FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5868, 493 aa 1>>>pF1KB5868 493 - 493 aa - 493 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1922+/-0.00115; mu= 15.8841+/- 0.069 mean_var=163.3310+/-31.197, 0's: 0 Z-trim(107.9): 184 B-trim: 0 in 0/53 Lambda= 0.100355 statistics sampled from 9699 (9897) to 9699 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.304), width: 16 Scan time: 2.460 The best scores are: opt bits E(32554) CCDS1857.1 EFEMP1 gene_id:2202|Hs108|chr2 ( 493) 3505 520.0 2.2e-147 CCDS8116.1 EFEMP2 gene_id:30008|Hs108|chr11 ( 443) 1550 236.9 3.4e-62 CCDS9898.1 FBLN5 gene_id:10516|Hs108|chr14 ( 448) 1304 201.3 1.8e-51 CCDS46762.1 FBLN2 gene_id:2199|Hs108|chr3 (1184) 865 138.3 4.4e-32 CCDS46761.1 FBLN2 gene_id:2199|Hs108|chr3 (1231) 865 138.3 4.5e-32 CCDS8103.1 LTBP3 gene_id:4054|Hs108|chr11 (1256) 652 107.5 8.8e-23 CCDS44647.1 LTBP3 gene_id:4054|Hs108|chr11 (1303) 652 107.5 9e-23 CCDS34222.1 FBN2 gene_id:2201|Hs108|chr5 (2912) 632 105.1 1.1e-21 CCDS74370.1 LTBP4 gene_id:8425|Hs108|chr19 (1557) 620 103.0 2.5e-21 CCDS74368.1 LTBP4 gene_id:8425|Hs108|chr19 (1587) 620 103.0 2.5e-21 CCDS74369.1 LTBP4 gene_id:8425|Hs108|chr19 (1624) 620 103.0 2.6e-21 CCDS32232.1 FBN1 gene_id:2200|Hs108|chr15 (2871) 621 103.5 3.3e-21 CCDS54345.1 LTBP1 gene_id:4052|Hs108|chr2 (1342) 585 97.8 7.7e-20 CCDS54344.1 LTBP1 gene_id:4052|Hs108|chr2 (1353) 585 97.8 7.7e-20 CCDS33178.2 LTBP1 gene_id:4052|Hs108|chr2 (1395) 585 97.8 7.8e-20 CCDS33177.2 LTBP1 gene_id:4052|Hs108|chr2 (1721) 585 98.0 8.9e-20 CCDS41237.1 MEGF6 gene_id:1953|Hs108|chr1 (1541) 534 90.5 1.4e-17 CCDS14067.1 FBLN1 gene_id:2192|Hs108|chr22 ( 703) 523 88.5 2.6e-17 CCDS43028.1 FBLN1 gene_id:2192|Hs108|chr22 ( 566) 515 87.2 5e-17 CCDS14068.1 FBLN1 gene_id:2192|Hs108|chr22 ( 601) 515 87.3 5.2e-17 CCDS14069.1 FBLN1 gene_id:2192|Hs108|chr22 ( 683) 515 87.3 5.7e-17 CCDS14048.1 SCUBE1 gene_id:80274|Hs108|chr22 ( 988) 502 85.6 2.6e-16 CCDS44864.1 NELL2 gene_id:4753|Hs108|chr12 ( 815) 470 80.9 5.8e-15 CCDS8746.1 NELL2 gene_id:4753|Hs108|chr12 ( 816) 470 80.9 5.8e-15 CCDS53781.1 NELL2 gene_id:4753|Hs108|chr12 ( 839) 470 80.9 5.9e-15 CCDS44863.1 NELL2 gene_id:4753|Hs108|chr12 ( 866) 470 80.9 6e-15 CCDS2923.1 PROS1 gene_id:5627|Hs108|chr3 ( 676) 465 80.1 8.5e-15 CCDS73268.1 NELL1 gene_id:4745|Hs108|chr11 ( 753) 456 78.8 2.2e-14 CCDS13149.1 CD93 gene_id:22918|Hs108|chr20 ( 652) 455 78.6 2.3e-14 CCDS7855.1 NELL1 gene_id:4745|Hs108|chr11 ( 810) 456 78.9 2.3e-14 CCDS73267.1 NELL1 gene_id:4745|Hs108|chr11 ( 838) 456 78.9 2.4e-14 CCDS12196.1 FBN3 gene_id:84467|Hs108|chr19 (2809) 459 80.0 3.8e-14 CCDS8002.1 VWCE gene_id:220001|Hs108|chr11 ( 955) 448 77.8 5.8e-14 CCDS908.1 NOTCH2 gene_id:4853|Hs108|chr1 (2471) 453 79.0 6.3e-14 CCDS7797.2 SCUBE2 gene_id:57758|Hs108|chr11 ( 971) 411 72.5 2.4e-12 CCDS43905.1 NOTCH1 gene_id:4851|Hs108|chr9 (2555) 416 73.7 2.7e-12 CCDS45072.1 GAS6 gene_id:2621|Hs108|chr13 ( 678) 406 71.5 3.2e-12 CCDS9831.1 LTBP2 gene_id:4053|Hs108|chr14 (1821) 408 72.4 4.8e-12 CCDS12326.1 NOTCH3 gene_id:4854|Hs108|chr19 (2321) 409 72.6 5e-12 CCDS44555.1 NELL1 gene_id:4745|Hs108|chr11 ( 763) 391 69.4 1.5e-11 CCDS13112.1 JAG1 gene_id:182|Hs108|chr20 (1218) 390 69.5 2.3e-11 CCDS53599.1 SCUBE2 gene_id:57758|Hs108|chr11 ( 807) 384 68.4 3.2e-11 CCDS81553.1 SCUBE2 gene_id:57758|Hs108|chr11 ( 999) 384 68.6 3.7e-11 >>CCDS1857.1 EFEMP1 gene_id:2202|Hs108|chr2 (493 aa) initn: 3505 init1: 3505 opt: 3505 Z-score: 2759.4 bits: 520.0 E(32554): 2.2e-147 Smith-Waterman score: 3505; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS18 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 430 440 450 460 470 480 490 pF1KB5 VLRLTIIVGPFSF ::::::::::::: CCDS18 VLRLTIIVGPFSF 490 >>CCDS8116.1 EFEMP2 gene_id:30008|Hs108|chr11 (443 aa) initn: 1790 init1: 692 opt: 1550 Z-score: 1230.2 bits: 236.9 E(32554): 3.4e-62 Smith-Waterman score: 1793; 50.0% identity (70.6% similar) in 494 aa overlap (1-493:13-443) 10 20 30 40 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDEC .: ::.: .: : . ::.:: .::.::::::::: :.:.:..:: CCDS81 MLPCASCLPGSLLLWALLLLLLGSA--SPQDSEEPDSYTECTDGYEWDPDSQHCRDVNEC 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 DIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMA .:.:::: :::.::::::::::..: .: :. CCDS81 LTIPEACKGEMKCINHYGGYLCLPRSAAVI--ND-------------------------- 60 70 80 90 110 120 130 140 150 160 pF1KB5 TSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEH : : :: :. : . : :: : ::: ... CCDS81 ----LHG----------EGPP------------PPVPPAQHP-NP-----CPPGYEPDDQ 100 110 170 180 190 200 210 220 pF1KB5 NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRC . : :.:::. . :.:: .: : :: ::. : :: ::.: : .::::::: ::..:: CCDS81 DSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRC 120 130 140 150 160 170 230 240 250 260 270 280 pF1KB5 VNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSD :: :::: ::: :::::. :: .:::.:::: . : :.:.: :.:.:.:.::::: : CCDS81 VNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRD 180 190 200 210 220 230 290 300 310 320 330 340 pF1KB5 RLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECRED ..: ::::: :::::::.:.::::.::: ::::::.. .: ::::.:::. ...: : CCDS81 GFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEA 240 250 260 270 280 290 350 360 370 380 390 400 pF1KB5 EMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVP . : :.:::.:: : : .::: . ::::.::.:: .::: :.:::..::.: :.:::: CCDS81 QTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVP 300 310 320 330 340 350 410 420 430 440 450 460 pF1KB5 SDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEM .:.::::::..: .. :.:.:..:: .:.::.:: . :::::::.. ..::::...:::: CCDS81 ADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEM 360 370 380 390 400 410 470 480 490 pF1KB5 LTVSSIGTFRTSSVLRLTIIVGPFSF .:..:. ..:.:::::::..:: ..: CCDS81 VTMNSLMSYRASSVLRLTVFVGAYTF 420 430 440 >>CCDS9898.1 FBLN5 gene_id:10516|Hs108|chr14 (448 aa) initn: 1431 init1: 534 opt: 1304 Z-score: 1037.6 bits: 201.3 E(32554): 1.8e-51 Smith-Waterman score: 1445; 42.8% identity (65.1% similar) in 493 aa overlap (3-493:6-448) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKG . : .:.:.: : . ... .:::.:.. : :: ::::: .:.::.: CCDS98 MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRG 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 GMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGG : :::. :::::.:.: . . : ..: : :: : CCDS98 DMMCVNQNGGYLCIPRTNPVY---RGPY--SNPY--------------STPYSGPYP--- 60 70 80 90 120 130 140 150 160 170 pF1KB5 FVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDEC :.: ...:.. : : : : . : ::...: : : :.::: CCDS98 --AAAPPLSAPNYPT------ISR----P----------LICRFGYQMDESNQCVDVDEC 100 110 120 130 180 190 200 210 220 230 pF1KB5 TAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYC .. .:.: :.::: .:...:.: :: ::.::::: ::.: :.:.:::. : CCDS98 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSC 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB5 QCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE :.::: : .. .: :.::: . : :.: : : :::::.:. :::: : ..: :.:: CCDS98 TCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB5 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHG : : .:::..:::.:: . : :: :: .. .:.:::::::: :. : .. :.: .: CCDS98 CSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQG 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB5 GFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQA ::.: :..::. .:::.::. : ::. : .:.:. :.. : ::::.::::.:: CCDS98 GFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KB5 TTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGT :: : .. :.::::::. :::.:::.:.:: ::... ..:::: .::::.::... . CCDS98 TTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVIN 380 390 400 410 420 430 480 490 pF1KB5 FRTSSVLRLTIIVGPFSF :: :::.:: : :. . : CCDS98 FRGSSVIRLRIYVSQYPF 440 >>CCDS46762.1 FBLN2 gene_id:2199|Hs108|chr3 (1184 aa) initn: 349 init1: 194 opt: 865 Z-score: 689.4 bits: 138.3 E(32554): 4.4e-32 Smith-Waterman score: 911; 32.5% identity (58.1% similar) in 465 aa overlap (29-467:704-1160) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : :: .:.::.:: .:. : CCDS46 PLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCEDINECVTDLHTCSRG 680 690 700 710 720 730 60 70 80 90 100 pF1KB5 MKCVNHYGGYLC---LPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMAT------ .::: :.. : : ... . .. . : :: : . .. .. CCDS46 EHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 740 750 760 770 780 790 110 120 130 140 150 160 pF1KB5 ----SGVL--PGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGY .: : : :. : .. : : .: : . :: . :: :: CCDS46 QRCMDGFLQDPEGNCVDINECTSLSE--PCRPGFSCI-NTVGSYTCQRNP---LICARGY 800 810 820 830 840 170 180 190 200 210 220 pF1KB5 EQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTI . :. .. : :..:: .:.: : ::: :: ::. :.: :.:. :. :.:..:: CCDS46 HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWA 850 860 870 880 890 900 230 240 250 260 270 pF1KB5 PP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQ : :.. : :: ::. :.:. :: :::.. : :.:::.:. .:.:.: :: ::. : CCDS46 SPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIYGSYQCY 910 920 930 940 950 960 280 290 300 310 320 330 pF1KB5 CNQGYELSSDRLNCEDIDEC-RTSSYLCQYQCVNEPGKFSCMCP-QGYQVVRS-RTCQDI : :::.:. : .: ::::: . .. :: ..:.: ::...: :: ::: .. . :.:.:. CCDS46 CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 970 980 990 1000 1010 1020 340 350 360 370 380 390 pF1KB5 NECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM--CRELPQS .:: :..: : : : : .:.::: : : :. . ...: . . . :.. : CCDS46 DECALGTHNCSEAETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPAR 1030 1040 1050 1060 1070 1080 400 410 420 430 440 450 pF1KB5 IVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLV :.. ..... ::. ::.: . ... .. : .:::.: : :. . .... : CCDS46 ITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQ 1090 1100 1110 1120 1130 1140 460 470 480 490 pF1KB5 KSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF ... ::. .:.:: CCDS46 RAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL 1150 1160 1170 1180 >>CCDS46761.1 FBLN2 gene_id:2199|Hs108|chr3 (1231 aa) initn: 349 init1: 194 opt: 865 Z-score: 689.2 bits: 138.3 E(32554): 4.5e-32 Smith-Waterman score: 925; 32.9% identity (58.7% similar) in 465 aa overlap (29-467:752-1207) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG :.::: . :. : ::.:: .:. : CCDS46 ECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNAHRK-CVDINECVTDLHTCSRG 730 740 750 760 770 780 60 70 80 90 100 pF1KB5 MKCVNHYGGYLC---LPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMAT------ .::: :.. : : ... . .. . : :: : . .. .. CCDS46 EHCVNTLGSFHCYKALTCEPGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQAR 790 800 810 820 830 840 110 120 130 140 150 160 pF1KB5 ----SGVL--PGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGY .: : : :. : .. : : .: : . :: . :: :: CCDS46 QRCMDGFLQDPEGNCVDINECTSLSE--PCRPGFSCI-NTVGSYTCQRNP---LICARGY 850 860 870 880 890 170 180 190 200 210 220 pF1KB5 EQSEHNV-CQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKR--GEQCVDIDECTI . :. .. : :..:: .:.: : ::: :: ::. :.: :.:. :. :.:..:: CCDS46 HASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRDAFGRGCIDVNECWA 900 910 920 930 940 950 230 240 250 260 270 pF1KB5 PP--YCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQ : :.. : :: ::. :.:. :: :::.. : :.:::.:. .:.:.: :: ::. : CCDS46 SPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQ-RCSQECANIYGSYQCY 960 970 980 990 1000 1010 280 290 300 310 320 330 pF1KB5 CNQGYELSSDRLNCEDIDEC-RTSSYLCQYQCVNEPGKFSCMCP-QGYQVVRS-RTCQDI : :::.:. : .: ::::: . .. :: ..:.: ::...: :: ::: .. . :.:.:. CCDS46 CRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDV 1020 1030 1040 1050 1060 1070 340 350 360 370 380 390 pF1KB5 NECET-TNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAM--CRELPQS .:: :..: : : : : .:.::: : : :. . ...: . . . :.. : CCDS46 DECALGTHNCSEAETCHNIQGSFRCL-RFECPPNYVQVSKTKCERTTCHDFLECQNSPAR 1080 1090 1100 1110 1120 1130 400 410 420 430 440 450 pF1KB5 IVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLV :.. ..... ::. ::.: . ... .. : .:::.: : :. . .... : CCDS46 ITHYQLNFQTGLLVPAHIFRIGPAPAFTGDTIALNIIKGNEEGYFGTRRLNAYTGVVYLQ 1140 1150 1160 1170 1180 1190 460 470 480 490 pF1KB5 KSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF ... ::. .:.:: CCDS46 RAVLEPRDFALDVEMKLWRQGSVTTFLAKMHIFFTTFAL 1200 1210 1220 1230 >>CCDS8103.1 LTBP3 gene_id:4054|Hs108|chr11 (1256 aa) initn: 397 init1: 281 opt: 652 Z-score: 522.4 bits: 107.5 E(32554): 8.8e-23 Smith-Waterman score: 652; 32.8% identity (51.9% similar) in 366 aa overlap (41-379:571-919) 20 30 40 50 60 70 pF1KB5 TLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC : . ::: . . : : .:: : : CCDS81 ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHG-ECVPGPPDYSC 550 560 570 580 590 80 90 100 110 pF1KB5 L--------PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSG----VLPGGGF :. . :: . :..: : : . . . : : :: CCDS81 HCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG--SYNCHCNRGYRLHVGAGGRS 600 610 620 630 640 650 120 130 140 150 160 170 pF1KB5 VASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH-RIQCAAGY--EQSEHNVCQDID .. : :.. : ..: : . :.: . .: :: . :. ::.::: CCDS81 CVDLNECAKPHL-CGDGGFCI-----------NFPGHYKCNCYPGYRLKASRPPVCEDID 660 670 680 690 700 180 190 200 210 220 230 pF1KB5 ECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE-QCVDIDECTIPPYCHQR-CVNTP :: . .: : : : ::: : : :::...: : :..::. : : : : CCDS81 ECRDPS-SC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 710 720 730 740 750 760 240 250 260 270 280 290 pF1KB5 GSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ-CYNILGSFICQCNQGYELSSDRLN ::: : :. :. : .. .:.:..::.:.. : . : : ::: ::: .::.:: :: . CCDS81 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSH 770 780 790 800 810 820 300 310 320 330 340 350 pF1KB5 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMC ::::::: . .:.: :.. :.::::...: .: ::::.:: . . : : CCDS81 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGAC 830 840 850 860 870 880 360 370 380 390 400 pF1KB5 WNYHGGFRCY---PRNPCQDPY----ILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSD : .:.. : .: :: . . :... : CCDS81 KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECC 890 900 910 920 930 940 410 420 430 440 450 460 pF1KB5 RSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIV CCDS81 CSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE 950 960 970 980 990 1000 >>CCDS44647.1 LTBP3 gene_id:4054|Hs108|chr11 (1303 aa) initn: 281 init1: 281 opt: 652 Z-score: 522.3 bits: 107.5 E(32554): 9e-23 Smith-Waterman score: 652; 32.8% identity (51.9% similar) in 366 aa overlap (41-379:571-919) 20 30 40 50 60 70 pF1KB5 TLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLC : . ::: . . : : .:: : : CCDS44 ELISRPSPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHG-ECVPGPPDYSC 550 560 570 580 590 80 90 100 110 pF1KB5 L--------PKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSG----VLPGGGF :. . :: . :..: : : . . . : : :: CCDS44 HCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGG--SYNCHCNRGYRLHVGAGGRS 600 610 620 630 640 650 120 130 140 150 160 170 pF1KB5 VASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSH-RIQCAAGY--EQSEHNVCQDID .. : :.. : ..: : . :.: . .: :: . :. ::.::: CCDS44 CVDLNECAKPHL-CGDGGFCI-----------NFPGHYKCNCYPGYRLKASRPPVCEDID 660 670 680 690 700 180 190 200 210 220 230 pF1KB5 ECTAGTHNCRADQVCINLRGSFAC-QCPPGYQKRGE-QCVDIDECTIPPYCHQR-CVNTP :: . .: : : : ::: : : :::...: : :..::. : : : : CCDS44 ECRDPS-SC-PDGKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLP 710 720 730 740 750 760 240 250 260 270 280 290 pF1KB5 GSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQ-CYNILGSFICQCNQGYELSSDRLN ::: : :. :. : .. .:.:..::.:.. : . : : ::: ::: .::.:: :: . CCDS44 GSFRCTCAQGYAPAPDGRSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSH 770 780 790 800 810 820 300 310 320 330 340 350 pF1KB5 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINEC-ETTNECREDEMC ::::::: . .:.: :.. :.::::...: .: ::::.:: . . : : CCDS44 CEDIDECDFPAACIGGDCINTNGSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGAC 830 840 850 860 870 880 360 370 380 390 400 pF1KB5 WNYHGGFRCY---PRNPCQDPY----ILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSD : .:.. : .: :: . . :... : CCDS44 KNLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECC 890 900 910 920 930 940 410 420 430 440 450 460 pF1KB5 RSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIV CCDS44 CSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSE 950 960 970 980 990 1000 >>CCDS34222.1 FBN2 gene_id:2201|Hs108|chr5 (2912 aa) initn: 1323 init1: 333 opt: 632 Z-score: 502.7 bits: 105.1 E(32554): 1.1e-21 Smith-Waterman score: 712; 31.3% identity (53.8% similar) in 431 aa overlap (29-431:1185-1584) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : :.: .: :..: ::.::.. . :..: CCDS34 NCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNG 1160 1170 1180 1190 1200 1210 60 70 80 90 100 110 pF1KB5 MKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGF :::: : : : . . : : .: . .. .. :. . :.. CCDS34 -KCVNMIGTYQC---------SCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSY 1220 1230 1240 1250 1260 120 130 140 150 160 170 pF1KB5 VASAAAVAGPEMQTGRNNFVI---RRNP--ADPQRIPSNPS-HRIQCAAGYEQS-EHNVC : . . : ::. : . :: : . . :. .: : :. : . ..: CCDS34 ECSCSE-GYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1270 1280 1290 1300 1310 1320 180 190 200 210 220 pF1KB5 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQ-KRGEQ-CVDIDECTIPPY-C--HQ :..:: ... : . : : .::: :.: ::. :.: :.:.::: : . : : CCDS34 IDVNECDLNSNICMFGE-CENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHA 1330 1340 1350 1360 1370 1380 230 240 250 260 270 280 pF1KB5 RCVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCA--QQCYNILGSFICQCNQGY :.: :::: :.: :. .:. :.:..:: ....::. :: : ::. : :..:. CCDS34 SCLNIPGSFKCSCREGW--IGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGF 1390 1400 1410 1420 1430 1440 290 300 310 320 330 340 pF1KB5 ELSSDRLNCEDIDECRTSSYLCQY-QCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETT ..: ..: :.::: . ::. ::.: :: . : : .:. . ::.::::.:: CCDS34 --TGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSFQ 1450 1460 1470 1480 1490 350 360 370 380 390 pF1KB5 NECREDEMCWNYHGGFRCYPRNPCQDPYIL-------TPENRCVCPVS--NAMCRELPQS : : : : : :.: :.: : : : ..:. :.. :..: . : CCDS34 NICVFGT-CNNLPGMFHCI----CDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPG- 1500 1510 1520 1530 1540 1550 400 410 420 430 440 450 pF1KB5 IVYKYMSIRSDRSVPSDIFQIQATTI--YANTINTFRIKSGNENGEFYLRQTSPVSAMLV : . . : : ::.. : . : ... .: : CCDS34 --------RYECNCPPD-FQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSR 1560 1570 1580 1590 1600 460 470 480 490 pF1KB5 LVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF CCDS34 SSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQG 1610 1620 1630 1640 1650 1660 >-- initn: 1323 init1: 333 opt: 632 Z-score: 502.7 bits: 105.1 E(32554): 1.1e-21 Smith-Waterman score: 650; 30.4% identity (55.8% similar) in 342 aa overlap (43-378:2448-2734) 20 30 40 50 60 70 pF1KB5 ALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLP .::::: ..:. : .: .:.: .:.. :. CCDS34 WGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG-QCINTMGSFRCFC 2420 2430 2440 2450 2460 2470 80 90 100 110 120 130 pF1KB5 KTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQT :. : :: . ..: . . .:. CCDS34 KV---------------------GYTTDISGTSCIDLD------------ECSQSPKP-- 2480 2490 2500 140 150 160 170 180 190 pF1KB5 GRNNFVIRRNPADPQRIPSNPSHRIQCAAGYE-QSEHNVCQDIDECTAGTHNCRADQVCI :.. . .. :.. .: :: : . ..:.:.::: . :::. .:. CCDS34 --CNYICKN---------TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQF--LCV 2510 2520 2530 2540 200 210 220 230 240 pF1KB5 NLRGSFACQCPPGYQKRGEQCVDIDEC-TIPPYCHQR--CVNTPGSFYCQCSPGFQLAAN : :.:.:.::::. .. :.: .:: . : : . : :::::: :.:. ::.: :. CCDS34 NTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDAT 2550 2560 2570 2580 2590 2600 250 260 270 280 290 300 pF1KB5 NYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQ . .: :..:::....: . : ::::.. : : ::: . .: : .:: . . . . CCDS34 GLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSAS 2610 2620 2630 2640 2650 2660 310 320 330 340 350 360 pF1KB5 CVNEPGKFSCMCPQGYQVVR-SRTCQDINECETT-NECREDEMCWNYHGGFRCYPRNPCQ : : :...: ::.:.. . : .:.:.::: .. : : . : : .::. : : CCDS34 CYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLC----GCP 2670 2680 2690 2700 2710 2720 370 380 390 400 410 420 pF1KB5 DPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTF : . ...:: CCDS34 PGYYRVGQGHCVSGMGFNKGQYLSLDTEVDEENALSPEACYECKINGYSKKDSRQKRSIH 2730 2740 2750 2760 2770 2780 >-- initn: 497 init1: 182 opt: 557 Z-score: 444.0 bits: 94.2 E(32554): 2.1e-18 Smith-Waterman score: 634; 31.2% identity (54.9% similar) in 381 aa overlap (28-392:1676-2026) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKG .: .:: . . :.::::: : .: CCDS34 IILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGP 1650 1660 1670 1680 1690 1700 60 70 80 90 100 110 pF1KB5 GMKCVNHYGGYLCLPKTAQIIVN---NEQPQQETQPAEGTSGATTGVVAASSMATSGVLP : : : :.: :. . :: : . .... .. .:.: . :: CCDS34 GT-CYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTC----------ENELP 1710 1720 1730 1740 1750 120 130 140 150 160 170 pF1KB5 GGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAA--GYEQSEHN-VC : .. ...:. .: .: :.. . . :. :. . :. CCDS34 ---FNVTKRMCCCT-YNVGKA----WNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKA 1760 1770 1780 1790 1800 180 190 200 210 220 pF1KB5 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQ--CVDIDECTIPPYCHQR-- ::::: : :. :::: ::: :.:: :.. : :::::. :: CCDS34 VDIDECKEIPGIC-ANGVCINQIGSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNA 1810 1820 1830 1840 1850 1860 230 240 250 260 270 280 pF1KB5 -CVNTPGSFYCQCSPGFQLAANNYTCVDINEC-DASNQCAQQ-CYNILGSFICQCNQGYE :.:.:::. :.:. ::.:. :. .::: ::: . : :.. : .. ::. : :..:.. CCDS34 DCINSPGSYRCECAAGFKLSPNG-ACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFK 1870 1880 1890 1900 1910 1920 290 300 310 320 330 340 pF1KB5 LSSDRLNCEDIDECRTSSYLC-QYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETT-- :.:. : :.:::. : . : : :...:.: :...... : ::.:: . CCDS34 ASQDQTMCMDVDECERHP--CGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFG 1930 1940 1950 1960 1970 1980 350 360 370 380 390 400 pF1KB5 NECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIR . ::. . :.: :.:.: :.. : :::... : ... : :: : CCDS34 QVCRNGR-CFNEIGSFKCL----CNEGYELTPDGKN-C-IDTNECVALPGSCSPGTCQNL 1990 2000 2010 2020 2030 410 420 430 440 450 460 pF1KB5 SDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREH CCDS34 EGSFRCICPPGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRR 2040 2050 2060 2070 2080 2090 >-- initn: 510 init1: 263 opt: 556 Z-score: 443.3 bits: 94.1 E(32554): 2.3e-18 Smith-Waterman score: 605; 32.0% identity (53.7% similar) in 378 aa overlap (29-387:2043-2396) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : ::: ..: ::.::: :. : : CCDS34 NCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKS--ENCIDINECDEDPNICLFG 2020 2030 2040 2050 2060 2070 60 70 80 90 100 110 pF1KB5 MKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGF .:.: ::. :: . .. .: . .:. . .. .: .. . .: CCDS34 -SCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPK----------AF 2080 2090 2100 2110 120 130 140 150 160 170 pF1KB5 VASAAAVAGPEMQTGRNNFVIRRNPADPQRI-PSNPSHRIQ--CAAGYEQ--SEHNVCQD .. : .: :.. .:: .. :.. .: : :. : :.. .: CCDS34 NTTKAKCCCSKMP-GEGW-------GDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTRED 2120 2130 2140 2150 2160 2170 180 190 200 210 220 230 pF1KB5 IDECTAGTHNCRADQVCINLRGSFACQCPPGYQ--KRGEQCVDIDECTIPPYC-HQRCVN ..:: . : : ::: ::: :.:: ::. : .::: :::.: : . :.: CCDS34 VNECLESPGICSNGQ-CINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNPCGNGTCTN 2180 2190 2200 2210 2220 2230 240 250 260 270 280 pF1KB5 TPGSFYCQCSPGFQLAANNYTCVDINECDASNQ--CAQQCYNILGSFICQCNQGYELSSD . ::: :.:. ::. . ..: ::::: :.: :: .:.: .::. : : :: : : CCDS34 VIGSFECNCNEGFE-PGPMMNCEDINEC-AQNPLLCAFRCMNTFGSYECTCPIGYALRED 2240 2250 2260 2270 2280 290 300 310 320 330 340 pF1KB5 RLNCEDIDECRTSSYLCQ---YQCVNEPGKFSCMCPQGY-QVVRSRTCQDINECETTNEC . :.:.::: . . :. ..: : : : :.:: :. . .. : : :::.: CCDS34 QKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGI 2290 2300 2310 2320 2330 2340 350 360 370 380 390 pF1KB5 REDEMCWNYHGGFRCYPRNPCQDPYILTP--ENR---CVCPVSNAMCRELPQSIVYKYMS :. : : :..:: . :. : .:: : : ...:. CCDS34 CENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKS 2350 2360 2370 2380 2390 2400 400 410 420 430 440 450 pF1KB5 IRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPR CCDS34 ECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNGQCINT 2410 2420 2430 2440 2450 2460 >-- initn: 528 init1: 239 opt: 526 Z-score: 419.8 bits: 89.7 E(32554): 4.6e-17 Smith-Waterman score: 563; 28.8% identity (50.1% similar) in 389 aa overlap (29-386:643-1003) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : :. : . : :.:::. .: : .: CCDS34 KNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQ-TPGICMNG 620 630 640 650 660 670 60 70 80 90 100 110 pF1KB5 MKCVNHYGGYLC-LPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGG .:.: :.. : : . .... . . . .: :: . .::. CCDS34 -HCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRP-------FPGA- 680 690 700 710 720 120 130 140 150 160 170 pF1KB5 FVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDEC . : :.:.. :. : .: .. . :..: . . .::.:: CCDS34 VTKSECCCANPDYGFGE--------PCQPCPAKNSAEFHGLCSSGVGITVDG--RDINEC 730 740 750 760 770 180 190 200 210 220 230 pF1KB5 TAGTHNCRADQVCINLRGSFACQCPPGYQK--RGEQCVDIDECTIPPY-CHQR-CVNTPG . : :. .: :::::. :.: ::. :..:.::::: . : . : :::: CCDS34 ALDPDIC-ANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPG 780 790 800 810 820 830 240 250 260 270 280 290 pF1KB5 SFYCQCSPGFQLAANNYTCVDINECDASNQCAQ-QCYNILGSFICQCNQGYELSSDRLNC :. : : ::. . ... :: :::::. :: :.. : : :::: :.:. : .::: : : CCDS34 SYSCTCPPGYVFRTETETCEDINECE-SNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC 840 850 860 870 880 890 300 310 320 pF1KB5 EDIDECRTSSYL------CQY---------QCVNEPG----------KFSCMCPQGYQVV :: . . .: :. .: : ... ::.: . CCDS34 --IDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARI 900 910 920 930 940 330 340 350 360 370 380 pF1KB5 RSRTCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCR .. ::.:.::::. . : : .:.:.: : . : .: . .: CCDS34 KGVTCEDVNECEVFPGVCPNGRCVNSKGSFHC----ECPEGLTLDGTGRVCLDIRMEQCY 950 960 970 980 990 1000 390 400 410 420 430 440 pF1KB5 ELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSA CCDS34 LKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDV 1010 1020 1030 1040 1050 1060 >-- initn: 618 init1: 219 opt: 465 Z-score: 372.1 bits: 80.9 E(32554): 2.1e-14 Smith-Waterman score: 536; 31.1% identity (54.2% similar) in 347 aa overlap (28-319:302-642) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKG .: :.. . . :.:.:::::.:.: :. CCDS34 GACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICET 280 290 300 310 320 330 60 70 80 pF1KB5 GMKCVNHYGGYLCLPKTAQI-------------------IVNN----EQPQQETQ----- : .: : :.:.:. . . .::. : : . :. CCDS34 G-ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCC 340 350 360 370 380 390 90 100 110 120 130 140 pF1KB5 -PAE----GT---SGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRR :.. :: . . : . .: :: ::. .::.. : :: :.:. CCDS34 EPGRCWGIGTIPEACPVRGSEEYRRLCMDG-LPMGGIPGSAGSRPGG---TGGNGFAPSG 400 410 420 430 440 150 160 170 180 pF1KB5 N-----PADPQRIPSNPSHRIQ---CAAGYEQSEHN--------VCQDIDECTAGTHNCR : :. :: .. .. .:: . .. . : :: : .. : CCDS34 NGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCL 450 460 470 480 490 500 190 200 210 220 230 240 pF1KB5 ADQVCINLRGSFACQCPPGYQKRGE-QCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQ . :: .:. :.: ::.. .. .:.:.:::: : . :::::::.::.: ::: CCDS34 NGR-CIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGDCVNTPGSYYCKCHAGFQ 510 520 530 540 550 560 250 260 270 280 290 300 pF1KB5 LAANNYTCVDINECDASN-QCAQ-QCYNILGSFICQCNQGYELSSDRLNCEDIDECRTSS . .. .:.::.:: .. : . .: : ::: : :: :.::..: :: : ::: :.. CCDS34 RTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTN 570 580 590 600 610 620 310 320 330 340 350 360 pF1KB5 YLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCYPR . . .:.:: :.:.:. CCDS34 MCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSFRCDCP 630 640 650 660 670 680 >>CCDS74370.1 LTBP4 gene_id:8425|Hs108|chr19 (1557 aa) initn: 618 init1: 195 opt: 620 Z-score: 496.4 bits: 103.0 E(32554): 2.5e-21 Smith-Waterman score: 646; 31.8% identity (50.6% similar) in 387 aa overlap (29-392:505-865) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : .:.. .: .: :.::: :: : : CCDS74 SGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG 480 490 500 510 520 530 60 70 80 90 100 pF1KB5 MKCVNHYGGYLCL--------PKTAQIIVNNE----QPQQETQPAEGTSGATTGVVAASS .: : :.. :. :..:. . .: : . :.: :. : :. CCDS74 -RCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY 540 550 560 570 580 590 110 120 130 140 150 160 pF1KB5 MATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQS .:. : :. .. . ::. . .:. : : : ::.. : CCDS74 QAA----PHGASCQDVDECTQSPGLCGRGAC---------KNLPG--SFRCVCPAGFRGS 600 610 620 630 170 180 190 200 210 220 pF1KB5 EHNVCQ-DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECT-IPP .:. :.:::. : . : : ::: : :: :...:: : :.:::. :: CCDS74 ---ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 640 650 660 670 680 690 230 240 250 260 270 pF1KB5 YC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC-AQQCYNILGSFICQ-C : . :: :: ::: : : ::: . . : :..::. : .:.: : ::: :. : CCDS74 PCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTC 700 710 720 730 740 750 280 290 300 310 320 330 pF1KB5 NQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSCMCPQGYQVVRSRT--CQDI .:..: : : :.::: ... : . .:.: :.: : : ::.. .: : :. CCDS74 PSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADV 760 770 780 790 800 810 340 350 360 370 380 390 pF1KB5 NECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVY ::: . : : : :.: : : : :.. :.. ..: :: CCDS74 NECLEGDFCFPHGECLNTDGSFAC----TCAPGYRPGPRGASCLDVDECSEEDLCQSGIC 820 830 840 850 860 400 410 420 430 440 450 pF1KB5 KYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSL CCDS74 TNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 870 880 890 900 910 920 >>CCDS74368.1 LTBP4 gene_id:8425|Hs108|chr19 (1587 aa) initn: 618 init1: 195 opt: 620 Z-score: 496.3 bits: 103.0 E(32554): 2.5e-21 Smith-Waterman score: 646; 31.8% identity (50.6% similar) in 387 aa overlap (29-392:535-895) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGG : .:.. .: .: :.::: :: : : CCDS74 SGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG 510 520 530 540 550 560 60 70 80 90 100 pF1KB5 MKCVNHYGGYLCL--------PKTAQIIVNNE----QPQQETQPAEGTSGATTGVVAASS .: : :.. :. :..:. . .: : . :.: :. : :. CCDS74 -RCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGSFLCVCPAGY 570 580 590 600 610 620 110 120 130 140 150 160 pF1KB5 MATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQS .:. : :. .. . ::. . .:. : : : ::.. : CCDS74 QAA----PHGASCQDVDECTQSPGLCGRGAC---------KNLPG--SFRCVCPAGFRGS 630 640 650 660 170 180 190 200 210 220 pF1KB5 EHNVCQ-DIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE--QCVDIDECT-IPP .:. :.:::. : . : : ::: : :: :...:: : :.:::. :: CCDS74 ---ACEEDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPP 670 680 690 700 710 720 230 240 250 260 270 pF1KB5 YC-HQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQC-AQQCYNILGSFICQ-C : . :: :: ::: : : ::: . . : :..::. : .:.: : ::: :. : CCDS74 PCTYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTC 730 740 750 760 770 780 280 290 300 310 320 330 pF1KB5 NQGYELSSDRLNCEDIDECRTSSYLC--QYQCVNEPGKFSCMCPQGYQVVRSRT--CQDI .:..: : : :.::: ... : . .:.: :.: : : ::.. .: : :. CCDS74 PSGHHLHRGR--CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADV 790 800 810 820 830 840 340 350 360 370 380 390 pF1KB5 NECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVY ::: . : : : :.: : : : :.. :.. ..: :: CCDS74 NECLEGDFCFPHGECLNTDGSFAC----TCAPGYRPGPRGASCLDVDECSEEDLCQSGIC 850 860 870 880 890 400 410 420 430 440 450 pF1KB5 KYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSL CCDS74 TNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDPGY 900 910 920 930 940 950 493 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:22:54 2016 done: Sat Nov 5 15:22:54 2016 Total Scan time: 2.460 Total Display time: 0.110 Function used was FASTA [36.3.4 Apr, 2011]