: 944 init1: 282 opt: 639 Z-score: 461.2 bits: 94.7 E(85289): 6e-19
Smith-Waterman score: 1080; 36.0% identity (63.2% similar) in 475 aa overlap (24-461:22-479)
10 20 30 40 50 60
pF1KB5 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
.:.: :.:...: ::::::::.... :::::.
NP_000 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECM
10 20 30 40 50
70 80 90 100 110 120
pF1KB5 EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
:: :..:::.:.:.. : : ::.:. ::::: . : : ..: : ::.: ..:
NP_000 EETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSP--------CQNQGKCKDGLGEYTC
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB5 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
: :.::. :. . : :::::: : ..: :: . :::: :: :.:. : :.
NP_000 TCLEGFEGKNCELFTRKL-CSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGP
120 130 140 150 160
190 200 210
pF1KB5 FPCGRPWKRMEKKRSHLKR-----------------DTEDQE-----------DQVDP--
.:::. . .:... . . :. : . .:..:
NP_000 YPCGK--QTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPER
170 180 190 200 210 220
220 230 240 250 260
pF1KB5 ------RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVR
:.. :. . :. :::..:.. ... ::.... ..::::::. ..:.. ::
NP_000 GDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVR
230 240 250 260 270 280
270 280 290 300 310 320
pF1KB5 LGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSG
.:. . .. : : ... :. : ..: : : :::.:.: : :. ....: :::.
NP_000 VGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERD
290 300 310 320 330 340
330 340 350 360 370 380
pF1KB5 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN
:: : .. . .:.:.: : .: :. : :.....: : .: :. : ....:
NP_000 WAESTL-MTQKTGIVSGFG----RTHEKGRQSTR-LKMLEVPYVDRNSCKLSSSFIITQN
350 360 370 380 390 400
390 400 410 420 430 440
pF1KB5 MLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDW
:.::: ..:::.:::::: :. :. :.:..:.:::::::. .::.::::. .: :
NP_000 MFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKW
410 420 430 440 450 460
450 460
pF1KB5 IHGHIRDKEAPQ-KSWAP
: .. . :. :: ::
NP_000 IDRSMKTRGLPKAKSHAPEVITSSPLK
470 480
461 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 10:32:36 2016 done: Sat Nov 5 10:32:38 2016
Total Scan time: 8.960 Total Display time: 0.090
Function used was FASTA [36.3.4 Apr, 2011]