FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5891, 498 aa 1>>>pF1KB5891 498 - 498 aa - 498 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 16.3205+/-0.00127; mu= -28.6639+/- 0.077 mean_var=857.7629+/-175.585, 0's: 0 Z-trim(117.8): 125 B-trim: 0 in 0/55 Lambda= 0.043792 statistics sampled from 18490 (18598) to 18490 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.811), E-opt: 0.2 (0.571), width: 16 Scan time: 4.320 The best scores are: opt bits E(32554) CCDS304.1 WASF2 gene_id:10163|Hs108|chr1 ( 498) 3525 237.7 2.3e-62 CCDS55582.1 WASF2 gene_id:10163|Hs108|chr1 ( 281) 1841 131.0 1.6e-30 CCDS76626.1 WASF3 gene_id:10810|Hs108|chr13 ( 499) 1690 121.7 1.8e-27 CCDS9318.1 WASF3 gene_id:10810|Hs108|chr13 ( 502) 1590 115.4 1.5e-25 CCDS5080.1 WASF1 gene_id:8936|Hs108|chr6 ( 559) 1240 93.4 7.2e-19 >>CCDS304.1 WASF2 gene_id:10163|Hs108|chr1 (498 aa) initn: 3525 init1: 3525 opt: 3525 Z-score: 1233.1 bits: 237.7 E(32554): 2.3e-62 Smith-Waterman score: 3525; 100.0% identity (100.0% similar) in 498 aa overlap (1-498:1-498) 10 20 30 40 50 60 pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 FAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS30 SDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVE 430 440 450 460 470 480 490 pF1KB5 YSDSEDDSSEFDEDDWSD :::::::::::::::::: CCDS30 YSDSEDDSSEFDEDDWSD 490 >>CCDS55582.1 WASF2 gene_id:10163|Hs108|chr1 (281 aa) initn: 1841 init1: 1841 opt: 1841 Z-score: 661.3 bits: 131.0 E(32554): 1.6e-30 Smith-Waterman score: 1841; 99.3% identity (99.6% similar) in 276 aa overlap (1-276:1-276) 10 20 30 40 50 60 pF1KB5 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 FASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 LETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 EKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVEN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHP :::::::::::::::::::::::::::::::::: . CCDS55 VDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFRFSAAQG 250 260 270 280 310 320 330 340 350 360 pF1KB5 PPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPD >>CCDS76626.1 WASF3 gene_id:10810|Hs108|chr13 (499 aa) initn: 1190 init1: 1190 opt: 1690 Z-score: 606.6 bits: 121.7 E(32554): 1.8e-27 Smith-Waterman score: 1690; 53.5% identity (71.5% similar) in 512 aa overlap (1-498:1-499) 10 20 30 40 50 pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..:: CCDS76 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP .: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: : CCDS76 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR : . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::... CCDS76 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 KEK-KDNPNRGN-VNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGC .:: : ::::.. :: ::..:::::::. ::: ::. . .:: .: .:: CCDS76 REKHKLNPNRNQQVNVRKVRTRKEEWERRKMGIEFMSDAKKLEQAGSAKEDRVPSGS--H 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 VENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKRSSVV . .: ::: :. . .: .::.. ..:: :: : .... :. .. .. CCDS76 ASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARHMALN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 SPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSF :..::: :: .: : . : : : :. : .. : :::: :: . CCDS76 RPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPPPPVI 300 310 320 330 340 360 370 380 390 400 pF1KB5 PP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPPPPPF : . :..: : :: ::. : :: :: ::::: ::::::::: : CCDS76 PSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPPGPG- 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 TGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDVVG .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: ::. :: CCDS76 SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVG 410 420 430 440 450 460 470 480 490 pF1KB5 NDVATILSRRIAVEYSDSEDDSSEFDEDDWSD ::::::::::::::::::.::: ::::.:::: CCDS76 NDVATILSRRIAVEYSDSDDDS-EFDENDWSD 470 480 490 >>CCDS9318.1 WASF3 gene_id:10810|Hs108|chr13 (502 aa) initn: 869 init1: 869 opt: 1590 Z-score: 572.4 bits: 115.4 E(32554): 1.5e-25 Smith-Waterman score: 1590; 50.6% identity (70.7% similar) in 516 aa overlap (1-498:1-502) 10 20 30 40 50 pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN :::: :::::::::: .:: .. :::::::: ::: .::::.::::.:::::::::..:: CCDS93 MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEAN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP .: :..:: .:.::: ::::::: :::::: :: .:::.:::.:::.. ..::.: : CCDS93 NFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR : . :: : ::::: ::::::: :..::::::::::::::::::::::.: ::::... CCDS93 VADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB5 KEKK-DNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIG-- ..:. :. .: . :: ..:..::. : . .:. . ..:. : : . ..::.. CCDS93 EQKRIDGTTREVKKVRKARNRRQEWNMMAYDKEL-RPDNRLSQSVYHGA--SSEGSLSPD 190 200 210 220 230 240 250 260 270 280 290 pF1KB5 ---CVENVDASSYPPPPQSDSASSP-SPSFSEDNLPPP-PAEFSYPVDNQRGSGLAGPKR . .: ::: :. . .: .::.. ..:: :: : .... :. .. CCDS93 TRSHASDVTDYSYPATPNHSLHPQPVTPSYAAGDVPPHGPA--SQAAEHEYRPPSASARH 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB5 SSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPS .. :..::: :: .: : . : : : :. : .. : :::: CCDS93 MALNRPQQPPPPPPPQAPEGSQ-------ASAPMAPADYGMLPAQIIEYYNPSGPPPPPP 300 310 320 330 340 360 370 380 390 400 pF1KB5 PPSFPP-HPDFAAP---PPPPPPPAADYPTLPPPPLSQPTG---GAPPPP-PPPPPPGPP :: .: . :..: : :: ::. : :: :: ::::: ::::::::: CCDS93 PPVIPSAQTAFVSPLQMPMQPPFPASASSTHAAPPHPPSTGLLVTAPPPPGPPPPPPGPP 350 360 370 380 390 400 410 420 430 440 450 460 pF1KB5 PPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KR : .. ...: ::.... . . . : .::::::::.:::.:.::..:.:::::: :: CCDS93 GPG-SSLSSSPMHGPPVAEAKRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKR 410 420 430 440 450 460 470 480 490 pF1KB5 DVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD . ::::::::::::::::::::.::: ::::.:::: CCDS93 EPVGNDVATILSRRIAVEYSDSDDDS-EFDENDWSD 470 480 490 500 >>CCDS5080.1 WASF1 gene_id:8936|Hs108|chr6 (559 aa) initn: 1140 init1: 954 opt: 1240 Z-score: 452.3 bits: 93.4 E(32554): 7.2e-19 Smith-Waterman score: 1490; 48.6% identity (65.9% similar) in 545 aa overlap (1-469:1-531) 10 20 30 40 50 pF1KB5 MPLVTRNIEPRHLCRQTLP-SVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQAN :::: :::.:::::. .:: ....::::::::.:::.::::.::::::::::::::..:. CCDS50 MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB5 TFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVP .:. ::.:: ::::::.:.::::::::::.::: :. ::::::::::::.::::..::.: CCDS50 SFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB5 VLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHR . :::..:. ::::: ::::::::::.:::::.::::::::::::::::.: :::::.. CCDS50 LQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQK 130 140 150 160 170 180 180 190 200 210 220 pF1KB5 KEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKL---------GTSGY----PP ... : :.. . :: . :..::.:. .: :..:. .: : ... : CCDS50 QKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDANLLHKHIEVANGPASHFETRPQ 190 200 210 220 230 240 230 240 250 260 270 pF1KB5 TLV-YQNGSIGCV---------------ENVDASSYPPPPQSDSASSPSPSFSEDNLPPP : : ...:: . : : . . ::: : : . . : CCDS50 TYVDHMDGSYSLSALPFSQMSELLTRAEERVLVRPHEPPP-------PPPMHGAGDAKPI 250 260 270 280 290 280 290 300 310 320 pF1KB5 PAEFSYP---VDNQRGSGLAGPKRSSV-VSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPP :. .: ..:. : .: :. : :::. ::: ::: : . . : . :::: CCDS50 PTCISSATGLIENRPQSPATG--RTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPP 300 310 320 330 340 350 330 340 350 360 370 pF1KB5 -PPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPP--PP-----PPPAADYP-- :: ::::: ... .:..::::.: .. : :::: :: :: : : CCDS50 VPP----PPPPPATALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVC 360 370 380 390 400 380 390 400 410 pF1KB5 -TLPPPPLSQ-PTGGAPPPPPPPP--PPG--------------PP----PPPFTGADGQ- :.: :: : . : :::::::: ::: :: : : : : : CCDS50 ETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVTALAHPPSGLHPTPST-APGPH 410 420 430 440 450 460 420 430 440 450 460 pF1KB5 -PAIPP-------PLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQE-KRDV : .:: : :. . :.::..::::: :: :::.:.:::.:::::::: :.. CCDS50 VPLMPPSPPSQVIPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHER 470 480 490 500 510 520 470 480 490 pF1KB5 VGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD . ::: CCDS50 IENDVATILSRRIAVEYSDSEDDSEFDEVDWLE 530 540 550 498 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 15:28:39 2016 done: Sat Nov 5 15:28:40 2016 Total Scan time: 4.320 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]