Result of FASTA (omim) for
pF1KB5878
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB5878, 495 aa
1>>>pF1KB5878 495 - 495 aa - 495 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 15.7845+/-0.000679; mu= -29.3790+/- 0.042
mean_var=819.3930+/-168.923, 0's: 0 Z-trim(117.3): 62 B-trim: 0 in 0/58
Lambda= 0.044805
statistics sampled from 29095 (29136) to 29095 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.342), width: 16
Scan time: 10.960
The best scores are: opt bits E(85289)
NP_060835 (OMIM: 610766) meiosis-specific nuclear ( 495) 3125 217.9 5.5e-56
NP_009044 (OMIM: 190370) trichohyalin [Homo sapien (1943) 420 43.6 0.0062
NP_036469 (OMIM: 605152) cilia- and flagella-assoc ( 551) 393 41.3 0.0086
>>NP_060835 (OMIM: 610766) meiosis-specific nuclear stru (495 aa)
initn: 3125 init1: 3125 opt: 3125 Z-score: 1126.1 bits: 217.9 E(85289): 5.5e-56
Smith-Waterman score: 3125; 99.8% identity (99.8% similar) in 495 aa overlap (1-495:1-495)
10 20 30 40 50 60
pF1KB5 MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB5 QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB5 LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB5 NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB5 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB5 ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMAL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB5 KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB5 ADKQRGLEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE
::::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEE
430 440 450 460 470 480
490
pF1KB5 FRKVYQQRSEICEEK
:::::::::::::::
NP_060 FRKVYQQRSEICEEK
490
>>NP_009044 (OMIM: 190370) trichohyalin [Homo sapiens] (1943 aa)
initn: 350 init1: 141 opt: 420 Z-score: 173.6 bits: 43.6 E(85289): 0.0062
Smith-Waterman score: 450; 25.8% identity (62.9% similar) in 450 aa overlap (12-435:266-700)
10 20 30 40
pF1KB5 MGSKRRNLSCSERHQKLVDEN-YCKKLHVQALKNVNSQIRN
.:...: .:. .::. : :. :.
NP_009 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR------RE
240 250 260 270 280
50 60 70 80 90
pF1KB5 QMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAE-----ENKRLKELQLKQEEKLAM
.. ......:..:.: :: :.:. . ..:: .. : :..: ..:. .:::. .
NP_009 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ
290 300 310 320 330 340
100 110 120 130 140
pF1KB5 ELAKLKHESLKDEKMR---------QQVRENSIELRELEKKLKAAYMNKE----RAAQIA
.: . ..: .....: ::.:... .::. .. . . .: : :.
NP_009 QLRREQEEERREQQLRREQEEERREQQLRREQ-QLRREQQLRREQQLRREQQLRREQQLR
350 360 370 380 390 400
150 160 170 180 190 200
pF1KB5 EKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKK
... .. ::. : . . .::... :.:. ...: : . . : :. :: :...
NP_009 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE
410 420 430 440 450 460
210 220 230 240 250 260
pF1KB5 QEAYEQLLKEKLMIDEIVR--KIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKR
:: .: ::. .. : :. ::.. :.:.. :.. .:: :: ..:: : :..
NP_009 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ--LRREQEE-RREQ---RLKRQ
470 480 490 500 510 520
270 280 290 300 310
pF1KB5 EEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDL----
:: :. .... ......:: : ....:::::. :. :.:.. ..:.:
NP_009 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE-QERREQRLKREQEERRDQLLKR
530 540 550 560 570 580
320 330 340 350 360 370
pF1KB5 -EQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENF
:. ::. ..:: : ...::.: ..:..... .: .... .: : : ::..
NP_009 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE
590 600 610 620 630 640
380 390 400 410 420 430
pF1KB5 RKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRGLEEWQLQQR
:. . . ...: : .... ..::.: :. ::::.: ::.... . ....:
NP_009 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHE-EERREQELAEEEQEQARERIKSR
650 660 670 680 690 700
440 450 460 470 480 490
pF1KB5 RQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK
NP_009 IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE
710 720 730 740 750 760
>--
initn: 350 init1: 141 opt: 427 Z-score: 176.1 bits: 44.0 E(85289): 0.0046
Smith-Waterman score: 433; 23.8% identity (60.6% similar) in 513 aa overlap (11-487:777-1281)
10 20 30
pF1KB5 MGSKRRNLSCSER-HQKLVDENYCKKLHVQALKNVNSQIR
::: .:.: . .. . . :. . : :
NP_009 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR
750 760 770 780 790 800
40 50 60 70 80 90
pF1KB5 NQMVQNENDNRVQRKQFLRLLQNE-QFELDMEEAIQKAEENKRLKE----LQLKQEEKLA
.: :.... ::.. : ..: :: :. :: .:. :. ..:.: :: ::.. .
NP_009 EQRFLPEEEEKEQRRRQRREREKELQF-LEEEEQLQRRERAQQLQEEEDGLQEDQERRRS
810 820 830 840 850 860
100 110 120 130 140 150
pF1KB5 MELAKLKHESLKDEKMRQQVREN---SIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQ
.: . .. . :. :.. :.. . :.: .: . ...:. : :.. . ..
NP_009 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE
870 880 890 900 910 920
160 170 180 190 200
pF1KB5 MKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDL-----EKQL--EEQEKKKQE
..:. . . ...:......:: . .:.. . :: : :.:: :: ::....
NP_009 QERQYREEEQLQQEEEQLLREERE-KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ
930 940 950 960 970 980
210 220 230 240 250 260
pF1KB5 AYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKK-REEM
:. .:. ... ... .:.. ::... : .:. : :.:. : :... ....
NP_009 EREKKYREEEELQQEEEQLLREER-EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL
990 1000 1010 1020 1030 1040
270 280 290 300 310
pF1KB5 EEENRKIIEFANMQQQRE----EDRMAKVQENEEKRLQLQNALTQKLEEMLRQ----RED
.:..:. : ..::..: :.: .. ... :.. . .. : :. :..::. :.
NP_009 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR
1050 1060 1070 1080 1090 1100
320 330 340 350 360 370
pF1KB5 LEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENF
:. :: .:: . .. :.:: :: :...:......:. ... : .:: :.
NP_009 QERERQCREEEELQQEEEQLLREEREK--RRRQELERQYREEEEVQQEEEQLLREEPEKR
1110 1120 1130 1140 1150 1160
380 390 400 410 420
pF1KB5 RKTMLAK-FAEDDRIE-----LMNAQKQRMKQLEHR--RAVEKLIEERRQQFLADK-QRG
:. : . . :..... :. .... .: ..: : :.: ...:.: :. ::.
NP_009 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS
1170 1180 1190 1200 1210 1220
430 440 450 460 470 480
pF1KB5 LEEWQLQQRRQGFI--NAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKV
.:: . .... . : . . : . :. .: . ...: ::::. ..
NP_009 DLKWQWEPEKENAVRDNKVYCKGREN---EQFRQLEDSQLRDRQSQQDLQHLLGEQQERD
1230 1240 1250 1260 1270
490
pF1KB5 YQQRSEICEEK
.:
NP_009 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF
1280 1290 1300 1310 1320 1330
>>NP_036469 (OMIM: 605152) cilia- and flagella-associate (551 aa)
initn: 300 init1: 300 opt: 393 Z-score: 171.1 bits: 41.3 E(85289): 0.0086
Smith-Waterman score: 393; 24.8% identity (63.5% similar) in 419 aa overlap (61-459:127-530)
40 50 60 70 80
pF1KB5 LKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRL---KELQL
... :. . : ... . :.. ::.
NP_036 PSGESLIISPEEFERIKWASHVLTREELEARDQAFKKEKEATMDAVMTRKKIMKQKEMVW
100 110 120 130 140 150
90 100 110 120 130 140
pF1KB5 KQEEKLA--MELAKLKHESL--KDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAE
....::. :.:: . ..: . .:.:.. .: ::... : . : . : ::: :
NP_036 NNNKKLSDLEEVAKERAQNLLQRANKLRMEQEE---ELKDMSKIILNAKCHAIRDAQILE
160 170 180 190 200 210
150 160 170 180 190 200
pF1KB5 KDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQ
:. :. : .. .. . : :... :.... : :: . . . .. .:.:.......
NP_036 KQQIQKELDTEEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERS
220 230 240 250 260 270
210 220 230 240 250
pF1KB5 EAYEQLLKEKLMIDEIVRKIYEED--QLEK--QQKLEKMNAMRRYIEEFQKEQA--LWRK
:: .:: .. : .... ::: ..:. ::::. . ..: .: ::..: : ..
NP_036 LLAEQREQEKEQMLEYMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQE
280 290 300 310 320 330
260 270 280 290 300 310
pF1KB5 KKREEMEEENRKIIEFANMQQQRE---EDRMAKVQENEEKRLQLQNALTQKLEEMLRQRE
: ..: ..::.. .. :: : .. ......::.. :. .: ... ...
NP_036 KLADQM------VMEFTKKKMAREAEFEAEQERIRREKEKEIARLRAMQEKAQDYQAEQD
340 350 360 370 380
320 330 340 350 360 370
pF1KB5 DLEQVR-QELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKE--LVLQAAKEE
:. : ::. ..: .. : ::.:.::.. . :.... ::.:.:: :..:. ...
NP_036 ALRAKRNQEVADRE----WRRKEKENARKKMETEAELRKSRLEQVAFKEHALAVQVQRDR
390 400 410 420 430 440
380 390 400 410 420 430
pF1KB5 EENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRGLEEWQ
.: :.. . :. . .. : .. .:. .:.: ... ..: .:. . .. .:: .
NP_036 DE-FERILRAQREQIEK-ERLEEEKKATGRLQHANELRRQVRENQQKEVQNRIATFEEGR
450 460 470 480 490 500
440 450 460 470 480 490
pF1KB5 -LQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSE
:... : . : : .: :: . .::.:
NP_036 RLKEEAQKRRERIDEIKRKKLEELRATGLPEKYCIEAERKANILPATSVN
510 520 530 540 550
495 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 08:21:01 2016 done: Sat Nov 5 08:21:03 2016
Total Scan time: 10.960 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]