FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5868, 493 aa 1>>>pF1KB5868 493 - 493 aa - 493 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8045+/-0.000498; mu= 12.0952+/- 0.030 mean_var=167.5880+/-34.368, 0's: 0 Z-trim(114.9): 452 B-trim: 1015 in 1/54 Lambda= 0.099072 statistics sampled from 24434 (24976) to 24434 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.293), width: 16 Scan time: 8.430 The best scores are: opt bits E(85289) NP_001034437 (OMIM: 126600,601548) EGF-containing ( 493) 3505 513.7 4.7e-145 NP_001034438 (OMIM: 126600,601548) EGF-containing ( 493) 3505 513.7 4.7e-145 XP_016859075 (OMIM: 126600,601548) PREDICTED: EGF- ( 413) 1742 261.6 3e-69 XP_005264262 (OMIM: 126600,601548) PREDICTED: EGF- ( 543) 1742 261.8 3.6e-69 NP_058634 (OMIM: 604633,614437) EGF-containing fib ( 443) 1550 234.2 5.8e-61 XP_016876418 (OMIM: 219100,604580,608895,614434) P ( 392) 1304 199.0 2e-50 NP_006320 (OMIM: 219100,604580,608895,614434) fibu ( 448) 1304 199.1 2.2e-50 XP_005267324 (OMIM: 219100,604580,608895,614434) P ( 465) 1304 199.1 2.3e-50 XP_011534660 (OMIM: 219100,604580,608895,614434) P ( 408) 1135 174.9 3.9e-43 XP_011534659 (OMIM: 219100,604580,608895,614434) P ( 464) 1135 174.9 4.3e-43 XP_011534658 (OMIM: 219100,604580,608895,614434) P ( 481) 1135 175.0 4.4e-43 NP_001989 (OMIM: 135821) fibulin-2 isoform b precu (1184) 865 136.8 3.3e-31 NP_001004019 (OMIM: 135821) fibulin-2 isoform a pr (1231) 865 136.8 3.4e-31 NP_001158507 (OMIM: 135821) fibulin-2 isoform a pr (1231) 865 136.8 3.4e-31 NP_001157738 (OMIM: 601216,602090,613097) latent-t (1139) 652 106.3 4.7e-22 NP_066548 (OMIM: 601216,602090,613097) latent-tran (1256) 652 106.4 5e-22 XP_011543335 (OMIM: 601216,602090,613097) PREDICTE (1265) 652 106.4 5.1e-22 NP_001123616 (OMIM: 601216,602090,613097) latent-t (1303) 652 106.4 5.2e-22 XP_011543334 (OMIM: 601216,602090,613097) PREDICTE (1312) 652 106.4 5.2e-22 XP_016864717 (OMIM: 121050,612570,616118) PREDICTE (2861) 632 103.9 6.4e-21 NP_001990 (OMIM: 121050,612570,616118) fibrillin-2 (2912) 632 103.9 6.5e-21 XP_011525689 (OMIM: 604710,613177) PREDICTED: late (1421) 620 101.9 1.3e-20 XP_011525688 (OMIM: 604710,613177) PREDICTED: late (1436) 620 101.9 1.3e-20 XP_011525687 (OMIM: 604710,613177) PREDICTED: late (1478) 620 101.9 1.3e-20 XP_011525686 (OMIM: 604710,613177) PREDICTED: late (1480) 620 101.9 1.3e-20 XP_011525685 (OMIM: 604710,613177) PREDICTED: late (1522) 620 101.9 1.4e-20 XP_016882842 (OMIM: 604710,613177) PREDICTED: late (1549) 620 101.9 1.4e-20 NP_001036010 (OMIM: 604710,613177) latent-transfor (1557) 620 101.9 1.4e-20 NP_003564 (OMIM: 604710,613177) latent-transformin (1587) 620 101.9 1.4e-20 XP_016882841 (OMIM: 604710,613177) PREDICTED: late (1591) 620 101.9 1.4e-20 XP_011525683 (OMIM: 604710,613177) PREDICTED: late (1593) 620 101.9 1.4e-20 XP_011525681 (OMIM: 604710,613177) PREDICTED: late (1595) 620 101.9 1.4e-20 XP_011525680 (OMIM: 604710,613177) PREDICTED: late (1611) 620 101.9 1.4e-20 NP_001036009 (OMIM: 604710,613177) latent-transfor (1624) 620 101.9 1.4e-20 XP_011525679 (OMIM: 604710,613177) PREDICTED: late (1635) 620 101.9 1.4e-20 XP_011525678 (OMIM: 604710,613177) PREDICTED: late (1662) 620 101.9 1.5e-20 NP_000129 (OMIM: 102370,129600,134797,154700,18490 (2871) 621 102.3 1.9e-20 XP_011525684 (OMIM: 604710,613177) PREDICTED: late (1554) 608 100.2 4.6e-20 XP_016882843 (OMIM: 604710,613177) PREDICTED: late (1438) 607 100.0 4.8e-20 XP_011525682 (OMIM: 604710,613177) PREDICTED: late (1593) 607 100.0 5.1e-20 XP_011531164 (OMIM: 150390) PREDICTED: latent-tran (1248) 585 96.8 3.8e-19 NP_001159738 (OMIM: 150390) latent-transforming gr (1300) 585 96.8 3.9e-19 NP_001159737 (OMIM: 150390) latent-transforming gr (1342) 585 96.8 4e-19 NP_001159736 (OMIM: 150390) latent-transforming gr (1353) 585 96.8 4.1e-19 NP_000618 (OMIM: 150390) latent-transforming growt (1395) 585 96.8 4.1e-19 XP_016859599 (OMIM: 150390) PREDICTED: latent-tran (1639) 586 97.1 4.2e-19 XP_016859597 (OMIM: 150390) PREDICTED: latent-tran (1681) 586 97.1 4.2e-19 XP_011531158 (OMIM: 150390) PREDICTED: latent-tran (1682) 586 97.1 4.2e-19 XP_005264375 (OMIM: 150390) PREDICTED: latent-tran (1626) 585 96.9 4.6e-19 XP_011531163 (OMIM: 150390) PREDICTED: latent-tran (1632) 585 96.9 4.6e-19 >>NP_001034437 (OMIM: 126600,601548) EGF-containing fibu (493 aa) initn: 3505 init1: 3505 opt: 3505 Z-score: 2725.1 bits: 513.7 E(85289): 4.7e-145 Smith-Waterman score: 3505; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 430 440 450 460 470 480 490 pF1KB5 VLRLTIIVGPFSF ::::::::::::: NP_001 VLRLTIIVGPFSF 490 >>NP_001034438 (OMIM: 126600,601548) EGF-containing fibu (493 aa) initn: 3505 init1: 3505 opt: 3505 Z-score: 2725.1 bits: 513.7 E(85289): 4.7e-145 Smith-Waterman score: 3505; 100.0% identity (100.0% similar) in 493 aa overlap (1-493:1-493) 10 20 30 40 50 60 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 430 440 450 460 470 480 490 pF1KB5 VLRLTIIVGPFSF ::::::::::::: NP_001 VLRLTIIVGPFSF 490 >>XP_016859075 (OMIM: 126600,601548) PREDICTED: EGF-cont (413 aa) initn: 1603 init1: 1603 opt: 1742 Z-score: 1364.2 bits: 261.6 E(85289): 3e-69 Smith-Waterman score: 2723; 83.8% identity (83.8% similar) in 493 aa overlap (1-493:1-413) 10 20 30 40 50 60 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKGGMK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGGFVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDECTAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYCQCS :::::::::::::::::::::::::::::::::::::: XP_016 THNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDEC---------------------- 190 200 210 250 260 270 280 290 300 pF1KB5 PGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDECRT :: XP_016 ----------------------------------------------------------RT 220 310 320 330 340 350 360 pF1KB5 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECETTNECREDEMCWNYHGGFRCY 230 240 250 260 270 280 370 380 390 400 410 420 pF1KB5 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQATTIYA 290 300 310 320 330 340 430 440 450 460 470 480 pF1KB5 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGTFRTSS 350 360 370 380 390 400 490 pF1KB5 VLRLTIIVGPFSF ::::::::::::: XP_016 VLRLTIIVGPFSF 410 >>XP_005264262 (OMIM: 126600,601548) PREDICTED: EGF-cont (543 aa) initn: 1603 init1: 1603 opt: 1742 Z-score: 1362.8 bits: 261.8 E(85289): 3.6e-69 Smith-Waterman score: 2723; 83.8% identity (83.8% similar) in 493 aa overlap (1-493:131-543) 10 20 30 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCT :::::::::::::::::::::::::::::: XP_005 SPRCPGPERSAAAQVFLLCCARNSASSRFTMLKALFLTMLTLALVKSQDTEETITYTQCT 110 120 130 140 150 160 40 50 60 70 80 90 pF1KB5 DGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGYEWDPVRQQCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQP 170 180 190 200 210 220 100 110 120 130 140 150 pF1KB5 AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AEGTSGATTGVVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIP 230 240 250 260 270 280 160 170 180 190 200 210 pF1KB5 SNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SNPSHRIQCAAGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGE 290 300 310 320 330 340 220 230 240 250 260 270 pF1KB5 QCVDIDECTIPPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYN :::::::: XP_005 QCVDIDEC---------------------------------------------------- 280 290 300 310 320 330 pF1KB5 ILGSFICQCNQGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR :::::::::::::::::::::::::::::::: XP_005 ----------------------------RTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSR 350 360 370 380 340 350 360 370 380 390 pF1KB5 TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TCQDINECETTNECREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELP 390 400 410 420 430 440 400 410 420 430 440 450 pF1KB5 QSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSIVYKYMSIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLV 450 460 470 480 490 500 460 470 480 490 pF1KB5 LVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF ::::::::::::::::::::::::::::::::::::::::::: XP_005 LVKSLSGPREHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF 510 520 530 540 >>NP_058634 (OMIM: 604633,614437) EGF-containing fibulin (443 aa) initn: 1790 init1: 692 opt: 1550 Z-score: 1215.5 bits: 234.2 E(85289): 5.8e-61 Smith-Waterman score: 1793; 50.0% identity (70.6% similar) in 494 aa overlap (1-493:13-443) 10 20 30 40 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDEC .: ::.: .: : . ::.:: .::.::::::::: :.:.:..:: NP_058 MLPCASCLPGSLLLWALLLLLLGSA--SPQDSEEPDSYTECTDGYEWDPDSQHCRDVNEC 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 DIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMA .:.:::: :::.::::::::::..: .: :. NP_058 LTIPEACKGEMKCINHYGGYLCLPRSAAVI--ND-------------------------- 60 70 80 90 110 120 130 140 150 160 pF1KB5 TSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEH : : :: :. : . : :: : ::: ... NP_058 ----LHG----------EGPP------------PPVPPAQHP-NP-----CPPGYEPDDQ 100 110 170 180 190 200 210 220 pF1KB5 NVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRC . : :.:::. . :.:: .: : :: ::. : :: ::.: : .::::::: ::..:: NP_058 DSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYR-YCQHRC 120 130 140 150 160 170 230 240 250 260 270 280 pF1KB5 VNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSD :: :::: ::: :::::. :: .:::.:::: . : :.:.: :.:.:.:.::::: : NP_058 VNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRD 180 190 200 210 220 230 290 300 310 320 330 340 pF1KB5 RLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVRSRTCQDINECET-TNECRED ..: ::::: :::::::.:.::::.::: ::::::.. .: ::::.:::. ...: : NP_058 GFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEA 240 250 260 270 280 290 350 360 370 380 390 400 pF1KB5 EMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVP . : :.:::.:: : : .::: . ::::.::.:: .::: :.:::..::.: :.:::: NP_058 QTCVNFHGGYRCVDTNRCVEPYIQVSENRCLCPASNPLCREQPSSIVHRYMTITSERSVP 300 310 320 330 340 350 410 420 430 440 450 460 pF1KB5 SDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEM .:.::::::..: .. :.:.:..:: .:.::.:: . :::::::.. ..::::...:::: NP_058 ADVFQIQATSVYPGAYNAFQIRAGNSQGDFYIRQINNVSAMLVLARPVTGPREYVLDLEM 360 370 380 390 400 410 470 480 490 pF1KB5 LTVSSIGTFRTSSVLRLTIIVGPFSF .:..:. ..:.:::::::..:: ..: NP_058 VTMNSLMSYRASSVLRLTVFVGAYTF 420 430 440 >>XP_016876418 (OMIM: 219100,604580,608895,614434) PREDI (392 aa) initn: 1290 init1: 534 opt: 1304 Z-score: 1026.1 bits: 199.0 E(85289): 2e-50 Smith-Waterman score: 1304; 48.3% identity (72.0% similar) in 354 aa overlap (144-493:40-392) 120 130 140 150 160 170 pF1KB5 PGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNP--SHRIQCAAGYEQSEHNVC : : :. : :. . : ::...: : : XP_016 YLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQC 10 20 30 40 50 60 180 190 200 210 220 230 pF1KB5 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNT :.:::.. .:.: :.::: .:...:.: :: ::.::::: ::.: :.:. XP_016 VDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANV 70 80 90 100 110 120 240 250 260 270 280 290 pF1KB5 PGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLN :::. : :.::: : .. .: :.::: . : :.: : : :::::.:. :::: : .. XP_016 PGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVH 130 140 150 160 170 180 300 310 320 330 340 pF1KB5 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEM : :.::: : .:::..:::.:: . : :: :: .. .:.:::::::: :. : .. XP_016 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 190 200 210 220 230 240 350 360 370 380 390 400 pF1KB5 CWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSD :.: .:::.: :..::. .:::.::. : ::. : .:.:. :.. : ::::.: XP_016 CYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPAD 250 260 270 280 290 300 410 420 430 440 450 460 pF1KB5 IFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLT :::.:::: : .. :.::::::. :::.:::.:.:: ::... ..:::: .::::.: XP_016 IFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMIT 310 320 330 340 350 360 470 480 490 pF1KB5 VSSIGTFRTSSVLRLTIIVGPFSF :... .:: :::.:: : :. . : XP_016 VNTVINFRGSSVIRLRIYVSQYPF 370 380 390 >>NP_006320 (OMIM: 219100,604580,608895,614434) fibulin- (448 aa) initn: 1431 init1: 534 opt: 1304 Z-score: 1025.4 bits: 199.1 E(85289): 2.2e-50 Smith-Waterman score: 1445; 42.8% identity (65.1% similar) in 493 aa overlap (3-493:6-448) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKG . : .:.:.: : . ... .:::.:.. : :: ::::: .:.::.: NP_006 MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRG 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 GMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGG : :::. :::::.:.: . . : ..: : :: : NP_006 DMMCVNQNGGYLCIPRTNPVY---RGPY--SNPY--------------STPYSGPYP--- 60 70 80 90 120 130 140 150 160 170 pF1KB5 FVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDEC :.: ...:.. : : : : . : ::...: : : :.::: NP_006 --AAAPPLSAPNYPT------ISR----P----------LICRFGYQMDESNQCVDVDEC 100 110 120 130 180 190 200 210 220 230 pF1KB5 TAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYC .. .:.: :.::: .:...:.: :: ::.::::: ::.: :.:.:::. : NP_006 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSC 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB5 QCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE :.::: : .. .: :.::: . : :.: : : :::::.:. :::: : ..: :.:: NP_006 TCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB5 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHG : : .:::..:::.:: . : :: :: .. .:.:::::::: :. : .. :.: .: NP_006 CSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQG 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB5 GFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQA ::.: :..::. .:::.::. : ::. : .:.:. :.. : ::::.::::.:: NP_006 GFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KB5 TTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGT :: : .. :.::::::. :::.:::.:.:: ::... ..:::: .::::.::... . NP_006 TTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDLEMITVNTVIN 380 390 400 410 420 430 480 490 pF1KB5 FRTSSVLRLTIIVGPFSF :: :::.:: : :. . : NP_006 FRGSSVIRLRIYVSQYPF 440 >>XP_005267324 (OMIM: 219100,604580,608895,614434) PREDI (465 aa) initn: 1431 init1: 534 opt: 1304 Z-score: 1025.2 bits: 199.1 E(85289): 2.3e-50 Smith-Waterman score: 1443; 43.0% identity (65.2% similar) in 491 aa overlap (5-493:25-465) 10 20 30 40 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQ : .:.:.: : . ... .:::.:.. : XP_005 MFVWDSHRSFKPMRSGNCRQRYMILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSG 10 20 30 40 50 50 60 70 80 90 100 pF1KB5 QCKDIDECDIVPDACKGGMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTG :: ::::: .:.::.: : :::. :::::.:.: . . : ..: XP_005 QCLDIDECRTIPEACRGDMMCVNQNGGYLCIPRTNPVY---RGPY--SNPY--------- 60 70 80 90 100 110 120 130 140 150 160 pF1KB5 VVAASSMATSGVLPGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCA : :: : :.: ...:.. : : : : . : XP_005 -----STPYSGPYP-----AAAPPLSAPNYPT------ISR-P-------------LICR 110 120 130 170 180 190 200 210 220 pF1KB5 AGYEQSEHNVCQDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTI ::...: : : :.:::.. .:.: :.::: .:...:.: :: ::.::::: XP_005 FGYQMDESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRY 140 150 160 170 180 190 230 240 250 260 270 280 pF1KB5 PPYCHQRCVNTPGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCN ::.: :.:.:::. : :.::: : .. .: :.::: . : :.: : : :::::.:. XP_005 G-YCQQLCANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCD 200 210 220 230 240 250 290 300 310 320 330 pF1KB5 QGYELSSDRLNCEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECE :::: : ..: :.::: : .:::..:::.:: . : :: :: .. .:.:::::::: XP_005 PGYELEEDGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECE 260 270 280 290 300 310 340 350 360 370 380 390 pF1KB5 TTNE-CREDEMCWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYM :. : .. :.: .:::.: :..::. .:::.::. : ::. : .:.:. : XP_005 HRNHTCNLQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDM 320 330 340 350 360 370 400 410 420 430 440 450 pF1KB5 SIRSDRSVPSDIFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGP .. : ::::.::::.:::: : .. :.::::::. :::.:::.:.:: ::... ..:: XP_005 DVVSGRSVPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGP 380 390 400 410 420 430 460 470 480 490 pF1KB5 REHIVDLEMLTVSSIGTFRTSSVLRLTIIVGPFSF :: .::::.::... .:: :::.:: : :. . : XP_005 REIQLDLEMITVNTVINFRGSSVIRLRIYVSQYPF 440 450 460 >>XP_011534660 (OMIM: 219100,604580,608895,614434) PREDI (408 aa) initn: 1121 init1: 478 opt: 1135 Z-score: 895.4 bits: 174.9 E(85289): 3.9e-43 Smith-Waterman score: 1135; 46.4% identity (70.3% similar) in 317 aa overlap (144-456:40-355) 120 130 140 150 160 170 pF1KB5 PGGGFVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNP--SHRIQCAAGYEQSEHNVC : : :. : :. . : ::...: : : XP_011 YLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMDESNQC 10 20 30 40 50 60 180 190 200 210 220 230 pF1KB5 QDIDECTAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNT :.:::.. .:.: :.::: .:...:.: :: ::.::::: ::.: :.:. XP_011 VDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANV 70 80 90 100 110 120 240 250 260 270 280 290 pF1KB5 PGSFYCQCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLN :::. : :.::: : .. .: :.::: . : :.: : : :::::.:. :::: : .. XP_011 PGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVH 130 140 150 160 170 180 300 310 320 330 340 pF1KB5 CEDIDECRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEM : :.::: : .:::..:::.:: . : :: :: .. .:.:::::::: :. : .. XP_011 CSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQT 190 200 210 220 230 240 350 360 370 380 390 400 pF1KB5 CWNYHGGFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSD :.: .:::.: :..::. .:::.::. : ::. : .:.:. :.. : ::::.: XP_011 CYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPAD 250 260 270 280 290 300 410 420 430 440 450 460 pF1KB5 IFQIQATTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLT :::.:::: : .. :.::::::. :::.:.. ..:. . ..:: XP_011 IFQMQATTRYPGAYYIFQIKSGNEGREFYMRRAFSTTAYEASSQALSVEKQTGCGLCPGG 310 320 330 340 350 360 470 480 490 pF1KB5 VSSIGTFRTSSVLRLTIIVGPFSF XP_011 THTHLSGEGENNLANTTQSGDSQVKSRPMGCKRAPSVPPW 370 380 390 400 >>XP_011534659 (OMIM: 219100,604580,608895,614434) PREDI (464 aa) initn: 1262 init1: 478 opt: 1135 Z-score: 894.7 bits: 174.9 E(85289): 4.3e-43 Smith-Waterman score: 1276; 41.0% identity (63.4% similar) in 456 aa overlap (3-456:6-411) 10 20 30 40 50 pF1KB5 MLKALFLTMLTLALVKSQDTEETITYTQCTDGYEWDPVRQQCKDIDECDIVPDACKG . : .:.:.: : . ... .:::.:.. : :: ::::: .:.::.: XP_011 MPGIKRILTVTILALCLPSPGNAQ-----AQCTNGFDLDRQSGQCLDIDECRTIPEACRG 10 20 30 40 50 60 70 80 90 100 110 pF1KB5 GMKCVNHYGGYLCLPKTAQIIVNNEQPQQETQPAEGTSGATTGVVAASSMATSGVLPGGG : :::. :::::.:.: . . : ..: : :: : XP_011 DMMCVNQNGGYLCIPRTNPVY---RGPY--SNPY--------------STPYSGPYP--- 60 70 80 90 120 130 140 150 160 170 pF1KB5 FVASAAAVAGPEMQTGRNNFVIRRNPADPQRIPSNPSHRIQCAAGYEQSEHNVCQDIDEC :.: ...:.. : : : : . : ::...: : : :.::: XP_011 --AAAPPLSAPNYPT------ISR-P-------------LICRFGYQMDESNQCVDVDEC 100 110 120 130 180 190 200 210 220 230 pF1KB5 TAGTHNCRADQVCINLRGSFACQCPPGYQKRGEQCVDIDECTIPPYCHQRCVNTPGSFYC .. .:.: :.::: .:...:.: :: ::.::::: ::.: :.:.:::. : XP_011 ATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYG-YCQQLCANVPGSYSC 140 150 160 170 180 190 240 250 260 270 280 290 pF1KB5 QCSPGFQLAANNYTCVDINECDASNQCAQQCYNILGSFICQCNQGYELSSDRLNCEDIDE :.::: : .. .: :.::: . : :.: : : :::::.:. :::: : ..: :.:: XP_011 TCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEEDGVHCSDMDE 200 210 220 230 240 250 300 310 320 330 340 350 pF1KB5 CRTSSYLCQYQCVNEPGKFSCMCPQGYQVVR-SRTCQDINECETTNE-CREDEMCWNYHG : : .:::..:::.:: . : :: :: .. .:.:::::::: :. : .. :.: .: XP_011 CSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCNLQQTCYNLQG 260 270 280 290 300 310 360 370 380 390 400 410 pF1KB5 GFRCYPRNPCQDPYILTPENRCVCPVSNAMCRELPQSIVYKYMSIRSDRSVPSDIFQIQA ::.: :..::. .:::.::. : ::. : .:.:. :.. : ::::.::::.:: XP_011 GFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRSVPADIFQMQA 320 330 340 350 360 370 420 430 440 450 460 470 pF1KB5 TTIYANTINTFRIKSGNENGEFYLRQTSPVSAMLVLVKSLSGPREHIVDLEMLTVSSIGT :: : .. :.::::::. :::.:.. ..:. . ..:: XP_011 TTRYPGAYYIFQIKSGNEGREFYMRRAFSTTAYEASSQALSVEKQTGCGLCPGGTHTHLS 380 390 400 410 420 430 480 490 pF1KB5 FRTSSVLRLTIIVGPFSF XP_011 GEGENNLANTTQSGDSQVKSRPMGCKRAPSVPPW 440 450 460 493 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:22:55 2016 done: Sat Nov 5 15:22:56 2016 Total Scan time: 8.430 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]